Eukaryotic initiation factor 4E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E type 6, putative

Species:

Leishmania major

UniProt:

Q4Q9G7_LEIMA

TriTrypDb:

LmjF.26.0240 , LMJLV39_260007300 , LMJSD75_260007200

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016281	eukaryotic translation initiation factor 4F complex	2	3
GO:0032991	protein-containing complex	1	3
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q9G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9G7

PDB structure(s): 7kcj_A , 7kcj_B

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000339	RNA cap binding	5	3
GO:0000340	RNA 7-methylguanosine cap binding	6	3
GO:0003676	nucleic acid binding	3	21
GO:0003723	RNA binding	4	21
GO:0003743	translation initiation factor activity	4	21
GO:0005488	binding	1	21
GO:0008135	translation factor activity, RNA binding	3	21
GO:0045182	translation regulator activity	1	21
GO:0090079	translation regulator activity, nucleic acid binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	102	106	PF00082	0.285
DEG_APCC_DBOX_1	101	109	PF00400	0.533
DOC_MAPK_MEF2A_6	142	149	PF00069	0.509
DOC_PP2B_PxIxI_1	171	177	PF00149	0.412
DOC_PP4_FxxP_1	26	29	PF00568	0.545
DOC_SPAK_OSR1_1	90	94	PF12202	0.545
DOC_WW_Pin1_4	151	156	PF00397	0.440
LIG_BIR_II_1	1	5	PF00653	0.675
LIG_deltaCOP1_diTrp_1	21	26	PF00928	0.510
LIG_FHA_1	104	110	PF00498	0.496
LIG_FHA_1	38	44	PF00498	0.550
LIG_FHA_2	156	162	PF00498	0.422
LIG_FHA_2	46	52	PF00498	0.463
LIG_LIR_Gen_1	50	61	PF02991	0.468
LIG_LIR_Gen_1	79	89	PF02991	0.417
LIG_LIR_Nem_3	21	27	PF02991	0.477
LIG_LIR_Nem_3	50	56	PF02991	0.431
LIG_LIR_Nem_3	79	85	PF02991	0.465
LIG_Pex14_1	23	27	PF04695	0.468
LIG_SH2_CRK	53	57	PF00017	0.510
LIG_SH2_NCK_1	53	57	PF00017	0.510
LIG_SH2_SRC	27	30	PF00017	0.510
LIG_SH2_STAT5	107	110	PF00017	0.530
LIG_SH2_STAT5	163	166	PF00017	0.328
LIG_SH2_STAT5	27	30	PF00017	0.427
LIG_SH2_STAT5	45	48	PF00017	0.468
LIG_SH3_2	15	20	PF14604	0.523
LIG_SH3_3	12	18	PF00018	0.508
LIG_TRAF2_1	48	51	PF00917	0.435
MOD_CK1_1	166	172	PF00069	0.509
MOD_CK1_1	4	10	PF00069	0.655
MOD_CK2_1	155	161	PF00069	0.578
MOD_CK2_1	44	50	PF00069	0.455
MOD_GlcNHglycan	12	15	PF01048	0.666
MOD_GlcNHglycan	137	140	PF01048	0.340
MOD_GlcNHglycan	168	171	PF01048	0.432
MOD_GlcNHglycan	176	179	PF01048	0.342
MOD_GSK3_1	151	158	PF00069	0.525
MOD_GSK3_1	4	11	PF00069	0.730
MOD_GSK3_1	51	58	PF00069	0.496
MOD_NEK2_1	1	6	PF00069	0.530
MOD_NEK2_1	164	169	PF00069	0.499
MOD_NEK2_1	71	76	PF00069	0.581
MOD_NEK2_1	89	94	PF00069	0.486
MOD_NEK2_2	141	146	PF00069	0.545
MOD_PIKK_1	96	102	PF00454	0.515
MOD_PKA_2	89	95	PF00069	0.468
MOD_Plk_4	103	109	PF00069	0.473
MOD_ProDKin_1	151	157	PF00069	0.440
MOD_SUMO_rev_2	35	43	PF00179	0.516
TRG_ENDOCYTIC_2	53	56	PF00928	0.510
TRG_NES_CRM1_1	103	115	PF08389	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E4	Leptomonas seymouri	74%	100%
A0A0N1ILF7	Leptomonas seymouri	34%	96%
A0A0S4IN32	Bodo saltans	38%	99%
A0A0S4IZ31	Bodo saltans	34%	100%
A0A1X0NSI0	Trypanosomatidae	44%	98%
A0A1X0P9L6	Trypanosomatidae	36%	87%
A0A3S7WZL5	Leishmania donovani	97%	100%
A0A3S7XAF1	Leishmania donovani	33%	85%
A0A422P286	Trypanosoma rangeli	32%	91%
A4HEN3	Leishmania braziliensis	92%	100%
A4HNR9	Leishmania braziliensis	33%	85%
A4I1W1	Leishmania infantum	97%	100%
A4ICS5	Leishmania infantum	33%	85%
C9ZS59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	98%
D0A2M9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	93%
E9ASH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	85%
E9AY06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q217	Leishmania major	34%	100%
V5BZH5	Trypanosoma cruzi	48%	98%