Putative mitotic cyclin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitotic cyclin, putative

Species:

Leishmania major

UniProt:

Q4Q9F8_LEIMA

TriTrypDb:

LmjF.26.0330 , LMJLV39_260008200 , LMJSD75_260008100

Length:

448

Annotations

LeishMANIAdb annotations

Cyclin protein, certainly non-TM

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	2
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0016020	membrane	2	6
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2

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Expansion

Sequence features

Q4Q9F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9F8

Function

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Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	2
GO:0001932	regulation of protein phosphorylation	7	2
GO:0009987	cellular process	1	2
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0022402	cell cycle process	2	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031399	regulation of protein modification process	6	2
GO:0042325	regulation of phosphorylation	7	2
GO:0043549	regulation of kinase activity	5	2

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Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	2
GO:0019207	kinase regulator activity	3	2
GO:0019887	protein kinase regulator activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.483
CLV_MEL_PAP_1	176	182	PF00089	0.530
CLV_NRD_NRD_1	100	102	PF00675	0.293
CLV_NRD_NRD_1	14	16	PF00675	0.637
CLV_NRD_NRD_1	258	260	PF00675	0.424
CLV_NRD_NRD_1	87	89	PF00675	0.494
CLV_PCSK_KEX2_1	100	102	PF00082	0.373
CLV_PCSK_KEX2_1	258	260	PF00082	0.376
CLV_PCSK_PC7_1	254	260	PF00082	0.424
CLV_PCSK_SKI1_1	119	123	PF00082	0.443

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Q6	Leptomonas seymouri	79%	90%
A0A0S4JSJ6	Bodo saltans	24%	90%
A0A3Q8ICR6	Leishmania donovani	95%	100%
A0A422NVH3	Trypanosoma rangeli	34%	96%
A4HEP0	Leishmania braziliensis	90%	100%
A4I1W9	Leishmania infantum	96%	100%
C9ZS50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
E9AY15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BQ13	Trypanosoma cruzi	33%	97%

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