Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9D4_LEIMA

TriTrypDb:

LmjF.26.0600 , LMJLV39_260011400 , LMJSD75_260009900

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9D4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0019905	syntaxin binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.287
CLV_C14_Caspase3-7	47	51	PF00656	0.403
CLV_MEL_PAP_1	134	140	PF00089	0.287
CLV_NRD_NRD_1	115	117	PF00675	0.274
CLV_NRD_NRD_1	152	154	PF00675	0.354
CLV_NRD_NRD_1	220	222	PF00675	0.281
CLV_NRD_NRD_1	64	66	PF00675	0.424
CLV_NRD_NRD_1	92	94	PF00675	0.303
CLV_PCSK_KEX2_1	114	116	PF00082	0.316
CLV_PCSK_KEX2_1	151	153	PF00082	0.407
CLV_PCSK_KEX2_1	220	222	PF00082	0.266
CLV_PCSK_KEX2_1	262	264	PF00082	0.475
CLV_PCSK_KEX2_1	304	306	PF00082	0.281
CLV_PCSK_KEX2_1	76	78	PF00082	0.391
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.366
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.463
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.281
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.391
CLV_PCSK_SKI1_1	230	234	PF00082	0.360
CLV_PCSK_SKI1_1	291	295	PF00082	0.281
CLV_PCSK_SKI1_1	34	38	PF00082	0.512
CLV_PCSK_SKI1_1	93	97	PF00082	0.331
DOC_USP7_MATH_1	129	133	PF00917	0.287
DOC_USP7_MATH_1	14	18	PF00917	0.641
DOC_USP7_MATH_1	2	6	PF00917	0.598
DOC_USP7_MATH_1	324	328	PF00917	0.309
DOC_WW_Pin1_4	19	24	PF00397	0.640
LIG_14-3-3_CanoR_1	137	145	PF00244	0.448
LIG_14-3-3_CanoR_1	223	227	PF00244	0.317
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_FHA_1	204	210	PF00498	0.268
LIG_FHA_2	162	168	PF00498	0.260
LIG_FHA_2	271	277	PF00498	0.393
LIG_FHA_2	313	319	PF00498	0.411
LIG_LIR_Gen_1	178	188	PF02991	0.418
LIG_LIR_Gen_1	192	202	PF02991	0.410
LIG_LIR_Nem_3	178	184	PF02991	0.304
LIG_LIR_Nem_3	192	198	PF02991	0.333
LIG_LIR_Nem_3	241	247	PF02991	0.302
LIG_Pex14_2	177	181	PF04695	0.360
LIG_SH2_SRC	202	205	PF00017	0.443
LIG_SH2_STAP1	240	244	PF00017	0.373
LIG_SH2_STAT3	104	107	PF00017	0.287
LIG_SH2_STAT3	240	243	PF00017	0.300
LIG_SH2_STAT5	104	107	PF00017	0.331
LIG_SH3_3	248	254	PF00018	0.331
LIG_SUMO_SIM_anti_2	208	213	PF11976	0.398
LIG_TRAF2_1	201	204	PF00917	0.411
LIG_TRAF2_1	327	330	PF00917	0.576
LIG_TRAF2_1	9	12	PF00917	0.570
LIG_TRAF2_1	97	100	PF00917	0.366
MOD_CK1_1	225	231	PF00069	0.461
MOD_CK2_1	161	167	PF00069	0.308
MOD_CK2_1	177	183	PF00069	0.242
MOD_CK2_1	270	276	PF00069	0.393
MOD_CK2_1	312	318	PF00069	0.419
MOD_CK2_1	324	330	PF00069	0.742
MOD_CK2_1	6	12	PF00069	0.667
MOD_GlcNHglycan	4	7	PF01048	0.649
MOD_GSK3_1	173	180	PF00069	0.364
MOD_GSK3_1	2	9	PF00069	0.648
MOD_GSK3_1	222	229	PF00069	0.393
MOD_N-GLC_1	19	24	PF02516	0.571
MOD_NEK2_1	1	6	PF00069	0.633
MOD_NEK2_1	109	114	PF00069	0.335
MOD_NEK2_1	177	182	PF00069	0.404
MOD_NEK2_1	28	33	PF00069	0.639
MOD_NEK2_1	52	57	PF00069	0.314
MOD_NEK2_2	84	89	PF00069	0.200
MOD_PKA_1	173	179	PF00069	0.421
MOD_PKA_2	136	142	PF00069	0.397
MOD_PKA_2	222	228	PF00069	0.439
MOD_PKA_2	270	276	PF00069	0.367
MOD_PKB_1	153	161	PF00069	0.287
MOD_Plk_1	177	183	PF00069	0.377
MOD_Plk_2-3	222	228	PF00069	0.348
MOD_Plk_4	141	147	PF00069	0.357
MOD_Plk_4	52	58	PF00069	0.283
MOD_ProDKin_1	19	25	PF00069	0.636
MOD_SUMO_for_1	252	255	PF00179	0.343
MOD_SUMO_for_1	303	306	PF00179	0.300
TRG_DiLeu_BaEn_1	194	199	PF01217	0.287
TRG_ENDOCYTIC_2	195	198	PF00928	0.386
TRG_ER_diArg_1	114	116	PF00400	0.288
TRG_ER_diArg_1	219	221	PF00400	0.309
TRG_NES_CRM1_1	70	82	PF08389	0.331
TRG_NLS_Bipartite_1	65	79	PF00514	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2W3	Leptomonas seymouri	65%	99%
A0A0S4JT11	Bodo saltans	31%	90%
A0A1X0NSF2	Trypanosomatidae	36%	93%
A0A3Q8IFN3	Leishmania donovani	92%	100%
A0A3R7M749	Trypanosoma rangeli	37%	91%
A4HER5	Leishmania braziliensis	82%	100%
A4I1Z2	Leishmania infantum	93%	100%
C9ZS22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	91%
E9AY39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BZC0	Trypanosoma cruzi	36%	91%