ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9G5_LEIMA

TriTrypDb:

LmjF.26.0260 , LMJLV39_260007500 , LMJSD75_260007400

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9G5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.561
CLV_C14_Caspase3-7	238	242	PF00656	0.355
CLV_C14_Caspase3-7	70	74	PF00656	0.610
CLV_NRD_NRD_1	143	145	PF00675	0.608
CLV_NRD_NRD_1	173	175	PF00675	0.587
CLV_NRD_NRD_1	346	348	PF00675	0.414
CLV_NRD_NRD_1	403	405	PF00675	0.554
CLV_NRD_NRD_1	414	416	PF00675	0.604
CLV_NRD_NRD_1	488	490	PF00675	0.460
CLV_NRD_NRD_1	529	531	PF00675	0.449
CLV_PCSK_FUR_1	401	405	PF00082	0.572
CLV_PCSK_KEX2_1	136	138	PF00082	0.670
CLV_PCSK_KEX2_1	145	147	PF00082	0.591
CLV_PCSK_KEX2_1	173	175	PF00082	0.598
CLV_PCSK_KEX2_1	38	40	PF00082	0.642
CLV_PCSK_KEX2_1	401	403	PF00082	0.545
CLV_PCSK_KEX2_1	488	490	PF00082	0.460
CLV_PCSK_KEX2_1	529	531	PF00082	0.449
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.736
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.710
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.598
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.521
CLV_PCSK_SKI1_1	175	179	PF00082	0.614
CLV_PCSK_SKI1_1	230	234	PF00082	0.463
CLV_PCSK_SKI1_1	265	269	PF00082	0.480
CLV_PCSK_SKI1_1	272	276	PF00082	0.411
CLV_PCSK_SKI1_1	326	330	PF00082	0.489
CLV_PCSK_SKI1_1	404	408	PF00082	0.589
CLV_PCSK_SKI1_1	469	473	PF00082	0.503
DEG_APCC_DBOX_1	229	237	PF00400	0.456
DEG_APCC_DBOX_1	257	265	PF00400	0.551
DOC_CDC14_PxL_1	376	384	PF14671	0.521
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.717
DOC_CYCLIN_yCln2_LP_2	370	376	PF00134	0.511
DOC_MAPK_gen_1	144	153	PF00069	0.626
DOC_MAPK_gen_1	263	270	PF00069	0.519
DOC_MAPK_MEF2A_6	146	155	PF00069	0.655
DOC_MAPK_MEF2A_6	19	26	PF00069	0.364
DOC_PP1_RVXF_1	228	235	PF00149	0.471
DOC_PP2B_LxvP_1	124	127	PF13499	0.711
DOC_PP2B_LxvP_1	370	373	PF13499	0.484
DOC_PP2B_PxIxI_1	19	25	PF00149	0.371
DOC_PP4_FxxP_1	184	187	PF00568	0.533
DOC_SPAK_OSR1_1	52	56	PF12202	0.535
DOC_USP7_MATH_1	218	222	PF00917	0.572
DOC_USP7_MATH_1	422	426	PF00917	0.684
DOC_USP7_MATH_1	428	432	PF00917	0.491
DOC_USP7_MATH_1	492	496	PF00917	0.556
DOC_USP7_MATH_1	536	540	PF00917	0.602
DOC_USP7_MATH_1	99	103	PF00917	0.581
DOC_WW_Pin1_4	223	228	PF00397	0.461
DOC_WW_Pin1_4	393	398	PF00397	0.548
DOC_WW_Pin1_4	424	429	PF00397	0.712
DOC_WW_Pin1_4	457	462	PF00397	0.495
LIG_14-3-3_CanoR_1	121	125	PF00244	0.615
LIG_14-3-3_CanoR_1	182	187	PF00244	0.538
LIG_14-3-3_CanoR_1	283	289	PF00244	0.612
LIG_14-3-3_CanoR_1	404	413	PF00244	0.521
LIG_14-3-3_CanoR_1	415	420	PF00244	0.574
LIG_14-3-3_CanoR_1	46	55	PF00244	0.578
LIG_14-3-3_CanoR_1	541	546	PF00244	0.519
LIG_14-3-3_CanoR_1	549	555	PF00244	0.371
LIG_14-3-3_CanoR_1	577	582	PF00244	0.517
LIG_APCC_ABBA_1	156	161	PF00400	0.689
LIG_APCC_ABBA_1	53	58	PF00400	0.594
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.600
LIG_BIR_III_4	217	221	PF00653	0.585
LIG_BRCT_BRCA1_1	438	442	PF00533	0.427
LIG_CtBP_PxDLS_1	592	596	PF00389	0.513
LIG_eIF4E_1	103	109	PF01652	0.623
LIG_eIF4E_1	435	441	PF01652	0.489
LIG_FHA_1	120	126	PF00498	0.650
LIG_FHA_1	283	289	PF00498	0.608
LIG_FHA_1	363	369	PF00498	0.330
LIG_FHA_1	551	557	PF00498	0.390
LIG_FHA_1	74	80	PF00498	0.537
LIG_FHA_2	212	218	PF00498	0.546
LIG_FHA_2	406	412	PF00498	0.612
LIG_FHA_2	472	478	PF00498	0.523
LIG_FHA_2	569	575	PF00498	0.515
LIG_GBD_Chelix_1	100	108	PF00786	0.490
LIG_LIR_Gen_1	226	236	PF02991	0.442
LIG_LIR_Gen_1	241	252	PF02991	0.384
LIG_LIR_Gen_1	558	569	PF02991	0.526
LIG_LIR_Nem_3	179	184	PF02991	0.631
LIG_LIR_Nem_3	217	222	PF02991	0.518
LIG_LIR_Nem_3	226	231	PF02991	0.423
LIG_LIR_Nem_3	241	247	PF02991	0.426
LIG_LIR_Nem_3	311	317	PF02991	0.528
LIG_LIR_Nem_3	558	564	PF02991	0.538
LIG_LIR_Nem_3	94	100	PF02991	0.605
LIG_MYND_1	494	498	PF01753	0.575
LIG_NRBOX	103	109	PF00104	0.424
LIG_NRBOX	232	238	PF00104	0.519
LIG_NRBOX	446	452	PF00104	0.437
LIG_NRBOX	482	488	PF00104	0.468
LIG_NRBOX	82	88	PF00104	0.571
LIG_PCNA_PIPBox_1	429	438	PF02747	0.468
LIG_PCNA_yPIPBox_3	423	436	PF02747	0.546
LIG_Pex14_2	467	471	PF04695	0.376
LIG_SH2_CRK	219	223	PF00017	0.532
LIG_SH2_CRK	228	232	PF00017	0.543
LIG_SH2_NCK_1	579	583	PF00017	0.547
LIG_SH2_PTP2	209	212	PF00017	0.518
LIG_SH2_STAP1	228	232	PF00017	0.543
LIG_SH2_STAP1	248	252	PF00017	0.294
LIG_SH2_STAP1	292	296	PF00017	0.629
LIG_SH2_STAT5	103	106	PF00017	0.608
LIG_SH2_STAT5	209	212	PF00017	0.516
LIG_SH2_STAT5	315	318	PF00017	0.562
LIG_SH2_STAT5	435	438	PF00017	0.487
LIG_SH2_STAT5	485	488	PF00017	0.520
LIG_SH2_STAT5	524	527	PF00017	0.414
LIG_SH2_STAT5	579	582	PF00017	0.552
LIG_SH3_1	488	494	PF00018	0.582
LIG_SH3_3	148	154	PF00018	0.604
LIG_SH3_3	488	494	PF00018	0.519
LIG_SH3_3	497	503	PF00018	0.387
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.566
LIG_SUMO_SIM_par_1	449	455	PF11976	0.443
LIG_SUMO_SIM_par_1	593	603	PF11976	0.529
LIG_TRAF2_1	138	141	PF00917	0.752
LIG_TRAF2_1	274	277	PF00917	0.563
LIG_TRFH_1	584	588	PF08558	0.384
LIG_UBA3_1	183	189	PF00899	0.634
MOD_CDK_SPxxK_3	223	230	PF00069	0.451
MOD_CK1_1	119	125	PF00069	0.643
MOD_CK1_1	431	437	PF00069	0.482
MOD_CK2_1	114	120	PF00069	0.689
MOD_CK2_1	135	141	PF00069	0.720
MOD_CK2_1	25	31	PF00069	0.472
MOD_CK2_1	471	477	PF00069	0.439
MOD_CK2_1	567	573	PF00069	0.500
MOD_GlcNHglycan	244	247	PF01048	0.492
MOD_GlcNHglycan	294	297	PF01048	0.530
MOD_GlcNHglycan	322	325	PF01048	0.551
MOD_GlcNHglycan	424	427	PF01048	0.708
MOD_GlcNHglycan	48	51	PF01048	0.588
MOD_GlcNHglycan	73	76	PF01048	0.551
MOD_GSK3_1	116	123	PF00069	0.622
MOD_GSK3_1	278	285	PF00069	0.379
MOD_GSK3_1	424	431	PF00069	0.693
MOD_GSK3_1	44	51	PF00069	0.434
MOD_GSK3_1	467	474	PF00069	0.438
MOD_GSK3_1	573	580	PF00069	0.576
MOD_NEK2_1	275	280	PF00069	0.465
MOD_NEK2_1	436	441	PF00069	0.490
MOD_NEK2_1	467	472	PF00069	0.431
MOD_NEK2_1	509	514	PF00069	0.477
MOD_NEK2_1	567	572	PF00069	0.439
MOD_NEK2_1	79	84	PF00069	0.532
MOD_NEK2_2	218	223	PF00069	0.574
MOD_NEK2_2	536	541	PF00069	0.600
MOD_NEK2_2	550	555	PF00069	0.267
MOD_PIKK_1	44	50	PF00454	0.609
MOD_PKA_1	415	421	PF00069	0.679
MOD_PKA_2	120	126	PF00069	0.619
MOD_PKA_2	278	284	PF00069	0.490
MOD_PKA_2	414	420	PF00069	0.645
MOD_PKA_2	68	74	PF00069	0.447
MOD_Plk_1	119	125	PF00069	0.657
MOD_Plk_1	275	281	PF00069	0.563
MOD_Plk_2-3	135	141	PF00069	0.617
MOD_Plk_4	120	126	PF00069	0.632
MOD_Plk_4	161	167	PF00069	0.708
MOD_Plk_4	284	290	PF00069	0.629
MOD_Plk_4	362	368	PF00069	0.386
MOD_Plk_4	431	437	PF00069	0.412
MOD_Plk_4	452	458	PF00069	0.449
MOD_Plk_4	492	498	PF00069	0.571
MOD_Plk_4	550	556	PF00069	0.413
MOD_Plk_4	56	62	PF00069	0.429
MOD_Plk_4	99	105	PF00069	0.520
MOD_ProDKin_1	223	229	PF00069	0.452
MOD_ProDKin_1	393	399	PF00069	0.540
MOD_ProDKin_1	424	430	PF00069	0.697
MOD_ProDKin_1	457	463	PF00069	0.493
TRG_DiLeu_BaEn_1	120	125	PF01217	0.721
TRG_DiLeu_BaEn_1	452	457	PF01217	0.513
TRG_DiLeu_BaEn_3	477	483	PF01217	0.558
TRG_DiLeu_BaEn_4	478	484	PF01217	0.564
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.575
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.396
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.565
TRG_ENDOCYTIC_2	181	184	PF00928	0.658
TRG_ENDOCYTIC_2	209	212	PF00928	0.440
TRG_ENDOCYTIC_2	219	222	PF00928	0.459
TRG_ENDOCYTIC_2	228	231	PF00928	0.300
TRG_ENDOCYTIC_2	506	509	PF00928	0.523
TRG_ER_diArg_1	401	404	PF00400	0.546
TRG_ER_diArg_1	487	489	PF00400	0.479
TRG_ER_diArg_1	529	531	PF00400	0.535
TRG_ER_diArg_1	540	543	PF00400	0.626
TRG_NLS_MonoCore_2	171	176	PF00514	0.585
TRG_NLS_MonoExtC_3	171	176	PF00514	0.602
TRG_NLS_MonoExtN_4	171	177	PF00514	0.585
TRG_NLS_MonoExtN_4	401	408	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	529	534	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P504	Leptomonas seymouri	67%	88%
A0A0S4IN30	Bodo saltans	26%	67%
A0A1X0NT69	Trypanosomatidae	34%	79%
A0A3Q8IGU6	Leishmania donovani	93%	100%
A0A3S5IS00	Trypanosoma rangeli	35%	85%
A4HEN5	Leishmania braziliensis	84%	100%
A4I1W3	Leishmania infantum	93%	100%
C9ZS57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	82%
E9AY08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BZE7	Trypanosoma cruzi	35%	86%