Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q9G8_LEIMA

TriTrypDb:

LmjF.26.0230 , LMJLV39_260007200 , LMJSD75_260007100

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9G8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.636
CLV_NRD_NRD_1	134	136	PF00675	0.657
CLV_NRD_NRD_1	57	59	PF00675	0.609
CLV_NRD_NRD_1	68	70	PF00675	0.457
CLV_PCSK_KEX2_1	335	337	PF00082	0.794
CLV_PCSK_KEX2_1	57	59	PF00082	0.609
CLV_PCSK_KEX2_1	68	70	PF00082	0.457
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.716
CLV_PCSK_SKI1_1	197	201	PF00082	0.694
CLV_PCSK_SKI1_1	79	83	PF00082	0.480
DEG_APCC_DBOX_1	85	93	PF00400	0.572
DEG_COP1_1	106	115	PF00400	0.694
DEG_Nend_UBRbox_2	1	3	PF02207	0.733
DEG_SCF_FBW7_1	115	122	PF00400	0.571
DEG_SPOP_SBC_1	311	315	PF00917	0.668
DEG_SPOP_SBC_1	99	103	PF00917	0.597
DOC_ANK_TNKS_1	239	246	PF00023	0.397
DOC_CKS1_1	116	121	PF01111	0.580
DOC_CKS1_1	324	329	PF01111	0.675
DOC_CYCLIN_RxL_1	194	203	PF00134	0.658
DOC_CYCLIN_yCln2_LP_2	318	324	PF00134	0.791
DOC_MAPK_gen_1	65	73	PF00069	0.584
DOC_PP1_RVXF_1	88	95	PF00149	0.686
DOC_PP4_FxxP_1	257	260	PF00568	0.535
DOC_PP4_FxxP_1	94	97	PF00568	0.715
DOC_USP7_MATH_1	306	310	PF00917	0.720
DOC_USP7_MATH_1	312	316	PF00917	0.731
DOC_USP7_MATH_1	47	51	PF00917	0.632
DOC_USP7_MATH_1	99	103	PF00917	0.605
DOC_WW_Pin1_4	107	112	PF00397	0.696
DOC_WW_Pin1_4	115	120	PF00397	0.641
DOC_WW_Pin1_4	170	175	PF00397	0.772
DOC_WW_Pin1_4	198	203	PF00397	0.665
DOC_WW_Pin1_4	207	212	PF00397	0.534
DOC_WW_Pin1_4	256	261	PF00397	0.536
DOC_WW_Pin1_4	323	328	PF00397	0.692
DOC_WW_Pin1_4	336	341	PF00397	0.656
DOC_WW_Pin1_4	371	376	PF00397	0.773
DOC_WW_Pin1_4	93	98	PF00397	0.628
LIG_14-3-3_CanoR_1	170	174	PF00244	0.591
LIG_14-3-3_CanoR_1	234	239	PF00244	0.507
LIG_14-3-3_CanoR_1	343	347	PF00244	0.727
LIG_14-3-3_CanoR_1	365	375	PF00244	0.644
LIG_14-3-3_CanoR_1	86	90	PF00244	0.523
LIG_Actin_WH2_1	343	361	PF00022	0.685
LIG_Actin_WH2_2	144	160	PF00022	0.602
LIG_Clathr_ClatBox_1	246	250	PF01394	0.596
LIG_FHA_1	262	268	PF00498	0.515
LIG_FHA_1	28	34	PF00498	0.581
LIG_FHA_1	61	67	PF00498	0.616
LIG_FHA_2	116	122	PF00498	0.606
LIG_FHA_2	201	207	PF00498	0.636
LIG_FHA_2	208	214	PF00498	0.614
LIG_FHA_2	349	355	PF00498	0.711
LIG_FHA_2	80	86	PF00498	0.637
LIG_LIR_Gen_1	183	192	PF02991	0.619
LIG_LIR_Gen_1	351	358	PF02991	0.697
LIG_LIR_Nem_3	13	19	PF02991	0.560
LIG_LIR_Nem_3	183	189	PF02991	0.630
LIG_LIR_Nem_3	284	290	PF02991	0.623
LIG_LIR_Nem_3	319	323	PF02991	0.790
LIG_LIR_Nem_3	351	355	PF02991	0.704
LIG_PAM2_1	198	210	PF00658	0.591
LIG_RPA_C_Fungi	63	75	PF08784	0.592
LIG_SH2_CRK	196	200	PF00017	0.624
LIG_SH2_CRK	287	291	PF00017	0.524
LIG_SH2_STAP1	120	124	PF00017	0.667
LIG_SH2_STAP1	186	190	PF00017	0.704
LIG_SH2_STAP1	23	27	PF00017	0.545
LIG_SH2_STAP1	352	356	PF00017	0.699
LIG_SH2_STAT3	23	26	PF00017	0.552
LIG_SH2_STAT5	207	210	PF00017	0.468
LIG_SH2_STAT5	282	285	PF00017	0.607
LIG_SH3_3	109	115	PF00018	0.607
LIG_SH3_3	264	270	PF00018	0.516
LIG_SH3_3	283	289	PF00018	0.514
LIG_SH3_3	318	324	PF00018	0.716
LIG_SUMO_SIM_par_1	262	269	PF11976	0.532
LIG_TRAF2_1	18	21	PF00917	0.602
LIG_TRAF2_1	351	354	PF00917	0.706
LIG_TRAF2_1	82	85	PF00917	0.672
LIG_TRFH_1	207	211	PF08558	0.621
LIG_TYR_ITIM	350	355	PF00017	0.666
MOD_CDK_SPxxK_3	336	343	PF00069	0.779
MOD_CK1_1	103	109	PF00069	0.615
MOD_CK1_1	172	178	PF00069	0.701
MOD_CK1_1	259	265	PF00069	0.548
MOD_CK1_1	281	287	PF00069	0.606
MOD_CK1_1	339	345	PF00069	0.774
MOD_CK1_1	348	354	PF00069	0.581
MOD_CK2_1	115	121	PF00069	0.571
MOD_CK2_1	200	206	PF00069	0.676
MOD_CK2_1	348	354	PF00069	0.719
MOD_CK2_1	48	54	PF00069	0.606
MOD_CK2_1	79	85	PF00069	0.639
MOD_GlcNHglycan	102	105	PF01048	0.585
MOD_GlcNHglycan	180	183	PF01048	0.751
MOD_GlcNHglycan	261	264	PF01048	0.583
MOD_GlcNHglycan	308	311	PF01048	0.795
MOD_GlcNHglycan	314	317	PF01048	0.722
MOD_GlcNHglycan	50	53	PF01048	0.616
MOD_GSK3_1	107	114	PF00069	0.750
MOD_GSK3_1	115	122	PF00069	0.530
MOD_GSK3_1	172	179	PF00069	0.710
MOD_GSK3_1	306	313	PF00069	0.744
MOD_GSK3_1	338	345	PF00069	0.779
MOD_GSK3_1	367	374	PF00069	0.693
MOD_GSK3_1	99	106	PF00069	0.677
MOD_NEK2_1	105	110	PF00069	0.759
MOD_NEK2_1	358	363	PF00069	0.560
MOD_NEK2_2	60	65	PF00069	0.473
MOD_OFUCOSY	34	40	PF10250	0.593
MOD_PIKK_1	172	178	PF00454	0.717
MOD_PIKK_1	345	351	PF00454	0.736
MOD_PIKK_1	79	85	PF00454	0.593
MOD_PK_1	234	240	PF00069	0.504
MOD_PKA_2	169	175	PF00069	0.626
MOD_PKA_2	342	348	PF00069	0.728
MOD_PKA_2	367	373	PF00069	0.683
MOD_PKA_2	85	91	PF00069	0.514
MOD_PKB_1	336	344	PF00069	0.726
MOD_PKB_1	77	85	PF00069	0.451
MOD_Plk_1	12	18	PF00069	0.567
MOD_Plk_1	205	211	PF00069	0.651
MOD_Plk_1	77	83	PF00069	0.574
MOD_Plk_4	147	153	PF00069	0.676
MOD_Plk_4	234	240	PF00069	0.493
MOD_Plk_4	261	267	PF00069	0.637
MOD_Plk_4	278	284	PF00069	0.496
MOD_Plk_4	342	348	PF00069	0.767
MOD_ProDKin_1	107	113	PF00069	0.695
MOD_ProDKin_1	115	121	PF00069	0.639
MOD_ProDKin_1	170	176	PF00069	0.773
MOD_ProDKin_1	198	204	PF00069	0.671
MOD_ProDKin_1	207	213	PF00069	0.536
MOD_ProDKin_1	256	262	PF00069	0.534
MOD_ProDKin_1	323	329	PF00069	0.693
MOD_ProDKin_1	336	342	PF00069	0.654
MOD_ProDKin_1	93	99	PF00069	0.636
MOD_SUMO_for_1	334	337	PF00179	0.712
MOD_SUMO_rev_2	353	361	PF00179	0.697
TRG_DiLeu_BaEn_1	144	149	PF01217	0.557
TRG_DiLeu_BaEn_1	244	249	PF01217	0.369
TRG_DiLeu_BaEn_4	353	359	PF01217	0.693
TRG_DiLeu_BaEn_4	84	90	PF01217	0.665
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.574
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.539
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.521
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.674
TRG_ENDOCYTIC_2	186	189	PF00928	0.603
TRG_ENDOCYTIC_2	196	199	PF00928	0.586
TRG_ENDOCYTIC_2	287	290	PF00928	0.517
TRG_ENDOCYTIC_2	352	355	PF00928	0.706
TRG_ER_diArg_1	56	58	PF00400	0.619
TRG_ER_diArg_1	68	70	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P503	Leptomonas seymouri	39%	94%
A0A3Q8IDK6	Leishmania donovani	88%	99%
A4HEN2	Leishmania braziliensis	71%	99%
A4I1W0	Leishmania infantum	88%	99%
E9AY05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%