Nfu_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Scaffold protein Nfu/NifU N terminal/NifU-like domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q9H2_LEIMA

TriTrypDb:

LmjF.26.0190 , LMJLV39_260006800 , LMJSD75_260006700

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9H2

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0019538	protein metabolic process	3	2
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	11
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005506	iron ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051539	4 iron, 4 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.445
CLV_NRD_NRD_1	226	228	PF00675	0.464
CLV_NRD_NRD_1	86	88	PF00675	0.313
CLV_PCSK_KEX2_1	19	21	PF00082	0.445
CLV_PCSK_PC7_1	15	21	PF00082	0.394
CLV_PCSK_SKI1_1	145	149	PF00082	0.223
CLV_PCSK_SKI1_1	153	157	PF00082	0.223
CLV_PCSK_SKI1_1	228	232	PF00082	0.526
DEG_APCC_KENBOX_2	111	115	PF00400	0.497
DEG_Nend_Nbox_1	1	3	PF02207	0.387
DOC_CYCLIN_RxL_1	142	150	PF00134	0.267
DOC_MAPK_MEF2A_6	36	44	PF00069	0.244
DOC_MAPK_RevD_3	72	88	PF00069	0.345
DOC_PP4_FxxP_1	44	47	PF00568	0.282
DOC_USP7_UBL2_3	224	228	PF12436	0.485
DOC_WW_Pin1_4	26	31	PF00397	0.284
DOC_WW_Pin1_4	52	57	PF00397	0.301
DOC_WW_Pin1_4	59	64	PF00397	0.239
LIG_14-3-3_CanoR_1	36	41	PF00244	0.282
LIG_FHA_1	170	176	PF00498	0.437
LIG_FHA_2	129	135	PF00498	0.452
LIG_LIR_Apic_2	41	47	PF02991	0.267
LIG_LIR_Gen_1	172	178	PF02991	0.437
LIG_LIR_Gen_1	81	90	PF02991	0.304
LIG_LIR_Gen_1	93	101	PF02991	0.265
LIG_LIR_Nem_3	172	177	PF02991	0.437
LIG_LIR_Nem_3	81	86	PF02991	0.284
LIG_LIR_Nem_3	93	97	PF02991	0.268
LIG_SH2_CRK	60	64	PF00017	0.286
LIG_SH2_PTP2	83	86	PF00017	0.267
LIG_SH2_STAT5	83	86	PF00017	0.281
LIG_SUMO_SIM_par_1	135	146	PF11976	0.373
LIG_TRAF2_1	119	122	PF00917	0.495
LIG_UBA3_1	97	102	PF00899	0.323
MOD_CK1_1	180	186	PF00069	0.438
MOD_CK1_1	187	193	PF00069	0.425
MOD_CK2_1	190	196	PF00069	0.513
MOD_GlcNHglycan	116	119	PF01048	0.433
MOD_GlcNHglycan	192	195	PF01048	0.241
MOD_GSK3_1	180	187	PF00069	0.432
MOD_GSK3_1	36	43	PF00069	0.267
MOD_GSK3_1	47	54	PF00069	0.267
MOD_N-GLC_1	128	133	PF02516	0.441
MOD_N-GLC_1	26	31	PF02516	0.387
MOD_NEK2_1	147	152	PF00069	0.437
MOD_NEK2_1	177	182	PF00069	0.439
MOD_NEK2_1	40	45	PF00069	0.268
MOD_NEK2_1	51	56	PF00069	0.290
MOD_NEK2_1	7	12	PF00069	0.544
MOD_Plk_1	40	46	PF00069	0.267
MOD_Plk_1	47	53	PF00069	0.267
MOD_Plk_4	169	175	PF00069	0.441
MOD_Plk_4	40	46	PF00069	0.231
MOD_ProDKin_1	26	32	PF00069	0.284
MOD_ProDKin_1	52	58	PF00069	0.301
MOD_ProDKin_1	59	65	PF00069	0.239
MOD_SUMO_for_1	45	48	PF00179	0.392
TRG_DiLeu_BaEn_2	169	175	PF01217	0.507
TRG_ENDOCYTIC_2	83	86	PF00928	0.267
TRG_ER_diArg_1	151	154	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Q0	Leptomonas seymouri	88%	82%
A0A0N1I735	Leptomonas seymouri	33%	92%
A0A0S4IJH0	Bodo saltans	61%	96%
A0A0S4IVB5	Bodo saltans	34%	92%
A0A1X0NST9	Trypanosomatidae	67%	85%
A0A1X0P8F8	Trypanosomatidae	30%	92%
A0A3R7MX73	Trypanosoma rangeli	62%	100%
A0A3S5H7F5	Leishmania donovani	95%	85%
A0A3S7XAI2	Leishmania donovani	34%	80%
A4HEM5	Leishmania braziliensis	90%	85%
A4HNU8	Leishmania braziliensis	33%	92%
A4I1V6	Leishmania infantum	95%	85%
A4ICP6	Leishmania infantum	34%	80%
B3MRT7	Drosophila ananassae	41%	84%
B3NYF7	Drosophila erecta	42%	85%
B4H303	Drosophila persimilis	40%	85%
B4IMF6	Drosophila sechellia	41%	85%
B4JWR9	Drosophila grimshawi	41%	81%
B4M375	Drosophila virilis	39%	81%
B4NE93	Drosophila willistoni	40%	83%
B4PZ52	Drosophila yakuba	41%	85%
B4R3T1	Drosophila simulans	41%	85%
B5DKJ8	Drosophila pseudoobscura pseudoobscura	40%	84%
C9ZS65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	86%
D0A2R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	92%
E9ASK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	80%
E9AY01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	85%
P32860	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	94%
Q4Q1Y8	Leishmania major	35%	77%
Q8SY96	Drosophila melanogaster	41%	85%
Q9C8J2	Arabidopsis thaliana	40%	87%
Q9LIG6	Arabidopsis thaliana	38%	85%
Q9QZ23	Mus musculus	41%	94%
Q9UMS0	Homo sapiens	42%	94%
Q9UUB8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	92%
V5DRN0	Trypanosoma cruzi	32%	92%