PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9D3_LEIMA

TriTrypDb:

LmjF.26.0610 , LMJLV39_260011500 , LMJSD75_260010000

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q9D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.382
CLV_C14_Caspase3-7	94	98	PF00656	0.696
CLV_NRD_NRD_1	11	13	PF00675	0.509
CLV_NRD_NRD_1	138	140	PF00675	0.319
CLV_NRD_NRD_1	27	29	PF00675	0.511
CLV_NRD_NRD_1	270	272	PF00675	0.247
CLV_NRD_NRD_1	307	309	PF00675	0.325
CLV_NRD_NRD_1	325	327	PF00675	0.249
CLV_NRD_NRD_1	334	336	PF00675	0.287
CLV_NRD_NRD_1	37	39	PF00675	0.475
CLV_PCSK_FUR_1	268	272	PF00082	0.299
CLV_PCSK_FUR_1	305	309	PF00082	0.359
CLV_PCSK_KEX2_1	11	13	PF00082	0.509
CLV_PCSK_KEX2_1	138	140	PF00082	0.330
CLV_PCSK_KEX2_1	27	29	PF00082	0.511
CLV_PCSK_KEX2_1	270	272	PF00082	0.238
CLV_PCSK_KEX2_1	307	309	PF00082	0.364
CLV_PCSK_KEX2_1	334	336	PF00082	0.296
CLV_PCSK_KEX2_1	37	39	PF00082	0.483
CLV_PCSK_SKI1_1	157	161	PF00082	0.299
CLV_PCSK_SKI1_1	38	42	PF00082	0.454
DEG_COP1_1	79	86	PF00400	0.655
DEG_COP1_1	9	17	PF00400	0.590
DEG_Nend_Nbox_1	1	3	PF02207	0.769
DEG_SCF_FBW7_1	344	351	PF00400	0.567
DEG_SPOP_SBC_1	384	388	PF00917	0.364
DEG_SPOP_SBC_1	86	90	PF00917	0.683
DOC_CKS1_1	113	118	PF01111	0.642
DOC_MAPK_gen_1	157	166	PF00069	0.514
DOC_MAPK_gen_1	305	313	PF00069	0.515
DOC_MAPK_MEF2A_6	305	313	PF00069	0.503
DOC_USP7_MATH_1	221	225	PF00917	0.435
DOC_USP7_MATH_1	348	352	PF00917	0.577
DOC_USP7_MATH_1	36	40	PF00917	0.803
DOC_USP7_MATH_1	385	389	PF00917	0.395
DOC_USP7_MATH_1	67	71	PF00917	0.701
DOC_USP7_MATH_1	82	86	PF00917	0.715
DOC_USP7_MATH_2	312	318	PF00917	0.495
DOC_USP7_UBL2_3	192	196	PF12436	0.378
DOC_WW_Pin1_4	112	117	PF00397	0.586
DOC_WW_Pin1_4	199	204	PF00397	0.452
DOC_WW_Pin1_4	344	349	PF00397	0.560
DOC_WW_Pin1_4	40	45	PF00397	0.616
DOC_WW_Pin1_4	46	51	PF00397	0.731
DOC_WW_Pin1_4	56	61	PF00397	0.717
DOC_WW_Pin1_4	87	92	PF00397	0.725
LIG_14-3-3_CanoR_1	165	175	PF00244	0.435
LIG_14-3-3_CanoR_1	185	189	PF00244	0.367
LIG_14-3-3_CanoR_1	271	279	PF00244	0.509
LIG_14-3-3_CanoR_1	37	46	PF00244	0.703
LIG_Actin_WH2_2	149	167	PF00022	0.446
LIG_Actin_WH2_2	171	187	PF00022	0.449
LIG_Actin_WH2_2	353	371	PF00022	0.294
LIG_AP2alpha_2	290	292	PF02296	0.515
LIG_BRCT_BRCA1_1	350	354	PF00533	0.522
LIG_EH1_1	353	361	PF00400	0.414
LIG_FHA_1	14	20	PF00498	0.614
LIG_FHA_1	78	84	PF00498	0.711
LIG_FHA_1	99	105	PF00498	0.725
LIG_FHA_2	101	107	PF00498	0.618
LIG_FHA_2	113	119	PF00498	0.509
LIG_FHA_2	92	98	PF00498	0.740
LIG_LIR_Gen_1	169	179	PF02991	0.516
LIG_LIR_Gen_1	224	234	PF02991	0.469
LIG_LIR_Gen_1	261	269	PF02991	0.447
LIG_LIR_Gen_1	278	287	PF02991	0.430
LIG_LIR_Gen_1	316	325	PF02991	0.455
LIG_LIR_Gen_1	341	349	PF02991	0.568
LIG_LIR_Gen_1	351	360	PF02991	0.447
LIG_LIR_Nem_3	169	174	PF02991	0.516
LIG_LIR_Nem_3	261	266	PF02991	0.472
LIG_LIR_Nem_3	278	282	PF02991	0.426
LIG_LIR_Nem_3	293	297	PF02991	0.440
LIG_LIR_Nem_3	314	318	PF02991	0.474
LIG_LIR_Nem_3	341	346	PF02991	0.488
LIG_LIR_Nem_3	351	355	PF02991	0.419
LIG_PCNA_yPIPBox_3	130	141	PF02747	0.515
LIG_PCNA_yPIPBox_3	350	360	PF02747	0.412
LIG_Pex14_1	294	298	PF04695	0.462
LIG_Pex14_2	68	72	PF04695	0.631
LIG_SH2_CRK	206	210	PF00017	0.419
LIG_SH2_CRK	279	283	PF00017	0.431
LIG_SH2_GRB2like	286	289	PF00017	0.419
LIG_SH2_SRC	140	143	PF00017	0.558
LIG_SH2_SRC	339	342	PF00017	0.493
LIG_SH2_STAP1	149	153	PF00017	0.472
LIG_SH2_STAP1	171	175	PF00017	0.514
LIG_SH2_STAP1	206	210	PF00017	0.431
LIG_SH2_STAP1	241	245	PF00017	0.419
LIG_SH2_STAP1	380	384	PF00017	0.394
LIG_SH2_STAT5	140	143	PF00017	0.522
LIG_SH2_STAT5	318	321	PF00017	0.489
LIG_SH2_STAT5	332	335	PF00017	0.468
LIG_SH2_STAT5	339	342	PF00017	0.476
LIG_SH2_STAT5	361	364	PF00017	0.277
LIG_SH2_STAT5	374	377	PF00017	0.263
LIG_SH3_3	110	116	PF00018	0.597
LIG_SH3_3	306	312	PF00018	0.604
LIG_SH3_3	57	63	PF00018	0.726
LIG_SH3_5	145	149	PF00018	0.446
LIG_UBA3_1	365	369	PF00899	0.239
MOD_CDK_SPxK_1	344	350	PF00069	0.566
MOD_CDK_SPxxK_3	40	47	PF00069	0.597
MOD_CK1_1	167	173	PF00069	0.446
MOD_CK1_1	177	183	PF00069	0.398
MOD_CK1_1	272	278	PF00069	0.514
MOD_CK1_1	30	36	PF00069	0.683
MOD_CK1_1	383	389	PF00069	0.428
MOD_CK1_1	39	45	PF00069	0.758
MOD_CK1_1	70	76	PF00069	0.734
MOD_CK1_1	85	91	PF00069	0.601
MOD_CK2_1	112	118	PF00069	0.553
MOD_CK2_1	166	172	PF00069	0.423
MOD_GlcNHglycan	160	163	PF01048	0.294
MOD_GlcNHglycan	166	169	PF01048	0.324
MOD_GlcNHglycan	179	182	PF01048	0.382
MOD_GlcNHglycan	20	23	PF01048	0.453
MOD_GlcNHglycan	248	251	PF01048	0.341
MOD_GlcNHglycan	29	32	PF01048	0.409
MOD_GlcNHglycan	69	72	PF01048	0.476
MOD_GlcNHglycan	84	87	PF01048	0.440
MOD_GSK3_1	173	180	PF00069	0.575
MOD_GSK3_1	32	39	PF00069	0.658
MOD_GSK3_1	344	351	PF00069	0.510
MOD_GSK3_1	379	386	PF00069	0.332
MOD_GSK3_1	42	49	PF00069	0.611
MOD_GSK3_1	50	57	PF00069	0.751
MOD_GSK3_1	82	89	PF00069	0.747
MOD_NEK2_1	123	128	PF00069	0.523
MOD_NEK2_1	164	169	PF00069	0.440
MOD_NEK2_1	174	179	PF00069	0.560
MOD_NEK2_1	18	23	PF00069	0.804
MOD_NEK2_1	243	248	PF00069	0.474
MOD_NEK2_1	72	77	PF00069	0.671
MOD_NEK2_2	221	226	PF00069	0.435
MOD_PKA_1	27	33	PF00069	0.701
MOD_PKA_2	164	170	PF00069	0.435
MOD_PKA_2	184	190	PF00069	0.367
MOD_PKA_2	264	270	PF00069	0.454
MOD_PKA_2	27	33	PF00069	0.695
MOD_PKA_2	272	278	PF00069	0.436
MOD_PKA_2	36	42	PF00069	0.662
MOD_Plk_1	147	153	PF00069	0.504
MOD_Plk_1	380	386	PF00069	0.438
MOD_Plk_4	174	180	PF00069	0.575
MOD_Plk_4	221	227	PF00069	0.453
MOD_Plk_4	314	320	PF00069	0.523
MOD_Plk_4	367	373	PF00069	0.324
MOD_Plk_4	387	393	PF00069	0.353
MOD_ProDKin_1	112	118	PF00069	0.583
MOD_ProDKin_1	199	205	PF00069	0.452
MOD_ProDKin_1	344	350	PF00069	0.566
MOD_ProDKin_1	40	46	PF00069	0.618
MOD_ProDKin_1	56	62	PF00069	0.728
MOD_ProDKin_1	87	93	PF00069	0.722
TRG_ENDOCYTIC_2	171	174	PF00928	0.514
TRG_ENDOCYTIC_2	191	194	PF00928	0.350
TRG_ENDOCYTIC_2	206	209	PF00928	0.398
TRG_ENDOCYTIC_2	241	244	PF00928	0.472
TRG_ENDOCYTIC_2	279	282	PF00928	0.419
TRG_ENDOCYTIC_2	286	289	PF00928	0.419
TRG_ENDOCYTIC_2	301	304	PF00928	0.462
TRG_ENDOCYTIC_2	318	321	PF00928	0.452
TRG_ENDOCYTIC_2	361	364	PF00928	0.319
TRG_ENDOCYTIC_2	374	377	PF00928	0.263
TRG_ER_diArg_1	137	139	PF00400	0.526
TRG_ER_diArg_1	270	273	PF00400	0.488
TRG_ER_diArg_1	304	307	PF00400	0.492
TRG_ER_diArg_1	308	311	PF00400	0.526
TRG_ER_diArg_1	333	335	PF00400	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW81	Leptomonas seymouri	65%	100%
A0A0S4JWX5	Bodo saltans	45%	100%
A0A1X0NSQ2	Trypanosomatidae	59%	100%
A0A3Q8ICT6	Leishmania donovani	94%	100%
A4HER6	Leishmania braziliensis	79%	100%
A4I1Z3	Leishmania infantum	94%	100%
C9ZS21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AY40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BUJ1	Trypanosoma cruzi	49%	100%