TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania major

UniProt:

Q4Q9F4_LEIMA

TriTrypDb:

LmjF.26.0370 , LMJLV39_260008600 , LMJSD75_260008500

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0000152	nuclear ubiquitin ligase complex	3	2
GO:0005680	anaphase-promoting complex	4	2
GO:0005737	cytoplasm	2	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q9F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9F4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0007088	regulation of mitotic nuclear division	6	2
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	5	2
GO:0007346	regulation of mitotic cell cycle	5	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0010564	regulation of cell cycle process	5	2
GO:0010638	positive regulation of organelle organization	6	2
GO:0010965	regulation of mitotic sister chromatid separation	6	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0022402	cell cycle process	2	2
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	2
GO:0030163	protein catabolic process	4	2
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0033043	regulation of organelle organization	5	2
GO:0033044	regulation of chromosome organization	6	2
GO:0033045	regulation of sister chromatid segregation	5	2
GO:0036211	protein modification process	4	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044770	cell cycle phase transition	3	2
GO:0044772	mitotic cell cycle phase transition	4	2
GO:0044784	metaphase/anaphase transition of cell cycle	4	2
GO:0045787	positive regulation of cell cycle	5	2
GO:0045840	positive regulation of mitotic nuclear division	7	2
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	2
GO:0045931	positive regulation of mitotic cell cycle	6	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0051301	cell division	2	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0051726	regulation of cell cycle	4	2
GO:0051783	regulation of nuclear division	6	2
GO:0051785	positive regulation of nuclear division	7	2
GO:0051983	regulation of chromosome segregation	4	2
GO:0065007	biological regulation	1	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0090068	positive regulation of cell cycle process	6	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901970	positive regulation of mitotic sister chromatid separation	7	2
GO:1901987	regulation of cell cycle phase transition	6	2
GO:1901989	positive regulation of cell cycle phase transition	7	2
GO:1901990	regulation of mitotic cell cycle phase transition	6	2
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	2
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	2
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	2
GO:1903047	mitotic cell cycle process	3	2
GO:1905818	regulation of chromosome separation	5	2
GO:1905820	positive regulation of chromosome separation	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.550
CLV_C14_Caspase3-7	507	511	PF00656	0.726
CLV_NRD_NRD_1	240	242	PF00675	0.506
CLV_NRD_NRD_1	363	365	PF00675	0.429
CLV_NRD_NRD_1	557	559	PF00675	0.499
CLV_NRD_NRD_1	80	82	PF00675	0.483
CLV_PCSK_FUR_1	240	244	PF00082	0.534
CLV_PCSK_KEX2_1	240	242	PF00082	0.506
CLV_PCSK_KEX2_1	363	365	PF00082	0.429
CLV_PCSK_KEX2_1	557	559	PF00082	0.472
CLV_PCSK_KEX2_1	80	82	PF00082	0.483
CLV_PCSK_KEX2_1	800	802	PF00082	0.513
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.530
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.513
CLV_PCSK_SKI1_1	107	111	PF00082	0.459
CLV_PCSK_SKI1_1	175	179	PF00082	0.486
CLV_PCSK_SKI1_1	364	368	PF00082	0.482
CLV_PCSK_SKI1_1	792	796	PF00082	0.411
CLV_PCSK_SKI1_1	797	801	PF00082	0.411
DEG_APCC_DBOX_1	363	371	PF00400	0.524
DEG_Nend_UBRbox_1	1	4	PF02207	0.697
DEG_SCF_FBW7_1	301	306	PF00400	0.487
DEG_SPOP_SBC_1	532	536	PF00917	0.727
DOC_CKS1_1	674	679	PF01111	0.529
DOC_CYCLIN_RxL_1	172	184	PF00134	0.589
DOC_CYCLIN_RxL_1	599	608	PF00134	0.556
DOC_CYCLIN_RxL_1	789	798	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.589
DOC_MAPK_gen_1	172	181	PF00069	0.587
DOC_MAPK_gen_1	257	266	PF00069	0.495
DOC_MAPK_gen_1	557	566	PF00069	0.496
DOC_MAPK_HePTP_8	343	355	PF00069	0.578
DOC_MAPK_HePTP_8	554	566	PF00069	0.591
DOC_MAPK_MEF2A_6	268	277	PF00069	0.468
DOC_MAPK_MEF2A_6	346	355	PF00069	0.572
DOC_MAPK_MEF2A_6	396	404	PF00069	0.617
DOC_MAPK_MEF2A_6	557	566	PF00069	0.598
DOC_PP1_RVXF_1	447	454	PF00149	0.529
DOC_PP1_RVXF_1	600	607	PF00149	0.552
DOC_PP2B_LxvP_1	769	772	PF13499	0.513
DOC_PP2B_LxvP_1	837	840	PF13499	0.529
DOC_USP7_MATH_1	328	332	PF00917	0.518
DOC_USP7_MATH_1	369	373	PF00917	0.466
DOC_USP7_MATH_1	383	387	PF00917	0.658
DOC_USP7_MATH_1	498	502	PF00917	0.755
DOC_USP7_MATH_1	575	579	PF00917	0.638
DOC_USP7_MATH_1	64	68	PF00917	0.590
DOC_USP7_MATH_1	659	663	PF00917	0.411
DOC_USP7_MATH_1	765	769	PF00917	0.319
DOC_USP7_MATH_1	781	785	PF00917	0.397
DOC_USP7_MATH_1	812	816	PF00917	0.624
DOC_USP7_MATH_2	494	500	PF00917	0.625
DOC_WW_Pin1_4	299	304	PF00397	0.765
DOC_WW_Pin1_4	489	494	PF00397	0.690
DOC_WW_Pin1_4	501	506	PF00397	0.537
DOC_WW_Pin1_4	673	678	PF00397	0.488
LIG_14-3-3_CanoR_1	2	11	PF00244	0.629
LIG_14-3-3_CanoR_1	219	227	PF00244	0.486
LIG_14-3-3_CanoR_1	368	377	PF00244	0.444
LIG_14-3-3_CanoR_1	396	404	PF00244	0.653
LIG_14-3-3_CanoR_1	455	463	PF00244	0.582
LIG_14-3-3_CanoR_1	476	485	PF00244	0.778
LIG_14-3-3_CanoR_1	49	53	PF00244	0.568
LIG_14-3-3_CanoR_1	624	633	PF00244	0.562
LIG_14-3-3_CanoR_1	648	654	PF00244	0.436
LIG_14-3-3_CanoR_1	692	700	PF00244	0.497
LIG_14-3-3_CanoR_1	792	797	PF00244	0.402
LIG_14-3-3_CanoR_1	80	86	PF00244	0.501
LIG_14-3-3_CanoR_1	98	106	PF00244	0.256
LIG_BIR_III_2	224	228	PF00653	0.441
LIG_eIF4E_1	681	687	PF01652	0.456
LIG_FHA_1	206	212	PF00498	0.494
LIG_FHA_1	338	344	PF00498	0.637
LIG_FHA_1	371	377	PF00498	0.520
LIG_FHA_1	5	11	PF00498	0.633
LIG_FHA_1	568	574	PF00498	0.500
LIG_FHA_1	58	64	PF00498	0.494
LIG_FHA_1	584	590	PF00498	0.680
LIG_FHA_1	662	668	PF00498	0.411
LIG_FHA_1	699	705	PF00498	0.470
LIG_FHA_1	98	104	PF00498	0.280
LIG_FHA_2	219	225	PF00498	0.584
LIG_FHA_2	287	293	PF00498	0.661
LIG_FHA_2	502	508	PF00498	0.778
LIG_FHA_2	793	799	PF00498	0.411
LIG_FHA_2	823	829	PF00498	0.519
LIG_GBD_Chelix_1	689	697	PF00786	0.586
LIG_LIR_Apic_2	828	833	PF02991	0.482
LIG_LIR_Gen_1	146	155	PF02991	0.524
LIG_LIR_Gen_1	421	432	PF02991	0.613
LIG_LIR_Gen_1	756	765	PF02991	0.416
LIG_LIR_Gen_1	784	794	PF02991	0.436
LIG_LIR_Gen_1	831	840	PF02991	0.540
LIG_LIR_Nem_3	146	152	PF02991	0.454
LIG_LIR_Nem_3	421	427	PF02991	0.529
LIG_LIR_Nem_3	450	456	PF02991	0.553
LIG_LIR_Nem_3	756	760	PF02991	0.416
LIG_LIR_Nem_3	784	789	PF02991	0.513
LIG_LIR_Nem_3	831	837	PF02991	0.547
LIG_PDZ_Class_3	848	853	PF00595	0.614
LIG_REV1ctd_RIR_1	451	459	PF16727	0.499
LIG_SH2_CRK	348	352	PF00017	0.531
LIG_SH2_CRK	683	687	PF00017	0.549
LIG_SH2_CRK	744	748	PF00017	0.478
LIG_SH2_CRK	757	761	PF00017	0.322
LIG_SH2_NCK_1	802	806	PF00017	0.411
LIG_SH2_NCK_1	830	834	PF00017	0.525
LIG_SH2_SRC	244	247	PF00017	0.591
LIG_SH2_SRC	42	45	PF00017	0.588
LIG_SH2_SRC	612	615	PF00017	0.580
LIG_SH2_SRC	681	684	PF00017	0.567
LIG_SH2_SRC	750	753	PF00017	0.513
LIG_SH2_SRC	802	805	PF00017	0.411
LIG_SH2_STAP1	244	248	PF00017	0.587
LIG_SH2_STAP1	612	616	PF00017	0.577
LIG_SH2_STAP1	750	754	PF00017	0.411
LIG_SH2_STAP1	802	806	PF00017	0.411
LIG_SH2_STAP1	99	103	PF00017	0.436
LIG_SH2_STAT3	643	646	PF00017	0.513
LIG_SH2_STAT5	204	207	PF00017	0.589
LIG_SH2_STAT5	42	45	PF00017	0.510
LIG_SH2_STAT5	528	531	PF00017	0.604
LIG_SH2_STAT5	644	647	PF00017	0.411
LIG_SH2_STAT5	99	102	PF00017	0.358
LIG_SH3_3	487	493	PF00018	0.731
LIG_SH3_3	846	852	PF00018	0.721
LIG_SUMO_SIM_anti_2	235	240	PF11976	0.572
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.467
LIG_SUMO_SIM_par_1	408	413	PF11976	0.443
LIG_TRAF2_1	143	146	PF00917	0.487
LIG_TRAF2_1	294	297	PF00917	0.629
LIG_TRAF2_1	840	843	PF00917	0.564
LIG_TRAF2_1	848	851	PF00917	0.629
LIG_TYR_ITIM	832	837	PF00017	0.546
MOD_CDK_SPK_2	501	506	PF00069	0.656
MOD_CDK_SPxK_1	299	305	PF00069	0.754
MOD_CK1_1	288	294	PF00069	0.488
MOD_CK1_1	331	337	PF00069	0.552
MOD_CK1_1	395	401	PF00069	0.667
MOD_CK1_1	501	507	PF00069	0.719
MOD_CK1_1	515	521	PF00069	0.754
MOD_CK1_1	567	573	PF00069	0.581
MOD_CK1_1	815	821	PF00069	0.654
MOD_CK2_1	286	292	PF00069	0.537
MOD_CK2_1	456	462	PF00069	0.575
MOD_CK2_1	476	482	PF00069	0.781
MOD_CK2_1	501	507	PF00069	0.796
MOD_CK2_1	515	521	PF00069	0.672
MOD_CK2_1	624	630	PF00069	0.673
MOD_CK2_1	792	798	PF00069	0.411
MOD_GlcNHglycan	107	110	PF01048	0.362
MOD_GlcNHglycan	326	329	PF01048	0.595
MOD_GlcNHglycan	385	388	PF01048	0.735
MOD_GlcNHglycan	517	521	PF01048	0.779
MOD_GlcNHglycan	60	63	PF01048	0.487
MOD_GlcNHglycan	783	786	PF01048	0.439
MOD_GlcNHglycan	816	820	PF01048	0.568
MOD_GSK3_1	164	171	PF00069	0.468
MOD_GSK3_1	299	306	PF00069	0.644
MOD_GSK3_1	324	331	PF00069	0.514
MOD_GSK3_1	337	344	PF00069	0.501
MOD_GSK3_1	47	54	PF00069	0.447
MOD_GSK3_1	496	503	PF00069	0.730
MOD_GSK3_1	512	519	PF00069	0.726
MOD_GSK3_1	526	533	PF00069	0.698
MOD_GSK3_1	573	580	PF00069	0.562
MOD_GSK3_1	581	588	PF00069	0.693
MOD_GSK3_1	620	627	PF00069	0.544
MOD_GSK3_1	669	676	PF00069	0.504
MOD_GSK3_1	777	784	PF00069	0.418
MOD_GSK3_1	97	104	PF00069	0.494
MOD_N-GLC_1	501	506	PF02516	0.726
MOD_N-GLC_2	91	93	PF02516	0.474
MOD_NEK2_1	1	6	PF00069	0.629
MOD_NEK2_1	205	210	PF00069	0.560
MOD_NEK2_1	232	237	PF00069	0.445
MOD_NEK2_1	285	290	PF00069	0.525
MOD_NEK2_1	31	36	PF00069	0.424
MOD_NEK2_1	314	319	PF00069	0.425
MOD_NEK2_1	370	375	PF00069	0.500
MOD_NEK2_1	377	382	PF00069	0.524
MOD_NEK2_1	410	415	PF00069	0.451
MOD_NEK2_1	48	53	PF00069	0.555
MOD_NEK2_1	564	569	PF00069	0.545
MOD_NEK2_1	820	825	PF00069	0.566
MOD_PIKK_1	437	443	PF00454	0.588
MOD_PIKK_1	496	502	PF00454	0.799
MOD_PIKK_1	573	579	PF00454	0.584
MOD_PIKK_1	661	667	PF00454	0.280
MOD_PK_1	341	347	PF00069	0.533
MOD_PK_1	512	518	PF00069	0.656
MOD_PKA_2	1	7	PF00069	0.644
MOD_PKA_2	218	224	PF00069	0.451
MOD_PKA_2	377	383	PF00069	0.648
MOD_PKA_2	395	401	PF00069	0.637
MOD_PKA_2	437	443	PF00069	0.613
MOD_PKA_2	48	54	PF00069	0.569
MOD_PKA_2	530	536	PF00069	0.736
MOD_PKA_2	691	697	PF00069	0.506
MOD_PKA_2	97	103	PF00069	0.376
MOD_Plk_1	341	347	PF00069	0.533
MOD_Plk_1	64	70	PF00069	0.483
MOD_Plk_1	842	848	PF00069	0.593
MOD_Plk_4	191	197	PF00069	0.478
MOD_Plk_4	206	212	PF00069	0.500
MOD_Plk_4	38	44	PF00069	0.489
MOD_Plk_4	81	87	PF00069	0.457
MOD_ProDKin_1	299	305	PF00069	0.754
MOD_ProDKin_1	489	495	PF00069	0.692
MOD_ProDKin_1	501	507	PF00069	0.537
MOD_ProDKin_1	673	679	PF00069	0.479
MOD_SUMO_for_1	523	526	PF00179	0.771
MOD_SUMO_rev_2	167	177	PF00179	0.481
TRG_DiLeu_BaEn_1	206	211	PF01217	0.521
TRG_DiLeu_BaEn_4	720	726	PF01217	0.690
TRG_DiLeu_LyEn_5	720	725	PF01217	0.573
TRG_ENDOCYTIC_2	348	351	PF00928	0.531
TRG_ENDOCYTIC_2	424	427	PF00928	0.468
TRG_ENDOCYTIC_2	683	686	PF00928	0.551
TRG_ENDOCYTIC_2	744	747	PF00928	0.411
TRG_ENDOCYTIC_2	757	760	PF00928	0.411
TRG_ENDOCYTIC_2	834	837	PF00928	0.546
TRG_ER_diArg_1	169	172	PF00400	0.519
TRG_ER_diArg_1	239	241	PF00400	0.487
TRG_ER_diArg_1	556	558	PF00400	0.488
TRG_ER_diArg_1	591	594	PF00400	0.511
TRG_ER_diArg_1	79	81	PF00400	0.511
TRG_NES_CRM1_1	408	421	PF08389	0.524
TRG_NLS_MonoExtC_3	240	246	PF00514	0.535
TRG_NLS_MonoExtN_4	172	179	PF00514	0.492
TRG_NLS_MonoExtN_4	240	245	PF00514	0.536
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P507	Leptomonas seymouri	51%	100%
A0A3Q8IDI5	Leishmania donovani	93%	100%
A4HEP3	Leishmania braziliensis	73%	100%
A4I1X3	Leishmania infantum	93%	100%
E9AY19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%