Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9I0_LEIMA

TriTrypDb:

LmjF.26.0070 , LMJLV39_260006000 , LMJSD75_260005900

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9I0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.388
CLV_NRD_NRD_1	249	251	PF00675	0.516
CLV_NRD_NRD_1	270	272	PF00675	0.589
CLV_NRD_NRD_1	273	275	PF00675	0.565
CLV_NRD_NRD_1	283	285	PF00675	0.475
CLV_NRD_NRD_1	342	344	PF00675	0.647
CLV_NRD_NRD_1	62	64	PF00675	0.367
CLV_PCSK_FUR_1	246	250	PF00082	0.400
CLV_PCSK_KEX2_1	248	250	PF00082	0.579
CLV_PCSK_KEX2_1	342	344	PF00082	0.679
CLV_PCSK_KEX2_1	62	64	PF00082	0.326
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.566
CLV_PCSK_PC7_1	244	250	PF00082	0.569
CLV_PCSK_PC7_1	58	64	PF00082	0.383
CLV_PCSK_SKI1_1	249	253	PF00082	0.438
CLV_PCSK_SKI1_1	284	288	PF00082	0.526
CLV_PCSK_SKI1_1	84	88	PF00082	0.496
DEG_APCC_DBOX_1	283	291	PF00400	0.351
DOC_MAPK_gen_1	284	290	PF00069	0.351
DOC_MAPK_gen_1	79	88	PF00069	0.432
DOC_MAPK_MEF2A_6	82	90	PF00069	0.406
DOC_PP2B_LxvP_1	90	93	PF13499	0.396
DOC_USP7_MATH_1	108	112	PF00917	0.417
DOC_USP7_MATH_1	329	333	PF00917	0.451
DOC_USP7_MATH_1	77	81	PF00917	0.347
DOC_USP7_UBL2_3	285	289	PF12436	0.536
DOC_WW_Pin1_4	218	223	PF00397	0.526
DOC_WW_Pin1_4	349	354	PF00397	0.733
LIG_14-3-3_CanoR_1	16	20	PF00244	0.528
LIG_14-3-3_CanoR_1	186	195	PF00244	0.421
LIG_14-3-3_CanoR_1	294	300	PF00244	0.377
LIG_14-3-3_CanoR_1	312	318	PF00244	0.244
LIG_Actin_WH2_2	275	291	PF00022	0.395
LIG_APCC_ABBAyCdc20_2	239	245	PF00400	0.430
LIG_BRCT_BRCA1_1	110	114	PF00533	0.389
LIG_BRCT_BRCA1_1	315	319	PF00533	0.468
LIG_Clathr_ClatBox_1	125	129	PF01394	0.301
LIG_FHA_1	121	127	PF00498	0.381
LIG_FHA_1	47	53	PF00498	0.428
LIG_FHA_2	150	156	PF00498	0.375
LIG_LIR_Apic_2	127	133	PF02991	0.362
LIG_LIR_Apic_2	96	102	PF02991	0.393
LIG_LIR_Gen_1	189	199	PF02991	0.353
LIG_LIR_Gen_1	301	311	PF02991	0.439
LIG_LIR_Gen_1	316	327	PF02991	0.389
LIG_LIR_Nem_3	189	194	PF02991	0.350
LIG_LIR_Nem_3	277	282	PF02991	0.502
LIG_LIR_Nem_3	293	299	PF02991	0.330
LIG_LIR_Nem_3	301	307	PF02991	0.473
LIG_LIR_Nem_3	316	322	PF02991	0.304
LIG_NRBOX	120	126	PF00104	0.238
LIG_NRBOX	336	342	PF00104	0.416
LIG_PTB_Apo_2	153	160	PF02174	0.431
LIG_RPA_C_Fungi	239	251	PF08784	0.488
LIG_SH2_NCK_1	237	241	PF00017	0.471
LIG_SH2_SRC	304	307	PF00017	0.549
LIG_SH2_STAP1	178	182	PF00017	0.410
LIG_SH2_STAP1	233	237	PF00017	0.547
LIG_SH2_STAP1	48	52	PF00017	0.465
LIG_SH2_STAT5	191	194	PF00017	0.452
LIG_SH2_STAT5	304	307	PF00017	0.404
LIG_SH2_STAT5	48	51	PF00017	0.363
LIG_SH2_STAT5	99	102	PF00017	0.328
LIG_SH3_3	133	139	PF00018	0.488
LIG_SH3_3	347	353	PF00018	0.588
LIG_SH3_3	47	53	PF00018	0.421
LIG_SH3_3	71	77	PF00018	0.320
LIG_Sin3_3	22	29	PF02671	0.334
LIG_SUMO_SIM_anti_2	120	127	PF11976	0.456
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.402
LIG_SUMO_SIM_par_1	122	127	PF11976	0.434
LIG_TRAF2_1	251	254	PF00917	0.382
LIG_WW_3	13	17	PF00397	0.510
LIG_WW_3	268	272	PF00397	0.469
MOD_CK1_1	120	126	PF00069	0.417
MOD_CK1_1	218	224	PF00069	0.524
MOD_CK1_1	295	301	PF00069	0.380
MOD_CK1_1	332	338	PF00069	0.436
MOD_CK2_1	149	155	PF00069	0.438
MOD_Cter_Amidation	1	4	PF01082	0.568
MOD_GlcNHglycan	110	113	PF01048	0.321
MOD_GlcNHglycan	300	303	PF01048	0.357
MOD_GlcNHglycan	79	82	PF01048	0.464
MOD_GSK3_1	313	320	PF00069	0.453
MOD_GSK3_1	329	336	PF00069	0.349
MOD_N-GLC_1	186	191	PF02516	0.330
MOD_N-GLC_1	280	285	PF02516	0.425
MOD_NEK2_1	159	164	PF00069	0.399
MOD_NEK2_1	215	220	PF00069	0.412
MOD_NEK2_1	280	285	PF00069	0.492
MOD_NEK2_1	311	316	PF00069	0.547
MOD_NEK2_2	292	297	PF00069	0.400
MOD_NEK2_2	93	98	PF00069	0.369
MOD_PKA_1	3	9	PF00069	0.565
MOD_PKA_2	15	21	PF00069	0.558
MOD_PKA_2	311	317	PF00069	0.409
MOD_PKB_1	184	192	PF00069	0.455
MOD_Plk_1	264	270	PF00069	0.483
MOD_Plk_1	292	298	PF00069	0.488
MOD_Plk_1	333	339	PF00069	0.561
MOD_Plk_4	117	123	PF00069	0.430
MOD_Plk_4	313	319	PF00069	0.522
MOD_ProDKin_1	218	224	PF00069	0.526
MOD_ProDKin_1	349	355	PF00069	0.736
MOD_SUMO_rev_2	267	276	PF00179	0.675
TRG_DiLeu_BaEn_1	117	122	PF01217	0.251
TRG_DiLeu_BaEn_4	210	216	PF01217	0.377
TRG_ENDOCYTIC_2	191	194	PF00928	0.402
TRG_ENDOCYTIC_2	304	307	PF00928	0.425
TRG_ENDOCYTIC_2	64	67	PF00928	0.360
TRG_ER_diArg_1	341	343	PF00400	0.480
TRG_ER_diArg_1	62	64	PF00400	0.326
TRG_NLS_MonoExtN_4	246	252	PF00514	0.389
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL9	Leptomonas seymouri	58%	89%
A0A0S4IRP2	Bodo saltans	27%	100%
A0A1X0NU99	Trypanosomatidae	40%	100%
A0A3Q8ICK6	Leishmania donovani	97%	100%
A0A422N352	Trypanosoma rangeli	39%	100%
A4HEL6	Leishmania braziliensis	89%	100%
A4I1U9	Leishmania infantum	97%	100%
C9ZS73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZS78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AHA8	Leishmania infantum	97%	100%
E9AXZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5DR77	Trypanosoma cruzi	40%	100%