LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q9L0_LEIMA
TriTrypDb:
LmjF.25.2260 , LMJLV39_250030300 , LMJSD75_250030600
Length:
123

Annotations

LeishMANIAdb annotations

Conserved in kinetoplastids, without more distant homologs.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

Q4Q9L0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9L0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 117 119 PF00675 0.702
CLV_NRD_NRD_1 4 6 PF00675 0.471
CLV_PCSK_SKI1_1 102 106 PF00082 0.603
DEG_Nend_UBRbox_2 1 3 PF02207 0.616
DOC_CKS1_1 46 51 PF01111 0.258
DOC_CYCLIN_RxL_1 99 109 PF00134 0.399
DOC_CYCLIN_yCln2_LP_2 46 52 PF00134 0.313
DOC_PP2B_LxvP_1 98 101 PF13499 0.415
DOC_PP4_FxxP_1 68 71 PF00568 0.446
DOC_WW_Pin1_4 18 23 PF00397 0.580
DOC_WW_Pin1_4 45 50 PF00397 0.278
LIG_LIR_Apic_2 70 75 PF02991 0.351
LIG_SH2_NCK_1 72 76 PF00017 0.343
LIG_SH2_STAP1 42 46 PF00017 0.454
LIG_SH2_STAP1 57 61 PF00017 0.330
LIG_SH2_STAT5 57 60 PF00017 0.413
LIG_TRAF2_1 94 97 PF00917 0.415
MOD_CAAXbox 120 123 PF01239 0.357
MOD_CK2_1 91 97 PF00069 0.388
MOD_NEK2_1 55 60 PF00069 0.409
MOD_PKA_2 28 34 PF00069 0.561
MOD_ProDKin_1 18 24 PF00069 0.574
MOD_ProDKin_1 45 51 PF00069 0.278
MOD_SUMO_rev_2 2 8 PF00179 0.609
MOD_SUMO_rev_2 76 82 PF00179 0.363
TRG_Pf-PMV_PEXEL_1 5 9 PF00026 0.464

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE87 Leptomonas seymouri 70% 100%
A0A1X0NZF8 Trypanosomatidae 53% 100%
A0A3Q8IFG6 Leishmania donovani 91% 100%
A0A3R7KZB6 Trypanosoma rangeli 53% 99%
A0A3R7MC34 Trypanosoma rangeli 50% 94%
A4I1S6 Leishmania infantum 91% 100%
C9ZKD4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AXW0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS