DUF2012 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2012), putative

Species:

Leishmania major

UniProt:

Q4Q9C6_LEIMA

TriTrypDb:

LmjF.26.0680 , LMJLV39_260012200 , LMJSD75_260010700

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 2
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0072546	EMC complex	3	2
GO:0098796	membrane protein complex	2	2
GO:0140534	endoplasmic reticulum protein-containing complex	2	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q9C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9C6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0030246	carbohydrate binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.255
CLV_PCSK_SKI1_1	206	210	PF00082	0.416
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.343
DOC_MAPK_FxFP_2	98	101	PF00069	0.269
DOC_MAPK_MEF2A_6	168	177	PF00069	0.343
DOC_PP2B_LxvP_1	36	39	PF13499	0.356
DOC_PP4_FxxP_1	69	72	PF00568	0.310
DOC_PP4_FxxP_1	98	101	PF00568	0.269
DOC_SPAK_OSR1_1	68	72	PF12202	0.270
DOC_USP7_UBL2_3	205	209	PF12436	0.694
DOC_USP7_UBL2_3	215	219	PF12436	0.691
DOC_WW_Pin1_4	139	144	PF00397	0.278
LIG_14-3-3_CanoR_1	122	130	PF00244	0.328
LIG_APCC_ABBA_1	185	190	PF00400	0.655
LIG_DCNL_PONY_1	1	4	PF03556	0.516
LIG_FHA_1	100	106	PF00498	0.284
LIG_FHA_1	86	92	PF00498	0.336
LIG_FHA_2	110	116	PF00498	0.270
LIG_FHA_2	71	77	PF00498	0.255
LIG_HP1_1	170	174	PF01393	0.374
LIG_LIR_Apic_2	153	157	PF02991	0.261
LIG_LIR_Gen_1	47	57	PF02991	0.308
LIG_LIR_Gen_1	94	103	PF02991	0.261
LIG_LIR_Nem_3	149	154	PF02991	0.326
LIG_LIR_Nem_3	31	36	PF02991	0.350
LIG_LIR_Nem_3	47	52	PF02991	0.409
LIG_LIR_Nem_3	76	82	PF02991	0.300
LIG_LIR_Nem_3	94	100	PF02991	0.207
LIG_PCNA_yPIPBox_3	158	167	PF02747	0.286
LIG_SH2_CRK	33	37	PF00017	0.318
LIG_SH2_CRK	82	86	PF00017	0.315
LIG_SH2_STAT3	32	35	PF00017	0.373
LIG_SH2_STAT3	63	66	PF00017	0.289
LIG_SH2_STAT3	89	92	PF00017	0.344
LIG_SH2_STAT5	155	158	PF00017	0.256
LIG_SH2_STAT5	42	45	PF00017	0.424
LIG_SH2_STAT5	89	92	PF00017	0.288
LIG_SH2_STAT5	97	100	PF00017	0.283
LIG_Sin3_3	12	19	PF02671	0.493
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.308
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.190
LIG_SUMO_SIM_par_1	16	22	PF11976	0.588
LIG_SUMO_SIM_par_1	173	178	PF11976	0.346
LIG_TRAF2_1	189	192	PF00917	0.641
LIG_TRAF2_1	24	27	PF00917	0.536
LIG_TRAF2_2	157	162	PF00917	0.308
LIG_UBA3_1	181	186	PF00899	0.376
LIG_WW_1	39	42	PF00397	0.377
MOD_CK1_1	210	216	PF00069	0.692
MOD_CK2_1	21	27	PF00069	0.565
MOD_GlcNHglycan	123	126	PF01048	0.585
MOD_GlcNHglycan	134	138	PF01048	0.534
MOD_GlcNHglycan	148	151	PF01048	0.453
MOD_GlcNHglycan	23	26	PF01048	0.667
MOD_GSK3_1	116	123	PF00069	0.315
MOD_GSK3_1	146	153	PF00069	0.351
MOD_GSK3_1	193	200	PF00069	0.676
MOD_GSK3_1	209	216	PF00069	0.479
MOD_NEK2_1	120	125	PF00069	0.305
MOD_NEK2_1	133	138	PF00069	0.241
MOD_NEK2_1	175	180	PF00069	0.283
MOD_NEK2_1	2	7	PF00069	0.593
MOD_NEK2_1	207	212	PF00069	0.670
MOD_PIKK_1	193	199	PF00454	0.662
MOD_PKA_2	109	115	PF00069	0.322
MOD_PKA_2	121	127	PF00069	0.334
MOD_PKA_2	193	199	PF00069	0.665
MOD_PKA_2	2	8	PF00069	0.602
MOD_Plk_4	116	122	PF00069	0.317
MOD_Plk_4	150	156	PF00069	0.276
MOD_Plk_4	162	168	PF00069	0.248
MOD_Plk_4	177	183	PF00069	0.355
MOD_Plk_4	28	34	PF00069	0.356
MOD_Plk_4	38	44	PF00069	0.379
MOD_Plk_4	56	62	PF00069	0.276
MOD_Plk_4	85	91	PF00069	0.310
MOD_ProDKin_1	139	145	PF00069	0.278
MOD_SUMO_rev_2	111	119	PF00179	0.270
TRG_DiLeu_BaEn_2	93	99	PF01217	0.270
TRG_ENDOCYTIC_2	33	36	PF00928	0.310
TRG_ENDOCYTIC_2	95	98	PF00928	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU9	Leptomonas seymouri	66%	98%
A0A0S4JJC6	Bodo saltans	35%	90%
A0A1X0NSE7	Trypanosomatidae	45%	90%
A0A3Q8IDJ8	Leishmania donovani	96%	100%
A0A422N2I9	Trypanosoma rangeli	39%	96%
A4HES3	Leishmania braziliensis	77%	99%
A4I200	Leishmania infantum	96%	100%
C9ZS15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	93%
E9AY47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DR28	Trypanosoma cruzi	48%	100%