Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 10, putative

Species:

Leishmania major

UniProt:

Q4Q9K8_LEIMA

TriTrypDb:

LmjF.25.2280 , LMJLV39_250030500 , LMJSD75_250030800

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q9K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9K8

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016409	palmitoyltransferase activity	5	11
GO:0016417	S-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	11
GO:0019707	protein-cysteine S-acyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.540
CLV_C14_Caspase3-7	281	285	PF00656	0.680
CLV_C14_Caspase3-7	320	324	PF00656	0.700
CLV_NRD_NRD_1	142	144	PF00675	0.261
CLV_NRD_NRD_1	8	10	PF00675	0.409
CLV_PCSK_KEX2_1	142	144	PF00082	0.261
CLV_PCSK_KEX2_1	8	10	PF00082	0.377
CLV_PCSK_SKI1_1	14	18	PF00082	0.384
CLV_PCSK_SKI1_1	243	247	PF00082	0.266
CLV_PCSK_SKI1_1	252	256	PF00082	0.353
CLV_PCSK_SKI1_1	28	32	PF00082	0.209
DEG_APCC_KENBOX_2	254	258	PF00400	0.475
DEG_MDM2_SWIB_1	163	171	PF02201	0.356
DEG_SCF_FBW7_2	194	199	PF00400	0.197
DEG_SPOP_SBC_1	305	309	PF00917	0.772
DOC_MAPK_gen_1	8	15	PF00069	0.587
DOC_MAPK_MEF2A_6	28	36	PF00069	0.128
DOC_MAPK_MEF2A_6	286	293	PF00069	0.731
DOC_MAPK_MEF2A_6	8	17	PF00069	0.593
DOC_PP2B_LxvP_1	3	6	PF13499	0.663
DOC_PP4_FxxP_1	22	25	PF00568	0.552
DOC_USP7_MATH_1	204	208	PF00917	0.317
DOC_USP7_MATH_1	303	307	PF00917	0.774
DOC_USP7_MATH_1	310	314	PF00917	0.726
DOC_USP7_MATH_1	92	96	PF00917	0.672
DOC_WW_Pin1_4	192	197	PF00397	0.361
DOC_WW_Pin1_4	301	306	PF00397	0.768
LIG_14-3-3_CanoR_1	28	33	PF00244	0.400
LIG_14-3-3_CanoR_1	55	59	PF00244	0.264
LIG_BIR_III_2	89	93	PF00653	0.660
LIG_BRCT_BRCA1_1	206	210	PF00533	0.311
LIG_BRCT_BRCA1_1	222	226	PF00533	0.373
LIG_BRCT_BRCA1_1	40	44	PF00533	0.358
LIG_FHA_1	193	199	PF00498	0.345
LIG_FHA_1	204	210	PF00498	0.244
LIG_FHA_1	236	242	PF00498	0.517
LIG_FHA_1	285	291	PF00498	0.695
LIG_FHA_1	29	35	PF00498	0.343
LIG_FHA_1	46	52	PF00498	0.317
LIG_FHA_1	55	61	PF00498	0.327
LIG_FHA_2	244	250	PF00498	0.461
LIG_FHA_2	279	285	PF00498	0.669
LIG_FHA_2	315	321	PF00498	0.729
LIG_GBD_Chelix_1	165	173	PF00786	0.425
LIG_GBD_Chelix_1	221	229	PF00786	0.225
LIG_Integrin_isoDGR_2	18	20	PF01839	0.407
LIG_LIR_Gen_1	161	171	PF02991	0.399
LIG_LIR_Gen_1	41	52	PF02991	0.412
LIG_LIR_Nem_3	161	166	PF02991	0.317
LIG_LIR_Nem_3	207	213	PF02991	0.298
LIG_LIR_Nem_3	223	229	PF02991	0.412
LIG_LIR_Nem_3	41	47	PF02991	0.344
LIG_PDZ_Class_1	322	327	PF00595	0.588
LIG_Pex14_2	163	167	PF04695	0.321
LIG_SH2_CRK	128	132	PF00017	0.470
LIG_SH2_SRC	239	242	PF00017	0.564
LIG_SH2_STAP1	120	124	PF00017	0.540
LIG_SH2_STAT3	135	138	PF00017	0.508
LIG_SH2_STAT5	102	105	PF00017	0.524
LIG_SH2_STAT5	135	138	PF00017	0.540
LIG_SH2_STAT5	162	165	PF00017	0.349
LIG_SH2_STAT5	239	242	PF00017	0.540
LIG_SH3_1	82	88	PF00018	0.671
LIG_SH3_2	88	93	PF14604	0.531
LIG_SH3_3	296	302	PF00018	0.755
LIG_SH3_3	78	84	PF00018	0.580
LIG_SH3_3	85	91	PF00018	0.606
LIG_SH3_CIN85_PxpxPR_1	88	93	PF14604	0.531
LIG_SUMO_SIM_anti_2	216	223	PF11976	0.262
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.340
LIG_SUMO_SIM_anti_2	65	70	PF11976	0.342
LIG_SUMO_SIM_par_1	216	223	PF11976	0.301
LIG_SUMO_SIM_par_1	33	38	PF11976	0.349
LIG_SUMO_SIM_par_1	61	67	PF11976	0.225
LIG_WRC_WIRS_1	181	186	PF05994	0.459
LIG_WRC_WIRS_1	221	226	PF05994	0.425
LIG_WRPW_2	125	128	PF00400	0.540
LIG_WW_3	5	9	PF00397	0.621
LIG_WW_3	90	94	PF00397	0.613
MOD_CK1_1	192	198	PF00069	0.330
MOD_CK1_1	203	209	PF00069	0.285
MOD_CK1_1	304	310	PF00069	0.730
MOD_CK1_1	314	320	PF00069	0.596
MOD_CK1_1	38	44	PF00069	0.421
MOD_GlcNHglycan	202	205	PF01048	0.495
MOD_GlcNHglycan	206	209	PF01048	0.486
MOD_GlcNHglycan	246	249	PF01048	0.352
MOD_GlcNHglycan	272	275	PF01048	0.271
MOD_GSK3_1	200	207	PF00069	0.290
MOD_GSK3_1	235	242	PF00069	0.368
MOD_GSK3_1	301	308	PF00069	0.748
MOD_GSK3_1	310	317	PF00069	0.718
MOD_GSK3_1	54	61	PF00069	0.430
MOD_N-GLC_1	243	248	PF02516	0.261
MOD_N-GLC_2	106	108	PF02516	0.261
MOD_NEK2_1	172	177	PF00069	0.342
MOD_NEK2_1	209	214	PF00069	0.273
MOD_NEK2_1	229	234	PF00069	0.128
MOD_NEK2_1	30	35	PF00069	0.314
MOD_OFUCOSY	147	153	PF10250	0.261
MOD_PKA_2	189	195	PF00069	0.364
MOD_PKA_2	54	60	PF00069	0.264
MOD_PKA_2	92	98	PF00069	0.619
MOD_Plk_4	167	173	PF00069	0.329
MOD_Plk_4	180	186	PF00069	0.284
MOD_Plk_4	220	226	PF00069	0.404
MOD_Plk_4	235	241	PF00069	0.263
MOD_Plk_4	260	266	PF00069	0.570
MOD_Plk_4	30	36	PF00069	0.345
MOD_Plk_4	38	44	PF00069	0.315
MOD_Plk_4	64	70	PF00069	0.342
MOD_Plk_4	92	98	PF00069	0.597
MOD_ProDKin_1	192	198	PF00069	0.361
MOD_ProDKin_1	301	307	PF00069	0.768
TRG_ENDOCYTIC_2	128	131	PF00928	0.457
TRG_ENDOCYTIC_2	162	165	PF00928	0.307
TRG_ER_diArg_1	7	9	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.429
TRG_PTS1	324	327	PF00515	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B1	Leptomonas seymouri	26%	100%
A0A0N1I542	Leptomonas seymouri	63%	100%
A0A0S4IT15	Bodo saltans	29%	92%
A0A0S4J156	Bodo saltans	28%	91%
A0A0S4JRL4	Bodo saltans	28%	91%
A0A1X0NY30	Trypanosomatidae	42%	100%
A0A1X0P5Q8	Trypanosomatidae	25%	100%
A0A3Q8ICY2	Leishmania donovani	23%	92%
A0A3R7P4J6	Trypanosoma rangeli	42%	100%
A0A3S7WSS8	Leishmania donovani	26%	100%
A0A3S7WZD9	Leishmania donovani	92%	100%
A4H7G8	Leishmania braziliensis	25%	100%
A4HVU9	Leishmania infantum	26%	100%
A4I1S8	Leishmania infantum	93%	100%
A4I395	Leishmania infantum	23%	92%
A4IBG8	Leishmania infantum	29%	100%
B3DN87	Arabidopsis thaliana	26%	97%
C9ZKD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A7S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E7FH11	Danio rerio	27%	70%
E9AIR6	Leishmania braziliensis	78%	100%
E9APK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AXW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AZI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	92%
F1QAM1	Danio rerio	28%	95%
F1R013	Danio rerio	31%	85%
O14345	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	99%
O74384	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	93%
O80685	Arabidopsis thaliana	26%	80%
P42836	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	97%
P59268	Mus musculus	29%	90%
Q06551	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	91%
Q0WQK2	Arabidopsis thaliana	31%	74%
Q2TGJ1	Rattus norvegicus	29%	85%
Q2TGK3	Rattus norvegicus	23%	100%
Q3EBC2	Arabidopsis thaliana	25%	82%
Q4QFX8	Leishmania major	26%	100%
Q4WC37	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	76%
Q58DA8	Bos taurus	30%	90%
Q5ADN9	Candida albicans (strain SC5314 / ATCC MYA-2876)	22%	87%
Q5PNZ1	Arabidopsis thaliana	26%	79%
Q5R5J8	Pongo abelii	28%	90%
Q5Y5T1	Mus musculus	27%	86%
Q5Y5T2	Mus musculus	29%	86%
Q6BHT4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	88%
Q6CPU8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
Q6CQB5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	92%
Q7RWM9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	76%
Q7ZVN4	Danio rerio	28%	84%
Q8BQQ1	Mus musculus	29%	67%
Q8IZN3	Homo sapiens	31%	67%
Q8R173	Mus musculus	23%	100%
Q8VYS8	Arabidopsis thaliana	28%	80%
Q9FLM3	Arabidopsis thaliana	29%	80%
Q9M1K5	Arabidopsis thaliana	30%	69%
Q9M306	Arabidopsis thaliana	31%	69%
Q9NUE0	Homo sapiens	28%	84%
Q9NYG2	Homo sapiens	23%	100%
Q9SB58	Arabidopsis thaliana	30%	80%
Q9Y397	Homo sapiens	29%	90%
V5B8P9	Trypanosoma cruzi	27%	94%
V5BCH8	Trypanosoma cruzi	41%	100%