Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9D1_LEIMA

TriTrypDb:

LmjF.26.0630 , LMJLV39_260011700 , LMJSD75_260010200

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q9D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9D1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0006633	fatty acid biosynthetic process	5	3
GO:0008152	metabolic process	1	3
GO:0008610	lipid biosynthetic process	4	3
GO:0009058	biosynthetic process	2	3
GO:0009987	cellular process	1	3
GO:0016053	organic acid biosynthetic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046394	carboxylic acid biosynthetic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072330	monocarboxylic acid biosynthetic process	6	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016790	thiolester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.453
CLV_C14_Caspase3-7	4	8	PF00656	0.460
CLV_C14_Caspase3-7	93	97	PF00656	0.302
CLV_NRD_NRD_1	253	255	PF00675	0.335
CLV_NRD_NRD_1	310	312	PF00675	0.303
CLV_PCSK_KEX2_1	253	255	PF00082	0.352
CLV_PCSK_SKI1_1	254	258	PF00082	0.295
CLV_PCSK_SKI1_1	283	287	PF00082	0.313
DEG_Nend_Nbox_1	1	3	PF02207	0.433
DOC_ANK_TNKS_1	2	9	PF00023	0.453
DOC_ANK_TNKS_1	294	301	PF00023	0.284
DOC_CDC14_PxL_1	15	23	PF14671	0.249
DOC_CKS1_1	162	167	PF01111	0.383
DOC_CYCLIN_yCln2_LP_2	296	299	PF00134	0.277
DOC_MAPK_FxFP_2	331	334	PF00069	0.297
DOC_MAPK_gen_1	396	405	PF00069	0.315
DOC_MAPK_RevD_3	299	312	PF00069	0.465
DOC_PP2B_LxvP_1	227	230	PF13499	0.456
DOC_PP2B_LxvP_1	296	299	PF13499	0.309
DOC_PP2B_LxvP_1	50	53	PF13499	0.278
DOC_PP2B_LxvP_1	58	61	PF13499	0.417
DOC_PP4_FxxP_1	102	105	PF00568	0.536
DOC_PP4_FxxP_1	331	334	PF00568	0.297
DOC_USP7_MATH_1	211	215	PF00917	0.363
DOC_USP7_MATH_1	232	236	PF00917	0.392
DOC_USP7_MATH_1	6	10	PF00917	0.387
DOC_USP7_UBL2_3	182	186	PF12436	0.403
DOC_WW_Pin1_4	161	166	PF00397	0.517
DOC_WW_Pin1_4	222	227	PF00397	0.552
LIG_14-3-3_CanoR_1	163	169	PF00244	0.456
LIG_14-3-3_CanoR_1	197	205	PF00244	0.493
LIG_14-3-3_CanoR_1	253	259	PF00244	0.318
LIG_14-3-3_CanoR_1	398	404	PF00244	0.432
LIG_Actin_WH2_2	244	261	PF00022	0.477
LIG_APCC_Cbox_2	397	403	PF00515	0.341
LIG_BRCT_BRCA1_1	108	112	PF00533	0.357
LIG_BRCT_BRCA1_1	206	210	PF00533	0.344
LIG_Clathr_ClatBox_1	332	336	PF01394	0.334
LIG_FHA_1	272	278	PF00498	0.407
LIG_FHA_1	358	364	PF00498	0.517
LIG_FHA_1	382	388	PF00498	0.334
LIG_FHA_1	400	406	PF00498	0.355
LIG_FHA_1	408	414	PF00498	0.442
LIG_FHA_2	255	261	PF00498	0.364
LIG_IBAR_NPY_1	97	99	PF08397	0.355
LIG_LIR_Apic_2	101	105	PF02991	0.393
LIG_LIR_Apic_2	328	334	PF02991	0.410
LIG_LIR_Apic_2	46	52	PF02991	0.254
LIG_LIR_Gen_1	128	137	PF02991	0.412
LIG_LIR_Nem_3	125	130	PF02991	0.314
LIG_LIR_Nem_3	131	137	PF02991	0.356
LIG_LIR_Nem_3	379	385	PF02991	0.317
LIG_LIR_Nem_3	85	91	PF02991	0.302
LIG_LIR_Nem_3	96	102	PF02991	0.350
LIG_PCNA_yPIPBox_3	173	186	PF02747	0.285
LIG_PCNA_yPIPBox_3	270	283	PF02747	0.317
LIG_PTB_Apo_2	121	128	PF02174	0.355
LIG_PTB_Apo_2	35	42	PF02174	0.414
LIG_PTB_Phospho_1	121	127	PF10480	0.419
LIG_SH2_CRK	130	134	PF00017	0.317
LIG_SH2_CRK	224	228	PF00017	0.594
LIG_SH2_CRK	293	297	PF00017	0.465
LIG_SH2_GRB2like	136	139	PF00017	0.273
LIG_SH2_STAP1	130	134	PF00017	0.520
LIG_SH2_STAP1	293	297	PF00017	0.456
LIG_SH2_STAT5	118	121	PF00017	0.505
LIG_SH2_STAT5	134	137	PF00017	0.332
LIG_SH2_STAT5	317	320	PF00017	0.312
LIG_SH2_STAT5	39	42	PF00017	0.415
LIG_SH2_STAT5	62	65	PF00017	0.637
LIG_SH2_STAT5	79	82	PF00017	0.506
LIG_SH3_2	334	339	PF14604	0.350
LIG_SH3_3	13	19	PF00018	0.297
LIG_SH3_3	234	240	PF00018	0.432
LIG_SH3_3	296	302	PF00018	0.378
LIG_SH3_3	331	337	PF00018	0.320
LIG_SH3_3	353	359	PF00018	0.576
LIG_SH3_3	382	388	PF00018	0.401
LIG_SUMO_SIM_par_1	274	280	PF11976	0.410
LIG_TRFH_1	102	106	PF08558	0.440
LIG_WRC_WIRS_1	148	153	PF05994	0.371
LIG_WW_3	104	108	PF00397	0.404
MOD_CAAXbox	411	414	PF01239	0.377
MOD_CK1_1	125	131	PF00069	0.412
MOD_CK1_1	225	231	PF00069	0.593
MOD_CK1_1	235	241	PF00069	0.467
MOD_CK1_1	82	88	PF00069	0.432
MOD_CK2_1	175	181	PF00069	0.317
MOD_CK2_1	254	260	PF00069	0.420
MOD_GlcNHglycan	206	209	PF01048	0.329
MOD_GlcNHglycan	213	216	PF01048	0.368
MOD_GlcNHglycan	227	230	PF01048	0.616
MOD_GlcNHglycan	7	11	PF01048	0.298
MOD_GSK3_1	128	135	PF00069	0.319
MOD_GSK3_1	147	154	PF00069	0.310
MOD_GSK3_1	171	178	PF00069	0.503
MOD_GSK3_1	182	189	PF00069	0.360
MOD_GSK3_1	211	218	PF00069	0.399
MOD_GSK3_1	254	261	PF00069	0.312
MOD_GSK3_1	321	328	PF00069	0.427
MOD_GSK3_1	342	349	PF00069	0.451
MOD_LATS_1	252	258	PF00433	0.281
MOD_N-GLC_1	123	128	PF02516	0.353
MOD_N-GLC_1	182	187	PF02516	0.446
MOD_N-GLC_1	211	216	PF02516	0.520
MOD_N-GLC_1	28	33	PF02516	0.375
MOD_N-GLC_1	82	87	PF02516	0.572
MOD_N-GLC_2	38	40	PF02516	0.413
MOD_NEK2_1	147	152	PF00069	0.301
MOD_NEK2_1	175	180	PF00069	0.292
MOD_NEK2_1	204	209	PF00069	0.326
MOD_NEK2_1	399	404	PF00069	0.423
MOD_PIKK_1	128	134	PF00454	0.237
MOD_PIKK_1	60	66	PF00454	0.606
MOD_PKA_2	106	112	PF00069	0.345
MOD_PKA_2	196	202	PF00069	0.370
MOD_PKA_2	258	264	PF00069	0.313
MOD_Plk_1	123	129	PF00069	0.388
MOD_Plk_1	211	217	PF00069	0.383
MOD_Plk_1	232	238	PF00069	0.295
MOD_Plk_1	28	34	PF00069	0.291
MOD_Plk_1	82	88	PF00069	0.358
MOD_Plk_4	125	131	PF00069	0.471
MOD_Plk_4	132	138	PF00069	0.395
MOD_Plk_4	171	177	PF00069	0.560
MOD_Plk_4	232	238	PF00069	0.295
MOD_Plk_4	82	88	PF00069	0.433
MOD_ProDKin_1	161	167	PF00069	0.516
MOD_ProDKin_1	222	228	PF00069	0.553
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.317
TRG_ENDOCYTIC_2	130	133	PF00928	0.314
TRG_ENDOCYTIC_2	134	137	PF00928	0.318
TRG_ENDOCYTIC_2	224	227	PF00928	0.595
TRG_ENDOCYTIC_2	293	296	PF00928	0.466
TRG_ENDOCYTIC_2	99	102	PF00928	0.527
TRG_NES_CRM1_1	191	202	PF08389	0.301
TRG_NES_CRM1_1	376	391	PF08389	0.452
TRG_NLS_MonoExtC_3	310	316	PF00514	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG55	Leptomonas seymouri	57%	97%
A0A0S4JIW4	Bodo saltans	26%	100%
A0A1X0NSG4	Trypanosomatidae	36%	100%
A0A3Q8INZ4	Leishmania donovani	91%	100%
A0A3R7M5A1	Trypanosoma rangeli	34%	100%
A4HER8	Leishmania braziliensis	71%	100%
A4I1Z5	Leishmania infantum	91%	100%
C9ZS19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AY42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5B9E8	Trypanosoma cruzi	34%	100%