Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9L2_LEIMA

TriTrypDb:

LmjF.25.2240 , LMJLV39_250030100 , LMJSD75_250030300

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q9L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9L2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.366
CLV_NRD_NRD_1	151	153	PF00675	0.659
CLV_NRD_NRD_1	399	401	PF00675	0.752
CLV_NRD_NRD_1	437	439	PF00675	0.689
CLV_NRD_NRD_1	457	459	PF00675	0.625
CLV_NRD_NRD_1	469	471	PF00675	0.653
CLV_NRD_NRD_1	516	518	PF00675	0.483
CLV_NRD_NRD_1	526	528	PF00675	0.393
CLV_PCSK_KEX2_1	153	155	PF00082	0.661
CLV_PCSK_KEX2_1	399	401	PF00082	0.716
CLV_PCSK_KEX2_1	437	439	PF00082	0.636
CLV_PCSK_KEX2_1	457	459	PF00082	0.664
CLV_PCSK_KEX2_1	469	471	PF00082	0.653
CLV_PCSK_KEX2_1	515	517	PF00082	0.494
CLV_PCSK_KEX2_1	526	528	PF00082	0.390
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.661
CLV_PCSK_SKI1_1	153	157	PF00082	0.577
CLV_PCSK_SKI1_1	249	253	PF00082	0.623
CLV_PCSK_SKI1_1	306	310	PF00082	0.584
CLV_PCSK_SKI1_1	411	415	PF00082	0.701
CLV_Separin_Metazoa	372	376	PF03568	0.441
DEG_COP1_1	250	260	PF00400	0.404
DEG_Nend_UBRbox_2	1	3	PF02207	0.433
DOC_ANK_TNKS_1	322	329	PF00023	0.407
DOC_CYCLIN_RxL_1	151	160	PF00134	0.354
DOC_CYCLIN_RxL_1	303	312	PF00134	0.375
DOC_CYCLIN_yCln2_LP_2	206	209	PF00134	0.520
DOC_MAPK_DCC_7	203	212	PF00069	0.517
DOC_MAPK_gen_1	152	159	PF00069	0.376
DOC_MAPK_gen_1	437	443	PF00069	0.481
DOC_MAPK_MEF2A_6	203	212	PF00069	0.471
DOC_MAPK_RevD_3	504	517	PF00069	0.294
DOC_PP1_RVXF_1	364	370	PF00149	0.459
DOC_PP2B_LxvP_1	206	209	PF13499	0.555
DOC_USP7_MATH_1	127	131	PF00917	0.423
DOC_USP7_MATH_1	256	260	PF00917	0.445
DOC_USP7_MATH_1	376	380	PF00917	0.507
DOC_USP7_MATH_1	398	402	PF00917	0.567
DOC_USP7_MATH_1	447	451	PF00917	0.534
DOC_USP7_MATH_1	462	466	PF00917	0.412
DOC_USP7_MATH_1	71	75	PF00917	0.486
DOC_USP7_MATH_1	95	99	PF00917	0.404
DOC_WW_Pin1_4	14	19	PF00397	0.541
DOC_WW_Pin1_4	309	314	PF00397	0.429
LIG_14-3-3_CanoR_1	147	151	PF00244	0.422
LIG_14-3-3_CanoR_1	19	29	PF00244	0.475
LIG_14-3-3_CanoR_1	249	255	PF00244	0.358
LIG_14-3-3_CanoR_1	296	304	PF00244	0.376
LIG_14-3-3_CanoR_1	332	337	PF00244	0.478
LIG_14-3-3_CanoR_1	366	370	PF00244	0.447
LIG_14-3-3_CanoR_1	375	384	PF00244	0.538
LIG_14-3-3_CanoR_1	399	406	PF00244	0.469
LIG_14-3-3_CanoR_1	437	442	PF00244	0.557
LIG_14-3-3_CanoR_1	469	478	PF00244	0.461
LIG_Actin_WH2_2	360	377	PF00022	0.453
LIG_BIR_III_2	403	407	PF00653	0.441
LIG_DLG_GKlike_1	332	339	PF00625	0.380
LIG_FHA_1	114	120	PF00498	0.472
LIG_FHA_1	130	136	PF00498	0.279
LIG_FHA_1	167	173	PF00498	0.453
LIG_FHA_1	175	181	PF00498	0.353
LIG_FHA_1	232	238	PF00498	0.363
LIG_FHA_1	275	281	PF00498	0.387
LIG_FHA_1	303	309	PF00498	0.451
LIG_FHA_1	316	322	PF00498	0.351
LIG_FHA_1	341	347	PF00498	0.471
LIG_FHA_1	430	436	PF00498	0.454
LIG_FHA_2	269	275	PF00498	0.477
LIG_FHA_2	45	51	PF00498	0.328
LIG_LIR_Apic_2	34	38	PF02991	0.480
LIG_LIR_Apic_2	472	478	PF02991	0.462
LIG_LIR_Gen_1	418	426	PF02991	0.424
LIG_LIR_Gen_1	499	508	PF02991	0.341
LIG_LIR_Nem_3	223	228	PF02991	0.455
LIG_LIR_Nem_3	26	31	PF02991	0.430
LIG_LIR_Nem_3	418	424	PF02991	0.506
LIG_LIR_Nem_3	499	505	PF02991	0.341
LIG_LYPXL_S_1	125	129	PF13949	0.604
LIG_LYPXL_yS_3	126	129	PF13949	0.405
LIG_NRBOX	48	54	PF00104	0.389
LIG_PCNA_yPIPBox_3	133	147	PF02747	0.383
LIG_SH2_CRK	225	229	PF00017	0.450
LIG_SH2_CRK	502	506	PF00017	0.453
LIG_SH2_STAP1	166	170	PF00017	0.370
LIG_SH2_STAP1	299	303	PF00017	0.402
LIG_SH2_STAP1	352	356	PF00017	0.366
LIG_SH2_STAT5	166	169	PF00017	0.448
LIG_SH2_STAT5	299	302	PF00017	0.361
LIG_SH2_STAT5	502	505	PF00017	0.389
LIG_SH2_STAT5	54	57	PF00017	0.466
LIG_SH3_2	453	458	PF14604	0.440
LIG_SH3_3	367	373	PF00018	0.487
LIG_SH3_3	450	456	PF00018	0.502
LIG_Sin3_3	168	175	PF02671	0.390
LIG_SUMO_SIM_par_1	312	318	PF11976	0.474
LIG_TRAF2_1	362	365	PF00917	0.538
LIG_TYR_ITIM	124	129	PF00017	0.404
LIG_WRC_WIRS_1	421	426	PF05994	0.469
LIG_WRC_WIRS_1	82	87	PF05994	0.399
MOD_CDK_SPK_2	14	19	PF00069	0.456
MOD_CK1_1	23	29	PF00069	0.519
MOD_CK1_1	250	256	PF00069	0.434
MOD_CK1_1	331	337	PF00069	0.452
MOD_CK1_1	340	346	PF00069	0.373
MOD_CK1_1	422	428	PF00069	0.532
MOD_CK1_1	44	50	PF00069	0.371
MOD_CK2_1	268	274	PF00069	0.468
MOD_CK2_1	491	497	PF00069	0.426
MOD_GlcNHglycan	105	108	PF01048	0.557
MOD_GlcNHglycan	116	119	PF01048	0.591
MOD_GlcNHglycan	129	132	PF01048	0.503
MOD_GlcNHglycan	184	187	PF01048	0.619
MOD_GlcNHglycan	22	25	PF01048	0.684
MOD_GlcNHglycan	258	261	PF01048	0.602
MOD_GlcNHglycan	443	446	PF01048	0.740
MOD_GlcNHglycan	471	474	PF01048	0.631
MOD_GlcNHglycan	497	501	PF01048	0.453
MOD_GlcNHglycan	56	60	PF01048	0.628
MOD_GSK3_1	160	167	PF00069	0.391
MOD_GSK3_1	19	26	PF00069	0.486
MOD_GSK3_1	328	335	PF00069	0.455
MOD_GSK3_1	416	423	PF00069	0.399
MOD_GSK3_1	429	436	PF00069	0.456
MOD_GSK3_1	437	444	PF00069	0.438
MOD_GSK3_1	464	471	PF00069	0.515
MOD_N-GLC_1	340	345	PF02516	0.680
MOD_N-GLC_1	42	47	PF02516	0.570
MOD_NEK2_1	148	153	PF00069	0.441
MOD_NEK2_1	157	162	PF00069	0.386
MOD_NEK2_1	233	238	PF00069	0.482
MOD_NEK2_1	273	278	PF00069	0.392
MOD_NEK2_1	304	309	PF00069	0.423
MOD_NEK2_1	31	36	PF00069	0.466
MOD_NEK2_1	315	320	PF00069	0.360
MOD_NEK2_1	346	351	PF00069	0.474
MOD_NEK2_1	41	46	PF00069	0.335
MOD_NEK2_1	481	486	PF00069	0.528
MOD_NEK2_1	496	501	PF00069	0.231
MOD_NEK2_2	447	452	PF00069	0.509
MOD_PIKK_1	315	321	PF00454	0.383
MOD_PIKK_1	346	352	PF00454	0.473
MOD_PIKK_1	405	411	PF00454	0.562
MOD_PIKK_1	95	101	PF00454	0.428
MOD_PK_1	247	253	PF00069	0.404
MOD_PKA_1	399	405	PF00069	0.563
MOD_PKA_1	437	443	PF00069	0.484
MOD_PKA_1	469	475	PF00069	0.503
MOD_PKA_2	146	152	PF00069	0.420
MOD_PKA_2	157	163	PF00069	0.346
MOD_PKA_2	221	227	PF00069	0.389
MOD_PKA_2	331	337	PF00069	0.438
MOD_PKA_2	365	371	PF00069	0.433
MOD_PKA_2	398	404	PF00069	0.564
MOD_PKA_2	429	435	PF00069	0.441
MOD_PKA_2	437	443	PF00069	0.569
MOD_PKA_2	456	462	PF00069	0.418
MOD_PKA_2	468	474	PF00069	0.465
MOD_Plk_1	315	321	PF00069	0.359
MOD_Plk_1	340	346	PF00069	0.479
MOD_Plk_1	352	358	PF00069	0.400
MOD_Plk_1	384	390	PF00069	0.509
MOD_Plk_1	496	502	PF00069	0.365
MOD_Plk_4	208	214	PF00069	0.510
MOD_Plk_4	233	239	PF00069	0.438
MOD_Plk_4	24	30	PF00069	0.511
MOD_Plk_4	268	274	PF00069	0.484
MOD_Plk_4	31	37	PF00069	0.485
MOD_Plk_4	352	358	PF00069	0.467
MOD_Plk_4	365	371	PF00069	0.374
MOD_Plk_4	44	50	PF00069	0.299
MOD_Plk_4	447	453	PF00069	0.512
MOD_Plk_4	491	497	PF00069	0.374
MOD_Plk_4	81	87	PF00069	0.367
MOD_ProDKin_1	14	20	PF00069	0.546
MOD_ProDKin_1	309	315	PF00069	0.424
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.464
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.510
TRG_ENDOCYTIC_2	126	129	PF00928	0.401
TRG_ENDOCYTIC_2	225	228	PF00928	0.450
TRG_ENDOCYTIC_2	266	269	PF00928	0.463
TRG_ENDOCYTIC_2	502	505	PF00928	0.424
TRG_ER_diArg_1	456	458	PF00400	0.503
TRG_ER_diArg_1	514	517	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.725

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD48	Leptomonas seymouri	36%	100%
A0A3S7WZJ8	Leishmania donovani	91%	100%
A4HEC9	Leishmania braziliensis	72%	99%
A4I1S4	Leishmania infantum	91%	100%
E9AXV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	95%