Putative ATPase subunit 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase subunit 9, putative

Species:

Leishmania major

UniProt:

Q4Q9E5_LEIMA

TriTrypDb:

LmjF.24.0630 , LMJLV39_240011900 , LMJSD75_240011500

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	4	2
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	2
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	2
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	4	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9E5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006164	purine nucleotide biosynthetic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006754	ATP biosynthetic process	8	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009141	nucleoside triphosphate metabolic process	5	2
GO:0009142	nucleoside triphosphate biosynthetic process	6	2
GO:0009144	purine nucleoside triphosphate metabolic process	6	2
GO:0009145	purine nucleoside triphosphate biosynthetic process	7	2
GO:0009150	purine ribonucleotide metabolic process	6	2
GO:0009152	purine ribonucleotide biosynthetic process	7	2
GO:0009165	nucleotide biosynthetic process	6	2
GO:0009199	ribonucleoside triphosphate metabolic process	6	2
GO:0009201	ribonucleoside triphosphate biosynthetic process	7	2
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	2
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	8	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009260	ribonucleotide biosynthetic process	6	2
GO:0009987	cellular process	1	2
GO:0015986	proton motive force-driven ATP synthesis	9	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046034	ATP metabolic process	7	2
GO:0046390	ribose phosphate biosynthetic process	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072522	purine-containing compound biosynthetic process	5	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901293	nucleoside phosphate biosynthetic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0005215	transporter activity	1	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015078	proton transmembrane transporter activity	5	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.590
CLV_NRD_NRD_1	149	151	PF00675	0.581
CLV_NRD_NRD_1	158	160	PF00675	0.565
CLV_PCSK_KEX2_1	107	109	PF00082	0.590
CLV_PCSK_KEX2_1	149	151	PF00082	0.581
CLV_PCSK_KEX2_1	158	160	PF00082	0.565
CLV_PCSK_SKI1_1	222	226	PF00082	0.259
CLV_PCSK_SKI1_1	72	76	PF00082	0.569
DEG_Nend_UBRbox_1	1	4	PF02207	0.361
DEG_SPOP_SBC_1	7	11	PF00917	0.338
DOC_CYCLIN_yClb5_NLxxxL_5	216	224	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.316
DOC_MAPK_MEF2A_6	172	181	PF00069	0.327
DOC_PP1_RVXF_1	13	19	PF00149	0.312
DOC_PP2B_LxvP_1	102	105	PF13499	0.360
DOC_PP2B_LxvP_1	52	55	PF13499	0.346
DOC_PP4_FxxP_1	53	56	PF00568	0.342
DOC_USP7_MATH_1	106	110	PF00917	0.387
DOC_USP7_MATH_1	128	132	PF00917	0.375
DOC_USP7_MATH_1	161	165	PF00917	0.360
DOC_USP7_MATH_1	7	11	PF00917	0.338
DOC_USP7_MATH_1	90	94	PF00917	0.353
DOC_WW_Pin1_4	124	129	PF00397	0.376
DOC_WW_Pin1_4	141	146	PF00397	0.379
LIG_14-3-3_CanoR_1	107	111	PF00244	0.389
LIG_14-3-3_CanoR_1	112	122	PF00244	0.384
LIG_14-3-3_CanoR_1	133	142	PF00244	0.386
LIG_14-3-3_CanoR_1	172	178	PF00244	0.339
LIG_BRCT_BRCA1_1	2	6	PF00533	0.356
LIG_EVH1_1	53	57	PF00568	0.340
LIG_FHA_1	174	180	PF00498	0.323
LIG_FHA_1	219	225	PF00498	0.457
LIG_FHA_1	233	239	PF00498	0.199
LIG_LIR_Gen_1	31	40	PF02991	0.320
LIG_LIR_Gen_1	47	58	PF02991	0.341
LIG_LIR_LC3C_4	164	169	PF02991	0.350
LIG_LIR_Nem_3	31	36	PF02991	0.319
LIG_LIR_Nem_3	47	53	PF02991	0.342
LIG_MYND_1	124	128	PF01753	0.374
LIG_PCNA_yPIPBox_3	216	224	PF02747	0.462
LIG_Pex14_2	247	251	PF04695	0.199
LIG_PTB_Apo_2	85	92	PF02174	0.357
LIG_SH2_CRK	227	231	PF00017	0.400
LIG_SH2_CRK	48	52	PF00017	0.344
LIG_SH2_STAT5	101	104	PF00017	0.358
LIG_SH2_STAT5	186	189	PF00017	0.253
LIG_SH2_STAT5	21	24	PF00017	0.306
LIG_SH2_STAT5	50	53	PF00017	0.348
LIG_SH3_2	55	60	PF14604	0.346
LIG_SH3_3	165	171	PF00018	0.345
LIG_SH3_3	51	57	PF00018	0.342
LIG_SH3_CIN85_PxpxPR_1	55	60	PF14604	0.346
LIG_SUMO_SIM_par_1	175	180	PF11976	0.321
LIG_SUMO_SIM_par_1	34	39	PF11976	0.321
LIG_TRFH_1	50	54	PF08558	0.346
LIG_TYR_ITIM	46	51	PF00017	0.337
LIG_TYR_ITIM	99	104	PF00017	0.357
LIG_WW_3	104	108	PF00397	0.376
LIG_WW_3	57	61	PF00397	0.357
MOD_CDK_SPK_2	141	146	PF00069	0.379
MOD_CK1_1	111	117	PF00069	0.385
MOD_CK1_1	131	137	PF00069	0.385
MOD_CK1_1	9	15	PF00069	0.323
MOD_GlcNHglycan	164	167	PF01048	0.554
MOD_GlcNHglycan	62	65	PF01048	0.588
MOD_GlcNHglycan	92	95	PF01048	0.549
MOD_GSK3_1	106	113	PF00069	0.389
MOD_GSK3_1	118	125	PF00069	0.382
MOD_GSK3_1	129	136	PF00069	0.383
MOD_GSK3_1	173	180	PF00069	0.326
MOD_GSK3_1	34	41	PF00069	0.322
MOD_N-GLC_1	138	143	PF02516	0.587
MOD_N-GLC_1	218	223	PF02516	0.263
MOD_N-GLC_2	138	140	PF02516	0.587
MOD_NEK2_1	110	115	PF00069	0.390
MOD_NEK2_1	36	41	PF00069	0.321
MOD_PIKK_1	113	119	PF00454	0.383
MOD_PK_1	100	106	PF00069	0.360
MOD_PKA_2	106	112	PF00069	0.389
MOD_Plk_1	138	144	PF00069	0.385
MOD_Plk_4	138	144	PF00069	0.385
MOD_Plk_4	44	50	PF00069	0.332
MOD_ProDKin_1	124	130	PF00069	0.377
MOD_ProDKin_1	141	147	PF00069	0.380
TRG_ENDOCYTIC_2	101	104	PF00928	0.358
TRG_ENDOCYTIC_2	227	230	PF00928	0.400
TRG_ENDOCYTIC_2	48	51	PF00928	0.344
TRG_ER_diArg_1	106	108	PF00400	0.385
TRG_ER_diArg_1	148	150	PF00400	0.378
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A1SHI6	NOCSJ	49%	100%
A1XQS5	PIG	39%	100%
A5CDC6	ORITB	36%	100%
A6H4Q2	VANPO	49%	100%
A8EX89	RICCK	41%	100%
A8GLV9	RICAH	42%	100%
A8GUJ2	RICB8	42%	100%
A8XDX2	CAEBR	54%	100%
A9HDM8	GLUDA	52%	100%
A9RAH4	DEBHA	49%	100%
B3CLG2	WOLPP	36%	100%
B3CQT8	ORITI	36%	100%
C0HK59	PICAN	50%	100%
C0R5U2	WOLWR	36%	100%
C3PM50	RICAE	46%	100%
C4K0P2	RICPU	45%	100%
C5CA73	MICLC	44%	100%
P00840	MAIZE	67%	100%
P00842	NEUCR	58%	100%
P05496	HUMAN	44%	100%
P07926	BOVIN	40%	100%
P0C518	ORYSI	67%	100%
P0C519	ORYSJ	67%	100%
P13547	WHEAT	67%	100%
P14571	BETVU	62%	100%
P15014	RHORU	39%	100%
P16000	EMENI	58%	100%
P17254	HELAN	55%	100%
P17605	SHEEP	39%	100%
P21537	SCHPO	54%	100%
P26855	MARPO	67%	100%
P32876	BOVIN	40%	100%
P47644	MYCGE	35%	100%
P48201	HUMAN	43%	100%
P48880	CHOCR	55%	100%
P48881	WICCA	50%	100%
P56383	MOUSE	57%	100%
P56384	MOUSE	57%	100%
P60112	ARATH	67%	100%
P60113	BRANA	63%	100%
P60114	SOLTU	67%	100%
P60115	OENBI	67%	100%
P60116	TOBAC	65%	100%
P60117	SOLLC	65%	100%
P60118	PETHY	65%	100%
P61828	SACPA	49%	100%
P61829	YEAST	49%	100%
P69420	PEA	67%	100%
P69421	SOYBN	67%	100%
P69422	VICFA	67%	100%
P92811	KLULA	50%	100%
Q01554	TRIRU	58%	100%
Q03672	PODAS	47%	100%
Q06055	HUMAN	57%	100%
Q06056	SHEEP	41%	100%
Q06645	RAT	40%	100%
Q06646	RAT	57%	100%
Q07060	PETSP	55%	100%
Q0BQY6	GRABC	57%	100%
Q0C0X2	HYPNA	41%	100%
Q0H8W9	USTMA	56%	100%
Q12635	NEUCR	58%	100%
Q1RGZ2	RICBR	42%	100%
Q2GE12	NEOSM	40%	100%
Q2LCR3	DICCI	53%	100%
Q2RPA5	RHORT	39%	100%
Q2W027	MAGSA	43%	100%
Q36852	CYBMR	44%	100%
Q37315	DICDI	53%	100%
Q37377	ACACA	56%	100%
Q37550	MALDO	59%	100%
Q37695	YARLI	57%	100%
Q3T4E5	RHIOR	58%	100%
Q3ZC75	BOVIN	57%	100%
Q4AAW2	MESHJ	33%	100%
Q4FPE8	PELUB	48%	100%
Q4UNH9	RICFE	42%	100%
Q59550	MYCPN	35%	100%
Q5FRW6	GLUOX	49%	100%
Q5RAP9	PONAB	57%	100%
Q5RFL2	PONAB	43%	100%
Q68XQ0	RICTY	39%	100%
Q71S46	RAT	43%	100%
Q73HW2	WOLPM	36%	100%
Q75G38	ASHGO	48%	100%
Q85Q98	CANGA	50%	100%
Q92JP1	RICCN	45%	100%
Q9B8D5	CANAL	49%	100%
Q9BKS0	CAEEL	54%	100%
Q9CR84	MOUSE	40%	100%
Q9U505	MANSE	57%	100%
Q9ZEC2	RICPR	38%	100%