RET2, RNA editing complex MP57

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing 3' terminal uridylyl transferase 1

Species:

Leishmania major

UniProt:

Q4Q9F2_LEIMA

TriTrypDb:

LmjF.14.0960 , LmjF.19.1410 , LMJLV39_260008800 , LMJSD75_140015700 , LMJSD75_190020200

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0031019	mitochondrial mRNA editing complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0045293	mRNA editing complex	3	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0005737	cytoplasm	2	21
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	22
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

Q4Q9F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9F2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	24
GO:0006396	RNA processing	6	24
GO:0006725	cellular aromatic compound metabolic process	3	24
GO:0006807	nitrogen compound metabolic process	2	24
GO:0008152	metabolic process	1	24
GO:0009987	cellular process	1	24
GO:0016070	RNA metabolic process	5	24
GO:0031123	RNA 3'-end processing	7	24
GO:0034641	cellular nitrogen compound metabolic process	3	24
GO:0043170	macromolecule metabolic process	3	24
GO:0044237	cellular metabolic process	2	24
GO:0044238	primary metabolic process	2	24
GO:0046483	heterocycle metabolic process	3	24
GO:0071076	RNA 3' uridylation	8	24
GO:0071704	organic substance metabolic process	2	24
GO:0090304	nucleic acid metabolic process	4	24
GO:1901360	organic cyclic compound metabolic process	3	24
GO:0006378	mRNA polyadenylation	7	1
GO:0006397	mRNA processing	7	1
GO:0016071	mRNA metabolic process	6	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0043631	RNA polyadenylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	24
GO:0005488	binding	1	24
GO:0016740	transferase activity	2	24
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	24
GO:0016779	nucleotidyltransferase activity	4	24
GO:0043167	ion binding	2	24
GO:0043169	cation binding	3	24
GO:0046872	metal ion binding	4	24
GO:0050265	RNA uridylyltransferase activity	4	24
GO:0070569	uridylyltransferase activity	5	24
GO:0140098	catalytic activity, acting on RNA	3	24
GO:0140640	catalytic activity, acting on a nucleic acid	2	24
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	4
GO:0070566	adenylyltransferase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.513
CLV_NRD_NRD_1	193	195	PF00675	0.286
CLV_NRD_NRD_1	495	497	PF00675	0.533
CLV_PCSK_KEX2_1	138	140	PF00082	0.276
CLV_PCSK_KEX2_1	148	150	PF00082	0.347
CLV_PCSK_KEX2_1	495	497	PF00082	0.498
CLV_PCSK_KEX2_1	71	73	PF00082	0.384
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.249
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.347
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.452
CLV_PCSK_SKI1_1	272	276	PF00082	0.373
CLV_PCSK_SKI1_1	473	477	PF00082	0.354
CLV_PCSK_SKI1_1	489	493	PF00082	0.439
CLV_PCSK_SKI1_1	63	67	PF00082	0.363
DEG_APCC_DBOX_1	155	163	PF00400	0.352
DEG_APCC_DBOX_1	196	204	PF00400	0.291
DEG_COP1_1	273	283	PF00400	0.291
DEG_SPOP_SBC_1	23	27	PF00917	0.620
DEG_SPOP_SBC_1	36	40	PF00917	0.694
DOC_CYCLIN_yClb5_NLxxxL_5	450	459	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.374
DOC_PP1_RVXF_1	353	360	PF00149	0.385
DOC_PP4_FxxP_1	126	129	PF00568	0.449
DOC_USP7_MATH_1	131	135	PF00917	0.467
DOC_USP7_MATH_1	23	27	PF00917	0.613
DOC_USP7_MATH_1	36	40	PF00917	0.635
DOC_USP7_UBL2_3	138	142	PF12436	0.460
DOC_USP7_UBL2_3	322	326	PF12436	0.320
DOC_WW_Pin1_4	164	169	PF00397	0.359
DOC_WW_Pin1_4	2	7	PF00397	0.678
DOC_WW_Pin1_4	30	35	PF00397	0.719
DOC_WW_Pin1_4	375	380	PF00397	0.400
DOC_WW_Pin1_4	94	99	PF00397	0.449
LIG_14-3-3_CanoR_1	182	188	PF00244	0.462
LIG_14-3-3_CanoR_1	194	203	PF00244	0.232
LIG_14-3-3_CanoR_1	232	236	PF00244	0.293
LIG_14-3-3_CanoR_1	414	420	PF00244	0.286
LIG_14-3-3_CanoR_1	473	479	PF00244	0.473
LIG_AP2alpha_2	361	363	PF02296	0.342
LIG_CaMK_CASK_1	226	232	PF00069	0.307
LIG_Clathr_ClatBox_1	438	442	PF01394	0.262
LIG_deltaCOP1_diTrp_1	422	427	PF00928	0.291
LIG_eIF4E_1	103	109	PF01652	0.533
LIG_FHA_1	12	18	PF00498	0.633
LIG_FHA_1	138	144	PF00498	0.471
LIG_FHA_1	165	171	PF00498	0.366
LIG_FHA_1	352	358	PF00498	0.376
LIG_FHA_2	187	193	PF00498	0.428
LIG_FHA_2	197	203	PF00498	0.392
LIG_FHA_2	242	248	PF00498	0.365
LIG_FHA_2	474	480	PF00498	0.460
LIG_LIR_Apic_2	422	428	PF02991	0.278
LIG_LIR_Gen_1	141	152	PF02991	0.517
LIG_LIR_Gen_1	434	441	PF02991	0.320
LIG_LIR_Gen_1	442	453	PF02991	0.327
LIG_LIR_Gen_1	5	13	PF02991	0.467
LIG_LIR_Nem_3	141	147	PF02991	0.551
LIG_LIR_Nem_3	289	295	PF02991	0.265
LIG_LIR_Nem_3	344	350	PF02991	0.313
LIG_LIR_Nem_3	376	380	PF02991	0.344
LIG_LIR_Nem_3	434	438	PF02991	0.338
LIG_LIR_Nem_3	442	448	PF02991	0.326
LIG_LIR_Nem_3	5	11	PF02991	0.487
LIG_NRBOX	387	393	PF00104	0.307
LIG_Pex14_1	288	292	PF04695	0.303
LIG_Pex14_2	284	288	PF04695	0.311
LIG_SH2_CRK	185	189	PF00017	0.426
LIG_SH2_GRB2like	174	177	PF00017	0.454
LIG_SH2_NCK_1	445	449	PF00017	0.307
LIG_SH2_PTP2	10	13	PF00017	0.477
LIG_SH2_SRC	445	448	PF00017	0.307
LIG_SH2_SRC	481	484	PF00017	0.530
LIG_SH2_SRC	8	11	PF00017	0.468
LIG_SH2_STAP1	270	274	PF00017	0.291
LIG_SH2_STAP1	341	345	PF00017	0.324
LIG_SH2_STAP1	399	403	PF00017	0.262
LIG_SH2_STAP1	405	409	PF00017	0.236
LIG_SH2_STAP1	47	51	PF00017	0.505
LIG_SH2_STAT3	150	153	PF00017	0.260
LIG_SH2_STAT5	103	106	PF00017	0.478
LIG_SH2_STAT5	174	177	PF00017	0.506
LIG_SH2_STAT5	185	188	PF00017	0.277
LIG_SH2_STAT5	215	218	PF00017	0.282
LIG_SH2_STAT5	270	273	PF00017	0.291
LIG_SH2_STAT5	279	282	PF00017	0.301
LIG_SH2_STAT5	301	304	PF00017	0.264
LIG_SH2_STAT5	306	309	PF00017	0.290
LIG_SH2_STAT5	350	353	PF00017	0.324
LIG_SH2_STAT5	437	440	PF00017	0.369
LIG_SH2_STAT5	481	484	PF00017	0.530
LIG_SH2_STAT5	58	61	PF00017	0.261
LIG_SH2_STAT5	8	11	PF00017	0.495
LIG_SH3_3	366	372	PF00018	0.360
LIG_SUMO_SIM_par_1	158	164	PF11976	0.298
LIG_SUMO_SIM_par_1	408	413	PF11976	0.326
LIG_TRAF2_1	189	192	PF00917	0.291
MOD_CDK_SPxxK_3	164	171	PF00069	0.355
MOD_CDK_SPxxK_3	94	101	PF00069	0.291
MOD_CK1_1	107	113	PF00069	0.291
MOD_CK1_1	196	202	PF00069	0.436
MOD_CK1_1	32	38	PF00069	0.637
MOD_CK1_1	39	45	PF00069	0.594
MOD_CK1_1	418	424	PF00069	0.306
MOD_CK1_1	46	52	PF00069	0.629
MOD_CK2_1	186	192	PF00069	0.291
MOD_CK2_1	241	247	PF00069	0.325
MOD_CK2_1	37	43	PF00069	0.723
MOD_CK2_1	473	479	PF00069	0.403
MOD_GlcNHglycan	19	22	PF01048	0.662
MOD_GlcNHglycan	26	29	PF01048	0.633
MOD_GlcNHglycan	327	330	PF01048	0.355
MOD_GlcNHglycan	34	37	PF01048	0.535
MOD_GSK3_1	160	167	PF00069	0.379
MOD_GSK3_1	32	39	PF00069	0.674
MOD_GSK3_1	337	344	PF00069	0.337
MOD_GSK3_1	427	434	PF00069	0.375
MOD_NEK2_1	17	22	PF00069	0.639
MOD_NEK2_1	337	342	PF00069	0.341
MOD_NEK2_1	351	356	PF00069	0.346
MOD_NEK2_1	78	83	PF00069	0.384
MOD_NEK2_2	415	420	PF00069	0.394
MOD_PK_1	142	148	PF00069	0.491
MOD_PKA_2	183	189	PF00069	0.486
MOD_PKA_2	193	199	PF00069	0.349
MOD_PKA_2	231	237	PF00069	0.281
MOD_PKA_2	415	421	PF00069	0.327
MOD_Plk_1	131	137	PF00069	0.262
MOD_Plk_1	230	236	PF00069	0.354
MOD_Plk_1	288	294	PF00069	0.302
MOD_Plk_1	487	493	PF00069	0.359
MOD_Plk_2-3	115	121	PF00069	0.278
MOD_Plk_4	104	110	PF00069	0.347
MOD_Plk_4	183	189	PF00069	0.535
MOD_Plk_4	196	202	PF00069	0.467
MOD_Plk_4	297	303	PF00069	0.258
MOD_Plk_4	341	347	PF00069	0.314
MOD_Plk_4	487	493	PF00069	0.444
MOD_ProDKin_1	164	170	PF00069	0.354
MOD_ProDKin_1	2	8	PF00069	0.679
MOD_ProDKin_1	30	36	PF00069	0.721
MOD_ProDKin_1	375	381	PF00069	0.408
MOD_ProDKin_1	94	100	PF00069	0.291
MOD_SUMO_for_1	467	470	PF00179	0.375
MOD_SUMO_rev_2	190	196	PF00179	0.317
MOD_SUMO_rev_2	94	102	PF00179	0.291
TRG_DiLeu_BaEn_1	387	392	PF01217	0.361
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.486
TRG_ENDOCYTIC_2	185	188	PF00928	0.397
TRG_ENDOCYTIC_2	445	448	PF00928	0.323
TRG_ENDOCYTIC_2	8	11	PF00928	0.511
TRG_ER_diArg_1	182	185	PF00400	0.377
TRG_ER_diArg_1	203	206	PF00400	0.394
TRG_ER_diArg_1	414	417	PF00400	0.309
TRG_ER_diArg_1	494	496	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P857	Leptomonas seymouri	25%	97%
A0A0N1IJQ4	Leptomonas seymouri	76%	100%
A0A0S4JJR1	Bodo saltans	69%	100%
A0A0S4JJT6	Bodo saltans	27%	87%
A0A1X0NSS0	Trypanosomatidae	76%	100%
A0A1X0NZU6	Trypanosomatidae	29%	97%
A0A3Q8IC11	Leishmania donovani	97%	100%
A0A3Q8IHZ8	Leishmania donovani	25%	100%
A0A3R7K3P5	Trypanosoma rangeli	29%	97%
A0A3R7KH85	Trypanosoma rangeli	26%	71%
A0A422NVH7	Trypanosoma rangeli	74%	100%
A4HEP5	Leishmania braziliensis	88%	99%
A4HGC0	Leishmania braziliensis	25%	100%
A4I1X5	Leishmania infantum	97%	100%
A4I3F3	Leishmania infantum	25%	100%
C9ZS45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
D0A7Y7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
E9AY21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AZP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q8J1	Leishmania major	25%	100%
Q86MV5	Trypanosoma brucei brucei	72%	100%
V5BG78	Trypanosoma cruzi	29%	97%
V5BQ07	Trypanosoma cruzi	74%	100%