Mini-chromosome maintenance complex-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mini-chromosome maintenance complex-binding protein

Species:

Leishmania major

UniProt:

Q4Q9H7_LEIMA

TriTrypDb:

LmjF.26.0150 , LMJLV39_260006300 , LMJSD75_260006200

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

Q4Q9H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9H7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006260	DNA replication	5	2
GO:0006261	DNA-templated DNA replication	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	2
GO:0005488	binding	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.305
CLV_C14_Caspase3-7	452	456	PF00656	0.258
CLV_C14_Caspase3-7	496	500	PF00656	0.305
CLV_C14_Caspase3-7	89	93	PF00656	0.428
CLV_NRD_NRD_1	133	135	PF00675	0.268
CLV_NRD_NRD_1	157	159	PF00675	0.443
CLV_NRD_NRD_1	560	562	PF00675	0.421
CLV_PCSK_KEX2_1	135	137	PF00082	0.268
CLV_PCSK_KEX2_1	560	562	PF00082	0.261
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.268
CLV_PCSK_SKI1_1	162	166	PF00082	0.259
CLV_PCSK_SKI1_1	520	524	PF00082	0.428
CLV_Separin_Metazoa	120	124	PF03568	0.174
CLV_Separin_Metazoa	370	374	PF03568	0.297
DEG_APCC_DBOX_1	494	502	PF00400	0.305
DEG_SCF_FBW7_1	268	275	PF00400	0.239
DEG_SPOP_SBC_1	147	151	PF00917	0.261
DEG_SPOP_SBC_1	175	179	PF00917	0.440
DOC_CKS1_1	282	287	PF01111	0.365
DOC_CYCLIN_RxL_1	259	271	PF00134	0.305
DOC_CYCLIN_RxL_1	517	526	PF00134	0.305
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.302
DOC_PP2B_LxvP_1	440	443	PF13499	0.343
DOC_PP2B_LxvP_1	504	507	PF13499	0.196
DOC_PP4_FxxP_1	189	192	PF00568	0.395
DOC_USP7_MATH_1	122	126	PF00917	0.273
DOC_USP7_MATH_1	148	152	PF00917	0.349
DOC_USP7_MATH_1	175	179	PF00917	0.447
DOC_USP7_MATH_1	190	194	PF00917	0.382
DOC_USP7_MATH_1	272	276	PF00917	0.387
DOC_USP7_MATH_1	584	588	PF00917	0.611
DOC_USP7_MATH_1	591	595	PF00917	0.695
DOC_WW_Pin1_4	192	197	PF00397	0.174
DOC_WW_Pin1_4	268	273	PF00397	0.327
DOC_WW_Pin1_4	281	286	PF00397	0.250
DOC_WW_Pin1_4	287	292	PF00397	0.203
DOC_WW_Pin1_4	31	36	PF00397	0.496
DOC_WW_Pin1_4	330	335	PF00397	0.339
DOC_WW_Pin1_4	341	346	PF00397	0.333
DOC_WW_Pin1_4	378	383	PF00397	0.288
DOC_WW_Pin1_4	470	475	PF00397	0.376
DOC_WW_Pin1_4	505	510	PF00397	0.255
DOC_WW_Pin1_4	582	587	PF00397	0.434
LIG_14-3-3_CanoR_1	162	171	PF00244	0.347
LIG_14-3-3_CanoR_1	38	46	PF00244	0.524
LIG_14-3-3_CanoR_1	465	471	PF00244	0.271
LIG_Actin_WH2_2	567	585	PF00022	0.174
LIG_BRCT_BRCA1_1	185	189	PF00533	0.378
LIG_deltaCOP1_diTrp_1	415	423	PF00928	0.305
LIG_EH_1	216	220	PF12763	0.305
LIG_EH1_1	4	12	PF00400	0.361
LIG_FHA_1	203	209	PF00498	0.264
LIG_FHA_1	282	288	PF00498	0.390
LIG_FHA_1	295	301	PF00498	0.297
LIG_FHA_1	302	308	PF00498	0.280
LIG_FHA_1	366	372	PF00498	0.435
LIG_FHA_1	391	397	PF00498	0.284
LIG_FHA_1	437	443	PF00498	0.270
LIG_FHA_1	446	452	PF00498	0.229
LIG_FHA_1	484	490	PF00498	0.378
LIG_FHA_2	1	7	PF00498	0.524
LIG_FHA_2	115	121	PF00498	0.394
LIG_FHA_2	150	156	PF00498	0.398
LIG_FHA_2	306	312	PF00498	0.395
LIG_FHA_2	38	44	PF00498	0.540
LIG_FHA_2	511	517	PF00498	0.261
LIG_Integrin_RGD_1	309	311	PF01839	0.174
LIG_IRF3_LxIS_1	338	343	PF10401	0.305
LIG_LIR_Apic_2	103	108	PF02991	0.257
LIG_LIR_Apic_2	186	192	PF02991	0.368
LIG_LIR_Gen_1	244	254	PF02991	0.314
LIG_LIR_Gen_1	314	324	PF02991	0.248
LIG_LIR_Gen_1	420	431	PF02991	0.281
LIG_LIR_Gen_1	434	444	PF02991	0.237
LIG_LIR_Nem_3	226	230	PF02991	0.240
LIG_LIR_Nem_3	244	249	PF02991	0.269
LIG_LIR_Nem_3	269	273	PF02991	0.288
LIG_LIR_Nem_3	314	320	PF02991	0.248
LIG_LIR_Nem_3	420	426	PF02991	0.378
LIG_LIR_Nem_3	434	440	PF02991	0.223
LIG_MYND_1	476	480	PF01753	0.174
LIG_PCNA_yPIPBox_3	4	12	PF02747	0.392
LIG_PTB_Apo_2	538	545	PF02174	0.240
LIG_SH2_CRK	270	274	PF00017	0.395
LIG_SH2_NCK_1	270	274	PF00017	0.404
LIG_SH2_PTP2	105	108	PF00017	0.268
LIG_SH2_SRC	105	108	PF00017	0.249
LIG_SH2_SRC	497	500	PF00017	0.395
LIG_SH2_STAP1	27	31	PF00017	0.388
LIG_SH2_STAT3	228	231	PF00017	0.395
LIG_SH2_STAT3	435	438	PF00017	0.268
LIG_SH2_STAT5	105	108	PF00017	0.249
LIG_SH2_STAT5	116	119	PF00017	0.261
LIG_SH2_STAT5	270	273	PF00017	0.386
LIG_SH2_STAT5	302	305	PF00017	0.318
LIG_SH2_STAT5	31	34	PF00017	0.497
LIG_SH2_STAT5	317	320	PF00017	0.274
LIG_SH2_STAT5	390	393	PF00017	0.305
LIG_SH2_STAT5	497	500	PF00017	0.248
LIG_SH3_3	203	209	PF00018	0.317
LIG_SH3_3	41	47	PF00018	0.475
LIG_SH3_3	473	479	PF00018	0.259
LIG_SUMO_SIM_par_1	337	344	PF11976	0.395
LIG_SUMO_SIM_par_1	441	448	PF11976	0.272
LIG_TRAF2_1	151	154	PF00917	0.261
LIG_TRAF2_1	479	482	PF00917	0.261
LIG_TYR_ITIM	268	273	PF00017	0.305
LIG_UBA3_1	422	428	PF00899	0.313
LIG_WW_3	120	124	PF00397	0.174
MOD_CDK_SPK_2	378	383	PF00069	0.288
MOD_CDK_SPxxK_3	31	38	PF00069	0.481
MOD_CDK_SPxxK_3	470	477	PF00069	0.261
MOD_CK1_1	15	21	PF00069	0.502
MOD_CK1_1	178	184	PF00069	0.453
MOD_CK1_1	290	296	PF00069	0.349
MOD_CK1_1	330	336	PF00069	0.230
MOD_CK1_1	410	416	PF00069	0.309
MOD_CK2_1	114	120	PF00069	0.381
MOD_CK2_1	147	153	PF00069	0.319
MOD_CK2_1	17	23	PF00069	0.534
MOD_CK2_1	410	416	PF00069	0.338
MOD_CK2_1	510	516	PF00069	0.248
MOD_CK2_1	592	598	PF00069	0.526
MOD_Cter_Amidation	558	561	PF01082	0.261
MOD_GlcNHglycan	124	127	PF01048	0.372
MOD_GlcNHglycan	17	20	PF01048	0.457
MOD_GlcNHglycan	180	183	PF01048	0.371
MOD_GlcNHglycan	249	252	PF01048	0.395
MOD_GlcNHglycan	329	332	PF01048	0.327
MOD_GlcNHglycan	351	355	PF01048	0.320
MOD_GlcNHglycan	490	493	PF01048	0.397
MOD_GlcNHglycan	594	597	PF01048	0.457
MOD_GlcNHglycan	84	87	PF01048	0.571
MOD_GSK3_1	13	20	PF00069	0.479
MOD_GSK3_1	142	149	PF00069	0.364
MOD_GSK3_1	163	170	PF00069	0.414
MOD_GSK3_1	171	178	PF00069	0.323
MOD_GSK3_1	268	275	PF00069	0.382
MOD_GSK3_1	290	297	PF00069	0.430
MOD_GSK3_1	301	308	PF00069	0.381
MOD_GSK3_1	466	473	PF00069	0.308
MOD_GSK3_1	483	490	PF00069	0.294
MOD_GSK3_1	512	519	PF00069	0.322
MOD_GSK3_1	550	557	PF00069	0.284
MOD_GSK3_1	585	592	PF00069	0.537
MOD_N-GLC_1	252	257	PF02516	0.305
MOD_N-GLC_1	399	404	PF02516	0.237
MOD_N-GLC_1	510	515	PF02516	0.174
MOD_N-GLC_1	540	545	PF02516	0.240
MOD_NEK2_1	14	19	PF00069	0.567
MOD_NEK2_1	266	271	PF00069	0.467
MOD_NEK2_1	303	308	PF00069	0.289
MOD_NEK2_1	340	345	PF00069	0.395
MOD_NEK2_1	466	471	PF00069	0.359
MOD_NEK2_1	50	55	PF00069	0.432
MOD_NEK2_1	523	528	PF00069	0.293
MOD_NEK2_1	550	555	PF00069	0.301
MOD_NEK2_1	74	79	PF00069	0.456
MOD_NEK2_1	81	86	PF00069	0.494
MOD_PIKK_1	45	51	PF00454	0.435
MOD_PKA_2	122	128	PF00069	0.261
MOD_PKA_2	247	253	PF00069	0.325
MOD_PKA_2	37	43	PF00069	0.534
MOD_PKA_2	516	522	PF00069	0.389
MOD_Plk_1	444	450	PF00069	0.288
MOD_Plk_1	510	516	PF00069	0.306
MOD_Plk_1	540	546	PF00069	0.240
MOD_Plk_4	100	106	PF00069	0.310
MOD_Plk_4	202	208	PF00069	0.244
MOD_Plk_4	585	591	PF00069	0.512
MOD_ProDKin_1	192	198	PF00069	0.174
MOD_ProDKin_1	268	274	PF00069	0.327
MOD_ProDKin_1	281	287	PF00069	0.250
MOD_ProDKin_1	31	37	PF00069	0.490
MOD_ProDKin_1	330	336	PF00069	0.339
MOD_ProDKin_1	341	347	PF00069	0.333
MOD_ProDKin_1	378	384	PF00069	0.288
MOD_ProDKin_1	470	476	PF00069	0.376
MOD_ProDKin_1	505	511	PF00069	0.255
MOD_ProDKin_1	582	588	PF00069	0.445
MOD_SUMO_rev_2	469	479	PF00179	0.174
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.398
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.279
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.395
TRG_DiLeu_BaLyEn_6	534	539	PF01217	0.395
TRG_ENDOCYTIC_2	270	273	PF00928	0.395
TRG_ENDOCYTIC_2	317	320	PF00928	0.240
TRG_ENDOCYTIC_2	419	422	PF00928	0.389
TRG_ENDOCYTIC_2	437	440	PF00928	0.208
TRG_ER_diArg_1	133	136	PF00400	0.289
TRG_ER_diArg_1	576	579	PF00400	0.378
TRG_NES_CRM1_1	441	455	PF08389	0.362
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.174
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHX8	Leptomonas seymouri	53%	95%
A0A0S4IND2	Bodo saltans	29%	100%
A0A0S4ISE5	Bodo saltans	29%	100%
A0A1X0NSJ6	Trypanosomatidae	35%	99%
A0A3Q8ICQ6	Leishmania donovani	93%	100%
A0A422NVG0	Trypanosoma rangeli	37%	100%
A4HEM0	Leishmania braziliensis	75%	100%
A4I1V2	Leishmania infantum	93%	100%
B1H268	Rattus norvegicus	22%	93%
C9ZS69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
E9AXZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q501D5	Arabidopsis thaliana	26%	100%
Q5ZJV4	Gallus gallus	22%	94%
Q7ZYP6	Xenopus laevis	23%	96%
Q803A6	Danio rerio	24%	95%
Q8R3C0	Mus musculus	23%	93%
Q9VM60	Drosophila melanogaster	24%	99%
V5BZF8	Trypanosoma cruzi	37%	100%