Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9I2_LEIMA

TriTrypDb:

LmjF.26.0115 , LMJLV39_260006100 , LMJSD75_260006000

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

Q4Q9I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9I2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004175	endopeptidase activity	4	3
GO:0004252	serine-type endopeptidase activity	5	3
GO:0008233	peptidase activity	3	4
GO:0008236	serine-type peptidase activity	4	3
GO:0016787	hydrolase activity	2	4
GO:0017171	serine hydrolase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.438
CLV_NRD_NRD_1	207	209	PF00675	0.649
CLV_PCSK_KEX2_1	142	144	PF00082	0.365
CLV_PCSK_KEX2_1	170	172	PF00082	0.400
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.376
CLV_PCSK_PC7_1	166	172	PF00082	0.493
CLV_PCSK_SKI1_1	208	212	PF00082	0.660
CLV_PCSK_SKI1_1	34	38	PF00082	0.531
CLV_PCSK_SKI1_1	72	76	PF00082	0.609
DOC_MAPK_gen_1	170	178	PF00069	0.580
DOC_MAPK_MEF2A_6	81	88	PF00069	0.311
DOC_USP7_MATH_1	102	106	PF00917	0.624
DOC_WW_Pin1_4	161	166	PF00397	0.629
LIG_14-3-3_CanoR_1	40	48	PF00244	0.386
LIG_Actin_WH2_2	126	144	PF00022	0.622
LIG_BIR_II_1	1	5	PF00653	0.441
LIG_BRCT_BRCA1_1	193	197	PF00533	0.420
LIG_BRCT_BRCA1_1	40	44	PF00533	0.387
LIG_eIF4E_1	126	132	PF01652	0.593
LIG_eIF4E_1	162	168	PF01652	0.651
LIG_eIF4E_1	87	93	PF01652	0.414
LIG_FHA_1	126	132	PF00498	0.546
LIG_FHA_1	56	62	PF00498	0.401
LIG_FHA_1	6	12	PF00498	0.407
LIG_FHA_1	73	79	PF00498	0.380
LIG_FHA_2	156	162	PF00498	0.573
LIG_FHA_2	198	204	PF00498	0.375
LIG_LIR_Apic_2	160	165	PF02991	0.539
LIG_LIR_Apic_2	42	48	PF02991	0.342
LIG_LIR_Gen_1	190	198	PF02991	0.414
LIG_LIR_Gen_1	94	104	PF02991	0.337
LIG_LIR_Nem_3	158	162	PF02991	0.594
LIG_LIR_Nem_3	190	196	PF02991	0.414
LIG_LIR_Nem_3	8	13	PF02991	0.300
LIG_LIR_Nem_3	94	99	PF02991	0.337
LIG_MLH1_MIPbox_1	194	198	PF16413	0.443
LIG_Pex14_2	96	100	PF04695	0.337
LIG_PTB_Apo_2	177	184	PF02174	0.488
LIG_REV1ctd_RIR_1	195	205	PF16727	0.579
LIG_SH2_CRK	126	130	PF00017	0.579
LIG_SH2_CRK	193	197	PF00017	0.411
LIG_SH2_PTP2	162	165	PF00017	0.555
LIG_SH2_STAP1	159	163	PF00017	0.542
LIG_SH2_STAP1	193	197	PF00017	0.414
LIG_SH2_STAT5	137	140	PF00017	0.544
LIG_SH2_STAT5	153	156	PF00017	0.512
LIG_SH2_STAT5	162	165	PF00017	0.547
LIG_SH2_STAT5	53	56	PF00017	0.321
LIG_SH2_STAT5	87	90	PF00017	0.367
LIG_SH2_STAT5	98	101	PF00017	0.277
LIG_SH3_3	67	73	PF00018	0.392
LIG_SUMO_SIM_anti_2	128	133	PF11976	0.553
LIG_SUMO_SIM_par_1	21	28	PF11976	0.397
LIG_TYR_ITIM	191	196	PF00017	0.451
LIG_WRC_WIRS_1	93	98	PF05994	0.328
LIG_WW_3	214	218	PF00397	0.464
MOD_CDK_SPK_2	161	166	PF00069	0.541
MOD_CK2_1	155	161	PF00069	0.461
MOD_GlcNHglycan	41	44	PF01048	0.453
MOD_GSK3_1	1	8	PF00069	0.540
MOD_GSK3_1	102	109	PF00069	0.524
MOD_GSK3_1	187	194	PF00069	0.393
MOD_N-GLC_1	115	120	PF02516	0.435
MOD_N-GLC_1	55	60	PF02516	0.524
MOD_NEK2_1	12	17	PF00069	0.515
MOD_NEK2_1	191	196	PF00069	0.324
MOD_NEK2_1	197	202	PF00069	0.467
MOD_NEK2_1	24	29	PF00069	0.445
MOD_NEK2_1	38	43	PF00069	0.405
MOD_NEK2_1	52	57	PF00069	0.388
MOD_NEK2_1	92	97	PF00069	0.343
MOD_PIKK_1	108	114	PF00454	0.489
MOD_PKA_2	25	31	PF00069	0.550
MOD_PKA_2	39	45	PF00069	0.497
MOD_Plk_1	202	208	PF00069	0.505
MOD_Plk_1	5	11	PF00069	0.535
MOD_Plk_4	127	133	PF00069	0.403
MOD_Plk_4	192	198	PF00069	0.328
MOD_Plk_4	5	11	PF00069	0.430
MOD_ProDKin_1	161	167	PF00069	0.553
TRG_ENDOCYTIC_2	126	129	PF00928	0.470
TRG_ENDOCYTIC_2	193	196	PF00928	0.411
TRG_ER_diArg_1	170	172	PF00400	0.623
TRG_ER_diArg_1	198	201	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z5	Leptomonas seymouri	78%	93%
A0A0S4INS6	Bodo saltans	45%	99%
A0A1X0NU17	Trypanosomatidae	60%	95%
A0A3Q8IDK2	Leishmania donovani	97%	94%
A0A422N342	Trypanosoma rangeli	61%	95%
A4HEL7	Leishmania braziliensis	86%	94%
A4I1V0	Leishmania infantum	97%	94%
C9ZS72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	94%
E9AXZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	94%
Q4Q9H9	Leishmania major	100%	100%
V5B9I6	Trypanosoma cruzi	61%	95%