Methylmalonyl-coa epimerase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylmalonyl-coa epimerase-like protein

Species:

Leishmania major

UniProt:

Q4Q9I9_LEIMA

TriTrypDb:

LmjF.26.0020 , LMJLV39_260005200 , LMJSD75_260005100

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9I9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006637	acyl-CoA metabolic process	4	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006790	sulfur compound metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009150	purine ribonucleotide metabolic process	6	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0033865	nucleoside bisphosphate metabolic process	5	2
GO:0033875	ribonucleoside bisphosphate metabolic process	6	2
GO:0034032	purine nucleoside bisphosphate metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0035383	thioester metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046491	L-methylmalonyl-CoA metabolic process	5	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004493	methylmalonyl-CoA epimerase activity	4	6
GO:0016853	isomerase activity	2	6
GO:0016854	racemase and epimerase activity	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_MAPK_MEF2A_6	7	15	PF00069	0.413
DOC_PP2B_LxvP_1	88	91	PF13499	0.391
DOC_PP4_FxxP_1	123	126	PF00568	0.474
DOC_USP7_MATH_1	17	21	PF00917	0.512
DOC_USP7_MATH_1	34	38	PF00917	0.391
DOC_WW_Pin1_4	66	71	PF00397	0.413
LIG_APCC_ABBA_1	48	53	PF00400	0.515
LIG_FHA_1	47	53	PF00498	0.413
LIG_FHA_2	132	138	PF00498	0.449
LIG_FHA_2	55	61	PF00498	0.437
LIG_FHA_2	97	103	PF00498	0.444
LIG_LIR_Gen_1	26	36	PF02991	0.437
LIG_LIR_Gen_1	49	59	PF02991	0.413
LIG_LIR_Nem_3	26	31	PF02991	0.515
LIG_LIR_Nem_3	49	54	PF02991	0.391
LIG_SH2_CRK	28	32	PF00017	0.413
LIG_SH2_NCK_1	28	32	PF00017	0.398
LIG_SH2_STAP1	28	32	PF00017	0.437
LIG_SH2_STAT5	28	31	PF00017	0.398
LIG_SH3_3	33	39	PF00018	0.413
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.413
LIG_UBA3_1	61	68	PF00899	0.282
MOD_CK2_1	131	137	PF00069	0.433
MOD_CK2_1	17	23	PF00069	0.515
MOD_CK2_1	54	60	PF00069	0.413
MOD_CK2_1	96	102	PF00069	0.360
MOD_NEK2_1	54	59	PF00069	0.396
MOD_NEK2_2	46	51	PF00069	0.413
MOD_NEK2_2	96	101	PF00069	0.360
MOD_ProDKin_1	66	72	PF00069	0.413
MOD_SUMO_for_1	40	43	PF00179	0.391
MOD_SUMO_rev_2	135	141	PF00179	0.508
TRG_ENDOCYTIC_2	28	31	PF00928	0.413
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K5	Leptomonas seymouri	79%	93%
A0A0S4INE6	Bodo saltans	62%	94%
A0A3S7WZI1	Leishmania donovani	94%	100%
A4HEL0	Leishmania braziliensis	82%	93%
A4I1U1	Leishmania infantum	93%	93%
E9AXY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	93%
O58010	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	32%	100%
P54540	Bacillus subtilis (strain 168)	32%	100%
Q2KIZ3	Bos taurus	59%	81%
Q3IZP4	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	57%	100%
Q553V2	Dictyostelium discoideum	62%	85%
Q96PE7	Homo sapiens	61%	80%
Q9D1I5	Mus musculus	59%	79%