Tagatose-6-phosphate kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tagatose-6-phosphate kinase-like protein

Species:

Leishmania major

UniProt:

Q4Q9J4_LEIMA

TriTrypDb:

LmjF.25.2440 , LMJLV39_020005100 , LMJSD75_020005100

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9J4

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	5
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0009024	tagatose-6-phosphate kinase activity	5	5
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.516
CLV_C14_Caspase3-7	261	265	PF00656	0.516
CLV_NRD_NRD_1	306	308	PF00675	0.539
CLV_PCSK_KEX2_1	306	308	PF00082	0.554
CLV_PCSK_SKI1_1	130	134	PF00082	0.316
CLV_PCSK_SKI1_1	169	173	PF00082	0.316
CLV_PCSK_SKI1_1	282	286	PF00082	0.316
CLV_PCSK_SKI1_1	31	35	PF00082	0.297
DEG_APCC_DBOX_1	129	137	PF00400	0.574
DEG_SPOP_SBC_1	319	323	PF00917	0.630
DOC_ANK_TNKS_1	305	312	PF00023	0.551
DOC_CKS1_1	205	210	PF01111	0.516
DOC_CYCLIN_RxL_1	14	23	PF00134	0.450
DOC_MAPK_gen_1	306	314	PF00069	0.566
DOC_PP1_RVXF_1	15	22	PF00149	0.429
DOC_PP1_SILK_1	189	194	PF00149	0.574
DOC_PP2B_LxvP_1	183	186	PF13499	0.473
DOC_PP2B_PxIxI_1	3	9	PF00149	0.529
DOC_USP7_MATH_1	149	153	PF00917	0.574
DOC_USP7_MATH_1	286	290	PF00917	0.516
DOC_USP7_MATH_1	319	323	PF00917	0.630
DOC_WW_Pin1_4	150	155	PF00397	0.516
DOC_WW_Pin1_4	204	209	PF00397	0.516
DOC_WW_Pin1_4	252	257	PF00397	0.516
DOC_WW_Pin1_4	273	278	PF00397	0.574
DOC_WW_Pin1_4	53	58	PF00397	0.486
LIG_14-3-3_CanoR_1	31	36	PF00244	0.525
LIG_14-3-3_CanoR_1	61	65	PF00244	0.545
LIG_BRCT_BRCA1_1	55	59	PF00533	0.508
LIG_FHA_1	109	115	PF00498	0.516
LIG_FHA_1	218	224	PF00498	0.516
LIG_FHA_1	273	279	PF00498	0.574
LIG_FHA_2	107	113	PF00498	0.516
LIG_FHA_2	274	280	PF00498	0.574
LIG_FHA_2	99	105	PF00498	0.516
LIG_LIR_Gen_1	158	167	PF02991	0.574
LIG_LIR_Gen_1	18	29	PF02991	0.492
LIG_LIR_Nem_3	18	24	PF02991	0.439
LIG_MAD2	222	230	PF02301	0.574
LIG_PDZ_Class_1	322	327	PF00595	0.726
LIG_PTB_Apo_2	9	16	PF02174	0.502
LIG_SH2_SRC	271	274	PF00017	0.516
LIG_SH2_STAP1	214	218	PF00017	0.574
LIG_SH2_STAT3	214	217	PF00017	0.574
LIG_SH2_STAT5	157	160	PF00017	0.574
LIG_SH2_STAT5	234	237	PF00017	0.516
LIG_SH2_STAT5	271	274	PF00017	0.516
LIG_SH2_STAT5	38	41	PF00017	0.516
LIG_SH3_3	242	248	PF00018	0.541
LIG_SH3_3	250	256	PF00018	0.521
LIG_SH3_3	5	11	PF00018	0.418
LIG_SH3_3	87	93	PF00018	0.570
LIG_SUMO_SIM_par_1	169	174	PF11976	0.516
LIG_SUMO_SIM_par_1	222	228	PF11976	0.516
LIG_WRC_WIRS_1	64	69	PF05994	0.516
MOD_CK1_1	108	114	PF00069	0.574
MOD_CK2_1	106	112	PF00069	0.538
MOD_CK2_1	203	209	PF00069	0.516
MOD_CK2_1	273	279	PF00069	0.574
MOD_GlcNHglycan	115	119	PF01048	0.343
MOD_GlcNHglycan	209	212	PF01048	0.316
MOD_GlcNHglycan	231	234	PF01048	0.316
MOD_GlcNHglycan	288	291	PF01048	0.316
MOD_GlcNHglycan	49	52	PF01048	0.316
MOD_GSK3_1	200	207	PF00069	0.516
MOD_GSK3_1	310	317	PF00069	0.479
MOD_GSK3_1	318	325	PF00069	0.558
MOD_GSK3_1	59	66	PF00069	0.516
MOD_GSK3_1	98	105	PF00069	0.574
MOD_N-GLC_1	106	111	PF02516	0.360
MOD_N-GLC_2	45	47	PF02516	0.316
MOD_NEK2_1	15	20	PF00069	0.443
MOD_NEK2_1	59	64	PF00069	0.574
MOD_NEK2_2	60	65	PF00069	0.486
MOD_PIKK_1	102	108	PF00454	0.574
MOD_PKA_2	158	164	PF00069	0.516
MOD_PKA_2	47	53	PF00069	0.492
MOD_PKA_2	60	66	PF00069	0.516
MOD_Plk_1	106	112	PF00069	0.574
MOD_Plk_1	179	185	PF00069	0.516
MOD_Plk_4	187	193	PF00069	0.516
MOD_Plk_4	63	69	PF00069	0.525
MOD_ProDKin_1	150	156	PF00069	0.516
MOD_ProDKin_1	204	210	PF00069	0.516
MOD_ProDKin_1	252	258	PF00069	0.516
MOD_ProDKin_1	273	279	PF00069	0.574
MOD_ProDKin_1	53	59	PF00069	0.486
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.599
TRG_ER_diArg_1	305	307	PF00400	0.552
TRG_NES_CRM1_1	217	228	PF08389	0.574
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6N7	Leptomonas seymouri	69%	100%
A0A3S5H4X6	Leishmania donovani	94%	100%
A2RGF2	Streptococcus pyogenes serotype M5 (strain Manfredo)	27%	100%
A3CPH5	Streptococcus sanguinis (strain SK36)	27%	100%
A5IUY2	Staphylococcus aureus (strain JH9)	27%	100%
A6QJ37	Staphylococcus aureus (strain Newman)	27%	100%
A6U3S3	Staphylococcus aureus (strain JH1)	27%	100%
A7X575	Staphylococcus aureus (strain Mu3 / ATCC 700698)	27%	100%
A8YYG0	Staphylococcus aureus (strain USA300 / TCH1516)	27%	100%
B1IBZ5	Streptococcus pneumoniae (strain Hungary19A-6)	29%	100%
B2IPT7	Streptococcus pneumoniae (strain CGSP14)	29%	100%
B5E4T0	Streptococcus pneumoniae serotype 19F (strain G54)	29%	100%
B5XII4	Streptococcus pyogenes serotype M49 (strain NZ131)	27%	100%
B8ZQ64	Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)	29%	100%
B9DU93	Streptococcus uberis (strain ATCC BAA-854 / 0140J)	28%	100%
C1C7G0	Streptococcus pneumoniae (strain 70585)	29%	100%
C1CEF2	Streptococcus pneumoniae (strain JJA)	29%	100%
C1CKT7	Streptococcus pneumoniae (strain P1031)	29%	100%
C1CRA6	Streptococcus pneumoniae (strain Taiwan19F-14)	29%	100%
D4GYE6	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	28%	100%
E9AC77	Leishmania major	100%	100%
E9AHA4	Leishmania infantum	94%	100%
O31714	Bacillus subtilis (strain 168)	27%	100%
P06999	Escherichia coli (strain K12)	25%	100%
P0A0B8	Staphylococcus aureus (strain MW2)	27%	100%
P0A0B9	Staphylococcus aureus (strain NCTC 8325 / PS 47)	27%	100%
P0AEW9	Escherichia coli (strain K12)	25%	100%
P0AEX0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	25%	100%
P0AEX1	Escherichia coli O157:H7	25%	100%
P0AEX2	Shigella flexneri	25%	100%
P0DC12	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	27%	100%
P0DC13	Streptococcus pyogenes serotype M3 (strain SSI-1)	27%	100%
P23391	Lactococcus lactis subsp. lactis	26%	100%
P26421	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	27%	100%
P44330	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
P65698	Staphylococcus aureus (strain Mu50 / ATCC 700699)	27%	100%
P65699	Staphylococcus aureus (strain N315)	27%	100%
P75038	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	26%	100%
P9WID2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	96%
P9WID3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	96%
Q04KC3	Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)	29%	100%
Q1J4Q3	Streptococcus pyogenes serotype M4 (strain MGAS10750)	26%	100%
Q1J9U8	Streptococcus pyogenes serotype M12 (strain MGAS2096)	27%	100%
Q1JEY9	Streptococcus pyogenes serotype M2 (strain MGAS10270)	26%	100%
Q1JJZ7	Streptococcus pyogenes serotype M12 (strain MGAS9429)	27%	100%
Q2FET9	Staphylococcus aureus (strain USA300)	27%	100%
Q2YYJ5	Staphylococcus aureus (strain bovine RF122 / ET3-1)	28%	100%
Q3JZ20	Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)	26%	100%
Q48RC4	Streptococcus pyogenes serotype M28 (strain MGAS6180)	26%	100%
Q4L872	Staphylococcus haemolyticus (strain JCSC1435)	25%	100%
Q5HE12	Staphylococcus aureus (strain COL)	27%	100%
Q5HM37	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	24%	100%
Q5X9Y3	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	26%	100%
Q6G7C1	Staphylococcus aureus (strain MSSA476)	27%	100%
Q6GEN6	Staphylococcus aureus (strain MRSA252)	28%	100%
Q833W9	Enterococcus faecalis (strain ATCC 700802 / V583)	24%	100%
Q8CRJ4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
Q8DPP1	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	29%	100%
Q8DXC2	Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)	27%	100%
Q8E346	Streptococcus agalactiae serotype III (strain NEM316)	27%	100%
Q8E4R7	Streptococcus agalactiae serotype III (strain NEM316)	26%	100%
Q8NZD9	Streptococcus pyogenes serotype M18 (strain MGAS8232)	27%	100%
Q8XNK5	Clostridium perfringens (strain 13 / Type A)	24%	100%
Q97QL2	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	29%	100%
Q99Y14	Streptococcus pyogenes serotype M1	27%	100%
Q9KM71	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	22%	100%