Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9I5_LEIMA

TriTrypDb:

LmjF.26.0055 , LMJLV39_260005700 , LMJSD75_260005600

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9I5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.522
CLV_NRD_NRD_1	120	122	PF00675	0.430
CLV_NRD_NRD_1	187	189	PF00675	0.569
CLV_NRD_NRD_1	242	244	PF00675	0.700
CLV_NRD_NRD_1	43	45	PF00675	0.502
CLV_NRD_NRD_1	81	83	PF00675	0.492
CLV_PCSK_FUR_1	78	82	PF00082	0.449
CLV_PCSK_KEX2_1	113	115	PF00082	0.522
CLV_PCSK_KEX2_1	187	189	PF00082	0.710
CLV_PCSK_KEX2_1	242	244	PF00082	0.621
CLV_PCSK_KEX2_1	42	44	PF00082	0.541
CLV_PCSK_KEX2_1	80	82	PF00082	0.507
CLV_PCSK_SKI1_1	114	118	PF00082	0.630
CLV_PCSK_SKI1_1	219	223	PF00082	0.487
CLV_PCSK_SKI1_1	22	26	PF00082	0.416
CLV_PCSK_SKI1_1	283	287	PF00082	0.701
DEG_APCC_DBOX_1	113	121	PF00400	0.494
DEG_APCC_DBOX_1	21	29	PF00400	0.440
DEG_COP1_1	250	260	PF00400	0.602
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DEG_SPOP_SBC_1	277	281	PF00917	0.504
DOC_PP2B_LxvP_1	162	165	PF13499	0.492
DOC_PP2B_LxvP_1	274	277	PF13499	0.504
DOC_USP7_MATH_1	157	161	PF00917	0.711
DOC_USP7_MATH_1	17	21	PF00917	0.508
DOC_USP7_MATH_1	225	229	PF00917	0.537
DOC_WW_Pin1_4	15	20	PF00397	0.513
DOC_WW_Pin1_4	163	168	PF00397	0.540
DOC_WW_Pin1_4	219	224	PF00397	0.521
DOC_WW_Pin1_4	245	250	PF00397	0.610
DOC_WW_Pin1_4	290	295	PF00397	0.647
DOC_WW_Pin1_4	46	51	PF00397	0.483
LIG_14-3-3_CanoR_1	242	249	PF00244	0.531
LIG_14-3-3_CanoR_1	36	41	PF00244	0.403
LIG_14-3-3_CanoR_1	81	87	PF00244	0.469
LIG_BRCT_BRCA1_1	185	189	PF00533	0.564
LIG_FHA_1	147	153	PF00498	0.535
LIG_FHA_1	95	101	PF00498	0.493
LIG_FHA_2	47	53	PF00498	0.443
LIG_FHA_2	94	100	PF00498	0.490
LIG_GSK3_LRP6_1	163	168	PF00069	0.485
LIG_LIR_Apic_2	207	213	PF02991	0.561
LIG_LIR_Gen_1	196	205	PF02991	0.565
LIG_LIR_Nem_3	196	202	PF02991	0.681
LIG_LIR_Nem_3	6	12	PF02991	0.563
LIG_Pex14_1	210	214	PF04695	0.545
LIG_SH2_CRK	89	93	PF00017	0.481
LIG_SH2_STAP1	89	93	PF00017	0.437
LIG_SH3_3	113	119	PF00018	0.664
LIG_SH3_3	161	167	PF00018	0.522
LIG_SH3_3	199	205	PF00018	0.602
LIG_SH3_3	221	227	PF00018	0.511
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.498
LIG_TRAF2_1	250	253	PF00917	0.613
LIG_WRC_WIRS_1	226	231	PF05994	0.496
MOD_CDK_SPxxK_3	15	22	PF00069	0.474
MOD_CK1_1	35	41	PF00069	0.433
MOD_CK2_1	105	111	PF00069	0.529
MOD_CK2_1	17	23	PF00069	0.500
MOD_CK2_1	241	247	PF00069	0.595
MOD_CK2_1	48	54	PF00069	0.444
MOD_GlcNHglycan	140	143	PF01048	0.495
MOD_GlcNHglycan	152	155	PF01048	0.515
MOD_GlcNHglycan	159	162	PF01048	0.564
MOD_GlcNHglycan	191	194	PF01048	0.538
MOD_GlcNHglycan	249	252	PF01048	0.614
MOD_GlcNHglycan	265	268	PF01048	0.509
MOD_GlcNHglycan	280	283	PF01048	0.552
MOD_GlcNHglycan	6	12	PF01048	0.529
MOD_GSK3_1	101	108	PF00069	0.552
MOD_GSK3_1	146	153	PF00069	0.606
MOD_GSK3_1	241	248	PF00069	0.650
MOD_GSK3_1	263	270	PF00069	0.590
MOD_GSK3_1	32	39	PF00069	0.478
MOD_N-GLC_1	15	20	PF02516	0.485
MOD_N-GLC_1	169	174	PF02516	0.630
MOD_N-GLC_1	270	275	PF02516	0.611
MOD_NEK2_1	101	106	PF00069	0.623
MOD_NEK2_1	183	188	PF00069	0.521
MOD_NEK2_1	189	194	PF00069	0.520
MOD_PIKK_1	101	107	PF00454	0.522
MOD_PKA_2	150	156	PF00069	0.493
MOD_PKA_2	241	247	PF00069	0.524
MOD_PKA_2	35	41	PF00069	0.383
MOD_PKB_1	80	88	PF00069	0.473
MOD_Plk_1	169	175	PF00069	0.558
MOD_Plk_1	270	276	PF00069	0.540
MOD_Plk_4	170	176	PF00069	0.587
MOD_Plk_4	225	231	PF00069	0.626
MOD_Plk_4	256	262	PF00069	0.606
MOD_Plk_4	270	276	PF00069	0.508
MOD_ProDKin_1	15	21	PF00069	0.506
MOD_ProDKin_1	163	169	PF00069	0.540
MOD_ProDKin_1	219	225	PF00069	0.520
MOD_ProDKin_1	245	251	PF00069	0.608
MOD_ProDKin_1	290	296	PF00069	0.647
MOD_ProDKin_1	46	52	PF00069	0.478
TRG_ENDOCYTIC_2	89	92	PF00928	0.484
TRG_ER_diArg_1	113	115	PF00400	0.594
TRG_ER_diArg_1	130	133	PF00400	0.382
TRG_ER_diArg_1	187	189	PF00400	0.569
TRG_ER_diArg_1	205	208	PF00400	0.578
TRG_ER_diArg_1	241	243	PF00400	0.756
TRG_ER_diArg_1	42	44	PF00400	0.507
TRG_ER_diArg_1	78	81	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M0	Leptomonas seymouri	39%	87%
A0A3Q8IDN0	Leishmania donovani	89%	100%
A4HEL4	Leishmania braziliensis	64%	100%
A4I1U5	Leishmania infantum	89%	100%
E9AXY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%