Putative aminopeptidase P1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Xaa-Pro aminopeptidase, putative

Species:

Leishmania major

UniProt:

Q4Q9J5_LEIMA

TriTrypDb:

LmjF.02.0040 , LMJLV39_020005200 , LMJSD75_020005300

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q9J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9J5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004177	aminopeptidase activity	5	13
GO:0005488	binding	1	13
GO:0008233	peptidase activity	3	13
GO:0008235	metalloexopeptidase activity	5	13
GO:0008237	metallopeptidase activity	4	13
GO:0008238	exopeptidase activity	4	13
GO:0016787	hydrolase activity	2	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0070006	metalloaminopeptidase activity	6	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.439
CLV_NRD_NRD_1	302	304	PF00675	0.419
CLV_NRD_NRD_1	63	65	PF00675	0.280
CLV_NRD_NRD_1	81	83	PF00675	0.350
CLV_PCSK_KEX2_1	302	304	PF00082	0.249
CLV_PCSK_KEX2_1	81	83	PF00082	0.418
CLV_PCSK_SKI1_1	175	179	PF00082	0.418
CLV_PCSK_SKI1_1	190	194	PF00082	0.336
CLV_PCSK_SKI1_1	211	215	PF00082	0.330
CLV_PCSK_SKI1_1	247	251	PF00082	0.441
CLV_PCSK_SKI1_1	368	372	PF00082	0.305
CLV_PCSK_SKI1_1	511	515	PF00082	0.239
DEG_APCC_DBOX_1	302	310	PF00400	0.249
DEG_APCC_DBOX_1	367	375	PF00400	0.365
DEG_Nend_UBRbox_1	1	4	PF02207	0.380
DOC_CYCLIN_RxL_1	507	518	PF00134	0.239
DOC_MAPK_gen_1	190	200	PF00069	0.249
DOC_MAPK_gen_1	211	219	PF00069	0.286
DOC_MAPK_gen_1	302	308	PF00069	0.418
DOC_MAPK_gen_1	91	99	PF00069	0.265
DOC_MAPK_HePTP_8	127	139	PF00069	0.418
DOC_MAPK_MEF2A_6	130	139	PF00069	0.314
DOC_MAPK_MEF2A_6	193	202	PF00069	0.249
DOC_MAPK_MEF2A_6	463	470	PF00069	0.397
DOC_PP1_RVXF_1	233	240	PF00149	0.286
DOC_PP1_RVXF_1	322	329	PF00149	0.286
DOC_PP4_FxxP_1	328	331	PF00568	0.286
DOC_PP4_MxPP_1	56	59	PF00568	0.572
DOC_USP7_MATH_1	348	352	PF00917	0.386
DOC_USP7_MATH_1	59	63	PF00917	0.360
DOC_USP7_MATH_2	293	299	PF00917	0.418
DOC_USP7_UBL2_3	61	65	PF12436	0.298
DOC_WW_Pin1_4	25	30	PF00397	0.472
DOC_WW_Pin1_4	289	294	PF00397	0.378
DOC_WW_Pin1_4	521	526	PF00397	0.535
LIG_14-3-3_CanoR_1	182	191	PF00244	0.376
LIG_14-3-3_CanoR_1	442	451	PF00244	0.498
LIG_Actin_WH2_2	195	213	PF00022	0.327
LIG_Actin_WH2_2	98	114	PF00022	0.305
LIG_BRCT_BRCA1_1	350	354	PF00533	0.418
LIG_BRCT_BRCA1_2	350	356	PF00533	0.418
LIG_eIF4E_1	508	514	PF01652	0.239
LIG_FHA_1	143	149	PF00498	0.391
LIG_FHA_1	195	201	PF00498	0.396
LIG_FHA_1	232	238	PF00498	0.303
LIG_FHA_1	317	323	PF00498	0.320
LIG_FHA_1	338	344	PF00498	0.283
LIG_FHA_1	356	362	PF00498	0.280
LIG_FHA_1	399	405	PF00498	0.249
LIG_FHA_1	508	514	PF00498	0.484
LIG_FHA_2	257	263	PF00498	0.447
LIG_FHA_2	31	37	PF00498	0.353
LIG_FHA_2	470	476	PF00498	0.278
LIG_FHA_2	75	81	PF00498	0.344
LIG_LIR_Apic_2	325	331	PF02991	0.286
LIG_LIR_Gen_1	129	139	PF02991	0.375
LIG_LIR_Gen_1	269	279	PF02991	0.295
LIG_LIR_Gen_1	337	347	PF02991	0.305
LIG_LIR_Gen_1	36	44	PF02991	0.508
LIG_LIR_Gen_1	388	396	PF02991	0.286
LIG_LIR_Gen_1	518	525	PF02991	0.556
LIG_LIR_Nem_3	115	121	PF02991	0.273
LIG_LIR_Nem_3	129	135	PF02991	0.273
LIG_LIR_Nem_3	157	161	PF02991	0.347
LIG_LIR_Nem_3	186	192	PF02991	0.418
LIG_LIR_Nem_3	269	274	PF02991	0.301
LIG_LIR_Nem_3	275	279	PF02991	0.283
LIG_LIR_Nem_3	337	342	PF02991	0.305
LIG_LIR_Nem_3	36	40	PF02991	0.498
LIG_LIR_Nem_3	388	392	PF02991	0.286
LIG_LIR_Nem_3	504	508	PF02991	0.410
LIG_LIR_Nem_3	518	523	PF02991	0.659
LIG_MYND_3	8	12	PF01753	0.372
LIG_PALB2_WD40_1	103	111	PF16756	0.249
LIG_Pex14_1	478	482	PF04695	0.407
LIG_PTB_Apo_2	116	123	PF02174	0.418
LIG_SH2_CRK	118	122	PF00017	0.292
LIG_SH2_CRK	339	343	PF00017	0.286
LIG_SH2_CRK	520	524	PF00017	0.557
LIG_SH2_GRB2like	132	135	PF00017	0.437
LIG_SH2_GRB2like	138	141	PF00017	0.397
LIG_SH2_NCK_1	118	122	PF00017	0.336
LIG_SH2_NCK_1	125	129	PF00017	0.322
LIG_SH2_NCK_1	255	259	PF00017	0.365
LIG_SH2_NCK_1	291	295	PF00017	0.351
LIG_SH2_PTP2	138	141	PF00017	0.418
LIG_SH2_PTP2	67	70	PF00017	0.407
LIG_SH2_SRC	123	126	PF00017	0.307
LIG_SH2_SRC	132	135	PF00017	0.300
LIG_SH2_SRC	378	381	PF00017	0.286
LIG_SH2_STAP1	123	127	PF00017	0.330
LIG_SH2_STAP1	339	343	PF00017	0.286
LIG_SH2_STAT5	138	141	PF00017	0.418
LIG_SH2_STAT5	236	239	PF00017	0.320
LIG_SH2_STAT5	30	33	PF00017	0.488
LIG_SH2_STAT5	307	310	PF00017	0.386
LIG_SH2_STAT5	339	342	PF00017	0.286
LIG_SH2_STAT5	451	454	PF00017	0.410
LIG_SH2_STAT5	505	508	PF00017	0.278
LIG_SH2_STAT5	520	523	PF00017	0.530
LIG_SH2_STAT5	67	70	PF00017	0.440
LIG_SH3_3	200	206	PF00018	0.428
LIG_SH3_3	3	9	PF00018	0.425
LIG_SUMO_SIM_anti_2	467	475	PF11976	0.459
LIG_SUMO_SIM_par_1	464	469	PF11976	0.340
LIG_SUMO_SIM_par_1	95	100	PF11976	0.362
LIG_TRAF2_1	10	13	PF00917	0.509
LIG_TRAF2_1	77	80	PF00917	0.397
LIG_TYR_ITIM	116	121	PF00017	0.351
LIG_UBA3_1	85	92	PF00899	0.351
LIG_WRC_WIRS_1	386	391	PF05994	0.286
MOD_CDK_SPxxK_3	521	528	PF00069	0.538
MOD_CK1_1	275	281	PF00069	0.286
MOD_CK1_1	414	420	PF00069	0.362
MOD_CK1_1	454	460	PF00069	0.451
MOD_CK1_1	469	475	PF00069	0.242
MOD_CK2_1	1	7	PF00069	0.541
MOD_CK2_1	256	262	PF00069	0.374
MOD_CK2_1	289	295	PF00069	0.407
MOD_CK2_1	30	36	PF00069	0.361
MOD_CK2_1	469	475	PF00069	0.278
MOD_CK2_1	74	80	PF00069	0.344
MOD_Cter_Amidation	173	176	PF01082	0.362
MOD_GlcNHglycan	297	300	PF01048	0.289
MOD_GlcNHglycan	310	313	PF01048	0.305
MOD_GlcNHglycan	358	361	PF01048	0.332
MOD_GlcNHglycan	445	448	PF01048	0.502
MOD_GlcNHglycan	99	102	PF01048	0.286
MOD_GSK3_1	289	296	PF00069	0.360
MOD_GSK3_1	316	323	PF00069	0.285
MOD_GSK3_1	445	452	PF00069	0.428
MOD_NEK2_1	1	6	PF00069	0.444
MOD_NEK2_1	308	313	PF00069	0.286
MOD_NEK2_2	196	201	PF00069	0.418
MOD_NEK2_2	59	64	PF00069	0.288
MOD_PIKK_1	1	7	PF00454	0.439
MOD_PKA_2	181	187	PF00069	0.418
MOD_PKA_2	38	44	PF00069	0.459
MOD_Plk_1	466	472	PF00069	0.356
MOD_Plk_1	59	65	PF00069	0.380
MOD_Plk_2-3	7	13	PF00069	0.513
MOD_Plk_4	337	343	PF00069	0.287
MOD_Plk_4	348	354	PF00069	0.283
MOD_Plk_4	385	391	PF00069	0.286
MOD_Plk_4	411	417	PF00069	0.342
MOD_Plk_4	466	472	PF00069	0.386
MOD_Plk_4	486	492	PF00069	0.157
MOD_Plk_4	518	524	PF00069	0.555
MOD_ProDKin_1	25	31	PF00069	0.478
MOD_ProDKin_1	289	295	PF00069	0.378
MOD_ProDKin_1	521	527	PF00069	0.536
MOD_SUMO_for_1	213	216	PF00179	0.332
MOD_SUMO_rev_2	162	171	PF00179	0.362
MOD_SUMO_rev_2	216	222	PF00179	0.249
MOD_SUMO_rev_2	524	530	PF00179	0.565
TRG_DiLeu_BaEn_1	337	342	PF01217	0.330
TRG_DiLeu_BaEn_1	518	523	PF01217	0.559
TRG_ENDOCYTIC_2	118	121	PF00928	0.301
TRG_ENDOCYTIC_2	125	128	PF00928	0.270
TRG_ENDOCYTIC_2	132	135	PF00928	0.249
TRG_ENDOCYTIC_2	138	141	PF00928	0.286
TRG_ENDOCYTIC_2	161	164	PF00928	0.291
TRG_ENDOCYTIC_2	339	342	PF00928	0.286
TRG_ENDOCYTIC_2	520	523	PF00928	0.563
TRG_ER_diArg_1	172	175	PF00400	0.249
TRG_ER_diArg_1	301	303	PF00400	0.249
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I539	Leptomonas seymouri	76%	89%
A0A1X0NZN4	Trypanosomatidae	58%	88%
A0A3Q8IFI4	Leishmania donovani	94%	100%
A0A3R7KZD6	Trypanosoma rangeli	57%	89%
A0A451EJE2	Leishmania donovani	94%	86%
A1CAQ1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	41%	81%
A1DF27	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	43%	81%
A2QGR5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	42%	86%
A4HEE5	Leishmania braziliensis	87%	88%
A4HRK6	Leishmania infantum	94%	86%
A4RF35	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	42%	86%
A6R035	Ajellomyces capsulatus (strain NAm1 / WU24)	40%	86%
A6RK67	Botryotinia fuckeliana (strain B05.10)	41%	88%
A7E4T8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	40%	88%
A8P5H7	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	41%	85%
B0DZL3	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	41%	83%
B0Y3V7	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	43%	81%
B1AVD1	Mus musculus	36%	79%
B2AWV6	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	38%	78%
B2VUU7	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	42%	89%
B6HQC9	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	41%	87%
B6QG01	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	43%	81%
B8M9W2	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	42%	81%
B8NEI6	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	41%	81%
C0NDZ7	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	40%	86%
C0SCV1	Paracoccidioides brasiliensis (strain Pb03)	42%	86%
C1GEY4	Paracoccidioides brasiliensis (strain Pb18)	41%	86%
C1H978	Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01)	42%	86%
C5FHR9	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	37%	85%
C5GXZ9	Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)	41%	86%
C5K105	Blastomyces gilchristii (strain SLH14081)	41%	86%
C5P7J2	Coccidioides posadasii (strain C735)	41%	82%
C6HSY3	Ajellomyces capsulatus (strain H143)	39%	83%
C7Z9Z7	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	43%	86%
C9SR45	Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)	40%	87%
C9ZKA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	86%
D1ZKF3	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	42%	86%
D4ARJ9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	37%	76%
D4D891	Trichophyton verrucosum (strain HKI 0517)	37%	76%
D5GAC6	Tuber melanosporum (strain Mel28)	41%	86%
E3QCU0	Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212)	39%	86%
E3S7K9	Pyrenophora teres f. teres (strain 0-1)	42%	81%
E4USI8	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	41%	84%
E5ABQ8	Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)	42%	88%
E9AC78	Leishmania major	99%	100%
E9AHA3	Leishmania infantum	94%	100%
E9CTR7	Coccidioides posadasii (strain RMSCC 757 / Silveira)	41%	87%
E9E9B2	Metarhizium acridum (strain CQMa 102)	40%	86%
E9EUE6	Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)	41%	86%
F4JQH3	Arabidopsis thaliana	36%	82%
O43895	Homo sapiens	35%	79%
O44750	Caenorhabditis elegans	35%	86%
O54975	Rattus norvegicus	40%	85%
Q07825	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	71%
Q09795	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	89%
Q0CDB3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	41%	81%
Q0UFY4	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	42%	82%
Q1JPJ2	Bos taurus	39%	85%
Q2H8T2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	39%	85%
Q2U7S5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	41%	81%
Q4WUD3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	43%	81%
Q54G06	Dictyostelium discoideum	37%	85%
Q5AVF0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	41%	81%
Q6P1B1	Mus musculus	39%	85%
Q7RYL6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	42%	78%
Q8RY11	Arabidopsis thaliana	36%	75%
Q95333	Sus scrofa	36%	79%
Q99MA2	Rattus norvegicus	36%	79%
Q9NQW7	Homo sapiens	39%	85%
Q9VJG0	Drosophila melanogaster	38%	87%
V5DIX7	Trypanosoma cruzi	57%	89%