Putative Qc-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qc-SNARE protein, putative

Species:

Leishmania major

UniProt:

Q4Q9C5_LEIMA

TriTrypDb:

LmjF.26.0690 , LMJLV39_260012300 , LMJSD75_260010800

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	9
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

Q4Q9C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9C5

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006886	intracellular protein transport	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	4
GO:0009987	cellular process	1	4
GO:0015031	protein transport	4	4
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0016192	vesicle-mediated transport	4	7

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Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.594
CLV_NRD_NRD_1	128	130	PF00675	0.353
CLV_NRD_NRD_1	215	217	PF00675	0.276
CLV_PCSK_KEX2_1	130	132	PF00082	0.351
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.406
CLV_PCSK_SKI1_1	202	206	PF00082	0.287
CLV_PCSK_SKI1_1	80	84	PF00082	0.368
DEG_Nend_UBRbox_3	1	3	PF02207	0.650
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.564
DOC_MAPK_gen_1	178	186	PF00069	0.603

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C8	Leptomonas seymouri	26%	100%
A0A0N1IK90	Leptomonas seymouri	77%	97%
A0A0S4JJL1	Bodo saltans	42%	100%
A0A1X0NSP4	Trypanosomatidae	56%	100%
A0A3Q8IBW4	Leishmania donovani	32%	100%
A0A3Q8IDN9	Leishmania donovani	95%	100%
A0A3R7KG01	Trypanosoma rangeli	58%	100%
A4HES4	Leishmania braziliensis	82%	100%
A4HZL4	Leishmania infantum	32%	100%
A4I201	Leishmania infantum	95%	100%

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