VPS9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 9 (VPS9) domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q9K3_LEIMA

TriTrypDb:

LmjF.25.2330 , LMJLV39_250031000 , LMJSD75_250031300

Length:

837

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9K3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.242
CLV_C14_Caspase3-7	28	32	PF00656	0.551
CLV_C14_Caspase3-7	313	317	PF00656	0.572
CLV_NRD_NRD_1	181	183	PF00675	0.477
CLV_NRD_NRD_1	320	322	PF00675	0.657
CLV_NRD_NRD_1	365	367	PF00675	0.434
CLV_NRD_NRD_1	593	595	PF00675	0.242
CLV_NRD_NRD_1	662	664	PF00675	0.574
CLV_PCSK_FUR_1	179	183	PF00082	0.465
CLV_PCSK_FUR_1	591	595	PF00082	0.242
CLV_PCSK_KEX2_1	181	183	PF00082	0.477
CLV_PCSK_KEX2_1	320	322	PF00082	0.657
CLV_PCSK_KEX2_1	365	367	PF00082	0.434
CLV_PCSK_KEX2_1	40	42	PF00082	0.414
CLV_PCSK_KEX2_1	593	595	PF00082	0.242
CLV_PCSK_KEX2_1	662	664	PF00082	0.549
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.414
CLV_PCSK_SKI1_1	355	359	PF00082	0.437
CLV_PCSK_SKI1_1	432	436	PF00082	0.500
CLV_PCSK_SKI1_1	663	667	PF00082	0.567
CLV_PCSK_SKI1_1	767	771	PF00082	0.623
DEG_APCC_DBOX_1	431	439	PF00400	0.493
DEG_Nend_UBRbox_1	1	4	PF02207	0.761
DEG_SCF_FBW7_1	76	82	PF00400	0.505
DEG_SPOP_SBC_1	569	573	PF00917	0.398
DOC_CKS1_1	76	81	PF01111	0.505
DOC_CYCLIN_RxL_1	764	774	PF00134	0.642
DOC_CYCLIN_RxL_1	819	828	PF00134	0.704
DOC_MAPK_FxFP_2	192	195	PF00069	0.531
DOC_MAPK_gen_1	355	363	PF00069	0.537
DOC_MAPK_gen_1	492	499	PF00069	0.582
DOC_MAPK_MEF2A_6	107	116	PF00069	0.452
DOC_MAPK_MEF2A_6	640	649	PF00069	0.582
DOC_MAPK_RevD_3	649	663	PF00069	0.408
DOC_PP1_RVXF_1	703	710	PF00149	0.578
DOC_PP2B_LxvP_1	284	287	PF13499	0.675
DOC_PP2B_LxvP_1	701	704	PF13499	0.571
DOC_PP2B_LxvP_1	738	741	PF13499	0.609
DOC_PP4_FxxP_1	192	195	PF00568	0.609
DOC_PP4_FxxP_1	737	740	PF00568	0.440
DOC_USP7_MATH_1	13	17	PF00917	0.683
DOC_USP7_MATH_1	171	175	PF00917	0.449
DOC_USP7_MATH_1	507	511	PF00917	0.636
DOC_USP7_MATH_1	568	572	PF00917	0.455
DOC_USP7_MATH_1	797	801	PF00917	0.517
DOC_USP7_MATH_1	818	822	PF00917	0.638
DOC_WW_Pin1_4	1	6	PF00397	0.725
DOC_WW_Pin1_4	275	280	PF00397	0.603
DOC_WW_Pin1_4	287	292	PF00397	0.660
DOC_WW_Pin1_4	75	80	PF00397	0.508
DOC_WW_Pin1_4	812	817	PF00397	0.707
LIG_14-3-3_CanoR_1	125	135	PF00244	0.578
LIG_14-3-3_CanoR_1	204	211	PF00244	0.681
LIG_14-3-3_CanoR_1	274	279	PF00244	0.596
LIG_14-3-3_CanoR_1	409	418	PF00244	0.524
LIG_14-3-3_CanoR_1	508	516	PF00244	0.580
LIG_14-3-3_CanoR_1	822	827	PF00244	0.646
LIG_APCC_ABBA_1	517	522	PF00400	0.448
LIG_BRCT_BRCA1_1	733	737	PF00533	0.400
LIG_Clathr_ClatBox_1	823	827	PF01394	0.654
LIG_CSL_BTD_1	701	704	PF09270	0.466
LIG_deltaCOP1_diTrp_1	247	255	PF00928	0.277
LIG_deltaCOP1_diTrp_1	301	308	PF00928	0.607
LIG_EH1_1	595	603	PF00400	0.413
LIG_eIF4E_1	449	455	PF01652	0.473
LIG_eIF4E_1	596	602	PF01652	0.328
LIG_FHA_1	186	192	PF00498	0.435
LIG_FHA_1	338	344	PF00498	0.574
LIG_FHA_1	351	357	PF00498	0.427
LIG_FHA_1	372	378	PF00498	0.619
LIG_FHA_1	519	525	PF00498	0.406
LIG_FHA_1	536	542	PF00498	0.254
LIG_FHA_1	597	603	PF00498	0.363
LIG_FHA_1	685	691	PF00498	0.565
LIG_FHA_1	78	84	PF00498	0.475
LIG_FHA_1	829	835	PF00498	0.674
LIG_FHA_2	496	502	PF00498	0.440
LIG_FHA_2	613	619	PF00498	0.337
LIG_FHA_2	727	733	PF00498	0.636
LIG_FHA_2	96	102	PF00498	0.466
LIG_GBD_Chelix_1	17	25	PF00786	0.556
LIG_LIR_Apic_2	190	195	PF02991	0.593
LIG_LIR_Apic_2	734	740	PF02991	0.579
LIG_LIR_Gen_1	305	315	PF02991	0.546
LIG_LIR_Gen_1	696	706	PF02991	0.528
LIG_LIR_Nem_3	106	111	PF02991	0.409
LIG_LIR_Nem_3	163	168	PF02991	0.344
LIG_LIR_Nem_3	305	311	PF02991	0.538
LIG_LIR_Nem_3	514	520	PF02991	0.511
LIG_LIR_Nem_3	696	701	PF02991	0.594
LIG_LIR_Nem_3	71	76	PF02991	0.443
LIG_LYPXL_yS_3	468	471	PF13949	0.504
LIG_MYND_1	287	291	PF01753	0.693
LIG_NRBOX	536	542	PF00104	0.449
LIG_NRBOX	829	835	PF00104	0.648
LIG_PCNA_yPIPBox_3	626	640	PF02747	0.437
LIG_Pex14_1	302	306	PF04695	0.498
LIG_Pex14_1	69	73	PF04695	0.530
LIG_Pex14_2	364	368	PF04695	0.403
LIG_Pex14_2	65	69	PF04695	0.544
LIG_PTB_Apo_2	722	729	PF02174	0.656
LIG_SH2_CRK	475	479	PF00017	0.488
LIG_SH2_CRK	73	77	PF00017	0.438
LIG_SH2_NCK_1	324	328	PF00017	0.602
LIG_SH2_NCK_1	475	479	PF00017	0.542
LIG_SH2_PTP2	698	701	PF00017	0.601
LIG_SH2_STAP1	475	479	PF00017	0.542
LIG_SH2_STAP1	520	524	PF00017	0.321
LIG_SH2_STAP1	756	760	PF00017	0.595
LIG_SH2_STAT5	108	111	PF00017	0.432
LIG_SH2_STAT5	153	156	PF00017	0.328
LIG_SH2_STAT5	176	179	PF00017	0.385
LIG_SH2_STAT5	342	345	PF00017	0.589
LIG_SH2_STAT5	369	372	PF00017	0.453
LIG_SH2_STAT5	520	523	PF00017	0.437
LIG_SH2_STAT5	585	588	PF00017	0.356
LIG_SH2_STAT5	698	701	PF00017	0.488
LIG_SH3_2	817	822	PF14604	0.715
LIG_SH3_3	113	119	PF00018	0.441
LIG_SH3_3	258	264	PF00018	0.363
LIG_SH3_3	40	46	PF00018	0.555
LIG_SH3_3	810	816	PF00018	0.600
LIG_SH3_3	97	103	PF00018	0.594
LIG_SUMO_SIM_anti_2	687	692	PF11976	0.603
LIG_SUMO_SIM_anti_2	731	737	PF11976	0.568
LIG_SUMO_SIM_par_1	686	692	PF11976	0.664
LIG_SUMO_SIM_par_1	821	828	PF11976	0.643
LIG_TRAF2_1	615	618	PF00917	0.413
LIG_TRAF2_1	729	732	PF00917	0.636
LIG_WRC_WIRS_1	145	150	PF05994	0.348
MOD_CDK_SPK_2	1	6	PF00069	0.734
MOD_CDK_SPxxK_3	287	294	PF00069	0.690
MOD_CK1_1	126	132	PF00069	0.419
MOD_CK1_1	16	22	PF00069	0.631
MOD_CK1_1	212	218	PF00069	0.667
MOD_CK1_1	310	316	PF00069	0.539
MOD_CK1_1	337	343	PF00069	0.541
MOD_CK1_1	675	681	PF00069	0.610
MOD_CK1_1	825	831	PF00069	0.601
MOD_CK1_1	95	101	PF00069	0.549
MOD_CK2_1	612	618	PF00069	0.354
MOD_CK2_1	726	732	PF00069	0.609
MOD_CK2_1	777	783	PF00069	0.685
MOD_CMANNOS	84	87	PF00535	0.386
MOD_GlcNHglycan	120	123	PF01048	0.636
MOD_GlcNHglycan	128	131	PF01048	0.554
MOD_GlcNHglycan	148	151	PF01048	0.265
MOD_GlcNHglycan	171	174	PF01048	0.381
MOD_GlcNHglycan	214	217	PF01048	0.716
MOD_GlcNHglycan	255	258	PF01048	0.455
MOD_GlcNHglycan	264	267	PF01048	0.421
MOD_GlcNHglycan	269	272	PF01048	0.517
MOD_GlcNHglycan	411	414	PF01048	0.603
MOD_GlcNHglycan	53	56	PF01048	0.479
MOD_GlcNHglycan	572	575	PF01048	0.335
MOD_GlcNHglycan	674	677	PF01048	0.588
MOD_GlcNHglycan	757	760	PF01048	0.582
MOD_GlcNHglycan	799	802	PF01048	0.505
MOD_GSK3_1	12	19	PF00069	0.669
MOD_GSK3_1	131	138	PF00069	0.553
MOD_GSK3_1	200	207	PF00069	0.687
MOD_GSK3_1	422	429	PF00069	0.397
MOD_GSK3_1	551	558	PF00069	0.455
MOD_GSK3_1	568	575	PF00069	0.398
MOD_GSK3_1	596	603	PF00069	0.449
MOD_GSK3_1	675	682	PF00069	0.615
MOD_GSK3_1	75	82	PF00069	0.497
MOD_GSK3_1	818	825	PF00069	0.677
MOD_N-GLC_1	274	279	PF02516	0.656
MOD_N-GLC_1	337	342	PF02516	0.607
MOD_N-GLC_1	714	719	PF02516	0.673
MOD_NEK2_1	169	174	PF00069	0.290
MOD_NEK2_1	17	22	PF00069	0.670
MOD_NEK2_1	185	190	PF00069	0.496
MOD_NEK2_1	350	355	PF00069	0.465
MOD_NEK2_1	371	376	PF00069	0.449
MOD_NEK2_1	426	431	PF00069	0.400
MOD_NEK2_1	486	491	PF00069	0.477
MOD_NEK2_1	587	592	PF00069	0.453
MOD_NEK2_1	611	616	PF00069	0.336
MOD_NEK2_1	620	625	PF00069	0.288
MOD_NEK2_1	755	760	PF00069	0.535
MOD_NEK2_1	94	99	PF00069	0.528
MOD_NEK2_2	391	396	PF00069	0.669
MOD_OFUCOSY	206	213	PF10250	0.659
MOD_OFUCOSY	370	375	PF10250	0.571
MOD_PIKK_1	473	479	PF00454	0.535
MOD_PIKK_1	509	515	PF00454	0.714
MOD_PIKK_1	535	541	PF00454	0.455
MOD_PIKK_1	555	561	PF00454	0.358
MOD_PIKK_1	585	591	PF00454	0.449
MOD_PIKK_1	613	619	PF00454	0.413
MOD_PIKK_1	726	732	PF00454	0.669
MOD_PIKK_1	787	793	PF00454	0.605
MOD_PKA_2	267	273	PF00069	0.512
MOD_PKA_2	302	308	PF00069	0.628
MOD_PKA_2	507	513	PF00069	0.633
MOD_PKA_2	555	561	PF00069	0.403
MOD_PKA_2	569	575	PF00069	0.447
MOD_PKA_2	777	783	PF00069	0.701
MOD_Plk_1	481	487	PF00069	0.475
MOD_Plk_1	731	737	PF00069	0.620
MOD_Plk_2-3	495	501	PF00069	0.458
MOD_Plk_2-3	684	690	PF00069	0.632
MOD_Plk_4	187	193	PF00069	0.438
MOD_Plk_4	307	313	PF00069	0.511
MOD_Plk_4	628	634	PF00069	0.332
MOD_Plk_4	731	737	PF00069	0.643
MOD_ProDKin_1	1	7	PF00069	0.724
MOD_ProDKin_1	275	281	PF00069	0.611
MOD_ProDKin_1	287	293	PF00069	0.651
MOD_ProDKin_1	75	81	PF00069	0.502
MOD_ProDKin_1	812	818	PF00069	0.710
MOD_SUMO_rev_2	212	221	PF00179	0.680
MOD_SUMO_rev_2	247	256	PF00179	0.242
TRG_DiLeu_BaEn_1	731	736	PF01217	0.603
TRG_DiLeu_BaLyEn_6	764	769	PF01217	0.622
TRG_DiLeu_BaLyEn_6	819	824	PF01217	0.672
TRG_ENDOCYTIC_2	108	111	PF00928	0.427
TRG_ENDOCYTIC_2	468	471	PF00928	0.450
TRG_ENDOCYTIC_2	475	478	PF00928	0.440
TRG_ENDOCYTIC_2	698	701	PF00928	0.574
TRG_ENDOCYTIC_2	73	76	PF00928	0.431
TRG_ER_diArg_1	180	182	PF00400	0.547
TRG_ER_diArg_1	320	322	PF00400	0.656
TRG_ER_diArg_1	364	366	PF00400	0.425
TRG_ER_diArg_1	58	61	PF00400	0.521
TRG_ER_diArg_1	591	594	PF00400	0.242
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	822	827	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV2	Leptomonas seymouri	62%	99%
A0A0S4IXM9	Bodo saltans	35%	78%
A0A1X0NY26	Trypanosomatidae	38%	92%
A0A3S7WZE1	Leishmania donovani	95%	100%
A0A422P4H0	Trypanosoma rangeli	39%	90%
A4HED6	Leishmania braziliensis	86%	100%
A4I1T3	Leishmania infantum	95%	100%
C9ZKD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	91%
E9AXW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BH11	Trypanosoma cruzi	41%	95%