Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9D8_LEIMA

TriTrypDb:

LmjF.26.0560 , LMJLV39_260010900 , LMJSD75_260009400

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q9D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9D8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.699
CLV_C14_Caspase3-7	12	16	PF00656	0.692
CLV_C14_Caspase3-7	183	187	PF00656	0.438
CLV_C14_Caspase3-7	323	327	PF00656	0.651
CLV_C14_Caspase3-7	536	540	PF00656	0.641
CLV_NRD_NRD_1	147	149	PF00675	0.388
CLV_NRD_NRD_1	237	239	PF00675	0.656
CLV_NRD_NRD_1	466	468	PF00675	0.460
CLV_NRD_NRD_1	611	613	PF00675	0.332
CLV_NRD_NRD_1	691	693	PF00675	0.518
CLV_PCSK_KEX2_1	147	149	PF00082	0.388
CLV_PCSK_KEX2_1	175	177	PF00082	0.618
CLV_PCSK_KEX2_1	237	239	PF00082	0.656
CLV_PCSK_KEX2_1	611	613	PF00082	0.332
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.618
CLV_PCSK_SKI1_1	168	172	PF00082	0.516
CLV_PCSK_SKI1_1	467	471	PF00082	0.449
CLV_PCSK_SKI1_1	612	616	PF00082	0.338
CLV_PCSK_SKI1_1	684	688	PF00082	0.333
CLV_Separin_Metazoa	314	318	PF03568	0.658
DEG_APCC_DBOX_1	139	147	PF00400	0.589
DEG_APCC_DBOX_1	220	228	PF00400	0.459
DEG_APCC_DBOX_1	610	618	PF00400	0.513
DEG_SPOP_SBC_1	351	355	PF00917	0.718
DOC_ANK_TNKS_1	489	496	PF00023	0.647
DOC_CKS1_1	332	337	PF01111	0.720
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.469
DOC_MAPK_gen_1	237	243	PF00069	0.457
DOC_MAPK_gen_1	611	619	PF00069	0.507
DOC_MAPK_MEF2A_6	280	289	PF00069	0.269
DOC_PP2B_LxvP_1	211	214	PF13499	0.462
DOC_PP2B_LxvP_1	289	292	PF13499	0.304
DOC_PP2B_LxvP_1	587	590	PF13499	0.583
DOC_PP4_FxxP_1	397	400	PF00568	0.696
DOC_PP4_FxxP_1	634	637	PF00568	0.531
DOC_USP7_MATH_1	162	166	PF00917	0.284
DOC_USP7_MATH_1	185	189	PF00917	0.473
DOC_USP7_MATH_1	202	206	PF00917	0.440
DOC_USP7_MATH_1	338	342	PF00917	0.802
DOC_USP7_MATH_1	351	355	PF00917	0.637
DOC_USP7_MATH_1	378	382	PF00917	0.746
DOC_USP7_MATH_1	434	438	PF00917	0.674
DOC_USP7_MATH_1	460	464	PF00917	0.685
DOC_USP7_MATH_1	479	483	PF00917	0.607
DOC_USP7_MATH_1	48	52	PF00917	0.673
DOC_USP7_MATH_1	511	515	PF00917	0.749
DOC_USP7_MATH_1	646	650	PF00917	0.581
DOC_USP7_UBL2_3	689	693	PF12436	0.583
DOC_WW_Pin1_4	114	119	PF00397	0.654
DOC_WW_Pin1_4	331	336	PF00397	0.687
DOC_WW_Pin1_4	344	349	PF00397	0.665
DOC_WW_Pin1_4	408	413	PF00397	0.693
DOC_WW_Pin1_4	423	428	PF00397	0.734
DOC_WW_Pin1_4	484	489	PF00397	0.740
DOC_WW_Pin1_4	500	505	PF00397	0.679
DOC_WW_Pin1_4	509	514	PF00397	0.690
DOC_WW_Pin1_4	648	653	PF00397	0.576
LIG_14-3-3_CanoR_1	116	126	PF00244	0.643
LIG_14-3-3_CanoR_1	140	144	PF00244	0.599
LIG_14-3-3_CanoR_1	168	174	PF00244	0.514
LIG_14-3-3_CanoR_1	221	225	PF00244	0.416
LIG_14-3-3_CanoR_1	306	315	PF00244	0.631
LIG_14-3-3_CanoR_1	440	448	PF00244	0.711
LIG_14-3-3_CanoR_1	533	538	PF00244	0.654
LIG_14-3-3_CanoR_1	568	574	PF00244	0.485
LIG_14-3-3_CanoR_1	611	617	PF00244	0.540
LIG_APCC_ABBA_1	26	31	PF00400	0.691
LIG_APCC_ABBA_1	70	75	PF00400	0.667
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BIR_III_2	345	349	PF00653	0.648
LIG_BRCT_BRCA1_1	122	126	PF00533	0.632
LIG_BRCT_BRCA1_1	90	94	PF00533	0.690
LIG_CtBP_PxDLS_1	590	594	PF00389	0.573
LIG_deltaCOP1_diTrp_1	273	278	PF00928	0.445
LIG_FHA_1	311	317	PF00498	0.654
LIG_FHA_1	420	426	PF00498	0.725
LIG_FHA_1	442	448	PF00498	0.724
LIG_FHA_1	596	602	PF00498	0.514
LIG_FHA_2	260	266	PF00498	0.464
LIG_LIR_Apic_2	632	637	PF02991	0.518
LIG_LIR_Gen_1	123	131	PF02991	0.656
LIG_LIR_Gen_1	208	217	PF02991	0.466
LIG_LIR_Gen_1	51	62	PF02991	0.712
LIG_LIR_Gen_1	670	680	PF02991	0.608
LIG_LIR_Gen_1	98	108	PF02991	0.646
LIG_LIR_Nem_3	123	129	PF02991	0.656
LIG_LIR_Nem_3	208	213	PF02991	0.427
LIG_LIR_Nem_3	51	57	PF02991	0.711
LIG_LIR_Nem_3	670	675	PF02991	0.633
LIG_LIR_Nem_3	98	104	PF02991	0.687
LIG_PCNA_yPIPBox_3	268	280	PF02747	0.446
LIG_Pex14_2	173	177	PF04695	0.459
LIG_Pex14_2	290	294	PF04695	0.304
LIG_SH2_CRK	101	105	PF00017	0.687
LIG_SH2_CRK	54	58	PF00017	0.709
LIG_SH2_CRK	682	686	PF00017	0.503
LIG_SH2_GRB2like	131	134	PF00017	0.643
LIG_SH2_GRB2like	210	213	PF00017	0.439
LIG_SH2_GRB2like	84	87	PF00017	0.663
LIG_SH2_NCK_1	101	105	PF00017	0.662
LIG_SH2_NCK_1	54	58	PF00017	0.663
LIG_SH2_PTP2	642	645	PF00017	0.512
LIG_SH2_SRC	210	213	PF00017	0.439
LIG_SH2_SRC	38	41	PF00017	0.736
LIG_SH2_STAP1	101	105	PF00017	0.662
LIG_SH2_STAP1	131	135	PF00017	0.611
LIG_SH2_STAP1	682	686	PF00017	0.634
LIG_SH2_STAT5	135	138	PF00017	0.724
LIG_SH2_STAT5	152	155	PF00017	0.208
LIG_SH2_STAT5	210	213	PF00017	0.470
LIG_SH2_STAT5	331	334	PF00017	0.643
LIG_SH2_STAT5	61	64	PF00017	0.750
LIG_SH2_STAT5	642	645	PF00017	0.512
LIG_SH2_STAT5	77	80	PF00017	0.624
LIG_SH3_1	280	286	PF00018	0.269
LIG_SH3_3	280	286	PF00018	0.269
LIG_SH3_3	329	335	PF00018	0.726
LIG_SH3_3	395	401	PF00018	0.693
LIG_SH3_3	409	415	PF00018	0.677
LIG_SH3_3	424	430	PF00018	0.751
LIG_SH3_3	503	509	PF00018	0.693
LIG_SH3_3	516	522	PF00018	0.692
LIG_SH3_3	571	577	PF00018	0.474
LIG_SUMO_SIM_anti_2	572	578	PF11976	0.509
LIG_SUMO_SIM_par_1	15	25	PF11976	0.713
LIG_SUMO_SIM_par_1	481	487	PF11976	0.701
LIG_SUMO_SIM_par_1	533	541	PF11976	0.645
LIG_SUMO_SIM_par_1	572	578	PF11976	0.493
LIG_TRAF2_1	30	33	PF00917	0.690
LIG_TRAF2_2	318	323	PF00917	0.598
LIG_TYR_ITIM	52	57	PF00017	0.710
LIG_TYR_ITIM	680	685	PF00017	0.493
LIG_UBA3_1	293	300	PF00899	0.325
LIG_WRC_WIRS_1	631	636	PF05994	0.548
MOD_CDC14_SPxK_1	336	339	PF00782	0.660
MOD_CDC14_SPxK_1	487	490	PF00782	0.644
MOD_CDK_SPxK_1	333	339	PF00069	0.661
MOD_CDK_SPxK_1	484	490	PF00069	0.641
MOD_CDK_SPxxK_3	513	520	PF00069	0.709
MOD_CK1_1	117	123	PF00069	0.646
MOD_CK1_1	180	186	PF00069	0.489
MOD_CK1_1	195	201	PF00069	0.401
MOD_CK1_1	205	211	PF00069	0.497
MOD_CK1_1	223	229	PF00069	0.357
MOD_CK1_1	24	30	PF00069	0.782
MOD_CK1_1	360	366	PF00069	0.717
MOD_CK1_1	372	378	PF00069	0.655
MOD_CK1_1	381	387	PF00069	0.691
MOD_CK1_1	42	48	PF00069	0.640
MOD_CK1_1	426	432	PF00069	0.747
MOD_CK1_1	441	447	PF00069	0.659
MOD_CK1_1	482	488	PF00069	0.719
MOD_CK1_1	55	61	PF00069	0.626
MOD_CK1_1	65	71	PF00069	0.749
MOD_CK1_1	657	663	PF00069	0.483
MOD_CK1_1	82	88	PF00069	0.597
MOD_CK2_1	223	229	PF00069	0.398
MOD_CK2_1	259	265	PF00069	0.462
MOD_CK2_1	27	33	PF00069	0.690
MOD_CMANNOS	275	278	PF00535	0.647
MOD_Cter_Amidation	465	468	PF01082	0.450
MOD_GlcNHglycan	112	115	PF01048	0.479
MOD_GlcNHglycan	159	162	PF01048	0.304
MOD_GlcNHglycan	179	182	PF01048	0.536
MOD_GlcNHglycan	194	197	PF01048	0.595
MOD_GlcNHglycan	207	210	PF01048	0.589
MOD_GlcNHglycan	254	257	PF01048	0.685
MOD_GlcNHglycan	308	311	PF01048	0.462
MOD_GlcNHglycan	354	357	PF01048	0.527
MOD_GlcNHglycan	359	362	PF01048	0.561
MOD_GlcNHglycan	376	379	PF01048	0.458
MOD_GlcNHglycan	383	386	PF01048	0.496
MOD_GlcNHglycan	577	580	PF01048	0.399
MOD_GlcNHglycan	67	70	PF01048	0.531
MOD_GSK3_1	100	107	PF00069	0.616
MOD_GSK3_1	110	117	PF00069	0.656
MOD_GSK3_1	121	128	PF00069	0.629
MOD_GSK3_1	180	187	PF00069	0.501
MOD_GSK3_1	201	208	PF00069	0.476
MOD_GSK3_1	274	281	PF00069	0.489
MOD_GSK3_1	306	313	PF00069	0.627
MOD_GSK3_1	327	334	PF00069	0.666
MOD_GSK3_1	368	375	PF00069	0.732
MOD_GSK3_1	38	45	PF00069	0.689
MOD_GSK3_1	383	390	PF00069	0.645
MOD_GSK3_1	419	426	PF00069	0.708
MOD_GSK3_1	434	441	PF00069	0.795
MOD_GSK3_1	478	485	PF00069	0.718
MOD_GSK3_1	48	55	PF00069	0.668
MOD_GSK3_1	509	516	PF00069	0.745
MOD_GSK3_1	533	540	PF00069	0.670
MOD_GSK3_1	591	598	PF00069	0.546
MOD_GSK3_1	60	67	PF00069	0.669
MOD_GSK3_1	71	78	PF00069	0.666
MOD_GSK3_1	88	95	PF00069	0.660
MOD_GSK3_1	9	16	PF00069	0.673
MOD_LATS_1	304	310	PF00433	0.620
MOD_LATS_1	438	444	PF00433	0.729
MOD_N-GLC_1	13	18	PF02516	0.461
MOD_N-GLC_1	310	315	PF02516	0.491
MOD_N-GLC_1	357	362	PF02516	0.468
MOD_NEK2_1	122	127	PF00069	0.629
MOD_NEK2_1	13	18	PF00069	0.676
MOD_NEK2_1	169	174	PF00069	0.468
MOD_NEK2_1	177	182	PF00069	0.421
MOD_NEK2_1	352	357	PF00069	0.693
MOD_NEK2_1	52	57	PF00069	0.664
MOD_NEK2_1	667	672	PF00069	0.535
MOD_OFUCOSY	192	199	PF10250	0.631
MOD_PIKK_1	39	45	PF00454	0.733
MOD_PIKK_1	442	448	PF00454	0.709
MOD_PK_1	533	539	PF00069	0.662
MOD_PKA_2	139	145	PF00069	0.595
MOD_PKA_2	220	226	PF00069	0.415
MOD_PKA_2	252	258	PF00069	0.440
MOD_PKA_2	338	344	PF00069	0.695
MOD_PKA_2	372	378	PF00069	0.711
MOD_PKA_2	381	387	PF00069	0.674
MOD_PKA_2	441	447	PF00069	0.759
MOD_PKA_2	65	71	PF00069	0.784
MOD_PKB_1	440	448	PF00069	0.717
MOD_Plk_1	13	19	PF00069	0.661
MOD_Plk_1	185	191	PF00069	0.421
MOD_Plk_1	21	27	PF00069	0.678
MOD_Plk_1	52	58	PF00069	0.681
MOD_Plk_1	538	544	PF00069	0.579
MOD_Plk_1	99	105	PF00069	0.662
MOD_Plk_4	100	106	PF00069	0.671
MOD_Plk_4	125	131	PF00069	0.697
MOD_Plk_4	223	229	PF00069	0.433
MOD_Plk_4	24	30	PF00069	0.736
MOD_Plk_4	327	333	PF00069	0.681
MOD_Plk_4	338	344	PF00069	0.696
MOD_Plk_4	479	485	PF00069	0.695
MOD_Plk_4	569	575	PF00069	0.480
MOD_Plk_4	603	609	PF00069	0.559
MOD_Plk_4	612	618	PF00069	0.642
MOD_Plk_4	79	85	PF00069	0.668
MOD_ProDKin_1	114	120	PF00069	0.653
MOD_ProDKin_1	331	337	PF00069	0.682
MOD_ProDKin_1	344	350	PF00069	0.659
MOD_ProDKin_1	408	414	PF00069	0.694
MOD_ProDKin_1	423	429	PF00069	0.734
MOD_ProDKin_1	484	490	PF00069	0.742
MOD_ProDKin_1	500	506	PF00069	0.677
MOD_ProDKin_1	509	515	PF00069	0.689
MOD_ProDKin_1	648	654	PF00069	0.571
TRG_DiLeu_BaLyEn_6	530	535	PF01217	0.618
TRG_DiLeu_BaLyEn_6	681	686	PF01217	0.527
TRG_ENDOCYTIC_2	101	104	PF00928	0.656
TRG_ENDOCYTIC_2	105	108	PF00928	0.642
TRG_ENDOCYTIC_2	152	155	PF00928	0.304
TRG_ENDOCYTIC_2	210	213	PF00928	0.424
TRG_ENDOCYTIC_2	54	57	PF00928	0.708
TRG_ENDOCYTIC_2	642	645	PF00928	0.483
TRG_ENDOCYTIC_2	682	685	PF00928	0.537
TRG_ER_diArg_1	146	148	PF00400	0.621
TRG_ER_diArg_1	236	238	PF00400	0.445
TRG_ER_diArg_1	316	319	PF00400	0.704
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A2	Leptomonas seymouri	50%	98%
A0A3S7WZN2	Leishmania donovani	94%	100%
A4HER1	Leishmania braziliensis	74%	100%
A4I1Y8	Leishmania infantum	94%	100%
E9AY35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%