GPN-loop GTPase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

GPN-loop GTPase 2

Gene product:

Conserved hypothetical ATP binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q9E3_LEIMA

TriTrypDb:

LmjF.26.0480 , LMJLV39_260010000 , LMJSD75_260008600

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9E3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	2
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.241
CLV_NRD_NRD_1	232	234	PF00675	0.263
CLV_NRD_NRD_1	238	240	PF00675	0.223
CLV_PCSK_KEX2_1	100	102	PF00082	0.241
CLV_PCSK_KEX2_1	149	151	PF00082	0.273
CLV_PCSK_KEX2_1	21	23	PF00082	0.230
CLV_PCSK_KEX2_1	232	234	PF00082	0.254
CLV_PCSK_KEX2_1	237	239	PF00082	0.229
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.273
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.241
CLV_PCSK_PC7_1	145	151	PF00082	0.271
CLV_PCSK_PC7_1	233	239	PF00082	0.271
CLV_PCSK_SKI1_1	22	26	PF00082	0.241
DEG_Nend_Nbox_1	1	3	PF02207	0.335
DOC_CKS1_1	257	262	PF01111	0.653
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.529
DOC_MAPK_FxFP_2	47	50	PF00069	0.430
DOC_MAPK_gen_1	116	125	PF00069	0.516
DOC_MAPK_gen_1	21	27	PF00069	0.441
DOC_MAPK_gen_1	283	291	PF00069	0.466
DOC_MAPK_MEF2A_6	116	125	PF00069	0.516
DOC_PP2B_LxvP_1	118	121	PF13499	0.527
DOC_PP4_FxxP_1	47	50	PF00568	0.430
DOC_WW_Pin1_4	256	261	PF00397	0.508
LIG_14-3-3_CanoR_1	150	156	PF00244	0.473
LIG_14-3-3_CanoR_1	22	28	PF00244	0.441
LIG_Actin_WH2_2	298	315	PF00022	0.505
LIG_eIF4E_1	282	288	PF01652	0.507
LIG_FHA_1	142	148	PF00498	0.463
LIG_FHA_1	155	161	PF00498	0.394
LIG_FHA_1	165	171	PF00498	0.429
LIG_FHA_1	269	275	PF00498	0.615
LIG_FHA_1	283	289	PF00498	0.457
LIG_FHA_1	29	35	PF00498	0.432
LIG_FHA_1	313	319	PF00498	0.377
LIG_FHA_2	14	20	PF00498	0.430
LIG_FHA_2	181	187	PF00498	0.441
LIG_FHA_2	207	213	PF00498	0.552
LIG_FHA_2	257	263	PF00498	0.632
LIG_FHA_2	268	274	PF00498	0.496
LIG_FHA_2	91	97	PF00498	0.497
LIG_GBD_Chelix_1	147	155	PF00786	0.327
LIG_GBD_Chelix_1	181	189	PF00786	0.178
LIG_HP1_1	33	37	PF01393	0.455
LIG_KLC1_Yacidic_2	132	136	PF13176	0.527
LIG_LIR_Apic_2	44	50	PF02991	0.430
LIG_LIR_Gen_1	196	206	PF02991	0.430
LIG_LIR_Nem_3	196	201	PF02991	0.430
LIG_LIR_Nem_3	293	298	PF02991	0.402
LIG_MYND_1	256	260	PF01753	0.496
LIG_SH2_CRK	284	288	PF00017	0.428
LIG_SH2_CRK	295	299	PF00017	0.343
LIG_SH2_PTP2	300	303	PF00017	0.453
LIG_SH2_SRC	134	137	PF00017	0.481
LIG_SH2_STAP1	284	288	PF00017	0.410
LIG_SH2_STAT5	122	125	PF00017	0.438
LIG_SH2_STAT5	134	137	PF00017	0.459
LIG_SH2_STAT5	17	20	PF00017	0.430
LIG_SH2_STAT5	173	176	PF00017	0.430
LIG_SH2_STAT5	216	219	PF00017	0.490
LIG_SH2_STAT5	284	287	PF00017	0.509
LIG_SH2_STAT5	300	303	PF00017	0.471
LIG_SH2_STAT5	76	79	PF00017	0.430
LIG_SH3_3	24	30	PF00018	0.441
LIG_SH3_3	3	9	PF00018	0.244
LIG_SUMO_SIM_par_1	175	183	PF11976	0.431
LIG_TRAF2_1	259	262	PF00917	0.606
LIG_TRAF2_1	93	96	PF00917	0.378
LIG_TYR_ITIM	298	303	PF00017	0.462
MOD_CDK_SPxxK_3	256	263	PF00069	0.602
MOD_CK1_1	12	18	PF00069	0.292
MOD_CK1_1	154	160	PF00069	0.314
MOD_CK1_1	180	186	PF00069	0.296
MOD_CK2_1	13	19	PF00069	0.273
MOD_CK2_1	256	262	PF00069	0.366
MOD_CK2_1	89	95	PF00069	0.359
MOD_Cter_Amidation	19	22	PF01082	0.289
MOD_GlcNHglycan	11	14	PF01048	0.289
MOD_GlcNHglycan	219	222	PF01048	0.464
MOD_GSK3_1	110	117	PF00069	0.280
MOD_GSK3_1	169	176	PF00069	0.303
MOD_GSK3_1	193	200	PF00069	0.409
MOD_GSK3_1	217	224	PF00069	0.409
MOD_GSK3_1	9	16	PF00069	0.292
MOD_N-GLC_1	72	77	PF02516	0.289
MOD_NEK2_1	110	115	PF00069	0.354
MOD_NEK2_1	151	156	PF00069	0.280
MOD_NEK2_1	217	222	PF00069	0.282
MOD_NEK2_2	114	119	PF00069	0.369
MOD_PIKK_1	312	318	PF00454	0.492
MOD_PKA_2	282	288	PF00069	0.464
MOD_PKA_2	312	318	PF00069	0.382
MOD_Plk_4	169	175	PF00069	0.273
MOD_Plk_4	180	186	PF00069	0.273
MOD_Plk_4	212	218	PF00069	0.277
MOD_Plk_4	23	29	PF00069	0.289
MOD_Plk_4	60	66	PF00069	0.362
MOD_Plk_4	72	78	PF00069	0.207
MOD_ProDKin_1	256	262	PF00069	0.383
TRG_DiLeu_BaEn_1	293	298	PF01217	0.520
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.518
TRG_ENDOCYTIC_2	122	125	PF00928	0.273
TRG_ENDOCYTIC_2	284	287	PF00928	0.426
TRG_ENDOCYTIC_2	295	298	PF00928	0.346
TRG_ENDOCYTIC_2	300	303	PF00928	0.250
TRG_ER_diArg_1	100	102	PF00400	0.289
TRG_ER_diArg_1	231	233	PF00400	0.311
TRG_ER_diArg_1	237	239	PF00400	0.266
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L3	Leptomonas seymouri	78%	95%
A0A0S4JJ66	Bodo saltans	38%	100%
A0A1X0NSR0	Trypanosomatidae	62%	100%
A0A3S5H7F7	Leishmania donovani	97%	100%
A0A3S7WZ40	Leishmania donovani	29%	100%
A0A422NVI7	Trypanosoma rangeli	64%	100%
A0A422P226	Trypanosoma rangeli	27%	100%
A4H7B1	Leishmania braziliensis	26%	100%
A4HEQ4	Leishmania braziliensis	88%	97%
A4I1I3	Leishmania infantum	29%	100%
A4I1Y3	Leishmania infantum	97%	100%
A6H7F2	Bos taurus	33%	100%
C9ZJY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZS35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
D0A6I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D4A7C0	Rattus norvegicus	34%	100%
E9AXL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AY30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O14443	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O42906	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	89%
P0CN94	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CN95	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
P47122	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	84%
Q08726	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	94%
Q28I42	Xenopus tropicalis	26%	100%
Q4IQT8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	100%
Q4PF70	Ustilago maydis (strain 521 / FGSC 9021)	25%	100%
Q4Q9V4	Leishmania major	28%	100%
Q4R579	Macaca fascicularis	34%	100%
Q4WT40	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	100%
Q54NK8	Dictyostelium discoideum	29%	100%
Q54TE7	Dictyostelium discoideum	30%	100%
Q56XY2	Arabidopsis thaliana	34%	100%
Q58DD9	Sus scrofa	34%	100%
Q5BJ53	Xenopus tropicalis	32%	100%
Q66KF6	Xenopus laevis	33%	100%
Q6CQA6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	100%
Q6FSS0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	100%
Q6PUR6	Danio rerio	35%	100%
Q6R518	Rattus norvegicus	29%	100%
Q6ZM63	Danio rerio	31%	100%
Q750Q9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q8VEJ1	Mus musculus	34%	100%
Q9H9Y4	Homo sapiens	34%	100%
Q9UTL7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
V5DR44	Trypanosoma cruzi	62%	100%