Trypsin-like peptidase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9C2_LEIMA

TriTrypDb:

LmjF.26.0720 , LMJLV39_260012600 , LMJSD75_260011100

Length:

1089

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.467
CLV_C14_Caspase3-7	623	627	PF00656	0.518
CLV_C14_Caspase3-7	672	676	PF00656	0.485
CLV_C14_Caspase3-7	871	875	PF00656	0.615
CLV_NRD_NRD_1	1056	1058	PF00675	0.587
CLV_NRD_NRD_1	330	332	PF00675	0.658
CLV_NRD_NRD_1	373	375	PF00675	0.577
CLV_NRD_NRD_1	772	774	PF00675	0.715
CLV_PCSK_FUR_1	1054	1058	PF00082	0.455
CLV_PCSK_KEX2_1	1056	1058	PF00082	0.603
CLV_PCSK_KEX2_1	329	331	PF00082	0.664
CLV_PCSK_KEX2_1	373	375	PF00082	0.580
CLV_PCSK_KEX2_1	653	655	PF00082	0.458
CLV_PCSK_KEX2_1	865	867	PF00082	0.758
CLV_PCSK_PC1ET2_1	653	655	PF00082	0.458
CLV_PCSK_PC1ET2_1	865	867	PF00082	0.644
CLV_PCSK_SKI1_1	1047	1051	PF00082	0.472
CLV_PCSK_SKI1_1	1073	1077	PF00082	0.535
CLV_PCSK_SKI1_1	23	27	PF00082	0.544
CLV_PCSK_SKI1_1	302	306	PF00082	0.648
CLV_PCSK_SKI1_1	434	438	PF00082	0.505
CLV_PCSK_SKI1_1	537	541	PF00082	0.666
CLV_PCSK_SKI1_1	648	652	PF00082	0.334
CLV_PCSK_SKI1_1	774	778	PF00082	0.575
CLV_PCSK_SKI1_1	990	994	PF00082	0.456
DEG_APCC_DBOX_1	808	816	PF00400	0.342
DOC_CYCLIN_RxL_1	1044	1053	PF00134	0.351
DOC_CYCLIN_RxL_1	1070	1079	PF00134	0.530
DOC_CYCLIN_RxL_1	430	438	PF00134	0.486
DOC_CYCLIN_RxL_1	984	994	PF00134	0.428
DOC_CYCLIN_yClb5_NLxxxL_5	696	705	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	345	351	PF00134	0.536
DOC_MAPK_gen_1	156	165	PF00069	0.568
DOC_MAPK_gen_1	865	872	PF00069	0.545
DOC_MAPK_gen_1	975	982	PF00069	0.542
DOC_MAPK_HePTP_8	981	993	PF00069	0.455
DOC_MAPK_MEF2A_6	156	165	PF00069	0.568
DOC_MAPK_MEF2A_6	358	366	PF00069	0.494
DOC_MAPK_MEF2A_6	38	46	PF00069	0.497
DOC_MAPK_MEF2A_6	420	429	PF00069	0.440
DOC_MAPK_MEF2A_6	699	707	PF00069	0.531
DOC_MAPK_MEF2A_6	754	762	PF00069	0.446
DOC_MAPK_MEF2A_6	809	817	PF00069	0.468
DOC_MAPK_MEF2A_6	984	993	PF00069	0.383
DOC_PP1_RVXF_1	933	939	PF00149	0.461
DOC_PP2B_LxvP_1	1022	1025	PF13499	0.621
DOC_PP2B_LxvP_1	345	348	PF13499	0.514
DOC_PP2B_LxvP_1	600	603	PF13499	0.765
DOC_PP2B_PxIxI_1	354	360	PF00149	0.467
DOC_PP4_FxxP_1	1029	1032	PF00568	0.613
DOC_PP4_FxxP_1	296	299	PF00568	0.744
DOC_USP7_MATH_1	1009	1013	PF00917	0.479
DOC_USP7_MATH_1	104	108	PF00917	0.627
DOC_USP7_MATH_1	194	198	PF00917	0.712
DOC_USP7_MATH_1	212	216	PF00917	0.521
DOC_USP7_MATH_1	312	316	PF00917	0.661
DOC_USP7_MATH_1	335	339	PF00917	0.564
DOC_USP7_MATH_1	502	506	PF00917	0.679
DOC_USP7_MATH_1	515	519	PF00917	0.666
DOC_USP7_MATH_1	521	525	PF00917	0.593
DOC_USP7_MATH_1	553	557	PF00917	0.704
DOC_USP7_MATH_1	572	576	PF00917	0.545
DOC_USP7_MATH_1	745	749	PF00917	0.480
DOC_USP7_MATH_1	868	872	PF00917	0.544
DOC_USP7_MATH_1	918	922	PF00917	0.645
DOC_USP7_MATH_1	923	927	PF00917	0.590
DOC_USP7_MATH_1	94	98	PF00917	0.646
DOC_USP7_MATH_1	967	971	PF00917	0.552
DOC_WW_Pin1_4	1031	1036	PF00397	0.639
DOC_WW_Pin1_4	1076	1081	PF00397	0.479
DOC_WW_Pin1_4	108	113	PF00397	0.621
DOC_WW_Pin1_4	128	133	PF00397	0.411
DOC_WW_Pin1_4	174	179	PF00397	0.655
DOC_WW_Pin1_4	243	248	PF00397	0.742
DOC_WW_Pin1_4	265	270	PF00397	0.696
DOC_WW_Pin1_4	286	291	PF00397	0.578
DOC_WW_Pin1_4	526	531	PF00397	0.746
DOC_WW_Pin1_4	557	562	PF00397	0.665
DOC_WW_Pin1_4	873	878	PF00397	0.702
DOC_WW_Pin1_4	912	917	PF00397	0.774
DOC_WW_Pin1_4	929	934	PF00397	0.502
LIG_14-3-3_CanoR_1	373	377	PF00244	0.531
LIG_14-3-3_CanoR_1	420	426	PF00244	0.459
LIG_14-3-3_CanoR_1	446	454	PF00244	0.614
LIG_14-3-3_CanoR_1	510	520	PF00244	0.660
LIG_14-3-3_CanoR_1	537	542	PF00244	0.629
LIG_14-3-3_CanoR_1	754	758	PF00244	0.457
LIG_14-3-3_CanoR_1	778	786	PF00244	0.501
LIG_14-3-3_CanoR_1	802	807	PF00244	0.474
LIG_14-3-3_CanoR_1	990	996	PF00244	0.441
LIG_APCC_ABBA_1	703	708	PF00400	0.595
LIG_BIR_III_4	542	546	PF00653	0.647
LIG_BRCT_BRCA1_1	138	142	PF00533	0.477
LIG_BRCT_BRCA1_1	72	76	PF00533	0.562
LIG_BRCT_BRCA1_1	936	940	PF00533	0.496
LIG_EVH1_2	1025	1029	PF00568	0.607
LIG_FHA_1	1043	1049	PF00498	0.483
LIG_FHA_1	123	129	PF00498	0.547
LIG_FHA_1	218	224	PF00498	0.570
LIG_FHA_1	38	44	PF00498	0.458
LIG_FHA_1	588	594	PF00498	0.519
LIG_FHA_1	683	689	PF00498	0.470
LIG_FHA_1	803	809	PF00498	0.470
LIG_FHA_1	812	818	PF00498	0.367
LIG_FHA_1	986	992	PF00498	0.525
LIG_FHA_2	1058	1064	PF00498	0.379
LIG_FHA_2	226	232	PF00498	0.519
LIG_FHA_2	233	239	PF00498	0.626
LIG_FHA_2	710	716	PF00498	0.504
LIG_FHA_2	843	849	PF00498	0.539
LIG_LIR_Apic_2	1027	1032	PF02991	0.611
LIG_LIR_Apic_2	294	299	PF02991	0.628
LIG_LIR_Gen_1	16	25	PF02991	0.572
LIG_LIR_Gen_1	226	234	PF02991	0.526
LIG_LIR_Gen_1	613	622	PF02991	0.491
LIG_LIR_Gen_1	831	841	PF02991	0.538
LIG_LIR_Gen_1	879	886	PF02991	0.547
LIG_LIR_Nem_3	16	21	PF02991	0.529
LIG_LIR_Nem_3	167	172	PF02991	0.552
LIG_LIR_Nem_3	226	232	PF02991	0.501
LIG_LIR_Nem_3	387	391	PF02991	0.460
LIG_LIR_Nem_3	394	399	PF02991	0.516
LIG_LIR_Nem_3	412	416	PF02991	0.484
LIG_LIR_Nem_3	613	617	PF02991	0.490
LIG_LIR_Nem_3	831	836	PF02991	0.551
LIG_LIR_Nem_3	879	884	PF02991	0.619
LIG_LIR_Nem_3	937	941	PF02991	0.477
LIG_LIR_Nem_3	994	998	PF02991	0.464
LIG_LYPXL_yS_3	867	870	PF13949	0.550
LIG_MLH1_MIPbox_1	936	940	PF16413	0.496
LIG_NRBOX	118	124	PF00104	0.505
LIG_NRBOX	424	430	PF00104	0.431
LIG_NRBOX	811	817	PF00104	0.453
LIG_NRBOX	988	994	PF00104	0.448
LIG_PCNA_yPIPBox_3	722	735	PF02747	0.440
LIG_PCNA_yPIPBox_3	800	809	PF02747	0.434
LIG_Pex14_2	614	618	PF04695	0.480
LIG_Pex14_2	833	837	PF04695	0.426
LIG_Pex14_2	840	844	PF04695	0.338
LIG_Rb_pABgroove_1	431	439	PF01858	0.490
LIG_SH2_CRK	633	637	PF00017	0.500
LIG_SH2_STAP1	736	740	PF00017	0.345
LIG_SH2_STAT3	376	379	PF00017	0.503
LIG_SH2_STAT3	720	723	PF00017	0.419
LIG_SH2_STAT5	127	130	PF00017	0.480
LIG_SH2_STAT5	205	208	PF00017	0.695
LIG_SH2_STAT5	229	232	PF00017	0.512
LIG_SH2_STAT5	388	391	PF00017	0.453
LIG_SH2_STAT5	720	723	PF00017	0.588
LIG_SH3_1	633	639	PF00018	0.443
LIG_SH3_1	910	916	PF00018	0.564
LIG_SH3_3	1029	1035	PF00018	0.639
LIG_SH3_3	110	116	PF00018	0.705
LIG_SH3_3	239	245	PF00018	0.704
LIG_SH3_3	600	606	PF00018	0.704
LIG_SH3_3	633	639	PF00018	0.552
LIG_SH3_3	910	916	PF00018	0.613
LIG_SH3_3	995	1001	PF00018	0.422
LIG_SH3_4	605	612	PF00018	0.557
LIG_SUMO_SIM_anti_2	1011	1017	PF11976	0.563
LIG_SUMO_SIM_anti_2	647	653	PF11976	0.345
LIG_SUMO_SIM_anti_2	810	817	PF11976	0.460
LIG_SUMO_SIM_par_1	1047	1053	PF11976	0.348
LIG_SUMO_SIM_par_1	347	352	PF11976	0.555
LIG_SUMO_SIM_par_1	598	604	PF11976	0.476
LIG_SUMO_SIM_par_1	708	715	PF11976	0.442
LIG_SUMO_SIM_par_1	956	962	PF11976	0.470
LIG_SxIP_EBH_1	347	358	PF03271	0.540
LIG_TRAF2_1	613	616	PF00917	0.497
LIG_TRAF2_1	678	681	PF00917	0.576
LIG_TYR_ITIM	227	232	PF00017	0.503
LIG_UBA3_1	350	358	PF00899	0.546
LIG_WRC_WIRS_1	1038	1043	PF05994	0.553
LIG_WRC_WIRS_1	611	616	PF05994	0.516
MOD_CDC14_SPxK_1	177	180	PF00782	0.645
MOD_CDC14_SPxK_1	932	935	PF00782	0.490
MOD_CDK_SPK_2	1031	1036	PF00069	0.639
MOD_CDK_SPK_2	174	179	PF00069	0.552
MOD_CDK_SPK_2	243	248	PF00069	0.592
MOD_CDK_SPK_2	557	562	PF00069	0.658
MOD_CDK_SPxK_1	174	180	PF00069	0.666
MOD_CDK_SPxK_1	929	935	PF00069	0.535
MOD_CDK_SPxxK_3	265	272	PF00069	0.631
MOD_CDK_SPxxK_3	873	880	PF00069	0.650
MOD_CK1_1	1030	1036	PF00069	0.688
MOD_CK1_1	1037	1043	PF00069	0.542
MOD_CK1_1	1059	1065	PF00069	0.471
MOD_CK1_1	107	113	PF00069	0.730
MOD_CK1_1	174	180	PF00069	0.660
MOD_CK1_1	251	257	PF00069	0.731
MOD_CK1_1	261	267	PF00069	0.674
MOD_CK1_1	450	456	PF00069	0.654
MOD_CK1_1	486	492	PF00069	0.582
MOD_CK1_1	514	520	PF00069	0.737
MOD_CK1_1	524	530	PF00069	0.617
MOD_CK1_1	557	563	PF00069	0.678
MOD_CK1_1	576	582	PF00069	0.591
MOD_CK1_1	741	747	PF00069	0.550
MOD_CK1_1	876	882	PF00069	0.689
MOD_CK1_1	925	931	PF00069	0.641
MOD_CK1_1	946	952	PF00069	0.501
MOD_CK2_1	1005	1011	PF00069	0.546
MOD_CK2_1	1037	1043	PF00069	0.493
MOD_CK2_1	1057	1063	PF00069	0.502
MOD_CK2_1	16	22	PF00069	0.524
MOD_CK2_1	225	231	PF00069	0.515
MOD_CK2_1	289	295	PF00069	0.704
MOD_CK2_1	392	398	PF00069	0.611
MOD_CK2_1	610	616	PF00069	0.532
MOD_CK2_1	709	715	PF00069	0.502
MOD_CK2_1	753	759	PF00069	0.407
MOD_CK2_1	882	888	PF00069	0.545
MOD_Cter_Amidation	371	374	PF01082	0.571
MOD_GlcNHglycan	1007	1010	PF01048	0.524
MOD_GlcNHglycan	1029	1032	PF01048	0.705
MOD_GlcNHglycan	1066	1069	PF01048	0.428
MOD_GlcNHglycan	166	169	PF01048	0.592
MOD_GlcNHglycan	173	176	PF01048	0.516
MOD_GlcNHglycan	18	21	PF01048	0.576
MOD_GlcNHglycan	253	256	PF01048	0.807
MOD_GlcNHglycan	260	263	PF01048	0.769
MOD_GlcNHglycan	269	272	PF01048	0.570
MOD_GlcNHglycan	314	317	PF01048	0.666
MOD_GlcNHglycan	34	37	PF01048	0.423
MOD_GlcNHglycan	351	354	PF01048	0.494
MOD_GlcNHglycan	401	404	PF01048	0.512
MOD_GlcNHglycan	468	471	PF01048	0.603
MOD_GlcNHglycan	478	481	PF01048	0.668
MOD_GlcNHglycan	513	516	PF01048	0.715
MOD_GlcNHglycan	64	67	PF01048	0.700
MOD_GlcNHglycan	685	688	PF01048	0.532
MOD_GlcNHglycan	743	746	PF01048	0.549
MOD_GlcNHglycan	747	750	PF01048	0.452
MOD_GlcNHglycan	755	758	PF01048	0.304
MOD_GlcNHglycan	859	862	PF01048	0.658
MOD_GlcNHglycan	894	897	PF01048	0.679
MOD_GlcNHglycan	96	99	PF01048	0.724
MOD_GSK3_1	1005	1012	PF00069	0.469
MOD_GSK3_1	1027	1034	PF00069	0.772
MOD_GSK3_1	104	111	PF00069	0.702
MOD_GSK3_1	170	177	PF00069	0.625
MOD_GSK3_1	182	189	PF00069	0.615
MOD_GSK3_1	190	197	PF00069	0.611
MOD_GSK3_1	254	261	PF00069	0.755
MOD_GSK3_1	263	270	PF00069	0.603
MOD_GSK3_1	466	473	PF00069	0.686
MOD_GSK3_1	492	499	PF00069	0.685
MOD_GSK3_1	511	518	PF00069	0.597
MOD_GSK3_1	537	544	PF00069	0.702
MOD_GSK3_1	553	560	PF00069	0.548
MOD_GSK3_1	572	579	PF00069	0.567
MOD_GSK3_1	601	608	PF00069	0.665
MOD_GSK3_1	70	77	PF00069	0.667
MOD_GSK3_1	741	748	PF00069	0.598
MOD_GSK3_1	888	895	PF00069	0.535
MOD_GSK3_1	918	925	PF00069	0.772
MOD_N-GLC_1	249	254	PF02516	0.586
MOD_N-GLC_1	570	575	PF02516	0.629
MOD_N-GLC_1	67	72	PF02516	0.705
MOD_N-GLC_2	490	492	PF02516	0.650
MOD_NEK2_1	122	127	PF00069	0.506
MOD_NEK2_1	150	155	PF00069	0.505
MOD_NEK2_1	171	176	PF00069	0.637
MOD_NEK2_1	225	230	PF00069	0.488
MOD_NEK2_1	249	254	PF00069	0.628
MOD_NEK2_1	349	354	PF00069	0.564
MOD_NEK2_1	364	369	PF00069	0.306
MOD_NEK2_1	428	433	PF00069	0.455
MOD_NEK2_1	496	501	PF00069	0.698
MOD_NEK2_1	6	11	PF00069	0.659
MOD_NEK2_1	62	67	PF00069	0.650
MOD_NEK2_1	752	757	PF00069	0.399
MOD_NEK2_1	796	801	PF00069	0.390
MOD_NEK2_1	941	946	PF00069	0.358
MOD_NEK2_1	991	996	PF00069	0.509
MOD_NEK2_2	882	887	PF00069	0.546
MOD_NEK2_2	985	990	PF00069	0.443
MOD_PIKK_1	249	255	PF00454	0.800
MOD_PIKK_1	25	31	PF00454	0.540
MOD_PIKK_1	605	611	PF00454	0.568
MOD_PIKK_1	777	783	PF00454	0.528
MOD_PIKK_1	85	91	PF00454	0.649
MOD_PKA_1	1056	1062	PF00069	0.477
MOD_PKA_2	1056	1062	PF00069	0.477
MOD_PKA_2	107	113	PF00069	0.728
MOD_PKA_2	186	192	PF00069	0.740
MOD_PKA_2	32	38	PF00069	0.526
MOD_PKA_2	372	378	PF00069	0.536
MOD_PKA_2	753	759	PF00069	0.460
MOD_PKA_2	772	778	PF00069	0.437
MOD_PKA_2	801	807	PF00069	0.478
MOD_PKB_1	1054	1062	PF00069	0.466
MOD_PKB_1	481	489	PF00069	0.562
MOD_Plk_1	136	142	PF00069	0.533
MOD_Plk_1	450	456	PF00069	0.582
MOD_Plk_1	54	60	PF00069	0.516
MOD_Plk_1	882	888	PF00069	0.618
MOD_Plk_2-3	217	223	PF00069	0.594
MOD_Plk_2-3	392	398	PF00069	0.560
MOD_Plk_4	1011	1017	PF00069	0.559
MOD_Plk_4	123	129	PF00069	0.469
MOD_Plk_4	428	434	PF00069	0.463
MOD_Plk_4	709	715	PF00069	0.550
MOD_Plk_4	730	736	PF00069	0.314
MOD_Plk_4	802	808	PF00069	0.472
MOD_Plk_4	811	817	PF00069	0.386
MOD_Plk_4	934	940	PF00069	0.432
MOD_ProDKin_1	1031	1037	PF00069	0.640
MOD_ProDKin_1	1076	1082	PF00069	0.484
MOD_ProDKin_1	108	114	PF00069	0.618
MOD_ProDKin_1	128	134	PF00069	0.410
MOD_ProDKin_1	174	180	PF00069	0.666
MOD_ProDKin_1	243	249	PF00069	0.742
MOD_ProDKin_1	265	271	PF00069	0.697
MOD_ProDKin_1	286	292	PF00069	0.578
MOD_ProDKin_1	526	532	PF00069	0.746
MOD_ProDKin_1	557	563	PF00069	0.666
MOD_ProDKin_1	873	879	PF00069	0.702
MOD_ProDKin_1	912	918	PF00069	0.773
MOD_ProDKin_1	929	935	PF00069	0.495
MOD_SUMO_for_1	178	181	PF00179	0.675
MOD_SUMO_for_1	652	655	PF00179	0.512
MOD_SUMO_rev_2	153	161	PF00179	0.475
MOD_SUMO_rev_2	962	970	PF00179	0.542
TRG_DiLeu_BaEn_1	647	652	PF01217	0.337
TRG_DiLeu_BaEn_1	987	992	PF01217	0.441
TRG_DiLeu_BaLyEn_6	1044	1049	PF01217	0.471
TRG_DiLeu_BaLyEn_6	1070	1075	PF01217	0.493
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.531
TRG_DiLeu_LyEn_5	987	992	PF01217	0.441
TRG_ENDOCYTIC_2	229	232	PF00928	0.512
TRG_ENDOCYTIC_2	3	6	PF00928	0.683
TRG_ENDOCYTIC_2	867	870	PF00928	0.550
TRG_ER_diArg_1	1054	1057	PF00400	0.557
TRG_ER_diArg_1	196	199	PF00400	0.617
TRG_ER_diArg_1	329	331	PF00400	0.634
TRG_ER_diArg_1	481	484	PF00400	0.588
TRG_ER_diArg_1	975	978	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICP8	Leishmania donovani	88%	100%
A4HES7	Leishmania braziliensis	67%	96%
A4I204	Leishmania infantum	88%	100%
E9AY51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%