DUF2062 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9H3_LEIMA

TriTrypDb:

LmjF.26.0185 , LMJLV39_260006700 , LMJSD75_260006600

Length:

161

Annotations

LeishMANIAdb annotations

A conserved eukaryotic protein family also seen in higher plants. Its function is, however very unclear.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q9H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.433
CLV_PCSK_KEX2_1	2	4	PF00082	0.393
CLV_PCSK_SKI1_1	123	127	PF00082	0.598
CLV_PCSK_SKI1_1	148	152	PF00082	0.447
CLV_PCSK_SKI1_1	2	6	PF00082	0.510
DEG_Nend_UBRbox_1	1	4	PF02207	0.702
DOC_CDC14_PxL_1	80	88	PF14671	0.415
DOC_CKS1_1	74	79	PF01111	0.357
DOC_MAPK_gen_1	13	20	PF00069	0.540
DOC_MAPK_MEF2A_6	13	20	PF00069	0.538
DOC_PP4_FxxP_1	41	44	PF00568	0.357
DOC_PP4_FxxP_1	74	77	PF00568	0.457
DOC_WW_Pin1_4	73	78	PF00397	0.345
LIG_14-3-3_CanoR_1	59	67	PF00244	0.653
LIG_Actin_WH2_2	130	146	PF00022	0.415
LIG_Actin_WH2_2	45	61	PF00022	0.399
LIG_FHA_1	113	119	PF00498	0.452
LIG_FHA_1	49	55	PF00498	0.348
LIG_FHA_1	61	67	PF00498	0.522
LIG_FHA_2	22	28	PF00498	0.435
LIG_FHA_2	59	65	PF00498	0.652
LIG_FHA_2	92	98	PF00498	0.476
LIG_LIR_Gen_1	113	118	PF02991	0.307
LIG_LIR_Gen_1	24	32	PF02991	0.426
LIG_LIR_Nem_3	113	117	PF02991	0.335
LIG_LIR_Nem_3	129	135	PF02991	0.391
LIG_LIR_Nem_3	24	28	PF02991	0.426
LIG_Pex14_2	41	45	PF04695	0.415
LIG_SH2_CRK	127	131	PF00017	0.422
LIG_SH2_NCK_1	127	131	PF00017	0.492
LIG_SH2_STAP1	114	118	PF00017	0.437
LIG_SH2_STAT5	114	117	PF00017	0.447
LIG_SH2_STAT5	57	60	PF00017	0.507
LIG_SH3_3	13	19	PF00018	0.588
LIG_SH3_3	132	138	PF00018	0.393
LIG_SUMO_SIM_par_1	27	33	PF11976	0.442
LIG_TRFH_1	80	84	PF08558	0.454
LIG_TYR_ITIM	125	130	PF00017	0.438
LIG_WRC_WIRS_1	114	119	PF05994	0.471
MOD_CK1_1	21	27	PF00069	0.427
MOD_CK1_1	48	54	PF00069	0.385
MOD_CK2_1	21	27	PF00069	0.435
MOD_CK2_1	58	64	PF00069	0.576
MOD_CK2_1	91	97	PF00069	0.469
MOD_GlcNHglycan	144	147	PF01048	0.383
MOD_GSK3_1	113	120	PF00069	0.452
MOD_GSK3_1	44	51	PF00069	0.351
MOD_NEK2_1	106	111	PF00069	0.412
MOD_NEK2_1	117	122	PF00069	0.363
MOD_NEK2_1	126	131	PF00069	0.372
MOD_NEK2_1	45	50	PF00069	0.351
MOD_NEK2_1	58	63	PF00069	0.548
MOD_NEK2_1	67	72	PF00069	0.448
MOD_PIKK_1	18	24	PF00454	0.286
MOD_PIKK_1	6	12	PF00454	0.672
MOD_PIKK_1	91	97	PF00454	0.392
MOD_PKA_2	58	64	PF00069	0.653
MOD_Plk_1	112	118	PF00069	0.435
MOD_Plk_4	113	119	PF00069	0.438
MOD_Plk_4	48	54	PF00069	0.355
MOD_ProDKin_1	73	79	PF00069	0.345
TRG_ENDOCYTIC_2	114	117	PF00928	0.389
TRG_ENDOCYTIC_2	127	130	PF00928	0.288
TRG_ER_diArg_1	1	3	PF00400	0.644
TRG_NES_CRM1_1	6	22	PF08389	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS7	Leptomonas seymouri	53%	93%
A0A1X0NSJ4	Trypanosomatidae	33%	100%
A0A3R7KTL0	Trypanosoma rangeli	34%	100%
A0A3S7WZK4	Leishmania donovani	93%	100%
A4HEM4	Leishmania braziliensis	73%	100%
A4I1V5	Leishmania infantum	93%	100%
E9AY00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%