Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9E7_LEIMA

TriTrypDb:

LmjF.26.0440 , LMJLV39_260009500

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q9E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9E7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	27	29	PF00675	0.488
CLV_PCSK_FUR_1	25	29	PF00082	0.402
CLV_PCSK_KEX2_1	27	29	PF00082	0.488
CLV_PCSK_SKI1_1	224	228	PF00082	0.316
DOC_CYCLIN_RxL_1	218	230	PF00134	0.602
DOC_MAPK_gen_1	22	31	PF00069	0.680
DOC_MAPK_MEF2A_6	25	33	PF00069	0.655
DOC_PP1_RVXF_1	222	229	PF00149	0.474
DOC_USP7_MATH_1	144	148	PF00917	0.737
DOC_USP7_MATH_1	155	159	PF00917	0.717
DOC_USP7_MATH_1	64	68	PF00917	0.789
DOC_WW_Pin1_4	100	105	PF00397	0.724
DOC_WW_Pin1_4	201	206	PF00397	0.757
DOC_WW_Pin1_4	44	49	PF00397	0.764
DOC_WW_Pin1_4	77	82	PF00397	0.716
LIG_14-3-3_CanoR_1	164	174	PF00244	0.710
LIG_14-3-3_CanoR_1	27	32	PF00244	0.716
LIG_14-3-3_CanoR_1	92	102	PF00244	0.694
LIG_BRCT_BRCA1_1	45	49	PF00533	0.713
LIG_BRCT_BRCA1_1	96	100	PF00533	0.686
LIG_deltaCOP1_diTrp_1	301	310	PF00928	0.454
LIG_FHA_1	19	25	PF00498	0.739
LIG_FHA_1	192	198	PF00498	0.729
LIG_FHA_2	122	128	PF00498	0.664
LIG_FHA_2	158	164	PF00498	0.794
LIG_FHA_2	56	62	PF00498	0.781
LIG_LIR_Gen_1	230	239	PF02991	0.335
LIG_LIR_Gen_1	308	316	PF02991	0.375
LIG_LIR_Nem_3	230	235	PF02991	0.320
LIG_LIR_Nem_3	300	306	PF02991	0.408
LIG_LIR_Nem_3	308	313	PF02991	0.386
LIG_PCNA_PIPBox_1	182	191	PF02747	0.677
LIG_Pex14_1	228	232	PF04695	0.335
LIG_SH2_CRK	223	227	PF00017	0.502
LIG_SH2_CRK	250	254	PF00017	0.415
LIG_SH2_STAP1	20	24	PF00017	0.591
LIG_SH2_STAT5	142	145	PF00017	0.627
LIG_SH2_STAT5	20	23	PF00017	0.593
LIG_SH2_STAT5	246	249	PF00017	0.472
LIG_SH2_STAT5	292	295	PF00017	0.444
LIG_SH3_2	211	216	PF14604	0.566
LIG_SH3_3	2	8	PF00018	0.734
LIG_SH3_3	207	213	PF00018	0.713
LIG_SH3_3	293	299	PF00018	0.453
LIG_SH3_3	30	36	PF00018	0.693
LIG_SH3_3	38	44	PF00018	0.739
LIG_SUMO_SIM_anti_2	30	35	PF11976	0.602
LIG_SUMO_SIM_par_1	292	297	PF11976	0.426
LIG_TRAF2_1	124	127	PF00917	0.696
LIG_TRAF2_1	317	320	PF00917	0.379
LIG_TYR_ITIM	221	226	PF00017	0.611
MOD_CK1_1	158	164	PF00069	0.751
MOD_CK1_1	172	178	PF00069	0.786
MOD_CK1_1	47	53	PF00069	0.761
MOD_CK1_1	80	86	PF00069	0.724
MOD_CK2_1	111	117	PF00069	0.626
MOD_CK2_1	121	127	PF00069	0.616
MOD_CK2_1	157	163	PF00069	0.776
MOD_CK2_1	314	320	PF00069	0.412
MOD_GlcNHglycan	113	116	PF01048	0.425
MOD_GlcNHglycan	146	149	PF01048	0.479
MOD_GlcNHglycan	159	163	PF01048	0.488
MOD_GlcNHglycan	171	174	PF01048	0.568
MOD_GlcNHglycan	191	194	PF01048	0.538
MOD_GlcNHglycan	310	313	PF01048	0.646
MOD_GlcNHglycan	66	69	PF01048	0.539
MOD_GSK3_1	165	172	PF00069	0.788
MOD_GSK3_1	43	50	PF00069	0.723
MOD_NEK2_1	138	143	PF00069	0.638
MOD_NEK2_1	178	183	PF00069	0.675
MOD_NEK2_1	189	194	PF00069	0.651
MOD_NEK2_1	227	232	PF00069	0.336
MOD_NEK2_1	235	240	PF00069	0.337
MOD_NEK2_1	49	54	PF00069	0.748
MOD_NEK2_1	94	99	PF00069	0.731
MOD_NEK2_2	249	254	PF00069	0.472
MOD_NEK2_2	285	290	PF00069	0.371
MOD_PIKK_1	95	101	PF00454	0.708
MOD_PK_1	27	33	PF00069	0.779
MOD_PKA_1	27	33	PF00069	0.753
MOD_PKA_2	144	150	PF00069	0.685
MOD_PKA_2	27	33	PF00069	0.753
MOD_PKA_2	314	320	PF00069	0.495
MOD_PKA_2	94	100	PF00069	0.695
MOD_PKB_1	25	33	PF00069	0.602
MOD_Plk_1	138	144	PF00069	0.578
MOD_Plk_4	173	179	PF00069	0.737
MOD_ProDKin_1	100	106	PF00069	0.723
MOD_ProDKin_1	201	207	PF00069	0.758
MOD_ProDKin_1	44	50	PF00069	0.767
MOD_ProDKin_1	77	83	PF00069	0.715
TRG_ENDOCYTIC_2	223	226	PF00928	0.561
TRG_ENDOCYTIC_2	250	253	PF00928	0.410
TRG_ER_diArg_1	24	27	PF00400	0.691
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P498	Leptomonas seymouri	47%	100%
A0A1X0NSG9	Trypanosomatidae	33%	100%
A0A3R7MX83	Trypanosoma rangeli	30%	100%
A0A3S7WZN6	Leishmania donovani	88%	100%
A4HEQ0	Leishmania braziliensis	61%	100%
A4I1Y0	Leishmania infantum	88%	100%
C9ZS39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AY26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5B9G1	Trypanosoma cruzi	36%	100%