Putative spliced leader RNA PSE-promoter transcription factor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spliced leader RNA PSE-promoter transcription factor, putative

Species:

Leishmania major

UniProt:

Q4Q9D5_LEIMA

TriTrypDb:

LmjF.26.0590 , LMJLV39_260011300 , LMJSD75_260009800

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9D5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9D5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.594
CLV_NRD_NRD_1	157	159	PF00675	0.649
CLV_NRD_NRD_1	323	325	PF00675	0.468
CLV_NRD_NRD_1	34	36	PF00675	0.641
CLV_NRD_NRD_1	342	344	PF00675	0.467
CLV_NRD_NRD_1	466	468	PF00675	0.578
CLV_NRD_NRD_1	500	502	PF00675	0.547
CLV_NRD_NRD_1	566	568	PF00675	0.569
CLV_NRD_NRD_1	577	579	PF00675	0.468
CLV_NRD_NRD_1	60	62	PF00675	0.599
CLV_NRD_NRD_1	93	95	PF00675	0.560
CLV_PCSK_FUR_1	58	62	PF00082	0.599
CLV_PCSK_FUR_1	90	94	PF00082	0.600
CLV_PCSK_KEX2_1	157	159	PF00082	0.617
CLV_PCSK_KEX2_1	34	36	PF00082	0.639
CLV_PCSK_KEX2_1	342	344	PF00082	0.467
CLV_PCSK_KEX2_1	465	467	PF00082	0.553
CLV_PCSK_KEX2_1	499	501	PF00082	0.572
CLV_PCSK_KEX2_1	566	568	PF00082	0.569
CLV_PCSK_KEX2_1	577	579	PF00082	0.468
CLV_PCSK_KEX2_1	60	62	PF00082	0.599
CLV_PCSK_KEX2_1	75	77	PF00082	0.584
CLV_PCSK_KEX2_1	89	91	PF00082	0.460
CLV_PCSK_KEX2_1	92	94	PF00082	0.434
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.669
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.621
CLV_PCSK_PC7_1	496	502	PF00082	0.623
CLV_PCSK_PC7_1	56	62	PF00082	0.600
CLV_PCSK_SKI1_1	256	260	PF00082	0.509
CLV_PCSK_SKI1_1	347	351	PF00082	0.439
CLV_PCSK_SKI1_1	375	379	PF00082	0.490
CLV_PCSK_SKI1_1	632	636	PF00082	0.408
CLV_PCSK_SKI1_1	668	672	PF00082	0.587
DEG_APCC_DBOX_1	255	263	PF00400	0.497
DEG_APCC_DBOX_1	355	363	PF00400	0.469
DEG_Nend_UBRbox_4	1	3	PF02207	0.576
DOC_CDC14_PxL_1	264	272	PF14671	0.532
DOC_CYCLIN_RxL_1	31	42	PF00134	0.584
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.564
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	639	645	PF00134	0.659
DOC_MAPK_DCC_7	75	83	PF00069	0.621
DOC_MAPK_gen_1	31	39	PF00069	0.704
DOC_MAPK_gen_1	564	572	PF00069	0.590
DOC_MAPK_gen_1	58	66	PF00069	0.596
DOC_MAPK_JIP1_4	58	64	PF00069	0.595
DOC_MAPK_MEF2A_6	290	297	PF00069	0.449
DOC_PP2B_LxvP_1	23	26	PF13499	0.627
DOC_PP2B_LxvP_1	239	242	PF13499	0.596
DOC_PP2B_LxvP_1	450	453	PF13499	0.754
DOC_PP2B_LxvP_1	531	534	PF13499	0.554
DOC_PP2B_LxvP_1	62	65	PF13499	0.596
DOC_PP2B_LxvP_1	643	646	PF13499	0.644
DOC_USP7_MATH_1	190	194	PF00917	0.637
DOC_USP7_MATH_1	209	213	PF00917	0.601
DOC_USP7_MATH_1	388	392	PF00917	0.443
DOC_USP7_MATH_1	428	432	PF00917	0.582
DOC_USP7_MATH_1	442	446	PF00917	0.686
DOC_USP7_MATH_1	539	543	PF00917	0.533
DOC_USP7_MATH_1	559	563	PF00917	0.287
DOC_USP7_MATH_1	655	659	PF00917	0.719
DOC_WW_Pin1_4	132	137	PF00397	0.490
DOC_WW_Pin1_4	180	185	PF00397	0.779
DOC_WW_Pin1_4	191	196	PF00397	0.566
DOC_WW_Pin1_4	201	206	PF00397	0.591
DOC_WW_Pin1_4	21	26	PF00397	0.621
DOC_WW_Pin1_4	234	239	PF00397	0.454
DOC_WW_Pin1_4	445	450	PF00397	0.646
DOC_WW_Pin1_4	541	546	PF00397	0.511
DOC_WW_Pin1_4	565	570	PF00397	0.573
DOC_WW_Pin1_4	644	649	PF00397	0.683
LIG_14-3-3_CanoR_1	157	161	PF00244	0.488
LIG_14-3-3_CanoR_1	34	38	PF00244	0.661
LIG_14-3-3_CanoR_1	640	646	PF00244	0.689
LIG_14-3-3_CanoR_1	668	677	PF00244	0.749
LIG_14-3-3_CanoR_1	693	703	PF00244	0.700
LIG_Actin_WH2_2	403	419	PF00022	0.494
LIG_BRCT_BRCA1_1	197	201	PF00533	0.634
LIG_BRCT_BRCA1_1	375	379	PF00533	0.377
LIG_BRCT_BRCA1_1	50	54	PF00533	0.712
LIG_CaM_IQ_9	328	344	PF13499	0.521
LIG_CaM_NSCaTE_8	346	353	PF13499	0.440
LIG_FHA_1	123	129	PF00498	0.578
LIG_FHA_1	219	225	PF00498	0.598
LIG_FHA_1	280	286	PF00498	0.515
LIG_FHA_1	4	10	PF00498	0.585
LIG_FHA_1	445	451	PF00498	0.752
LIG_FHA_1	511	517	PF00498	0.578
LIG_FHA_1	671	677	PF00498	0.720
LIG_FHA_2	136	142	PF00498	0.582
LIG_FHA_2	477	483	PF00498	0.509
LIG_FHA_2	651	657	PF00498	0.709
LIG_FHA_2	694	700	PF00498	0.683
LIG_Integrin_isoDGR_2	666	668	PF01839	0.695
LIG_Integrin_RGD_1	250	252	PF01839	0.532
LIG_LIR_Gen_1	228	239	PF02991	0.531
LIG_LIR_Gen_1	376	387	PF02991	0.332
LIG_LIR_Gen_1	585	594	PF02991	0.545
LIG_LIR_Nem_3	114	119	PF02991	0.567
LIG_LIR_Nem_3	228	234	PF02991	0.461
LIG_LIR_Nem_3	261	267	PF02991	0.459
LIG_LIR_Nem_3	376	382	PF02991	0.312
LIG_LIR_Nem_3	51	57	PF02991	0.701
LIG_LIR_Nem_3	526	531	PF02991	0.545
LIG_LIR_Nem_3	585	591	PF02991	0.529
LIG_LYPXL_SIV_4	148	156	PF13949	0.546
LIG_LYPXL_yS_3	267	270	PF13949	0.454
LIG_MLH1_MIPbox_1	50	54	PF16413	0.712
LIG_MYND_1	21	25	PF01753	0.624
LIG_NRBOX	141	147	PF00104	0.543
LIG_PCNA_PIPBox_1	631	640	PF02747	0.429
LIG_PDZ_Class_2	698	703	PF00595	0.628
LIG_Pex14_1	373	377	PF04695	0.509
LIG_Pex14_2	377	381	PF04695	0.490
LIG_PTB_Apo_2	76	83	PF02174	0.586
LIG_SH2_CRK	116	120	PF00017	0.479
LIG_SH2_CRK	588	592	PF00017	0.561
LIG_SH2_NCK_1	149	153	PF00017	0.475
LIG_SH2_NCK_1	197	201	PF00017	0.661
LIG_SH2_STAP1	197	201	PF00017	0.661
LIG_SH2_STAT3	557	560	PF00017	0.613
LIG_SH2_STAT5	53	56	PF00017	0.734
LIG_SH2_STAT5	602	605	PF00017	0.419
LIG_SH2_STAT5	612	615	PF00017	0.453
LIG_SH2_STAT5	638	641	PF00017	0.429
LIG_SH3_3	19	25	PF00018	0.626
LIG_SH3_3	62	68	PF00018	0.619
LIG_SH3_3	684	690	PF00018	0.799
LIG_Sin3_3	551	558	PF02671	0.555
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.589
LIG_SUMO_SIM_par_1	220	226	PF11976	0.614
LIG_SUMO_SIM_par_1	257	263	PF11976	0.524
LIG_SUMO_SIM_par_1	568	573	PF11976	0.467
LIG_SUMO_SIM_par_1	578	585	PF11976	0.501
LIG_TRAF2_1	480	483	PF00917	0.616
LIG_TRAF2_1	696	699	PF00917	0.689
LIG_WRC_WIRS_1	374	379	PF05994	0.500
MOD_CDC14_SPxK_1	651	654	PF00782	0.670
MOD_CDK_SPK_2	132	137	PF00069	0.475
MOD_CDK_SPK_2	180	185	PF00069	0.735
MOD_CDK_SPxK_1	648	654	PF00069	0.650
MOD_CK1_1	16	22	PF00069	0.621
MOD_CK1_1	212	218	PF00069	0.707
MOD_CK1_1	24	30	PF00069	0.556
MOD_CK1_1	445	451	PF00069	0.720
MOD_CK1_1	644	650	PF00069	0.698
MOD_CK2_1	170	176	PF00069	0.806
MOD_CK2_1	220	226	PF00069	0.594
MOD_CK2_1	452	458	PF00069	0.668
MOD_CK2_1	476	482	PF00069	0.527
MOD_CK2_1	644	650	PF00069	0.700
MOD_CK2_1	693	699	PF00069	0.632
MOD_GlcNHglycan	152	155	PF01048	0.473
MOD_GlcNHglycan	187	190	PF01048	0.650
MOD_GlcNHglycan	214	217	PF01048	0.684
MOD_GlcNHglycan	264	267	PF01048	0.545
MOD_GlcNHglycan	351	354	PF01048	0.444
MOD_GlcNHglycan	389	393	PF01048	0.452
MOD_GlcNHglycan	444	447	PF01048	0.733
MOD_GlcNHglycan	505	509	PF01048	0.556
MOD_GlcNHglycan	623	626	PF01048	0.568
MOD_GlcNHglycan	643	646	PF01048	0.397
MOD_GSK3_1	12	19	PF00069	0.588
MOD_GSK3_1	170	177	PF00069	0.763
MOD_GSK3_1	191	198	PF00069	0.625
MOD_GSK3_1	208	215	PF00069	0.615
MOD_GSK3_1	21	28	PF00069	0.530
MOD_GSK3_1	29	36	PF00069	0.507
MOD_GSK3_1	444	451	PF00069	0.682
MOD_GSK3_1	644	651	PF00069	0.644
MOD_GSK3_1	656	663	PF00069	0.714
MOD_GSK3_1	66	73	PF00069	0.588
MOD_N-GLC_1	185	190	PF02516	0.653
MOD_NEK2_1	156	161	PF00069	0.626
MOD_NEK2_1	254	259	PF00069	0.428
MOD_NEK2_1	260	265	PF00069	0.434
MOD_NEK2_1	279	284	PF00069	0.272
MOD_NEK2_1	33	38	PF00069	0.726
MOD_NEK2_1	387	392	PF00069	0.562
MOD_NEK2_1	39	44	PF00069	0.698
MOD_NEK2_1	405	410	PF00069	0.310
MOD_NEK2_1	504	509	PF00069	0.557
MOD_NEK2_1	540	545	PF00069	0.538
MOD_PIKK_1	122	128	PF00454	0.576
MOD_PIKK_1	405	411	PF00454	0.398
MOD_PIKK_1	510	516	PF00454	0.585
MOD_PK_1	108	114	PF00069	0.577
MOD_PKA_2	156	162	PF00069	0.633
MOD_PKA_2	33	39	PF00069	0.665
MOD_PKB_1	691	699	PF00069	0.668
MOD_Plk_1	108	114	PF00069	0.468
MOD_Plk_1	260	266	PF00069	0.498
MOD_Plk_1	457	463	PF00069	0.534
MOD_Plk_1	600	606	PF00069	0.426
MOD_Plk_1	627	633	PF00069	0.480
MOD_Plk_2-3	220	226	PF00069	0.653
MOD_Plk_4	141	147	PF00069	0.544
MOD_Plk_4	618	624	PF00069	0.473
MOD_ProDKin_1	132	138	PF00069	0.486
MOD_ProDKin_1	180	186	PF00069	0.777
MOD_ProDKin_1	191	197	PF00069	0.565
MOD_ProDKin_1	201	207	PF00069	0.594
MOD_ProDKin_1	21	27	PF00069	0.623
MOD_ProDKin_1	234	240	PF00069	0.458
MOD_ProDKin_1	445	451	PF00069	0.648
MOD_ProDKin_1	541	547	PF00069	0.503
MOD_ProDKin_1	565	571	PF00069	0.575
MOD_ProDKin_1	644	650	PF00069	0.691
TRG_DiLeu_BaEn_1	281	286	PF01217	0.418
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.567
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.407
TRG_DiLeu_BaLyEn_6	531	536	PF01217	0.538
TRG_ENDOCYTIC_2	116	119	PF00928	0.525
TRG_ENDOCYTIC_2	267	270	PF00928	0.435
TRG_ENDOCYTIC_2	403	406	PF00928	0.483
TRG_ENDOCYTIC_2	528	531	PF00928	0.599
TRG_ENDOCYTIC_2	588	591	PF00928	0.548
TRG_ENDOCYTIC_2	597	600	PF00928	0.459
TRG_ENDOCYTIC_2	638	641	PF00928	0.493
TRG_ER_diArg_1	156	158	PF00400	0.639
TRG_ER_diArg_1	268	271	PF00400	0.415
TRG_ER_diArg_1	319	322	PF00400	0.529
TRG_ER_diArg_1	33	35	PF00400	0.650
TRG_ER_diArg_1	342	344	PF00400	0.467
TRG_ER_diArg_1	397	400	PF00400	0.547
TRG_ER_diArg_1	414	417	PF00400	0.377
TRG_ER_diArg_1	464	467	PF00400	0.586
TRG_ER_diArg_1	499	501	PF00400	0.665
TRG_ER_diArg_1	565	567	PF00400	0.561
TRG_ER_diArg_1	57	60	PF00400	0.613
TRG_ER_diArg_1	576	578	PF00400	0.480
TRG_ER_diArg_1	690	693	PF00400	0.774
TRG_ER_diArg_1	90	93	PF00400	0.549
TRG_NES_CRM1_1	312	326	PF08389	0.507
TRG_NLS_Bipartite_1	75	93	PF00514	0.607
TRG_NLS_MonoExtC_3	88	93	PF00514	0.603
TRG_NLS_MonoExtN_4	86	93	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	399	404	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A3	Leptomonas seymouri	64%	100%
A0A0S4JUQ3	Bodo saltans	37%	100%
A0A1X0NT43	Trypanosomatidae	48%	100%
A0A3Q8ICN9	Leishmania donovani	95%	100%
A0A422N5D7	Trypanosoma rangeli	47%	100%
A4HER4	Leishmania braziliensis	82%	100%
A4I1Z1	Leishmania infantum	95%	100%
C9ZS25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AY38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BPZ1	Trypanosoma cruzi	47%	100%