Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pentapeptide repeats (9 copies), putative

Species:

Leishmania major

UniProt:

Q4Q9C4_LEIMA

TriTrypDb:

LmjF.26.0700 , LMJLV39_260012400 , LMJSD75_260010900

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9C4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.482
CLV_C14_Caspase3-7	271	275	PF00656	0.630
CLV_NRD_NRD_1	15	17	PF00675	0.571
CLV_NRD_NRD_1	249	251	PF00675	0.376
CLV_NRD_NRD_1	293	295	PF00675	0.586
CLV_NRD_NRD_1	375	377	PF00675	0.468
CLV_NRD_NRD_1	437	439	PF00675	0.486
CLV_NRD_NRD_1	95	97	PF00675	0.554
CLV_PCSK_KEX2_1	15	17	PF00082	0.590
CLV_PCSK_KEX2_1	200	202	PF00082	0.674
CLV_PCSK_KEX2_1	293	295	PF00082	0.622
CLV_PCSK_KEX2_1	375	377	PF00082	0.468
CLV_PCSK_KEX2_1	437	439	PF00082	0.495
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.674
CLV_PCSK_SKI1_1	250	254	PF00082	0.436
CLV_PCSK_SKI1_1	321	325	PF00082	0.515
CLV_PCSK_SKI1_1	361	365	PF00082	0.468
CLV_PCSK_SKI1_1	465	469	PF00082	0.433
DEG_APCC_DBOX_1	249	257	PF00400	0.431
DEG_SPOP_SBC_1	157	161	PF00917	0.572
DEG_SPOP_SBC_1	304	308	PF00917	0.502
DOC_CYCLIN_RxL_1	244	257	PF00134	0.346
DOC_CYCLIN_RxL_1	332	343	PF00134	0.268
DOC_MAPK_gen_1	200	210	PF00069	0.636
DOC_MAPK_gen_1	250	258	PF00069	0.432
DOC_MAPK_gen_1	437	445	PF00069	0.465
DOC_MAPK_MEF2A_6	201	210	PF00069	0.665
DOC_MAPK_MEF2A_6	437	445	PF00069	0.584
DOC_PP1_RVXF_1	249	256	PF00149	0.429
DOC_PP2B_LxvP_1	313	316	PF13499	0.429
DOC_USP7_MATH_1	119	123	PF00917	0.521
DOC_USP7_MATH_1	139	143	PF00917	0.429
DOC_USP7_MATH_1	149	153	PF00917	0.529
DOC_USP7_MATH_1	157	161	PF00917	0.628
DOC_USP7_MATH_1	177	181	PF00917	0.636
DOC_USP7_MATH_1	215	219	PF00917	0.639
DOC_USP7_MATH_1	225	229	PF00917	0.592
DOC_USP7_MATH_1	289	293	PF00917	0.795
DOC_USP7_MATH_1	304	308	PF00917	0.470
DOC_USP7_MATH_1	31	35	PF00917	0.528
DOC_USP7_MATH_1	415	419	PF00917	0.539
DOC_USP7_MATH_1	59	63	PF00917	0.740
DOC_WW_Pin1_4	101	106	PF00397	0.571
DOC_WW_Pin1_4	153	158	PF00397	0.636
DOC_WW_Pin1_4	170	175	PF00397	0.530
DOC_WW_Pin1_4	262	267	PF00397	0.582
DOC_WW_Pin1_4	85	90	PF00397	0.754
LIG_14-3-3_CanoR_1	296	305	PF00244	0.470
LIG_14-3-3_CanoR_1	32	36	PF00244	0.705
LIG_14-3-3_CanoR_1	335	340	PF00244	0.301
LIG_14-3-3_CanoR_1	348	354	PF00244	0.306
LIG_14-3-3_CanoR_1	390	399	PF00244	0.507
LIG_14-3-3_CanoR_1	473	480	PF00244	0.385
LIG_14-3-3_CanoR_1	70	78	PF00244	0.732
LIG_14-3-3_CanoR_1	8	13	PF00244	0.604
LIG_14-3-3_CanoR_1	87	93	PF00244	0.602
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_BRCT_BRCA1_1	441	445	PF00533	0.420
LIG_FHA_1	201	207	PF00498	0.605
LIG_FHA_1	263	269	PF00498	0.532
LIG_FHA_1	378	384	PF00498	0.373
LIG_FHA_2	186	192	PF00498	0.487
LIG_FHA_2	351	357	PF00498	0.268
LIG_FHA_2	395	401	PF00498	0.376
LIG_FHA_2	69	75	PF00498	0.593
LIG_FHA_2	9	15	PF00498	0.616
LIG_LIR_Gen_1	175	186	PF02991	0.520
LIG_LIR_Gen_1	343	352	PF02991	0.268
LIG_LIR_Nem_3	175	181	PF02991	0.528
LIG_LIR_Nem_3	343	347	PF02991	0.268
LIG_SH2_CRK	9	13	PF00017	0.589
LIG_SH2_STAP1	125	129	PF00017	0.448
LIG_SUMO_SIM_par_1	115	122	PF11976	0.413
LIG_UBA3_1	314	321	PF00899	0.289
LIG_WRC_WIRS_1	238	243	PF05994	0.507
LIG_WW_3	29	33	PF00397	0.510
MOD_CK1_1	156	162	PF00069	0.544
MOD_CK1_1	218	224	PF00069	0.659
MOD_CK1_1	229	235	PF00069	0.543
MOD_CK1_1	260	266	PF00069	0.478
MOD_CK1_1	300	306	PF00069	0.682
MOD_CK1_1	350	356	PF00069	0.268
MOD_CK1_1	391	397	PF00069	0.474
MOD_CK1_1	88	94	PF00069	0.675
MOD_CK2_1	14	20	PF00069	0.762
MOD_CK2_1	394	400	PF00069	0.380
MOD_CK2_1	68	74	PF00069	0.593
MOD_GlcNHglycan	121	124	PF01048	0.474
MOD_GlcNHglycan	160	163	PF01048	0.557
MOD_GlcNHglycan	220	223	PF01048	0.637
MOD_GlcNHglycan	262	265	PF01048	0.474
MOD_GlcNHglycan	299	302	PF01048	0.680
MOD_GlcNHglycan	307	310	PF01048	0.485
MOD_GlcNHglycan	473	476	PF01048	0.507
MOD_GSK3_1	149	156	PF00069	0.595
MOD_GSK3_1	225	232	PF00069	0.594
MOD_GSK3_1	233	240	PF00069	0.577
MOD_GSK3_1	262	269	PF00069	0.559
MOD_GSK3_1	270	277	PF00069	0.557
MOD_GSK3_1	296	303	PF00069	0.745
MOD_GSK3_1	388	395	PF00069	0.479
MOD_GSK3_1	467	474	PF00069	0.571
MOD_GSK3_1	66	73	PF00069	0.618
MOD_GSK3_1	79	86	PF00069	0.581
MOD_GSK3_1	88	95	PF00069	0.601
MOD_LATS_1	333	339	PF00433	0.268
MOD_N-GLC_1	260	265	PF02516	0.481
MOD_N-GLC_1	377	382	PF02516	0.513
MOD_NEK2_1	118	123	PF00069	0.409
MOD_NEK2_1	359	364	PF00069	0.361
MOD_NEK2_1	455	460	PF00069	0.426
MOD_NEK2_1	92	97	PF00069	0.641
MOD_NEK2_2	149	154	PF00069	0.519
MOD_PIKK_1	274	280	PF00454	0.653
MOD_PIKK_1	455	461	PF00454	0.486
MOD_PKA_1	200	206	PF00069	0.522
MOD_PKA_2	14	20	PF00069	0.516
MOD_PKA_2	200	206	PF00069	0.726
MOD_PKA_2	295	301	PF00069	0.502
MOD_PKA_2	31	37	PF00069	0.635
MOD_PKA_2	347	353	PF00069	0.275
MOD_PKA_2	389	395	PF00069	0.510
MOD_PKA_2	7	13	PF00069	0.607
MOD_PKA_2	83	89	PF00069	0.635
MOD_PKA_2	92	98	PF00069	0.607
MOD_PKB_1	294	302	PF00069	0.500
MOD_PKB_1	6	14	PF00069	0.517
MOD_Plk_1	342	348	PF00069	0.268
MOD_Plk_1	79	85	PF00069	0.632
MOD_Plk_4	233	239	PF00069	0.505
MOD_Plk_4	335	341	PF00069	0.293
MOD_Plk_4	368	374	PF00069	0.378
MOD_ProDKin_1	101	107	PF00069	0.563
MOD_ProDKin_1	153	159	PF00069	0.636
MOD_ProDKin_1	170	176	PF00069	0.528
MOD_ProDKin_1	262	268	PF00069	0.591
MOD_ProDKin_1	85	91	PF00069	0.755
MOD_SUMO_rev_2	137	142	PF00179	0.492
MOD_SUMO_rev_2	245	253	PF00179	0.388
MOD_SUMO_rev_2	451	458	PF00179	0.290
TRG_ENDOCYTIC_2	178	181	PF00928	0.534
TRG_ENDOCYTIC_2	9	12	PF00928	0.616
TRG_ER_diArg_1	374	376	PF00400	0.268
TRG_ER_diArg_1	480	483	PF00400	0.542
TRG_ER_diArg_1	6	9	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M8	Leptomonas seymouri	40%	100%
A0A3Q8IC33	Leishmania donovani	86%	96%
A4HES5	Leishmania braziliensis	64%	93%
A4I202	Leishmania infantum	86%	95%
E9AY49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%