Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9E0_LEIMA

TriTrypDb:

LmjF.26.0540 , LMJLV39_260010700 , LMJSD75_260009200

Length:

1155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9E0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.532
CLV_C14_Caspase3-7	26	30	PF00656	0.589
CLV_C14_Caspase3-7	299	303	PF00656	0.589
CLV_C14_Caspase3-7	431	435	PF00656	0.659
CLV_C14_Caspase3-7	541	545	PF00656	0.702
CLV_C14_Caspase3-7	679	683	PF00656	0.682
CLV_C14_Caspase3-7	700	704	PF00656	0.693
CLV_C14_Caspase3-7	903	907	PF00656	0.667
CLV_NRD_NRD_1	1019	1021	PF00675	0.767
CLV_NRD_NRD_1	104	106	PF00675	0.536
CLV_NRD_NRD_1	1108	1110	PF00675	0.576
CLV_NRD_NRD_1	1148	1150	PF00675	0.714
CLV_NRD_NRD_1	237	239	PF00675	0.590
CLV_NRD_NRD_1	249	251	PF00675	0.652
CLV_NRD_NRD_1	26	28	PF00675	0.548
CLV_NRD_NRD_1	502	504	PF00675	0.789
CLV_NRD_NRD_1	916	918	PF00675	0.580
CLV_NRD_NRD_1	962	964	PF00675	0.802
CLV_PCSK_FUR_1	235	239	PF00082	0.708
CLV_PCSK_FUR_1	499	503	PF00082	0.816
CLV_PCSK_KEX2_1	1019	1021	PF00082	0.709
CLV_PCSK_KEX2_1	1108	1110	PF00082	0.576
CLV_PCSK_KEX2_1	1148	1150	PF00082	0.714
CLV_PCSK_KEX2_1	237	239	PF00082	0.691
CLV_PCSK_KEX2_1	249	251	PF00082	0.555
CLV_PCSK_KEX2_1	499	501	PF00082	0.801
CLV_PCSK_KEX2_1	502	504	PF00082	0.783
CLV_PCSK_KEX2_1	916	918	PF00082	0.580
CLV_PCSK_KEX2_1	962	964	PF00082	0.744
CLV_PCSK_SKI1_1	1108	1112	PF00082	0.569
CLV_PCSK_SKI1_1	152	156	PF00082	0.550
CLV_PCSK_SKI1_1	237	241	PF00082	0.617
CLV_PCSK_SKI1_1	271	275	PF00082	0.742
CLV_PCSK_SKI1_1	28	32	PF00082	0.665
CLV_PCSK_SKI1_1	348	352	PF00082	0.691
CLV_PCSK_SKI1_1	427	431	PF00082	0.722
CLV_Separin_Metazoa	1105	1109	PF03568	0.574
DEG_APCC_DBOX_1	236	244	PF00400	0.697
DEG_APCC_DBOX_1	270	278	PF00400	0.678
DEG_MDM2_SWIB_1	984	991	PF02201	0.636
DEG_Nend_UBRbox_2	1	3	PF02207	0.680
DEG_SCF_FBW7_1	1044	1051	PF00400	0.763
DEG_SCF_TRCP1_1	302	308	PF00400	0.659
DEG_SPOP_SBC_1	170	174	PF00917	0.715
DEG_SPOP_SBC_1	697	701	PF00917	0.655
DOC_CYCLIN_RxL_1	235	246	PF00134	0.638
DOC_CYCLIN_RxL_1	470	483	PF00134	0.700
DOC_CYCLIN_yClb5_NLxxxL_5	685	694	PF00134	0.717
DOC_MAPK_DCC_7	218	228	PF00069	0.505
DOC_MAPK_gen_1	218	228	PF00069	0.505
DOC_MAPK_gen_1	235	243	PF00069	0.700
DOC_MAPK_gen_1	27	35	PF00069	0.567
DOC_MAPK_MEF2A_6	221	230	PF00069	0.630
DOC_MAPK_MEF2A_6	614	623	PF00069	0.549
DOC_PP1_RVXF_1	359	365	PF00149	0.514
DOC_PP1_RVXF_1	425	431	PF00149	0.674
DOC_PP1_RVXF_1	915	922	PF00149	0.667
DOC_PP2B_LxvP_1	1041	1044	PF13499	0.842
DOC_PP2B_LxvP_1	457	460	PF13499	0.730
DOC_PP2B_LxvP_1	645	648	PF13499	0.576
DOC_PP4_FxxP_1	662	665	PF00568	0.683
DOC_USP7_MATH_1	1011	1015	PF00917	0.690
DOC_USP7_MATH_1	1091	1095	PF00917	0.736
DOC_USP7_MATH_1	16	20	PF00917	0.733
DOC_USP7_MATH_1	170	174	PF00917	0.782
DOC_USP7_MATH_1	186	190	PF00917	0.741
DOC_USP7_MATH_1	245	249	PF00917	0.643
DOC_USP7_MATH_1	296	300	PF00917	0.605
DOC_USP7_MATH_1	377	381	PF00917	0.664
DOC_USP7_MATH_1	438	442	PF00917	0.740
DOC_USP7_MATH_1	44	48	PF00917	0.677
DOC_USP7_MATH_1	56	60	PF00917	0.577
DOC_USP7_MATH_1	663	667	PF00917	0.690
DOC_USP7_MATH_1	697	701	PF00917	0.655
DOC_USP7_MATH_1	794	798	PF00917	0.730
DOC_USP7_MATH_1	947	951	PF00917	0.575
DOC_WW_Pin1_4	1006	1011	PF00397	0.570
DOC_WW_Pin1_4	1044	1049	PF00397	0.780
DOC_WW_Pin1_4	1083	1088	PF00397	0.693
DOC_WW_Pin1_4	132	137	PF00397	0.714
DOC_WW_Pin1_4	468	473	PF00397	0.682
DOC_WW_Pin1_4	480	485	PF00397	0.552
DOC_WW_Pin1_4	510	515	PF00397	0.588
DOC_WW_Pin1_4	594	599	PF00397	0.778
DOC_WW_Pin1_4	614	619	PF00397	0.599
DOC_WW_Pin1_4	639	644	PF00397	0.725
DOC_WW_Pin1_4	677	682	PF00397	0.727
DOC_WW_Pin1_4	792	797	PF00397	0.712
DOC_WW_Pin1_4	802	807	PF00397	0.663
LIG_14-3-3_CanoR_1	105	109	PF00244	0.536
LIG_14-3-3_CanoR_1	166	175	PF00244	0.598
LIG_14-3-3_CanoR_1	218	224	PF00244	0.510
LIG_14-3-3_CanoR_1	255	259	PF00244	0.525
LIG_14-3-3_CanoR_1	263	272	PF00244	0.647
LIG_14-3-3_CanoR_1	345	351	PF00244	0.614
LIG_14-3-3_CanoR_1	376	385	PF00244	0.640
LIG_14-3-3_CanoR_1	505	510	PF00244	0.740
LIG_14-3-3_CanoR_1	580	585	PF00244	0.664
LIG_14-3-3_CanoR_1	705	715	PF00244	0.588
LIG_Actin_WH2_2	878	895	PF00022	0.546
LIG_BIR_III_2	544	548	PF00653	0.639
LIG_BIR_III_4	906	910	PF00653	0.669
LIG_BRCT_BRCA1_1	760	764	PF00533	0.689
LIG_deltaCOP1_diTrp_1	466	473	PF00928	0.715
LIG_EVH1_2	460	464	PF00568	0.628
LIG_FHA_1	1	7	PF00498	0.726
LIG_FHA_1	1048	1054	PF00498	0.591
LIG_FHA_1	129	135	PF00498	0.649
LIG_FHA_1	176	182	PF00498	0.608
LIG_FHA_1	223	229	PF00498	0.617
LIG_FHA_1	306	312	PF00498	0.755
LIG_FHA_1	419	425	PF00498	0.731
LIG_FHA_1	481	487	PF00498	0.721
LIG_FHA_1	534	540	PF00498	0.585
LIG_FHA_1	600	606	PF00498	0.667
LIG_FHA_1	691	697	PF00498	0.633
LIG_FHA_1	707	713	PF00498	0.597
LIG_FHA_1	72	78	PF00498	0.640
LIG_FHA_1	953	959	PF00498	0.502
LIG_FHA_2	1097	1103	PF00498	0.685
LIG_FHA_2	807	813	PF00498	0.693
LIG_LIR_Apic_2	1006	1010	PF02991	0.672
LIG_LIR_Apic_2	661	665	PF02991	0.680
LIG_LIR_Gen_1	108	119	PF02991	0.657
LIG_LIR_Gen_1	1102	1112	PF02991	0.568
LIG_LIR_Gen_1	12	21	PF02991	0.687
LIG_LIR_Gen_1	206	214	PF02991	0.608
LIG_LIR_Gen_1	314	322	PF02991	0.640
LIG_LIR_Nem_3	108	114	PF02991	0.661
LIG_LIR_Nem_3	1102	1107	PF02991	0.570
LIG_LIR_Nem_3	12	17	PF02991	0.688
LIG_LIR_Nem_3	206	210	PF02991	0.589
LIG_LIR_Nem_3	314	318	PF02991	0.698
LIG_LIR_Nem_3	356	362	PF02991	0.690
LIG_LIR_Nem_3	692	698	PF02991	0.659
LIG_LIR_Nem_3	985	991	PF02991	0.571
LIG_NRBOX	346	352	PF00104	0.723
LIG_NRBOX	862	868	PF00104	0.687
LIG_PCNA_yPIPBox_3	338	351	PF02747	0.605
LIG_Pex14_2	156	160	PF04695	0.565
LIG_Pex14_2	464	468	PF04695	0.622
LIG_Pex14_2	984	988	PF04695	0.530
LIG_Rb_pABgroove_1	978	986	PF01858	0.538
LIG_SH2_CRK	1007	1011	PF00017	0.564
LIG_SH2_CRK	14	18	PF00017	0.693
LIG_SH2_NCK_1	1098	1102	PF00017	0.584
LIG_SH2_PTP2	695	698	PF00017	0.595
LIG_SH2_STAP1	420	424	PF00017	0.626
LIG_SH2_STAT5	1007	1010	PF00017	0.564
LIG_SH2_STAT5	1098	1101	PF00017	0.585
LIG_SH2_STAT5	207	210	PF00017	0.717
LIG_SH2_STAT5	315	318	PF00017	0.634
LIG_SH2_STAT5	385	388	PF00017	0.627
LIG_SH2_STAT5	420	423	PF00017	0.623
LIG_SH2_STAT5	450	453	PF00017	0.669
LIG_SH2_STAT5	566	569	PF00017	0.591
LIG_SH2_STAT5	611	614	PF00017	0.570
LIG_SH2_STAT5	695	698	PF00017	0.547
LIG_SH3_3	130	136	PF00018	0.717
LIG_SH3_3	227	233	PF00018	0.714
LIG_SH3_3	390	396	PF00018	0.537
LIG_SH3_3	441	447	PF00018	0.738
LIG_SH3_3	455	461	PF00018	0.547
LIG_SH3_3	640	646	PF00018	0.650
LIG_SH3_3	709	715	PF00018	0.676
LIG_SH3_3	815	821	PF00018	0.517
LIG_Sin3_3	926	933	PF02671	0.425
LIG_SUMO_SIM_anti_2	206	213	PF11976	0.636
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.621
LIG_SUMO_SIM_anti_2	76	81	PF11976	0.661
LIG_SUMO_SIM_par_1	2	8	PF11976	0.720
LIG_SUMO_SIM_par_1	597	603	PF11976	0.781
LIG_TRAF2_1	800	803	PF00917	0.745
LIG_TRFH_1	725	729	PF08558	0.676
LIG_TYR_ITSM	691	698	PF00017	0.665
MOD_CDC14_SPxK_1	513	516	PF00782	0.600
MOD_CDK_SPK_2	1044	1049	PF00069	0.642
MOD_CDK_SPxK_1	510	516	PF00069	0.588
MOD_CDK_SPxxK_3	1006	1013	PF00069	0.574
MOD_CK1_1	1078	1084	PF00069	0.741
MOD_CK1_1	1094	1100	PF00069	0.619
MOD_CK1_1	145	151	PF00069	0.664
MOD_CK1_1	158	164	PF00069	0.680
MOD_CK1_1	169	175	PF00069	0.600
MOD_CK1_1	19	25	PF00069	0.665
MOD_CK1_1	222	228	PF00069	0.704
MOD_CK1_1	303	309	PF00069	0.713
MOD_CK1_1	314	320	PF00069	0.580
MOD_CK1_1	38	44	PF00069	0.418
MOD_CK1_1	531	537	PF00069	0.646
MOD_CK1_1	594	600	PF00069	0.784
MOD_CK1_1	720	726	PF00069	0.720
MOD_CK1_1	965	971	PF00069	0.647
MOD_CK2_1	1096	1102	PF00069	0.697
MOD_CK2_1	186	192	PF00069	0.747
MOD_CK2_1	44	50	PF00069	0.709
MOD_CK2_1	798	804	PF00069	0.781
MOD_CK2_1	806	812	PF00069	0.616
MOD_CMANNOS	973	976	PF00535	0.677
MOD_DYRK1A_RPxSP_1	614	618	PF00069	0.524
MOD_GlcNHglycan	1058	1061	PF01048	0.754
MOD_GlcNHglycan	1062	1065	PF01048	0.788
MOD_GlcNHglycan	1093	1096	PF01048	0.663
MOD_GlcNHglycan	1099	1102	PF01048	0.727
MOD_GlcNHglycan	1116	1119	PF01048	0.642
MOD_GlcNHglycan	157	160	PF01048	0.706
MOD_GlcNHglycan	163	166	PF01048	0.689
MOD_GlcNHglycan	168	171	PF01048	0.631
MOD_GlcNHglycan	188	191	PF01048	0.655
MOD_GlcNHglycan	196	199	PF01048	0.634
MOD_GlcNHglycan	294	297	PF01048	0.683
MOD_GlcNHglycan	302	305	PF01048	0.645
MOD_GlcNHglycan	324	327	PF01048	0.720
MOD_GlcNHglycan	37	40	PF01048	0.532
MOD_GlcNHglycan	434	438	PF01048	0.654
MOD_GlcNHglycan	46	49	PF01048	0.587
MOD_GlcNHglycan	488	491	PF01048	0.781
MOD_GlcNHglycan	493	496	PF01048	0.714
MOD_GlcNHglycan	550	553	PF01048	0.696
MOD_GlcNHglycan	593	596	PF01048	0.634
MOD_GlcNHglycan	602	605	PF01048	0.604
MOD_GlcNHglycan	675	678	PF01048	0.649
MOD_GlcNHglycan	69	72	PF01048	0.644
MOD_GlcNHglycan	700	703	PF01048	0.651
MOD_GlcNHglycan	731	735	PF01048	0.726
MOD_GlcNHglycan	760	763	PF01048	0.655
MOD_GlcNHglycan	796	799	PF01048	0.745
MOD_GlcNHglycan	827	830	PF01048	0.681
MOD_GlcNHglycan	888	891	PF01048	0.530
MOD_GlcNHglycan	894	897	PF01048	0.488
MOD_GlcNHglycan	942	945	PF01048	0.682
MOD_GlcNHglycan	965	968	PF01048	0.734
MOD_GlcNHglycan	996	999	PF01048	0.592
MOD_GSK3_1	100	107	PF00069	0.723
MOD_GSK3_1	1044	1051	PF00069	0.721
MOD_GSK3_1	1056	1063	PF00069	0.741
MOD_GSK3_1	1070	1077	PF00069	0.682
MOD_GSK3_1	1089	1096	PF00069	0.670
MOD_GSK3_1	128	135	PF00069	0.626
MOD_GSK3_1	139	146	PF00069	0.681
MOD_GSK3_1	154	161	PF00069	0.632
MOD_GSK3_1	16	23	PF00069	0.664
MOD_GSK3_1	166	173	PF00069	0.730
MOD_GSK3_1	182	189	PF00069	0.665
MOD_GSK3_1	209	216	PF00069	0.589
MOD_GSK3_1	254	261	PF00069	0.670
MOD_GSK3_1	292	299	PF00069	0.624
MOD_GSK3_1	34	41	PF00069	0.445
MOD_GSK3_1	414	421	PF00069	0.735
MOD_GSK3_1	438	445	PF00069	0.704
MOD_GSK3_1	482	489	PF00069	0.712
MOD_GSK3_1	491	498	PF00069	0.610
MOD_GSK3_1	52	59	PF00069	0.583
MOD_GSK3_1	590	597	PF00069	0.789
MOD_GSK3_1	610	617	PF00069	0.741
MOD_GSK3_1	624	631	PF00069	0.455
MOD_GSK3_1	650	657	PF00069	0.597
MOD_GSK3_1	67	74	PF00069	0.506
MOD_GSK3_1	673	680	PF00069	0.618
MOD_GSK3_1	684	691	PF00069	0.616
MOD_GSK3_1	713	720	PF00069	0.686
MOD_GSK3_1	749	756	PF00069	0.642
MOD_GSK3_1	783	790	PF00069	0.724
MOD_GSK3_1	794	801	PF00069	0.612
MOD_GSK3_1	802	809	PF00069	0.586
MOD_GSK3_1	961	968	PF00069	0.752
MOD_N-GLC_1	555	560	PF02516	0.457
MOD_N-GLC_1	688	693	PF02516	0.708
MOD_N-GLC_1	940	945	PF02516	0.646
MOD_N-GLC_2	194	196	PF02516	0.643
MOD_N-GLC_2	730	732	PF02516	0.569
MOD_NEK2_1	214	219	PF00069	0.565
MOD_NEK2_1	311	316	PF00069	0.664
MOD_NEK2_1	428	433	PF00069	0.650
MOD_NEK2_1	555	560	PF00069	0.642
MOD_NEK2_1	622	627	PF00069	0.541
MOD_NEK2_1	629	634	PF00069	0.642
MOD_NEK2_1	649	654	PF00069	0.601
MOD_NEK2_1	69	74	PF00069	0.622
MOD_NEK2_1	690	695	PF00069	0.686
MOD_NEK2_1	753	758	PF00069	0.695
MOD_NEK2_1	892	897	PF00069	0.555
MOD_NEK2_2	258	263	PF00069	0.708
MOD_NEK2_2	708	713	PF00069	0.577
MOD_PIKK_1	442	448	PF00454	0.616
MOD_PIKK_1	612	618	PF00454	0.620
MOD_PK_1	505	511	PF00069	0.739
MOD_PK_1	580	586	PF00069	0.483
MOD_PK_1	713	719	PF00069	0.642
MOD_PKA_1	962	968	PF00069	0.685
MOD_PKA_2	104	110	PF00069	0.592
MOD_PKA_2	1048	1054	PF00069	0.632
MOD_PKA_2	112	118	PF00069	0.645
MOD_PKA_2	214	220	PF00069	0.523
MOD_PKA_2	243	249	PF00069	0.638
MOD_PKA_2	254	260	PF00069	0.586
MOD_PKA_2	311	317	PF00069	0.661
MOD_PKA_2	353	359	PF00069	0.676
MOD_PKA_2	504	510	PF00069	0.759
MOD_PKA_2	892	898	PF00069	0.556
MOD_PKA_2	961	967	PF00069	0.686
MOD_PKB_1	503	511	PF00069	0.756
MOD_Plk_1	28	34	PF00069	0.704
MOD_Plk_1	774	780	PF00069	0.647
MOD_Plk_1	940	946	PF00069	0.686
MOD_Plk_4	28	34	PF00069	0.746
MOD_Plk_4	305	311	PF00069	0.675
MOD_Plk_4	414	420	PF00069	0.721
MOD_Plk_4	505	511	PF00069	0.739
MOD_Plk_4	545	551	PF00069	0.530
MOD_Plk_4	650	656	PF00069	0.644
MOD_Plk_4	680	686	PF00069	0.755
MOD_Plk_4	690	696	PF00069	0.515
MOD_Plk_4	713	719	PF00069	0.683
MOD_Plk_4	720	726	PF00069	0.604
MOD_Plk_4	774	780	PF00069	0.523
MOD_ProDKin_1	1006	1012	PF00069	0.568
MOD_ProDKin_1	1044	1050	PF00069	0.779
MOD_ProDKin_1	1083	1089	PF00069	0.686
MOD_ProDKin_1	132	138	PF00069	0.716
MOD_ProDKin_1	468	474	PF00069	0.676
MOD_ProDKin_1	480	486	PF00069	0.559
MOD_ProDKin_1	510	516	PF00069	0.588
MOD_ProDKin_1	594	600	PF00069	0.779
MOD_ProDKin_1	614	620	PF00069	0.592
MOD_ProDKin_1	639	645	PF00069	0.723
MOD_ProDKin_1	677	683	PF00069	0.728
MOD_ProDKin_1	792	798	PF00069	0.714
MOD_ProDKin_1	802	808	PF00069	0.660
TRG_DiLeu_BaEn_1	1102	1107	PF01217	0.571
TRG_DiLeu_BaEn_1	388	393	PF01217	0.567
TRG_DiLeu_BaEn_4	802	808	PF01217	0.709
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.650
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.669
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.707
TRG_ENDOCYTIC_2	1104	1107	PF00928	0.560
TRG_ENDOCYTIC_2	14	17	PF00928	0.692
TRG_ENDOCYTIC_2	207	210	PF00928	0.684
TRG_ENDOCYTIC_2	315	318	PF00928	0.609
TRG_ENDOCYTIC_2	695	698	PF00928	0.556
TRG_ER_diArg_1	1107	1109	PF00400	0.571
TRG_ER_diArg_1	1148	1150	PF00400	0.714
TRG_ER_diArg_1	235	238	PF00400	0.679
TRG_ER_diArg_1	343	346	PF00400	0.632
TRG_ER_diArg_1	351	354	PF00400	0.622
TRG_ER_diArg_1	360	363	PF00400	0.660
TRG_ER_diArg_1	499	502	PF00400	0.815
TRG_ER_diArg_1	503	506	PF00400	0.762
TRG_ER_diArg_1	668	671	PF00400	0.566
TRG_ER_diArg_1	89	92	PF00400	0.681
TRG_ER_diArg_1	916	918	PF00400	0.464
TRG_NES_CRM1_1	1102	1114	PF08389	0.674
TRG_NES_CRM1_1	124	138	PF08389	0.710
TRG_NLS_Bipartite_1	237	256	PF00514	0.714
TRG_NLS_MonoExtN_4	249	256	PF00514	0.742
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAP0	Leptomonas seymouri	36%	98%
A0A3S7WZP9	Leishmania donovani	91%	100%
A4HEQ9	Leishmania braziliensis	70%	100%
A4I1Y6	Leishmania infantum	91%	100%
E9AY33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%