Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9E6_LEIMA

TriTrypDb:

LMJLV39_260009600

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 2
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9E6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.456
CLV_NRD_NRD_1	107	109	PF00675	0.561
CLV_NRD_NRD_1	285	287	PF00675	0.470
CLV_NRD_NRD_1	93	95	PF00675	0.495
CLV_PCSK_KEX2_1	107	109	PF00082	0.467
CLV_PCSK_KEX2_1	93	95	PF00082	0.539
CLV_PCSK_SKI1_1	152	156	PF00082	0.586
CLV_PCSK_SKI1_1	286	290	PF00082	0.496
CLV_PCSK_SKI1_1	424	428	PF00082	0.372
CLV_PCSK_SKI1_1	446	450	PF00082	0.500
DEG_APCC_DBOX_1	137	145	PF00400	0.550
DEG_APCC_DBOX_1	285	293	PF00400	0.473
DOC_CKS1_1	257	262	PF01111	0.568
DOC_CKS1_1	59	64	PF01111	0.549
DOC_MAPK_HePTP_8	9	21	PF00069	0.440
DOC_MAPK_MEF2A_6	12	21	PF00069	0.424
DOC_MAPK_MEF2A_6	234	243	PF00069	0.481
DOC_MAPK_MEF2A_6	74	83	PF00069	0.430
DOC_MAPK_RevD_3	78	94	PF00069	0.419
DOC_PP2B_LxvP_1	123	126	PF13499	0.490
DOC_PP4_FxxP_1	155	158	PF00568	0.493
DOC_PP4_FxxP_1	347	350	PF00568	0.417
DOC_USP7_MATH_1	137	141	PF00917	0.545
DOC_USP7_MATH_1	249	253	PF00917	0.492
DOC_USP7_MATH_1	385	389	PF00917	0.509
DOC_USP7_MATH_1	438	442	PF00917	0.522
DOC_USP7_UBL2_3	212	216	PF12436	0.257
DOC_WW_Pin1_4	256	261	PF00397	0.612
DOC_WW_Pin1_4	434	439	PF00397	0.514
DOC_WW_Pin1_4	58	63	PF00397	0.536
LIG_14-3-3_CanoR_1	120	124	PF00244	0.645
LIG_14-3-3_CanoR_1	138	142	PF00244	0.501
LIG_14-3-3_CanoR_1	224	231	PF00244	0.549
LIG_14-3-3_CanoR_1	280	289	PF00244	0.489
LIG_14-3-3_CanoR_1	396	406	PF00244	0.563
LIG_14-3-3_CanoR_1	56	60	PF00244	0.507
LIG_Actin_WH2_2	137	154	PF00022	0.496
LIG_APCC_ABBA_1	427	432	PF00400	0.358
LIG_FHA_1	18	24	PF00498	0.407
LIG_FHA_1	277	283	PF00498	0.406
LIG_FHA_1	308	314	PF00498	0.590
LIG_FHA_1	8	14	PF00498	0.429
LIG_FHA_2	183	189	PF00498	0.514
LIG_FHA_2	257	263	PF00498	0.609
LIG_LIR_Gen_1	162	172	PF02991	0.518
LIG_LIR_LC3C_4	237	241	PF02991	0.427
LIG_LIR_Nem_3	162	167	PF02991	0.452
LIG_LIR_Nem_3	399	405	PF02991	0.563
LIG_MYND_1	126	130	PF01753	0.476
LIG_NRP_CendR_1	450	451	PF00754	0.503
LIG_Pex14_2	343	347	PF04695	0.502
LIG_SH2_CRK	164	168	PF00017	0.427
LIG_SH2_CRK	214	218	PF00017	0.387
LIG_SH2_CRK	370	374	PF00017	0.569
LIG_SH2_STAP1	214	218	PF00017	0.387
LIG_SH2_STAP1	300	304	PF00017	0.585
LIG_SH2_STAP1	444	448	PF00017	0.486
LIG_SH2_STAT5	184	187	PF00017	0.505
LIG_SH2_STAT5	209	212	PF00017	0.482
LIG_SH2_STAT5	273	276	PF00017	0.458
LIG_SH2_STAT5	281	284	PF00017	0.439
LIG_SH2_STAT5	297	300	PF00017	0.389
LIG_SH2_STAT5	8	11	PF00017	0.522
LIG_SH3_3	168	174	PF00018	0.518
LIG_SH3_3	356	362	PF00018	0.610
LIG_SH3_3	56	62	PF00018	0.494
LIG_SUMO_SIM_anti_2	237	243	PF11976	0.475
LIG_SUMO_SIM_par_1	15	20	PF11976	0.328
LIG_SUMO_SIM_par_1	239	245	PF11976	0.468
LIG_SUMO_SIM_par_1	79	85	PF11976	0.464
LIG_TRAF2_1	186	189	PF00917	0.438
LIG_TYR_ITSM	160	167	PF00017	0.491
MOD_CDK_SPK_2	256	261	PF00069	0.508
MOD_CK1_1	139	145	PF00069	0.542
MOD_CK1_1	183	189	PF00069	0.568
MOD_CK1_1	388	394	PF00069	0.660
MOD_CK1_1	397	403	PF00069	0.575
MOD_CK1_1	58	64	PF00069	0.550
MOD_CK1_1	66	72	PF00069	0.533
MOD_CK1_1	89	95	PF00069	0.536
MOD_CK2_1	137	143	PF00069	0.508
MOD_CK2_1	182	188	PF00069	0.502
MOD_GlcNHglycan	131	134	PF01048	0.525
MOD_GlcNHglycan	226	229	PF01048	0.496
MOD_GlcNHglycan	356	359	PF01048	0.650
MOD_GlcNHglycan	409	412	PF01048	0.557
MOD_GSK3_1	394	401	PF00069	0.559
MOD_GSK3_1	434	441	PF00069	0.516
MOD_GSK3_1	54	61	PF00069	0.572
MOD_N-GLC_1	159	164	PF02516	0.465
MOD_N-GLC_1	327	332	PF02516	0.631
MOD_N-GLC_1	351	356	PF02516	0.418
MOD_N-GLC_1	417	422	PF02516	0.585
MOD_N-GLC_1	96	101	PF02516	0.520
MOD_NEK2_1	17	22	PF00069	0.363
MOD_NEK2_1	182	187	PF00069	0.515
MOD_NEK2_1	337	342	PF00069	0.610
MOD_NEK2_1	395	400	PF00069	0.645
MOD_NEK2_2	249	254	PF00069	0.537
MOD_NEK2_2	281	286	PF00069	0.478
MOD_PIKK_1	201	207	PF00454	0.498
MOD_PKA_2	119	125	PF00069	0.557
MOD_PKA_2	137	143	PF00069	0.588
MOD_PKA_2	385	391	PF00069	0.680
MOD_PKA_2	395	401	PF00069	0.538
MOD_PKA_2	55	61	PF00069	0.497
MOD_Plk_1	159	165	PF00069	0.447
MOD_Plk_1	180	186	PF00069	0.590
MOD_Plk_1	201	207	PF00069	0.485
MOD_Plk_1	380	386	PF00069	0.522
MOD_Plk_4	17	23	PF00069	0.380
MOD_Plk_4	319	325	PF00069	0.620
MOD_Plk_4	422	428	PF00069	0.393
MOD_Plk_4	55	61	PF00069	0.519
MOD_Plk_4	86	92	PF00069	0.541
MOD_ProDKin_1	256	262	PF00069	0.615
MOD_ProDKin_1	434	440	PF00069	0.512
MOD_ProDKin_1	58	64	PF00069	0.543
TRG_ENDOCYTIC_2	164	167	PF00928	0.454
TRG_ENDOCYTIC_2	214	217	PF00928	0.438
TRG_ENDOCYTIC_2	370	373	PF00928	0.516
TRG_ENDOCYTIC_2	405	408	PF00928	0.529
TRG_ER_diArg_1	106	108	PF00400	0.529
TRG_ER_diArg_1	449	451	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P2	Leptomonas seymouri	37%	97%
A0A3Q8ICS7	Leishmania donovani	90%	100%
A0A3R7NPG1	Trypanosoma rangeli	23%	100%
A4HEQ1	Leishmania braziliensis	70%	100%
A4I1Y1	Leishmania infantum	90%	100%
C9ZS38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AY27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%