Ribonuclease inhibitor-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9E1_LEIMA

TriTrypDb:

LmjF.26.0500 , LMJLV39_260010200 , LMJSD75_260008800

Length:

429

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

Q4Q9E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9E1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.266
CLV_NRD_NRD_1	198	200	PF00675	0.455
CLV_PCSK_KEX2_1	113	115	PF00082	0.303
CLV_PCSK_KEX2_1	198	200	PF00082	0.484
CLV_PCSK_KEX2_1	384	386	PF00082	0.553
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.329
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.404
CLV_PCSK_PC7_1	380	386	PF00082	0.406
CLV_PCSK_SKI1_1	198	202	PF00082	0.338
CLV_PCSK_SKI1_1	281	285	PF00082	0.492
DEG_APCC_DBOX_1	280	288	PF00400	0.327
DEG_APCC_DBOX_1	9	17	PF00400	0.289
DEG_Nend_UBRbox_3	1	3	PF02207	0.534
DOC_ANK_TNKS_1	120	127	PF00023	0.327
DOC_CYCLIN_RxL_1	110	119	PF00134	0.429
DOC_CYCLIN_RxL_1	279	291	PF00134	0.182
DOC_MAPK_gen_1	192	202	PF00069	0.346
DOC_MAPK_MEF2A_6	163	171	PF00069	0.364
DOC_PP1_SILK_1	159	164	PF00149	0.328
DOC_WW_Pin1_4	24	29	PF00397	0.437
DOC_WW_Pin1_4	51	56	PF00397	0.449
LIG_14-3-3_CanoR_1	101	107	PF00244	0.388
LIG_14-3-3_CanoR_1	136	140	PF00244	0.376
LIG_14-3-3_CanoR_1	163	167	PF00244	0.404
LIG_14-3-3_CanoR_1	198	203	PF00244	0.483
LIG_14-3-3_CanoR_1	301	306	PF00244	0.348
LIG_Actin_RPEL_3	16	35	PF02755	0.387
LIG_Actin_WH2_2	298	315	PF00022	0.483
LIG_DLG_GKlike_1	104	112	PF00625	0.387
LIG_FHA_1	271	277	PF00498	0.456
LIG_FHA_1	29	35	PF00498	0.415
LIG_FHA_1	333	339	PF00498	0.538
LIG_FHA_1	40	46	PF00498	0.244
LIG_FHA_2	17	23	PF00498	0.365
LIG_FHA_2	191	197	PF00498	0.464
LIG_FHA_2	222	228	PF00498	0.359
LIG_GBD_Chelix_1	302	310	PF00786	0.338
LIG_LIR_Nem_3	57	63	PF02991	0.424
LIG_NRBOX	385	391	PF00104	0.401
LIG_PCNA_yPIPBox_3	364	372	PF02747	0.427
LIG_PCNA_yPIPBox_3	380	390	PF02747	0.392
LIG_SH2_NCK_1	63	67	PF00017	0.340
LIG_SH2_STAT3	407	410	PF00017	0.625
LIG_SH2_STAT5	139	142	PF00017	0.266
LIG_SH2_STAT5	178	181	PF00017	0.439
LIG_SH3_3	396	402	PF00018	0.487
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.278
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.300
LIG_SUMO_SIM_anti_2	339	344	PF11976	0.310
LIG_SUMO_SIM_par_1	255	260	PF11976	0.355
LIG_SUMO_SIM_par_1	30	36	PF11976	0.272
LIG_SUMO_SIM_par_1	338	344	PF11976	0.296
LIG_SUMO_SIM_par_1	367	373	PF11976	0.351
LIG_TRAF2_1	224	227	PF00917	0.450
LIG_TYR_ITIM	61	66	PF00017	0.334
MOD_CK1_1	107	113	PF00069	0.371
MOD_CK1_1	304	310	PF00069	0.430
MOD_CK1_1	54	60	PF00069	0.446
MOD_CK2_1	143	149	PF00069	0.277
MOD_CK2_1	150	156	PF00069	0.394
MOD_CK2_1	190	196	PF00069	0.464
MOD_CK2_1	221	227	PF00069	0.316
MOD_CK2_1	257	263	PF00069	0.327
MOD_CK2_1	308	314	PF00069	0.285
MOD_CK2_1	46	52	PF00069	0.389
MOD_GlcNHglycan	152	155	PF01048	0.375
MOD_GlcNHglycan	259	262	PF01048	0.306
MOD_GlcNHglycan	296	299	PF01048	0.423
MOD_GlcNHglycan	420	423	PF01048	0.713
MOD_GlcNHglycan	94	97	PF01048	0.461
MOD_GSK3_1	102	109	PF00069	0.321
MOD_GSK3_1	12	19	PF00069	0.459
MOD_GSK3_1	135	142	PF00069	0.317
MOD_GSK3_1	24	31	PF00069	0.545
MOD_GSK3_1	270	277	PF00069	0.408
MOD_GSK3_1	288	295	PF00069	0.236
MOD_GSK3_1	301	308	PF00069	0.280
MOD_GSK3_1	332	339	PF00069	0.414
MOD_GSK3_1	46	53	PF00069	0.400
MOD_N-GLC_1	221	226	PF02516	0.332
MOD_N-GLC_1	250	255	PF02516	0.345
MOD_N-GLC_1	315	320	PF02516	0.264
MOD_N-GLC_1	332	337	PF02516	0.534
MOD_N-GLC_1	376	381	PF02516	0.458
MOD_N-GLC_1	78	83	PF02516	0.341
MOD_NEK2_1	102	107	PF00069	0.333
MOD_NEK2_1	143	148	PF00069	0.274
MOD_NEK2_1	162	167	PF00069	0.518
MOD_NEK2_1	257	262	PF00069	0.323
MOD_NEK2_1	287	292	PF00069	0.306
MOD_NEK2_1	294	299	PF00069	0.305
MOD_NEK2_1	305	310	PF00069	0.323
MOD_NEK2_1	80	85	PF00069	0.459
MOD_PIKK_1	270	276	PF00454	0.424
MOD_PIKK_1	353	359	PF00454	0.290
MOD_PKA_1	198	204	PF00069	0.478
MOD_PKA_2	135	141	PF00069	0.376
MOD_PKA_2	162	168	PF00069	0.343
MOD_PKA_2	198	204	PF00069	0.478
MOD_PKA_2	22	28	PF00069	0.472
MOD_Plk_1	143	149	PF00069	0.251
MOD_Plk_1	221	227	PF00069	0.294
MOD_Plk_1	250	256	PF00069	0.345
MOD_Plk_1	270	276	PF00069	0.445
MOD_Plk_1	376	382	PF00069	0.411
MOD_Plk_4	135	141	PF00069	0.349
MOD_Plk_4	16	22	PF00069	0.438
MOD_Plk_4	162	168	PF00069	0.415
MOD_Plk_4	301	307	PF00069	0.336
MOD_ProDKin_1	24	30	PF00069	0.435
MOD_ProDKin_1	51	57	PF00069	0.445
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.455
TRG_ENDOCYTIC_2	63	66	PF00928	0.344
TRG_ER_diArg_1	197	199	PF00400	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH0	Leptomonas seymouri	75%	91%
A0A0N1I317	Leptomonas seymouri	28%	100%
A0A0N1PD72	Leptomonas seymouri	25%	96%
A0A0S4IK39	Bodo saltans	26%	68%
A0A0S4JE02	Bodo saltans	23%	80%
A0A0S4JGH2	Bodo saltans	27%	100%
A0A0S4JHR1	Bodo saltans	24%	69%
A0A0S4JL85	Bodo saltans	24%	100%
A0A0S4JPV3	Bodo saltans	38%	89%
A0A0S4JXN4	Bodo saltans	25%	99%
A0A1X0NTY3	Trypanosomatidae	54%	96%
A0A1X0P2M5	Trypanosomatidae	30%	100%
A0A1X0P364	Trypanosomatidae	26%	100%
A0A3Q8IDE6	Leishmania donovani	26%	100%
A0A3R7L7Y9	Trypanosoma rangeli	54%	96%
A0A3R7P015	Trypanosoma rangeli	24%	91%
A0A3S5H5G2	Leishmania donovani	27%	97%
A0A3S7WXH1	Leishmania donovani	25%	100%
A0A3S7WZL6	Leishmania donovani	95%	100%
A4H461	Leishmania braziliensis	28%	97%
A4HCM9	Leishmania braziliensis	25%	100%
A4HEQ6	Leishmania braziliensis	79%	100%
A4HFQ6	Leishmania braziliensis	26%	100%
A4HSD0	Leishmania infantum	28%	97%
A4I053	Leishmania infantum	24%	100%
A4I1Y5	Leishmania infantum	95%	100%
A4I2T1	Leishmania infantum	26%	100%
C9ZPX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	96%
E9ADA9	Leishmania major	28%	100%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	97%
E9AW16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	91%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O13066	Xenopus laevis	23%	74%
P10775	Sus scrofa	28%	94%
P13489	Homo sapiens	25%	93%
P29315	Rattus norvegicus	27%	94%
P46060	Homo sapiens	24%	73%
P46061	Mus musculus	24%	73%
Q4QBG0	Leishmania major	25%	100%
Q4QJI8	Leishmania major	27%	97%
Q4V8D9	Rattus norvegicus	26%	100%
Q6ZQY2	Homo sapiens	31%	100%
Q8HZP9	Pan troglodytes	25%	93%
Q8IZ02	Homo sapiens	25%	92%
Q91VI7	Mus musculus	27%	94%
Q9DAM1	Mus musculus	25%	100%
Q9LE82	Arabidopsis thaliana	26%	80%
Q9VIW3	Drosophila melanogaster	24%	72%
V5BJF0	Trypanosoma cruzi	24%	87%
V5BPZ7	Trypanosoma cruzi	55%	96%
V5DHF2	Trypanosoma cruzi	28%	100%