ApaG domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF525), putative

Species:

Leishmania major

UniProt:

Q4Q9D6_LEIMA

TriTrypDb:

LmjF.26.0580 , LMJLV39_260011100 , LMJSD75_260009600

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0009295	nucleoid	2	2
GO:0042645	mitochondrial nucleoid	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9D6

Function

Biological processes
Term	Name	Level	Count
GO:0000731	DNA synthesis involved in DNA repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006301	postreplication repair	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019985	translesion synthesis	7	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0070987	error-free translesion synthesis	8	2
GO:0071704	organic substance metabolic process	2	2
GO:0071897	DNA biosynthetic process	5	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.683
CLV_NRD_NRD_1	182	184	PF00675	0.555
CLV_NRD_NRD_1	292	294	PF00675	0.651
CLV_NRD_NRD_1	308	310	PF00675	0.386
CLV_NRD_NRD_1	322	324	PF00675	0.464
CLV_NRD_NRD_1	84	86	PF00675	0.388
CLV_PCSK_KEX2_1	102	104	PF00082	0.682
CLV_PCSK_KEX2_1	181	183	PF00082	0.602
CLV_PCSK_KEX2_1	292	294	PF00082	0.539
CLV_PCSK_KEX2_1	308	310	PF00082	0.386
CLV_PCSK_KEX2_1	322	324	PF00082	0.466
CLV_PCSK_KEX2_1	422	424	PF00082	0.363
CLV_PCSK_KEX2_1	84	86	PF00082	0.388
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.363
CLV_PCSK_PC7_1	178	184	PF00082	0.593
CLV_PCSK_SKI1_1	292	296	PF00082	0.626
CLV_PCSK_SKI1_1	520	524	PF00082	0.566
CLV_PCSK_SKI1_1	9	13	PF00082	0.388
CLV_Separin_Metazoa	319	323	PF03568	0.466
DEG_SCF_FBW7_1	128	133	PF00400	0.601
DEG_SPOP_SBC_1	370	374	PF00917	0.736
DOC_MAPK_gen_1	292	299	PF00069	0.592
DOC_MAPK_MEF2A_6	480	487	PF00069	0.354
DOC_PP4_FxxP_1	206	209	PF00568	0.534
DOC_PP4_FxxP_1	59	62	PF00568	0.440
DOC_SPAK_OSR1_1	205	209	PF12202	0.548
DOC_USP7_MATH_1	118	122	PF00917	0.664
DOC_USP7_MATH_1	130	134	PF00917	0.646
DOC_USP7_MATH_1	210	214	PF00917	0.527
DOC_USP7_MATH_1	217	221	PF00917	0.415
DOC_USP7_MATH_1	246	250	PF00917	0.587
DOC_USP7_MATH_1	287	291	PF00917	0.664
DOC_USP7_MATH_1	354	358	PF00917	0.647
DOC_USP7_MATH_1	363	367	PF00917	0.618
DOC_USP7_MATH_1	460	464	PF00917	0.295
DOC_USP7_MATH_1	562	566	PF00917	0.628
DOC_USP7_MATH_1	74	78	PF00917	0.539
DOC_WW_Pin1_4	124	129	PF00397	0.706
DOC_WW_Pin1_4	352	357	PF00397	0.732
DOC_WW_Pin1_4	372	377	PF00397	0.569
LIG_14-3-3_CanoR_1	152	162	PF00244	0.511
LIG_14-3-3_CanoR_1	505	509	PF00244	0.480
LIG_14-3-3_CanoR_1	75	83	PF00244	0.441
LIG_Actin_WH2_2	48	63	PF00022	0.427
LIG_Actin_WH2_2	76	92	PF00022	0.464
LIG_APCC_ABBA_1	485	490	PF00400	0.441
LIG_BIR_III_2	125	129	PF00653	0.580
LIG_BRCT_BRCA1_1	143	147	PF00533	0.634
LIG_BRCT_BRCA1_1	462	466	PF00533	0.354
LIG_BRCT_BRCA1_1	76	80	PF00533	0.448
LIG_Clathr_ClatBox_1	433	437	PF01394	0.354
LIG_CtBP_PxDLS_1	196	200	PF00389	0.580
LIG_EVH1_2	202	206	PF00568	0.559
LIG_FHA_1	153	159	PF00498	0.691
LIG_FHA_1	226	232	PF00498	0.385
LIG_FHA_1	299	305	PF00498	0.590
LIG_FHA_1	324	330	PF00498	0.404
LIG_FHA_1	339	345	PF00498	0.396
LIG_FHA_1	372	378	PF00498	0.576
LIG_FHA_1	505	511	PF00498	0.449
LIG_FHA_1	55	61	PF00498	0.462
LIG_FHA_2	310	316	PF00498	0.433
LIG_LIR_Apic_2	19	25	PF02991	0.421
LIG_LIR_Apic_2	57	62	PF02991	0.429
LIG_LIR_Gen_1	27	37	PF02991	0.433
LIG_LIR_Gen_1	77	86	PF02991	0.441
LIG_LIR_LC3C_4	430	435	PF02991	0.354
LIG_LIR_Nem_3	220	225	PF02991	0.433
LIG_LIR_Nem_3	27	33	PF02991	0.372
LIG_LIR_Nem_3	49	54	PF02991	0.463
LIG_LIR_Nem_3	6	11	PF02991	0.420
LIG_LIR_Nem_3	77	83	PF02991	0.441
LIG_MYND_1	456	460	PF01753	0.295
LIG_PTB_Apo_2	41	48	PF02174	0.419
LIG_PTB_Phospho_1	41	47	PF10480	0.417
LIG_SH2_CRK	8	12	PF00017	0.380
LIG_SH2_NCK_1	22	26	PF00017	0.477
LIG_SH2_PTP2	409	412	PF00017	0.354
LIG_SH2_SRC	22	25	PF00017	0.477
LIG_SH2_SRC	409	412	PF00017	0.354
LIG_SH2_STAT5	214	217	PF00017	0.472
LIG_SH2_STAT5	343	346	PF00017	0.478
LIG_SH2_STAT5	404	407	PF00017	0.300
LIG_SH2_STAT5	409	412	PF00017	0.291
LIG_SH3_3	155	161	PF00018	0.646
LIG_SH3_3	190	196	PF00018	0.567
LIG_SH3_3	206	212	PF00018	0.416
LIG_SUMO_SIM_par_1	213	221	PF11976	0.590
LIG_SUMO_SIM_par_1	228	235	PF11976	0.276
LIG_SUMO_SIM_par_1	332	338	PF11976	0.399
LIG_SUMO_SIM_par_1	432	437	PF11976	0.399
LIG_SUMO_SIM_par_1	506	512	PF11976	0.504
LIG_TRAF2_1	282	285	PF00917	0.641
LIG_TRAF2_1	313	316	PF00917	0.491
LIG_TRAF2_1	522	525	PF00917	0.579
LIG_TYR_ITIM	407	412	PF00017	0.354
MOD_CDK_SPxK_1	372	378	PF00069	0.576
MOD_CK1_1	113	119	PF00069	0.594
MOD_CK1_1	121	127	PF00069	0.623
MOD_CK1_1	146	152	PF00069	0.757
MOD_CK1_1	235	241	PF00069	0.402
MOD_CK1_1	346	352	PF00069	0.617
MOD_CK1_1	372	378	PF00069	0.565
MOD_CK1_1	391	397	PF00069	0.656
MOD_CK1_1	468	474	PF00069	0.296
MOD_CK1_1	73	79	PF00069	0.551
MOD_CK2_1	279	285	PF00069	0.631
MOD_CK2_1	309	315	PF00069	0.424
MOD_CK2_1	354	360	PF00069	0.721
MOD_CK2_1	470	476	PF00069	0.354
MOD_GlcNHglycan	112	115	PF01048	0.641
MOD_GlcNHglycan	120	123	PF01048	0.623
MOD_GlcNHglycan	133	136	PF01048	0.774
MOD_GlcNHglycan	234	237	PF01048	0.347
MOD_GlcNHglycan	255	258	PF01048	0.694
MOD_GlcNHglycan	265	268	PF01048	0.667
MOD_GlcNHglycan	270	273	PF01048	0.684
MOD_GlcNHglycan	348	351	PF01048	0.656
MOD_GlcNHglycan	356	359	PF01048	0.636
MOD_GlcNHglycan	388	391	PF01048	0.691
MOD_GlcNHglycan	467	470	PF01048	0.302
MOD_GlcNHglycan	472	475	PF01048	0.313
MOD_GlcNHglycan	5	8	PF01048	0.445
MOD_GlcNHglycan	511	514	PF01048	0.682
MOD_GlcNHglycan	532	536	PF01048	0.759
MOD_GlcNHglycan	538	541	PF01048	0.822
MOD_GlcNHglycan	556	559	PF01048	0.578
MOD_GlcNHglycan	72	75	PF01048	0.410
MOD_GlcNHglycan	76	79	PF01048	0.387
MOD_GSK3_1	120	127	PF00069	0.595
MOD_GSK3_1	146	153	PF00069	0.640
MOD_GSK3_1	259	266	PF00069	0.697
MOD_GSK3_1	325	332	PF00069	0.423
MOD_GSK3_1	504	511	PF00069	0.481
MOD_GSK3_1	70	77	PF00069	0.482
MOD_N-GLC_1	185	190	PF02516	0.594
MOD_N-GLC_1	288	293	PF02516	0.614
MOD_NEK2_1	232	237	PF00069	0.337
MOD_NEK2_1	263	268	PF00069	0.576
MOD_NEK2_1	304	309	PF00069	0.498
MOD_NEK2_1	371	376	PF00069	0.573
MOD_NEK2_1	479	484	PF00069	0.354
MOD_NEK2_1	516	521	PF00069	0.608
MOD_NEK2_1	89	94	PF00069	0.628
MOD_PIKK_1	146	152	PF00454	0.608
MOD_PKA_2	170	176	PF00069	0.595
MOD_PKA_2	177	183	PF00069	0.595
MOD_PKA_2	268	274	PF00069	0.650
MOD_PKA_2	479	485	PF00069	0.295
MOD_PKA_2	504	510	PF00069	0.453
MOD_PKA_2	568	574	PF00069	0.647
MOD_PKA_2	60	66	PF00069	0.399
MOD_PKA_2	74	80	PF00069	0.388
MOD_PKB_1	529	537	PF00069	0.622
MOD_Plk_2-3	274	280	PF00069	0.663
MOD_Plk_4	170	176	PF00069	0.536
MOD_Plk_4	210	216	PF00069	0.530
MOD_Plk_4	235	241	PF00069	0.458
MOD_ProDKin_1	124	130	PF00069	0.704
MOD_ProDKin_1	352	358	PF00069	0.729
MOD_ProDKin_1	372	378	PF00069	0.576
MOD_SUMO_for_1	522	525	PF00179	0.556
MOD_SUMO_rev_2	399	403	PF00179	0.358
MOD_SUMO_rev_2	545	555	PF00179	0.631
TRG_DiLeu_BaEn_1	165	170	PF01217	0.597
TRG_DiLeu_BaEn_1	211	216	PF01217	0.516
TRG_DiLeu_BaEn_1	316	321	PF01217	0.479
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.524
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.295
TRG_ENDOCYTIC_2	404	407	PF00928	0.344
TRG_ENDOCYTIC_2	409	412	PF00928	0.336
TRG_ENDOCYTIC_2	8	11	PF00928	0.380
TRG_ER_diArg_1	101	103	PF00400	0.683
TRG_ER_diArg_1	181	183	PF00400	0.642
TRG_ER_diArg_1	308	310	PF00400	0.386
TRG_ER_diArg_1	321	323	PF00400	0.483
TRG_ER_diArg_1	412	415	PF00400	0.354
TRG_ER_diArg_1	83	85	PF00400	0.392
TRG_ER_diArg_1	96	99	PF00400	0.563
TRG_ER_diLys_1	574	579	PF00400	0.695
TRG_NES_CRM1_1	27	41	PF08389	0.374
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I464	Leptomonas seymouri	61%	97%
A0A1X0NSE4	Trypanosomatidae	32%	100%
A0A3Q8IGW6	Leishmania donovani	95%	100%
A4HER3	Leishmania braziliensis	79%	97%
A4I1Z0	Leishmania infantum	95%	100%
E9AY37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%