Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania major

UniProt:

Q4Q9F1_LEIMA

TriTrypDb:

LmjF.26.0400 , LMJLV39_260008900

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q9F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9F1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	372	374	PF00675	0.326
CLV_NRD_NRD_1	379	381	PF00675	0.343
CLV_NRD_NRD_1	541	543	PF00675	0.437
CLV_PCSK_KEX2_1	371	373	PF00082	0.352
CLV_PCSK_KEX2_1	379	381	PF00082	0.340
CLV_PCSK_KEX2_1	518	520	PF00082	0.258
CLV_PCSK_KEX2_1	541	543	PF00082	0.396
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.242
CLV_PCSK_SKI1_1	20	24	PF00082	0.471
CLV_PCSK_SKI1_1	284	288	PF00082	0.496
CLV_PCSK_SKI1_1	379	383	PF00082	0.564
DEG_APCC_DBOX_1	378	386	PF00400	0.431
DOC_ANK_TNKS_1	145	152	PF00023	0.537
DOC_CDC14_PxL_1	332	340	PF14671	0.306
DOC_CYCLIN_RxL_1	281	290	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	61	64	PF00134	0.431
DOC_MAPK_MEF2A_6	221	229	PF00069	0.406
DOC_PP2B_LxvP_1	142	145	PF13499	0.451
DOC_PP2B_LxvP_1	15	18	PF13499	0.498
DOC_PP2B_LxvP_1	229	232	PF13499	0.412
DOC_PP2B_LxvP_1	61	64	PF13499	0.431
DOC_PP2B_PxIxI_1	277	283	PF00149	0.289
DOC_USP7_MATH_1	233	237	PF00917	0.476
DOC_USP7_MATH_1	266	270	PF00917	0.535
DOC_USP7_MATH_1	312	316	PF00917	0.653
DOC_USP7_MATH_1	397	401	PF00917	0.436
DOC_WW_Pin1_4	101	106	PF00397	0.593
DOC_WW_Pin1_4	109	114	PF00397	0.590
DOC_WW_Pin1_4	116	121	PF00397	0.531
DOC_WW_Pin1_4	183	188	PF00397	0.562
DOC_WW_Pin1_4	204	209	PF00397	0.680
DOC_WW_Pin1_4	318	323	PF00397	0.504
DOC_WW_Pin1_4	80	85	PF00397	0.441
LIG_14-3-3_CanoR_1	284	292	PF00244	0.374
LIG_14-3-3_CanoR_1	311	317	PF00244	0.653
LIG_14-3-3_CanoR_1	325	335	PF00244	0.322
LIG_14-3-3_CanoR_1	535	541	PF00244	0.445
LIG_14-3-3_CanoR_1	88	92	PF00244	0.442
LIG_Actin_WH2_2	84	100	PF00022	0.423
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_BIR_III_4	52	56	PF00653	0.420
LIG_Clathr_ClatBox_1	338	342	PF01394	0.393
LIG_FHA_1	198	204	PF00498	0.630
LIG_FHA_1	232	238	PF00498	0.437
LIG_FHA_1	311	317	PF00498	0.777
LIG_FHA_1	510	516	PF00498	0.458
LIG_FHA_1	518	524	PF00498	0.458
LIG_FHA_1	67	73	PF00498	0.437
LIG_FHA_2	344	350	PF00498	0.350
LIG_FHA_2	472	478	PF00498	0.458
LIG_FHA_2	520	526	PF00498	0.500
LIG_FHA_2	547	553	PF00498	0.605
LIG_Integrin_RGD_1	532	534	PF01839	0.300
LIG_LIR_Apic_2	479	484	PF02991	0.462
LIG_LIR_Gen_1	400	409	PF02991	0.413
LIG_LIR_Gen_1	442	451	PF02991	0.479
LIG_LIR_Gen_1	472	478	PF02991	0.500
LIG_LIR_LC3C_4	499	502	PF02991	0.454
LIG_LIR_Nem_3	437	443	PF02991	0.483
LIG_LIR_Nem_3	52	57	PF02991	0.551
LIG_LIR_Nem_3	552	558	PF02991	0.479
LIG_LIR_Nem_3	69	74	PF02991	0.282
LIG_LYPXL_yS_3	555	558	PF13949	0.457
LIG_PDZ_Class_3	557	562	PF00595	0.417
LIG_Pex14_1	32	36	PF04695	0.395
LIG_Pex14_2	377	381	PF04695	0.328
LIG_REV1ctd_RIR_1	34	41	PF16727	0.368
LIG_SH2_SRC	441	444	PF00017	0.534
LIG_SH2_STAP1	161	165	PF00017	0.327
LIG_SH2_STAT5	258	261	PF00017	0.374
LIG_SH2_STAT5	368	371	PF00017	0.413
LIG_SH2_STAT5	473	476	PF00017	0.500
LIG_SH2_STAT5	494	497	PF00017	0.500
LIG_SH3_3	330	336	PF00018	0.436
LIG_SH3_3	422	428	PF00018	0.500
LIG_SH3_3	484	490	PF00018	0.500
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.422
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.374
LIG_SUMO_SIM_anti_2	499	504	PF11976	0.458
LIG_SUMO_SIM_par_1	466	472	PF11976	0.461
LIG_SUMO_SIM_par_1	499	504	PF11976	0.404
LIG_TRAF2_1	296	299	PF00917	0.573
LIG_TRAF2_1	347	350	PF00917	0.429
LIG_UBA3_1	11	16	PF00899	0.419
LIG_WRC_WIRS_1	527	532	PF05994	0.504
LIG_WW_3	17	21	PF00397	0.475
MOD_CDK_SPxxK_3	318	325	PF00069	0.478
MOD_CK1_1	109	115	PF00069	0.751
MOD_CK1_1	157	163	PF00069	0.515
MOD_CK1_1	185	191	PF00069	0.603
MOD_CK1_1	207	213	PF00069	0.622
MOD_CK1_1	242	248	PF00069	0.579
MOD_CK1_1	469	475	PF00069	0.500
MOD_CK2_1	343	349	PF00069	0.395
MOD_CK2_1	471	477	PF00069	0.473
MOD_CK2_1	519	525	PF00069	0.500
MOD_CK2_1	546	552	PF00069	0.485
MOD_GlcNHglycan	116	119	PF01048	0.635
MOD_GlcNHglycan	156	159	PF01048	0.476
MOD_GlcNHglycan	178	181	PF01048	0.527
MOD_GlcNHglycan	187	190	PF01048	0.604
MOD_GlcNHglycan	248	251	PF01048	0.614
MOD_GSK3_1	114	121	PF00069	0.646
MOD_GSK3_1	157	164	PF00069	0.522
MOD_GSK3_1	181	188	PF00069	0.635
MOD_GSK3_1	203	210	PF00069	0.676
MOD_GSK3_1	239	246	PF00069	0.565
MOD_GSK3_1	286	293	PF00069	0.481
MOD_GSK3_1	310	317	PF00069	0.766
MOD_GSK3_1	509	516	PF00069	0.514
MOD_GSK3_1	517	524	PF00069	0.490
MOD_GSK3_1	542	549	PF00069	0.581
MOD_N-GLC_1	106	111	PF02516	0.525
MOD_N-GLC_1	410	415	PF02516	0.204
MOD_NEK2_1	127	132	PF00069	0.384
MOD_NEK2_1	203	208	PF00069	0.634
MOD_NEK2_1	22	27	PF00069	0.534
MOD_NEK2_1	285	290	PF00069	0.408
MOD_NEK2_1	466	471	PF00069	0.454
MOD_NEK2_1	476	481	PF00069	0.450
MOD_NEK2_1	536	541	PF00069	0.500
MOD_PIKK_1	310	316	PF00454	0.577
MOD_PIKK_1	542	548	PF00454	0.468
MOD_PKA_2	310	316	PF00069	0.588
MOD_PKA_2	397	403	PF00069	0.435
MOD_PKA_2	534	540	PF00069	0.445
MOD_PKA_2	546	552	PF00069	0.419
MOD_PKA_2	87	93	PF00069	0.448
MOD_Plk_1	476	482	PF00069	0.487
MOD_Plk_4	161	167	PF00069	0.516
MOD_Plk_4	220	226	PF00069	0.425
MOD_Plk_4	233	239	PF00069	0.444
MOD_Plk_4	397	403	PF00069	0.435
MOD_Plk_4	471	477	PF00069	0.450
MOD_ProDKin_1	101	107	PF00069	0.597
MOD_ProDKin_1	109	115	PF00069	0.589
MOD_ProDKin_1	116	122	PF00069	0.529
MOD_ProDKin_1	183	189	PF00069	0.566
MOD_ProDKin_1	204	210	PF00069	0.678
MOD_ProDKin_1	318	324	PF00069	0.493
MOD_ProDKin_1	80	86	PF00069	0.447
MOD_SUMO_rev_2	343	353	PF00179	0.469
TRG_DiLeu_BaEn_1	92	97	PF01217	0.415
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.422
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.391
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.402
TRG_ENDOCYTIC_2	402	405	PF00928	0.421
TRG_ENDOCYTIC_2	443	446	PF00928	0.497
TRG_ENDOCYTIC_2	473	476	PF00928	0.500
TRG_ENDOCYTIC_2	555	558	PF00928	0.520
TRG_ER_diArg_1	267	270	PF00400	0.577
TRG_ER_diArg_1	309	312	PF00400	0.599
TRG_ER_diArg_1	361	364	PF00400	0.437
TRG_ER_diArg_1	371	373	PF00400	0.321
TRG_ER_diArg_1	379	381	PF00400	0.284
TRG_ER_diArg_1	405	408	PF00400	0.341
TRG_ER_diArg_1	540	542	PF00400	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB74	Leptomonas seymouri	52%	100%
A0A1X0NTZ1	Trypanosomatidae	43%	100%
A0A3Q8IGV6	Leishmania donovani	91%	100%
A4HEP6	Leishmania braziliensis	72%	100%
A4I1X6	Leishmania infantum	91%	100%
E9AY22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%