DNA polymerase sigma-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase sigma-like protein

Species:

Leishmania major

UniProt:

Q4Q9E2_LEIMA

TriTrypDb:

LmjF.26.0490 , LMJLV39_260010100 , LMJSD75_260008700

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	11
GO:0031499	TRAMP complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11
GO:0140513	nuclear protein-containing complex	2	11

Expansion

Sequence features

Q4Q9E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9E2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0031123	RNA 3'-end processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043631	RNA polyadenylation	6	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071076	RNA 3' uridylation	8	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	11
GO:0005488	binding	1	7
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016779	nucleotidyltransferase activity	4	11
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0050265	RNA uridylyltransferase activity	4	11
GO:0070566	adenylyltransferase activity	5	11
GO:0070569	uridylyltransferase activity	5	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	334	340	PF00089	0.544
CLV_NRD_NRD_1	235	237	PF00675	0.488
CLV_NRD_NRD_1	260	262	PF00675	0.507
CLV_NRD_NRD_1	364	366	PF00675	0.414
CLV_NRD_NRD_1	454	456	PF00675	0.523
CLV_NRD_NRD_1	55	57	PF00675	0.707
CLV_NRD_NRD_1	76	78	PF00675	0.728
CLV_PCSK_FUR_1	258	262	PF00082	0.491
CLV_PCSK_FUR_1	53	57	PF00082	0.768
CLV_PCSK_KEX2_1	221	223	PF00082	0.375
CLV_PCSK_KEX2_1	260	262	PF00082	0.507
CLV_PCSK_KEX2_1	364	366	PF00082	0.313
CLV_PCSK_KEX2_1	454	456	PF00082	0.526
CLV_PCSK_KEX2_1	53	55	PF00082	0.678
CLV_PCSK_KEX2_1	76	78	PF00082	0.650
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.424
CLV_PCSK_PC7_1	450	456	PF00082	0.524
CLV_PCSK_SKI1_1	119	123	PF00082	0.528
CLV_PCSK_SKI1_1	218	222	PF00082	0.512
CLV_PCSK_SKI1_1	374	378	PF00082	0.386
CLV_PCSK_SKI1_1	398	402	PF00082	0.474
DEG_SPOP_SBC_1	96	100	PF00917	0.620
DOC_CYCLIN_yCln2_LP_2	111	114	PF00134	0.679
DOC_MAPK_gen_1	258	268	PF00069	0.392
DOC_MAPK_MEF2A_6	158	165	PF00069	0.492
DOC_MAPK_MEF2A_6	260	268	PF00069	0.420
DOC_PP2B_LxvP_1	111	114	PF13499	0.679
DOC_PP2B_LxvP_1	173	176	PF13499	0.356
DOC_PP4_FxxP_1	376	379	PF00568	0.425
DOC_PP4_FxxP_1	6	9	PF00568	0.563
DOC_USP7_MATH_1	211	215	PF00917	0.523
DOC_USP7_MATH_1	23	27	PF00917	0.539
DOC_USP7_MATH_1	426	430	PF00917	0.310
DOC_USP7_MATH_1	88	92	PF00917	0.683
DOC_USP7_UBL2_3	374	378	PF12436	0.425
DOC_WW_Pin1_4	133	138	PF00397	0.410
DOC_WW_Pin1_4	424	429	PF00397	0.493
DOC_WW_Pin1_4	91	96	PF00397	0.658
LIG_14-3-3_CanoR_1	153	157	PF00244	0.454
LIG_14-3-3_CanoR_1	222	231	PF00244	0.439
LIG_14-3-3_CanoR_1	234	244	PF00244	0.400
LIG_14-3-3_CanoR_1	413	419	PF00244	0.460
LIG_14-3-3_CanoR_1	76	86	PF00244	0.764
LIG_BIR_II_1	1	5	PF00653	0.493
LIG_BRCT_BRCA1_1	237	241	PF00533	0.409
LIG_BRCT_BRCA1_1	414	418	PF00533	0.495
LIG_EH1_1	105	113	PF00400	0.413
LIG_EH1_1	319	327	PF00400	0.347
LIG_FHA_1	169	175	PF00498	0.431
LIG_FHA_1	403	409	PF00498	0.400
LIG_FHA_1	441	447	PF00498	0.468
LIG_FHA_1	80	86	PF00498	0.731
LIG_FHA_2	136	142	PF00498	0.454
LIG_FHA_2	357	363	PF00498	0.376
LIG_IRF3_LxIS_1	97	104	PF10401	0.616
LIG_LIR_Apic_2	375	379	PF02991	0.458
LIG_LIR_Gen_1	238	248	PF02991	0.437
LIG_LIR_Nem_3	238	244	PF02991	0.387
LIG_LIR_Nem_3	360	366	PF02991	0.427
LIG_LIR_Nem_3	415	421	PF02991	0.402
LIG_NRBOX	127	133	PF00104	0.459
LIG_NRBOX	280	286	PF00104	0.498
LIG_PCNA_yPIPBox_3	337	350	PF02747	0.440
LIG_SH2_CRK	166	170	PF00017	0.424
LIG_SH2_STAT3	329	332	PF00017	0.495
LIG_SH2_STAT3	370	373	PF00017	0.419
LIG_SH2_STAT5	133	136	PF00017	0.444
LIG_SH2_STAT5	280	283	PF00017	0.472
LIG_SH2_STAT5	329	332	PF00017	0.454
LIG_SH2_STAT5	370	373	PF00017	0.383
LIG_SH2_STAT5	385	388	PF00017	0.398
LIG_SH2_STAT5	438	441	PF00017	0.481
LIG_SH2_STAT5	474	477	PF00017	0.427
LIG_SH3_3	386	392	PF00018	0.400
LIG_SUMO_SIM_anti_2	323	328	PF11976	0.339
LIG_SUMO_SIM_par_1	181	190	PF11976	0.296
LIG_SUMO_SIM_par_1	203	209	PF11976	0.453
LIG_TRFH_1	133	137	PF08558	0.476
LIG_UBA3_1	296	301	PF00899	0.349
MOD_CK1_1	136	142	PF00069	0.456
MOD_CK1_1	168	174	PF00069	0.335
MOD_CK1_1	194	200	PF00069	0.490
MOD_CK1_1	35	41	PF00069	0.803
MOD_CK1_1	427	433	PF00069	0.458
MOD_CK1_1	57	63	PF00069	0.762
MOD_CK1_1	70	76	PF00069	0.771
MOD_CK1_1	91	97	PF00069	0.598
MOD_CK2_1	184	190	PF00069	0.509
MOD_CK2_1	426	432	PF00069	0.378
MOD_GlcNHglycan	193	196	PF01048	0.457
MOD_GlcNHglycan	208	211	PF01048	0.550
MOD_GlcNHglycan	271	275	PF01048	0.445
MOD_GlcNHglycan	30	33	PF01048	0.638
MOD_GlcNHglycan	338	341	PF01048	0.513
MOD_GlcNHglycan	414	417	PF01048	0.507
MOD_GlcNHglycan	56	59	PF01048	0.768
MOD_GlcNHglycan	60	63	PF01048	0.767
MOD_GlcNHglycan	69	72	PF01048	0.695
MOD_GlcNHglycan	90	93	PF01048	0.697
MOD_GSK3_1	194	201	PF00069	0.484
MOD_GSK3_1	235	242	PF00069	0.461
MOD_GSK3_1	266	273	PF00069	0.482
MOD_GSK3_1	28	35	PF00069	0.718
MOD_GSK3_1	316	323	PF00069	0.336
MOD_GSK3_1	398	405	PF00069	0.381
MOD_GSK3_1	426	433	PF00069	0.398
MOD_GSK3_1	54	61	PF00069	0.773
MOD_GSK3_1	77	84	PF00069	0.706
MOD_GSK3_1	91	98	PF00069	0.498
MOD_N-GLC_1	424	429	PF02516	0.521
MOD_N-GLC_2	305	307	PF02516	0.471
MOD_NEK2_1	196	201	PF00069	0.412
MOD_NEK2_1	235	240	PF00069	0.418
MOD_NEK2_1	270	275	PF00069	0.404
MOD_NEK2_1	303	308	PF00069	0.268
MOD_NEK2_1	342	347	PF00069	0.438
MOD_NEK2_1	402	407	PF00069	0.349
MOD_NEK2_1	97	102	PF00069	0.638
MOD_PIKK_1	235	241	PF00454	0.531
MOD_PIKK_1	430	436	PF00454	0.486
MOD_PKA_1	54	60	PF00069	0.792
MOD_PKA_2	141	147	PF00069	0.521
MOD_PKA_2	152	158	PF00069	0.504
MOD_PKA_2	23	29	PF00069	0.740
MOD_PKA_2	235	241	PF00069	0.413
MOD_PKA_2	336	342	PF00069	0.477
MOD_PKA_2	412	418	PF00069	0.461
MOD_PKA_2	54	60	PF00069	0.792
MOD_PKB_1	77	85	PF00069	0.681
MOD_Plk_1	266	272	PF00069	0.367
MOD_Plk_4	107	113	PF00069	0.630
MOD_Plk_4	398	404	PF00069	0.375
MOD_Plk_4	414	420	PF00069	0.369
MOD_Plk_4	81	87	PF00069	0.745
MOD_ProDKin_1	133	139	PF00069	0.421
MOD_ProDKin_1	424	430	PF00069	0.488
MOD_ProDKin_1	91	97	PF00069	0.660
MOD_SUMO_rev_2	139	146	PF00179	0.507
MOD_SUMO_rev_2	262	266	PF00179	0.480
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.443
TRG_ENDOCYTIC_2	166	169	PF00928	0.426
TRG_ER_diArg_1	258	261	PF00400	0.495
TRG_ER_diArg_1	334	337	PF00400	0.543
TRG_ER_diArg_1	363	365	PF00400	0.380
TRG_ER_diArg_1	53	56	PF00400	0.732
TRG_ER_diArg_1	76	79	PF00400	0.683
TRG_NES_CRM1_1	164	179	PF08389	0.458
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD64	Leptomonas seymouri	63%	85%
A0A1X0NU61	Trypanosomatidae	34%	100%
A0A3Q8IDQ5	Leishmania donovani	92%	80%
A0A3S5IS02	Trypanosoma rangeli	36%	100%
A4HEQ5	Leishmania braziliensis	71%	92%
A4I1Y4	Leishmania infantum	92%	80%
C9ZS34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
E9AY31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q503I9	Danio rerio	22%	98%
Q68ED3	Mus musculus	23%	76%
Q8NDF8	Homo sapiens	23%	84%
V5B9F7	Trypanosoma cruzi	35%	100%