Putative Qc-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qc-SNARE protein, putative

Species:

Leishmania major

UniProt:

Q4Q9C5_LEIMA

TriTrypDb:

LmjF.26.0690 , LMJLV39_260012300 , LMJSD75_260010800

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	9
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q9C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9C5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006886	intracellular protein transport	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	4
GO:0009987	cellular process	1	4
GO:0015031	protein transport	4	4
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2
GO:0033036	macromolecule localization	2	4
GO:0045184	establishment of protein localization	3	4
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	4
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	4
GO:0071702	organic substance transport	4	4
GO:0071705	nitrogen compound transport	4	4
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2
GO:0016192	vesicle-mediated transport	4	7

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.594
CLV_NRD_NRD_1	128	130	PF00675	0.353
CLV_NRD_NRD_1	215	217	PF00675	0.276
CLV_PCSK_KEX2_1	130	132	PF00082	0.351
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.406
CLV_PCSK_SKI1_1	202	206	PF00082	0.287
CLV_PCSK_SKI1_1	80	84	PF00082	0.368
DEG_Nend_UBRbox_3	1	3	PF02207	0.650
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.564
DOC_MAPK_gen_1	178	186	PF00069	0.603
DOC_MAPK_gen_1	228	236	PF00069	0.448
DOC_MAPK_MEF2A_6	228	236	PF00069	0.446
DOC_PP2B_LxvP_1	15	18	PF13499	0.560
DOC_USP7_MATH_1	21	25	PF00917	0.770
DOC_USP7_MATH_1	4	8	PF00917	0.666
LIG_14-3-3_CanoR_1	171	179	PF00244	0.691
LIG_Actin_RPEL_3	221	240	PF02755	0.520
LIG_AP2alpha_2	28	30	PF02296	0.569
LIG_EH1_1	237	245	PF00400	0.395
LIG_FHA_2	23	29	PF00498	0.686
LIG_FHA_2	83	89	PF00498	0.544
LIG_FHA_2	94	100	PF00498	0.504
LIG_GBD_Chelix_1	241	249	PF00786	0.269
LIG_TRAF2_1	96	99	PF00917	0.565
MOD_CK2_1	21	27	PF00069	0.677
MOD_CK2_1	4	10	PF00069	0.554
MOD_CK2_1	82	88	PF00069	0.548
MOD_CK2_1	93	99	PF00069	0.598
MOD_GlcNHglycan	141	144	PF01048	0.499
MOD_GlcNHglycan	173	176	PF01048	0.440
MOD_GSK3_1	13	20	PF00069	0.726
MOD_GSK3_1	51	58	PF00069	0.596
MOD_GSK3_1	89	96	PF00069	0.653
MOD_NEK2_1	221	226	PF00069	0.470
MOD_NEK2_1	51	56	PF00069	0.605
MOD_PIKK_1	189	195	PF00454	0.645
MOD_PIKK_1	4	10	PF00454	0.622
MOD_PKA_2	170	176	PF00069	0.679
MOD_PKA_2	51	57	PF00069	0.634
MOD_Plk_1	165	171	PF00069	0.616
MOD_Plk_2-3	165	171	PF00069	0.616
MOD_Plk_4	55	61	PF00069	0.542
TRG_DiLeu_BaEn_2	145	151	PF01217	0.596
TRG_ER_diArg_1	129	132	PF00400	0.602
TRG_NES_CRM1_1	198	212	PF08389	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C8	Leptomonas seymouri	26%	100%
A0A0N1IK90	Leptomonas seymouri	77%	97%
A0A0S4JJL1	Bodo saltans	42%	100%
A0A1X0NSP4	Trypanosomatidae	56%	100%
A0A3Q8IBW4	Leishmania donovani	32%	100%
A0A3Q8IDN9	Leishmania donovani	95%	100%
A0A3R7KG01	Trypanosoma rangeli	58%	100%
A4HES4	Leishmania braziliensis	82%	100%
A4HZL4	Leishmania infantum	32%	100%
A4I201	Leishmania infantum	95%	100%
E9AY48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O43752	Homo sapiens	29%	98%
O60499	Homo sapiens	27%	100%
Q5R6Q2	Pongo abelii	29%	98%
Q63635	Rattus norvegicus	31%	98%
Q946Y7	Arabidopsis thaliana	29%	100%
Q9JKK1	Mus musculus	31%	98%
V5BUP0	Trypanosoma cruzi	56%	100%