Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9K1_LEIMA

TriTrypDb:

LmjF.25.2350 , LMJLV39_250031200 , LMJSD75_250031500

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.575
CLV_C14_Caspase3-7	280	284	PF00656	0.615
CLV_C14_Caspase3-7	3	7	PF00656	0.715
CLV_NRD_NRD_1	32	34	PF00675	0.591
CLV_NRD_NRD_1	328	330	PF00675	0.530
CLV_NRD_NRD_1	345	347	PF00675	0.442
CLV_NRD_NRD_1	357	359	PF00675	0.651
CLV_NRD_NRD_1	49	51	PF00675	0.500
CLV_PCSK_KEX2_1	272	274	PF00082	0.602
CLV_PCSK_KEX2_1	32	34	PF00082	0.591
CLV_PCSK_KEX2_1	328	330	PF00082	0.476
CLV_PCSK_KEX2_1	345	347	PF00082	0.387
CLV_PCSK_KEX2_1	356	358	PF00082	0.578
CLV_PCSK_KEX2_1	48	50	PF00082	0.520
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.633
CLV_PCSK_SKI1_1	137	141	PF00082	0.358
CLV_PCSK_SKI1_1	220	224	PF00082	0.555
CLV_PCSK_SKI1_1	345	349	PF00082	0.526
DEG_SCF_FBW7_2	182	187	PF00400	0.560
DEG_SIAH_1	16	24	PF03145	0.587
DOC_CDC14_PxL_1	78	86	PF14671	0.725
DOC_PP2B_LxvP_1	84	87	PF13499	0.690
DOC_PP4_FxxP_1	79	82	PF00568	0.657
DOC_USP7_MATH_1	101	105	PF00917	0.642
DOC_USP7_MATH_1	133	137	PF00917	0.578
DOC_USP7_MATH_1	175	179	PF00917	0.713
DOC_USP7_MATH_1	239	243	PF00917	0.639
DOC_USP7_MATH_1	336	340	PF00917	0.485
DOC_WW_Pin1_4	129	134	PF00397	0.624
DOC_WW_Pin1_4	178	183	PF00397	0.706
DOC_WW_Pin1_4	60	65	PF00397	0.751
LIG_14-3-3_CanoR_1	220	229	PF00244	0.536
LIG_14-3-3_CanoR_1	240	246	PF00244	0.668
LIG_14-3-3_CanoR_1	356	363	PF00244	0.707
LIG_14-3-3_CanoR_1	85	91	PF00244	0.561
LIG_APCC_ABBA_1	75	80	PF00400	0.514
LIG_BRCT_BRCA1_1	25	29	PF00533	0.588
LIG_FHA_1	194	200	PF00498	0.600
LIG_FHA_1	260	266	PF00498	0.715
LIG_FHA_1	292	298	PF00498	0.512
LIG_FHA_2	158	164	PF00498	0.534
LIG_FHA_2	181	187	PF00498	0.638
LIG_FHA_2	202	208	PF00498	0.613
LIG_FHA_2	68	74	PF00498	0.668
LIG_LIR_Gen_1	294	303	PF02991	0.473
LIG_LIR_Nem_3	214	218	PF02991	0.499
LIG_LIR_Nem_3	294	299	PF02991	0.473
LIG_NRBOX	302	308	PF00104	0.587
LIG_Rb_pABgroove_1	23	31	PF01858	0.589
LIG_SH2_CRK	14	18	PF00017	0.619
LIG_SH2_PTP2	296	299	PF00017	0.560
LIG_SH2_STAP1	218	222	PF00017	0.433
LIG_SH2_STAP1	245	249	PF00017	0.697
LIG_SH2_STAP1	275	279	PF00017	0.531
LIG_SH2_STAP1	95	99	PF00017	0.579
LIG_SH2_STAT5	296	299	PF00017	0.560
LIG_SH3_3	17	23	PF00018	0.507
LIG_SH3_3	62	68	PF00018	0.779
LIG_SUMO_SIM_anti_2	300	309	PF11976	0.556
LIG_SUMO_SIM_par_1	276	283	PF11976	0.579
LIG_TRAF2_1	184	187	PF00917	0.562
LIG_TRAF2_1	211	214	PF00917	0.573
LIG_WRC_WIRS_1	24	29	PF05994	0.590
MOD_CK1_1	124	130	PF00069	0.621
MOD_CK1_1	132	138	PF00069	0.515
MOD_CK1_1	178	184	PF00069	0.709
MOD_CK1_1	243	249	PF00069	0.615
MOD_CK1_1	60	66	PF00069	0.749
MOD_CK2_1	161	167	PF00069	0.541
MOD_CK2_1	180	186	PF00069	0.786
MOD_CK2_1	222	228	PF00069	0.509
MOD_CK2_1	37	43	PF00069	0.535
MOD_GlcNHglycan	176	180	PF01048	0.596
MOD_GlcNHglycan	256	259	PF01048	0.668
MOD_GlcNHglycan	267	270	PF01048	0.566
MOD_GlcNHglycan	60	63	PF01048	0.782
MOD_GSK3_1	117	124	PF00069	0.583
MOD_GSK3_1	125	132	PF00069	0.676
MOD_GSK3_1	138	145	PF00069	0.410
MOD_GSK3_1	157	164	PF00069	0.583
MOD_GSK3_1	239	246	PF00069	0.472
MOD_GSK3_1	254	261	PF00069	0.680
MOD_GSK3_1	34	41	PF00069	0.561
MOD_N-GLC_1	101	106	PF02516	0.606
MOD_NEK2_1	161	166	PF00069	0.524
MOD_NEK2_1	199	204	PF00069	0.571
MOD_NEK2_1	221	226	PF00069	0.538
MOD_NEK2_1	229	234	PF00069	0.575
MOD_NEK2_1	34	39	PF00069	0.512
MOD_PIKK_1	121	127	PF00454	0.582
MOD_PIKK_1	351	357	PF00454	0.410
MOD_PK_1	107	113	PF00069	0.435
MOD_PK_1	260	266	PF00069	0.571
MOD_PKA_1	356	362	PF00069	0.472
MOD_PKA_2	239	245	PF00069	0.470
MOD_PKA_2	356	362	PF00069	0.519
MOD_Plk_1	107	113	PF00069	0.629
MOD_Plk_1	161	167	PF00069	0.660
MOD_Plk_1	185	191	PF00069	0.720
MOD_Plk_1	34	40	PF00069	0.575
MOD_Plk_2-3	157	163	PF00069	0.567
MOD_Plk_2-3	277	283	PF00069	0.624
MOD_Plk_2-3	309	315	PF00069	0.554
MOD_Plk_4	117	123	PF00069	0.538
MOD_Plk_4	138	144	PF00069	0.529
MOD_Plk_4	23	29	PF00069	0.558
MOD_Plk_4	260	266	PF00069	0.712
MOD_Plk_4	34	40	PF00069	0.341
MOD_ProDKin_1	129	135	PF00069	0.616
MOD_ProDKin_1	178	184	PF00069	0.706
MOD_ProDKin_1	60	66	PF00069	0.751
MOD_SUMO_rev_2	224	232	PF00179	0.520
TRG_Cilium_Arf4_1	360	364	PF00025	0.510
TRG_DiLeu_BaEn_4	276	282	PF01217	0.616
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.505
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.497
TRG_ENDOCYTIC_2	218	221	PF00928	0.526
TRG_ENDOCYTIC_2	275	278	PF00928	0.476
TRG_ENDOCYTIC_2	296	299	PF00928	0.560
TRG_ER_diArg_1	31	33	PF00400	0.587
TRG_ER_diArg_1	337	340	PF00400	0.439
TRG_ER_diArg_1	356	358	PF00400	0.481
TRG_ER_diArg_1	47	50	PF00400	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKE1	Leptomonas seymouri	44%	100%
A0A1X0NZJ6	Trypanosomatidae	29%	100%
A0A3R7KZA5	Trypanosoma rangeli	27%	91%
A0A3S5H7F3	Leishmania donovani	86%	100%
A4HED8	Leishmania braziliensis	71%	100%
A4I1T5	Leishmania infantum	85%	100%
C9ZKE3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AXW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%