Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9H9_LEIMA

TriTrypDb:

LmjF.26.0115 , LMJLV39_260006100 , LMJSD75_260006000

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

Q4Q9H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9H9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004175	endopeptidase activity	4	3
GO:0004252	serine-type endopeptidase activity	5	3
GO:0008233	peptidase activity	3	4
GO:0008236	serine-type peptidase activity	4	3
GO:0016787	hydrolase activity	2	4
GO:0017171	serine hydrolase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.437
CLV_NRD_NRD_1	220	222	PF00675	0.649
CLV_PCSK_KEX2_1	155	157	PF00082	0.370
CLV_PCSK_KEX2_1	183	185	PF00082	0.400
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.393
CLV_PCSK_PC7_1	179	185	PF00082	0.492
CLV_PCSK_SKI1_1	221	225	PF00082	0.650
CLV_PCSK_SKI1_1	47	51	PF00082	0.526
CLV_PCSK_SKI1_1	85	89	PF00082	0.587
DOC_MAPK_gen_1	183	191	PF00069	0.584
DOC_MAPK_MEF2A_6	94	101	PF00069	0.311
DOC_USP7_MATH_1	115	119	PF00917	0.623
DOC_WW_Pin1_4	174	179	PF00397	0.625
LIG_14-3-3_CanoR_1	53	61	PF00244	0.384
LIG_Actin_WH2_2	139	157	PF00022	0.620
LIG_BRCT_BRCA1_1	206	210	PF00533	0.420
LIG_BRCT_BRCA1_1	53	57	PF00533	0.385
LIG_eIF4E_1	100	106	PF01652	0.414
LIG_eIF4E_1	139	145	PF01652	0.562
LIG_eIF4E_1	175	181	PF01652	0.649
LIG_FHA_1	139	145	PF00498	0.542
LIG_FHA_1	19	25	PF00498	0.414
LIG_FHA_1	6	12	PF00498	0.536
LIG_FHA_1	69	75	PF00498	0.391
LIG_FHA_1	86	92	PF00498	0.365
LIG_FHA_2	169	175	PF00498	0.581
LIG_FHA_2	211	217	PF00498	0.368
LIG_LIR_Apic_2	173	178	PF02991	0.538
LIG_LIR_Apic_2	55	61	PF02991	0.341
LIG_LIR_Gen_1	107	117	PF02991	0.337
LIG_LIR_Gen_1	203	211	PF02991	0.414
LIG_LIR_Gen_1	3	12	PF02991	0.597
LIG_LIR_Nem_3	107	112	PF02991	0.337
LIG_LIR_Nem_3	171	175	PF02991	0.592
LIG_LIR_Nem_3	203	209	PF02991	0.414
LIG_LIR_Nem_3	21	26	PF02991	0.385
LIG_LIR_Nem_3	3	7	PF02991	0.661
LIG_MLH1_MIPbox_1	207	211	PF16413	0.443
LIG_Pex14_2	109	113	PF04695	0.330
LIG_PTB_Apo_2	190	197	PF02174	0.488
LIG_REV1ctd_RIR_1	208	218	PF16727	0.557
LIG_SH2_CRK	139	143	PF00017	0.577
LIG_SH2_CRK	206	210	PF00017	0.411
LIG_SH2_NCK_1	4	8	PF00017	0.586
LIG_SH2_PTP2	175	178	PF00017	0.554
LIG_SH2_SRC	4	7	PF00017	0.641
LIG_SH2_STAP1	172	176	PF00017	0.540
LIG_SH2_STAP1	206	210	PF00017	0.414
LIG_SH2_STAT5	100	103	PF00017	0.414
LIG_SH2_STAT5	111	114	PF00017	0.328
LIG_SH2_STAT5	150	153	PF00017	0.539
LIG_SH2_STAT5	166	169	PF00017	0.474
LIG_SH2_STAT5	175	178	PF00017	0.536
LIG_SH2_STAT5	66	69	PF00017	0.314
LIG_SH3_3	80	86	PF00018	0.381
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.545
LIG_SUMO_SIM_par_1	34	41	PF11976	0.399
LIG_TYR_ITIM	204	209	PF00017	0.451
LIG_WRC_WIRS_1	106	111	PF05994	0.328
LIG_WW_3	227	231	PF00397	0.454
MOD_CDK_SPK_2	174	179	PF00069	0.539
MOD_CK2_1	168	174	PF00069	0.473
MOD_GlcNHglycan	54	57	PF01048	0.451
MOD_GSK3_1	115	122	PF00069	0.457
MOD_GSK3_1	14	21	PF00069	0.370
MOD_GSK3_1	200	207	PF00069	0.375
MOD_N-GLC_1	128	133	PF02516	0.455
MOD_N-GLC_1	68	73	PF02516	0.513
MOD_NEK2_1	105	110	PF00069	0.343
MOD_NEK2_1	204	209	PF00069	0.328
MOD_NEK2_1	210	215	PF00069	0.437
MOD_NEK2_1	25	30	PF00069	0.520
MOD_NEK2_1	37	42	PF00069	0.374
MOD_NEK2_1	51	56	PF00069	0.368
MOD_NEK2_1	65	70	PF00069	0.375
MOD_PIKK_1	121	127	PF00454	0.488
MOD_PKA_2	38	44	PF00069	0.552
MOD_PKA_2	52	58	PF00069	0.495
MOD_Plk_1	18	24	PF00069	0.414
MOD_Plk_1	215	221	PF00069	0.504
MOD_Plk_4	140	146	PF00069	0.363
MOD_Plk_4	18	24	PF00069	0.385
MOD_Plk_4	205	211	PF00069	0.328
MOD_Plk_4	7	13	PF00069	0.349
MOD_ProDKin_1	174	180	PF00069	0.547
TRG_ENDOCYTIC_2	139	142	PF00928	0.431
TRG_ENDOCYTIC_2	206	209	PF00928	0.411
TRG_ENDOCYTIC_2	4	7	PF00928	0.575
TRG_ER_diArg_1	183	185	PF00400	0.622
TRG_ER_diArg_1	211	214	PF00400	0.480
TRG_NES_CRM1_1	6	19	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z5	Leptomonas seymouri	78%	99%
A0A0S4INS6	Bodo saltans	45%	100%
A0A1X0NU17	Trypanosomatidae	60%	100%
A0A3Q8IDK2	Leishmania donovani	97%	100%
A0A422N342	Trypanosoma rangeli	61%	100%
A4HEL7	Leishmania braziliensis	86%	100%
A4I1V0	Leishmania infantum	97%	100%
C9ZS72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AXZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q9I2	Leishmania major	100%	100%
V5B9I6	Trypanosoma cruzi	61%	100%