Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania major

UniProt:

Q4Q9C7_LEIMA

TriTrypDb:

LmjF.26.0670 , LMJLV39_260012100 , LMJSD75_260010600

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	2
GO:0016020	membrane	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9C7

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0015035	protein-disulfide reductase activity	3	2
GO:0015036	disulfide oxidoreductase activity	4	2
GO:0016491	oxidoreductase activity	2	2
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	2
GO:0140096	catalytic activity, acting on a protein	2	4
GO:0003756	protein disulfide isomerase activity	3	2
GO:0016853	isomerase activity	2	2
GO:0016860	intramolecular oxidoreductase activity	3	2
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.468
CLV_NRD_NRD_1	43	45	PF00675	0.621
CLV_PCSK_SKI1_1	65	69	PF00082	0.472
DOC_CDC14_PxL_1	25	33	PF14671	0.554
DOC_CYCLIN_yCln2_LP_2	130	133	PF00134	0.314
DOC_MAPK_gen_1	63	71	PF00069	0.272
DOC_MAPK_MEF2A_6	63	71	PF00069	0.272
DOC_PP2B_LxvP_1	130	133	PF13499	0.317
LIG_14-3-3_CanoR_1	4	10	PF00244	0.611
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_deltaCOP1_diTrp_1	74	82	PF00928	0.272
LIG_eIF4E_1	125	131	PF01652	0.314
LIG_FHA_1	125	131	PF00498	0.314
LIG_FHA_1	135	141	PF00498	0.314
LIG_FHA_1	20	26	PF00498	0.335
LIG_KLC1_Yacidic_2	70	74	PF13176	0.272
LIG_LIR_Gen_1	55	66	PF02991	0.314
LIG_LIR_Gen_1	8	17	PF02991	0.547
LIG_LIR_Gen_1	81	89	PF02991	0.312
LIG_LIR_Nem_3	123	128	PF02991	0.351
LIG_LIR_Nem_3	54	60	PF02991	0.275
LIG_LIR_Nem_3	74	78	PF02991	0.147
LIG_LIR_Nem_3	8	12	PF02991	0.682
LIG_LIR_Nem_3	81	85	PF02991	0.276
LIG_LIR_Nem_3	87	92	PF02991	0.256
LIG_LYPXL_yS_3	125	128	PF13949	0.314
LIG_Pex14_2	16	20	PF04695	0.322
LIG_Pex14_2	71	75	PF04695	0.314
LIG_SH2_STAT5	57	60	PF00017	0.264
LIG_SH2_STAT5	72	75	PF00017	0.218
LIG_SH2_STAT5	78	81	PF00017	0.305
LIG_SH2_STAT5	92	95	PF00017	0.324
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.314
LIG_WRC_WIRS_1	6	11	PF05994	0.657
MOD_CK1_1	124	130	PF00069	0.272
MOD_GSK3_1	120	127	PF00069	0.397
MOD_N-GLC_1	120	125	PF02516	0.472
MOD_NEK2_1	16	21	PF00069	0.326
MOD_Plk_1	120	126	PF00069	0.272
MOD_Plk_2-3	81	87	PF00069	0.293
MOD_Plk_4	124	130	PF00069	0.314
MOD_Plk_4	16	22	PF00069	0.317
MOD_Plk_4	81	87	PF00069	0.270
MOD_SUMO_for_1	159	162	PF00179	0.474
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.552
TRG_ENDOCYTIC_2	125	128	PF00928	0.314
TRG_ENDOCYTIC_2	57	60	PF00928	0.314
TRG_ENDOCYTIC_2	86	89	PF00928	0.397
TRG_ER_diArg_1	63	66	PF00400	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJS7	Leptomonas seymouri	53%	100%
A0A1X0NT33	Trypanosomatidae	26%	100%
A4HES2	Leishmania braziliensis	60%	100%
E9AY46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
P42115	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	100%