Vacuolar protein sorting-associated protein 52 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vps52 / Sac2 family, putative

Species:

Leishmania major

UniProt:

Q4Q9F6_LEIMA

TriTrypDb:

LmjF.26.0350 , LMJLV39_260008400 , LMJSD75_260008300

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000938	GARP complex	3	2
GO:0005794	Golgi apparatus	5	9
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0099023	vesicle tethering complex	2	2
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

Q4Q9F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9F6

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006892	post-Golgi vesicle-mediated transport	6	2
GO:0006896	Golgi to vacuole transport	5	2
GO:0007034	vacuolar transport	4	2
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0016482	cytosolic transport	4	2

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Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019905	syntaxin binding	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.541
CLV_NRD_NRD_1	160	162	PF00675	0.293
CLV_NRD_NRD_1	230	232	PF00675	0.355
CLV_NRD_NRD_1	310	312	PF00675	0.416
CLV_NRD_NRD_1	637	639	PF00675	0.577
CLV_NRD_NRD_1	680	682	PF00675	0.570
CLV_NRD_NRD_1	775	777	PF00675	0.640
CLV_PCSK_FUR_1	634	638	PF00082	0.557
CLV_PCSK_KEX2_1	29	31	PF00082	0.593
CLV_PCSK_KEX2_1	529	531	PF00082	0.409

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E7	Leptomonas seymouri	66%	98%
A0A1X0NSI1	Trypanosomatidae	34%	100%
A0A3S5H7F6	Leishmania donovani	93%	100%
A0A422NVH8	Trypanosoma rangeli	37%	100%
A4HEP1	Leishmania braziliensis	80%	100%
A4I1X1	Leishmania infantum	93%	100%
C9ZS49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AY17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BUK9	Trypanosoma cruzi	36%	100%

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