Lipid droplet-associated hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised conserved protein (DUF2305), putative

Species:

Leishmania major

UniProt:

Q4Q9G9_LEIMA

TriTrypDb:

LmjF.26.0220 , LMJLV39_260007100 , LMJSD75_260007000

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005811	lipid droplet	5	12
GO:0016020	membrane	2	8
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q9G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9G9

Function

Biological processes
Term	Name	Level	Count
GO:0019915	lipid storage	3	12
GO:0051179	localization	1	12
GO:0051235	maintenance of location	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016298	lipase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.654
CLV_NRD_NRD_1	121	123	PF00675	0.329
CLV_NRD_NRD_1	170	172	PF00675	0.364
CLV_NRD_NRD_1	224	226	PF00675	0.480
CLV_NRD_NRD_1	43	45	PF00675	0.425
CLV_NRD_NRD_1	49	51	PF00675	0.274
CLV_PCSK_KEX2_1	170	172	PF00082	0.306
CLV_PCSK_KEX2_1	224	226	PF00082	0.480
CLV_PCSK_KEX2_1	43	45	PF00082	0.400
CLV_PCSK_SKI1_1	170	174	PF00082	0.268
CLV_PCSK_SKI1_1	199	203	PF00082	0.493
CLV_PCSK_SKI1_1	225	229	PF00082	0.436
CLV_PCSK_SKI1_1	239	243	PF00082	0.482
CLV_PCSK_SKI1_1	255	259	PF00082	0.390
CLV_PCSK_SKI1_1	50	54	PF00082	0.251
DEG_APCC_DBOX_1	254	262	PF00400	0.356
DOC_CYCLIN_RxL_1	196	205	PF00134	0.301
DOC_MAPK_FxFP_2	54	57	PF00069	0.390
DOC_PP1_RVXF_1	48	55	PF00149	0.548
DOC_PP4_FxxP_1	54	57	PF00568	0.465
DOC_PP4_FxxP_1	65	68	PF00568	0.518
DOC_USP7_MATH_1	131	135	PF00917	0.501
DOC_USP7_MATH_1	158	162	PF00917	0.554
DOC_USP7_MATH_1	86	90	PF00917	0.470
DOC_WW_Pin1_4	163	168	PF00397	0.458
LIG_14-3-3_CanoR_1	146	150	PF00244	0.469
LIG_14-3-3_CanoR_1	44	54	PF00244	0.584
LIG_14-3-3_CanoR_1	97	102	PF00244	0.537
LIG_Actin_WH2_2	234	252	PF00022	0.285
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BRCT_BRCA1_1	175	179	PF00533	0.217
LIG_deltaCOP1_diTrp_1	264	271	PF00928	0.301
LIG_eIF4E_1	196	202	PF01652	0.332
LIG_FHA_1	226	232	PF00498	0.287
LIG_FHA_2	202	208	PF00498	0.329
LIG_Integrin_isoDGR_2	168	170	PF01839	0.334
LIG_LIR_Gen_1	230	240	PF02991	0.300
LIG_LIR_Gen_1	75	86	PF02991	0.461
LIG_LIR_Nem_3	236	241	PF02991	0.255
LIG_LIR_Nem_3	264	269	PF02991	0.311
LIG_LIR_Nem_3	75	81	PF02991	0.461
LIG_NRBOX	197	203	PF00104	0.360
LIG_PTB_Apo_2	226	233	PF02174	0.312
LIG_PTB_Phospho_1	226	232	PF10480	0.337
LIG_SH2_CRK	147	151	PF00017	0.556
LIG_SH2_STAT5	174	177	PF00017	0.399
LIG_SH2_STAT5	260	263	PF00017	0.264
LIG_SH2_STAT5	32	35	PF00017	0.555
LIG_SH3_3	54	60	PF00018	0.460
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.458
LIG_SUMO_SIM_par_1	199	205	PF11976	0.316
LIG_TRAF2_1	34	37	PF00917	0.656
LIG_TRFH_1	154	158	PF08558	0.512
LIG_UBA3_1	190	197	PF00899	0.380
LIG_Vh1_VBS_1	173	191	PF01044	0.390
MOD_CDK_SPxxK_3	163	170	PF00069	0.485
MOD_CK1_1	3	9	PF00069	0.622
MOD_CK2_1	201	207	PF00069	0.319
MOD_CK2_1	267	273	PF00069	0.356
MOD_CK2_1	31	37	PF00069	0.598
MOD_CK2_1	86	92	PF00069	0.526
MOD_Cter_Amidation	168	171	PF01082	0.304
MOD_Cter_Amidation	41	44	PF01082	0.501
MOD_GSK3_1	107	114	PF00069	0.525
MOD_GSK3_1	31	38	PF00069	0.652
MOD_LATS_1	223	229	PF00433	0.190
MOD_N-GLC_1	208	213	PF02516	0.390
MOD_N-GLC_1	299	304	PF02516	0.571
MOD_NEK2_1	111	116	PF00069	0.492
MOD_NEK2_1	173	178	PF00069	0.498
MOD_NEK2_1	201	206	PF00069	0.277
MOD_NEK2_1	227	232	PF00069	0.320
MOD_NEK2_1	23	28	PF00069	0.580
MOD_NEK2_1	72	77	PF00069	0.515
MOD_PKA_2	145	151	PF00069	0.529
MOD_Plk_1	208	214	PF00069	0.259
MOD_Plk_4	107	113	PF00069	0.512
MOD_Plk_4	145	151	PF00069	0.494
MOD_Plk_4	175	181	PF00069	0.320
MOD_Plk_4	227	233	PF00069	0.345
MOD_Plk_4	3	9	PF00069	0.603
MOD_ProDKin_1	163	169	PF00069	0.458
TRG_DiLeu_BaEn_1	237	242	PF01217	0.337
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.329
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.317
TRG_ENDOCYTIC_2	147	150	PF00928	0.537
TRG_ENDOCYTIC_2	232	235	PF00928	0.333
TRG_ENDOCYTIC_2	66	69	PF00928	0.451
TRG_ER_diArg_1	170	172	PF00400	0.529
TRG_ER_diArg_1	43	45	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJP9	Leptomonas seymouri	68%	100%
A0A0S4IN66	Bodo saltans	37%	100%
A0A1X0NSK1	Trypanosomatidae	46%	100%
A0A3S7WZH7	Leishmania donovani	94%	100%
A0A422NVG9	Trypanosoma rangeli	43%	100%
A4HEN1	Leishmania braziliensis	82%	100%
A4I1V9	Leishmania infantum	94%	100%
C9ZS60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	98%
E9AY04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q54LL8	Dictyostelium discoideum	27%	100%
Q5F477	Gallus gallus	26%	97%
Q5HZX7	Rattus norvegicus	25%	97%
Q5R7E8	Pongo abelii	25%	97%
Q8BVA5	Mus musculus	25%	96%
Q9H6V9	Homo sapiens	25%	97%
Q9W0H3	Drosophila melanogaster	25%	100%
V5BUL9	Trypanosoma cruzi	44%	100%