Pseudouridylate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pseudouridylate synthase-like protein

Species:

Leishmania major

UniProt:

Q4Q9E9_LEIMA

TriTrypDb:

LmjF.26.0420 , LMJLV39_260009200

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

Q4Q9E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9E9

Function

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Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006399	tRNA metabolic process	7	7
GO:0006400	tRNA modification	6	5
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008033	tRNA processing	8	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0004730	pseudouridylate synthase activity	5	8
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	8
GO:0016836	hydro-lyase activity	4	8
GO:0016853	isomerase activity	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	447	451	PF00656	0.355
CLV_C14_Caspase3-7	681	685	PF00656	0.765
CLV_NRD_NRD_1	13	15	PF00675	0.572
CLV_NRD_NRD_1	149	151	PF00675	0.359
CLV_NRD_NRD_1	246	248	PF00675	0.478
CLV_NRD_NRD_1	380	382	PF00675	0.323
CLV_NRD_NRD_1	561	563	PF00675	0.597
CLV_NRD_NRD_1	691	693	PF00675	0.740
CLV_NRD_NRD_1	694	696	PF00675	0.740
CLV_NRD_NRD_1	8	10	PF00675	0.618

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5J6	Leptomonas seymouri	60%	100%
A0A0S4KL20	Bodo saltans	35%	94%
A0A1X0NSY0	Trypanosomatidae	40%	100%
A0A3Q8ICM8	Leishmania donovani	94%	100%
A0A3R7KTM1	Trypanosoma rangeli	39%	100%
A4HEP8	Leishmania braziliensis	80%	100%
A4I1X8	Leishmania infantum	94%	100%
C9ZS41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AY24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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