Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9L1_LEIMA

TriTrypDb:

LmjF.25.2250 , LMJLV39_250030200 , LMJSD75_250030400

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q9L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9L1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.578
CLV_NRD_NRD_1	126	128	PF00675	0.516
CLV_NRD_NRD_1	213	215	PF00675	0.408
CLV_NRD_NRD_1	257	259	PF00675	0.725
CLV_NRD_NRD_1	269	271	PF00675	0.609
CLV_PCSK_KEX2_1	125	127	PF00082	0.514
CLV_PCSK_KEX2_1	213	215	PF00082	0.408
CLV_PCSK_KEX2_1	257	259	PF00082	0.725
CLV_PCSK_KEX2_1	281	283	PF00082	0.763
CLV_PCSK_KEX2_1	63	65	PF00082	0.603
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.763
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.603
CLV_PCSK_PC7_1	122	128	PF00082	0.508
CLV_PCSK_SKI1_1	54	58	PF00082	0.747
DOC_MAPK_gen_1	210	219	PF00069	0.608
DOC_MAPK_MEF2A_6	210	219	PF00069	0.608
DOC_PP2B_LxvP_1	137	140	PF13499	0.730
DOC_PP4_FxxP_1	11	14	PF00568	0.635
DOC_PP4_FxxP_1	192	195	PF00568	0.780
DOC_USP7_MATH_1	181	185	PF00917	0.625
DOC_USP7_MATH_1	78	82	PF00917	0.443
DOC_WW_Pin1_4	36	41	PF00397	0.491
DOC_WW_Pin1_4	91	96	PF00397	0.461
LIG_14-3-3_CanoR_1	100	105	PF00244	0.577
LIG_14-3-3_CanoR_1	131	135	PF00244	0.578
LIG_14-3-3_CanoR_1	270	275	PF00244	0.527
LIG_BRCT_BRCA1_1	142	146	PF00533	0.683
LIG_DLG_GKlike_1	13	21	PF00625	0.618
LIG_EVH1_1	11	15	PF00568	0.635
LIG_FHA_1	116	122	PF00498	0.482
LIG_FHA_1	146	152	PF00498	0.704
LIG_FHA_1	199	205	PF00498	0.763
LIG_FHA_1	218	224	PF00498	0.214
LIG_FHA_1	72	78	PF00498	0.594
LIG_FHA_2	271	277	PF00498	0.530
LIG_LIR_Apic_2	130	135	PF02991	0.617
LIG_LIR_Apic_2	190	195	PF02991	0.779
LIG_LIR_Apic_2	231	235	PF02991	0.258
LIG_LIR_Gen_1	27	35	PF02991	0.466
LIG_LIR_Gen_1	81	91	PF02991	0.587
LIG_LIR_Nem_3	143	149	PF02991	0.590
LIG_LIR_Nem_3	260	266	PF02991	0.535
LIG_LIR_Nem_3	276	280	PF02991	0.380
LIG_LIR_Nem_3	49	53	PF02991	0.493
LIG_LIR_Nem_3	81	87	PF02991	0.496
LIG_MYND_1	135	139	PF01753	0.698
LIG_NRBOX	52	58	PF00104	0.544
LIG_NRP_CendR_1	296	298	PF00754	0.804
LIG_Pex14_2	124	128	PF04695	0.710
LIG_REV1ctd_RIR_1	190	194	PF16727	0.780
LIG_SH2_CRK	132	136	PF00017	0.620
LIG_SH2_NCK_1	132	136	PF00017	0.578
LIG_SH2_NCK_1	180	184	PF00017	0.764
LIG_SH2_SRC	149	152	PF00017	0.566
LIG_SH2_STAT3	266	269	PF00017	0.526
LIG_SH2_STAT5	149	152	PF00017	0.566
LIG_SH2_STAT5	232	235	PF00017	0.594
LIG_SH2_STAT5	237	240	PF00017	0.451
LIG_SH2_STAT5	55	58	PF00017	0.547
LIG_SH3_1	132	138	PF00018	0.616
LIG_SH3_2	95	100	PF14604	0.467
LIG_SH3_3	132	138	PF00018	0.699
LIG_SH3_3	152	158	PF00018	0.587
LIG_SH3_3	3	9	PF00018	0.623
LIG_SH3_3	37	43	PF00018	0.456
LIG_SH3_3	92	98	PF00018	0.464
LIG_SH3_CIN85_PxpxPR_1	8	13	PF14604	0.627
LIG_TRAF2_1	286	289	PF00917	0.571
LIG_TRAF2_1	80	83	PF00917	0.582
LIG_TRFH_1	226	230	PF08558	0.258
LIG_WW_2	135	138	PF00397	0.443
MOD_CK1_1	130	136	PF00069	0.446
MOD_CK1_1	36	42	PF00069	0.339
MOD_CK1_1	49	55	PF00069	0.637
MOD_CK1_1	99	105	PF00069	0.495
MOD_CK2_1	21	27	PF00069	0.451
MOD_CK2_1	270	276	PF00069	0.658
MOD_CK2_1	283	289	PF00069	0.528
MOD_CK2_1	76	82	PF00069	0.672
MOD_CMANNOS	274	277	PF00535	0.665
MOD_GlcNHglycan	113	116	PF01048	0.491
MOD_GlcNHglycan	132	135	PF01048	0.405
MOD_GlcNHglycan	181	184	PF01048	0.726
MOD_GlcNHglycan	21	24	PF01048	0.450
MOD_GlcNHglycan	210	213	PF01048	0.587
MOD_GlcNHglycan	220	223	PF01048	0.345
MOD_GlcNHglycan	285	288	PF01048	0.720
MOD_GlcNHglycan	91	94	PF01048	0.738
MOD_GSK3_1	111	118	PF00069	0.272
MOD_GSK3_1	140	147	PF00069	0.572
MOD_GSK3_1	42	49	PF00069	0.491
MOD_GSK3_1	96	103	PF00069	0.667
MOD_N-GLC_1	283	288	PF02516	0.716
MOD_NEK2_1	144	149	PF00069	0.544
MOD_NEK2_1	217	222	PF00069	0.491
MOD_NEK2_1	265	270	PF00069	0.659
MOD_NEK2_1	46	51	PF00069	0.674
MOD_PIKK_1	265	271	PF00454	0.662
MOD_PKA_1	270	276	PF00069	0.658
MOD_PKA_2	130	136	PF00069	0.455
MOD_PKA_2	248	254	PF00069	0.632
MOD_PKA_2	99	105	PF00069	0.495
MOD_PKB_1	125	133	PF00069	0.658
MOD_Plk_4	115	121	PF00069	0.258
MOD_Plk_4	140	146	PF00069	0.442
MOD_Plk_4	21	27	PF00069	0.451
MOD_Plk_4	228	234	PF00069	0.386
MOD_Plk_4	250	256	PF00069	0.638
MOD_ProDKin_1	36	42	PF00069	0.491
MOD_ProDKin_1	91	97	PF00069	0.568
TRG_DiLeu_BaEn_4	82	88	PF01217	0.740
TRG_ER_diArg_1	124	127	PF00400	0.636
TRG_ER_diArg_1	162	165	PF00400	0.523
TRG_ER_diArg_1	193	196	PF00400	0.738
TRG_ER_diArg_1	213	215	PF00400	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICI6	Leishmania donovani	85%	100%
A4I1S5	Leishmania infantum	86%	100%