Regulator of chromosome condensation (RCC1) family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of chromosome condensation (RCC1) repeat, putative

Species:

Leishmania major

UniProt:

Q4Q9C0_LEIMA

TriTrypDb:

LmjF.26.0740 , LMJLV39_260012800 , LMJSD75_260011300

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9C0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.433
CLV_NRD_NRD_1	357	359	PF00675	0.402
CLV_NRD_NRD_1	469	471	PF00675	0.385
CLV_NRD_NRD_1	835	837	PF00675	0.429
CLV_PCSK_KEX2_1	306	308	PF00082	0.275
CLV_PCSK_KEX2_1	469	471	PF00082	0.385
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.275
CLV_PCSK_SKI1_1	254	258	PF00082	0.442
CLV_PCSK_SKI1_1	492	496	PF00082	0.299
CLV_PCSK_SKI1_1	562	566	PF00082	0.354
CLV_PCSK_SKI1_1	726	730	PF00082	0.421
CLV_PCSK_SKI1_1	795	799	PF00082	0.451
CLV_PCSK_SKI1_1	83	87	PF00082	0.417
DEG_APCC_DBOX_1	82	90	PF00400	0.479
DEG_Nend_UBRbox_3	1	3	PF02207	0.607
DEG_SCF_FBW7_2	728	735	PF00400	0.376
DOC_CKS1_1	5	10	PF01111	0.380
DOC_CKS1_1	55	60	PF01111	0.422
DOC_CKS1_1	678	683	PF01111	0.369
DOC_CKS1_1	727	732	PF01111	0.519
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.404
DOC_MAPK_DCC_7	625	634	PF00069	0.486
DOC_MAPK_gen_1	304	311	PF00069	0.436
DOC_MAPK_MEF2A_6	239	248	PF00069	0.512
DOC_MAPK_MEF2A_6	427	436	PF00069	0.359
DOC_PP1_RVXF_1	505	511	PF00149	0.389
DOC_PP1_RVXF_1	560	567	PF00149	0.333
DOC_PP2B_LxvP_1	423	426	PF13499	0.366
DOC_PP2B_LxvP_1	434	437	PF13499	0.378
DOC_USP7_MATH_1	137	141	PF00917	0.429
DOC_USP7_MATH_1	144	148	PF00917	0.371
DOC_USP7_MATH_1	181	185	PF00917	0.476
DOC_USP7_MATH_1	267	271	PF00917	0.344
DOC_USP7_MATH_1	312	316	PF00917	0.386
DOC_USP7_MATH_1	770	774	PF00917	0.519
DOC_WW_Pin1_4	16	21	PF00397	0.455
DOC_WW_Pin1_4	230	235	PF00397	0.562
DOC_WW_Pin1_4	293	298	PF00397	0.317
DOC_WW_Pin1_4	4	9	PF00397	0.520
DOC_WW_Pin1_4	54	59	PF00397	0.397
DOC_WW_Pin1_4	627	632	PF00397	0.476
DOC_WW_Pin1_4	677	682	PF00397	0.341
DOC_WW_Pin1_4	726	731	PF00397	0.512
LIG_14-3-3_CanoR_1	367	373	PF00244	0.308
LIG_14-3-3_CanoR_1	513	523	PF00244	0.344
LIG_14-3-3_CanoR_1	557	561	PF00244	0.357
LIG_14-3-3_CanoR_1	683	690	PF00244	0.444
LIG_Actin_WH2_2	438	453	PF00022	0.448
LIG_BRCT_BRCA1_1	770	774	PF00533	0.411
LIG_FHA_1	20	26	PF00498	0.511
LIG_FHA_1	275	281	PF00498	0.386
LIG_FHA_1	316	322	PF00498	0.322
LIG_FHA_1	368	374	PF00498	0.314
LIG_FHA_1	416	422	PF00498	0.423
LIG_FHA_1	427	433	PF00498	0.370
LIG_FHA_1	462	468	PF00498	0.361
LIG_FHA_1	611	617	PF00498	0.546
LIG_FHA_1	622	628	PF00498	0.497
LIG_FHA_1	729	735	PF00498	0.379
LIG_FHA_1	819	825	PF00498	0.543
LIG_FHA_2	126	132	PF00498	0.545
LIG_FHA_2	216	222	PF00498	0.375
LIG_FHA_2	528	534	PF00498	0.487
LIG_HCF-1_HBM_1	676	679	PF13415	0.350
LIG_IRF3_LxIS_1	463	468	PF10401	0.374
LIG_LIR_Apic_2	343	347	PF02991	0.350
LIG_LIR_Apic_2	676	681	PF02991	0.417
LIG_LIR_Gen_1	140	148	PF02991	0.432
LIG_LIR_Gen_1	191	200	PF02991	0.337
LIG_LIR_Gen_1	315	322	PF02991	0.401
LIG_LIR_Gen_1	771	781	PF02991	0.479
LIG_LIR_Nem_3	140	146	PF02991	0.432
LIG_LIR_Nem_3	191	196	PF02991	0.369
LIG_LIR_Nem_3	315	319	PF02991	0.395
LIG_LIR_Nem_3	406	411	PF02991	0.360
LIG_LIR_Nem_3	579	583	PF02991	0.384
LIG_LIR_Nem_3	593	597	PF02991	0.321
LIG_LIR_Nem_3	676	682	PF02991	0.483
LIG_LIR_Nem_3	755	761	PF02991	0.396
LIG_LIR_Nem_3	76	82	PF02991	0.379
LIG_LIR_Nem_3	771	777	PF02991	0.405
LIG_Pex14_2	316	320	PF04695	0.320
LIG_PTB_Apo_2	98	105	PF02174	0.522
LIG_REV1ctd_RIR_1	508	517	PF16727	0.389
LIG_REV1ctd_RIR_1	687	696	PF16727	0.428
LIG_SH2_CRK	143	147	PF00017	0.442
LIG_SH2_CRK	174	178	PF00017	0.525
LIG_SH2_CRK	193	197	PF00017	0.365
LIG_SH2_CRK	266	270	PF00017	0.454
LIG_SH2_CRK	344	348	PF00017	0.416
LIG_SH2_CRK	53	57	PF00017	0.562
LIG_SH2_CRK	555	559	PF00017	0.354
LIG_SH2_CRK	679	683	PF00017	0.428
LIG_SH2_GRB2like	12	15	PF00017	0.461
LIG_SH2_NCK_1	143	147	PF00017	0.442
LIG_SH2_NCK_1	266	270	PF00017	0.376
LIG_SH2_NCK_1	53	57	PF00017	0.562
LIG_SH2_STAP1	193	197	PF00017	0.429
LIG_SH2_STAP1	408	412	PF00017	0.436
LIG_SH2_STAP1	838	842	PF00017	0.468
LIG_SH2_STAT3	838	841	PF00017	0.540
LIG_SH2_STAT5	12	15	PF00017	0.550
LIG_SH2_STAT5	276	279	PF00017	0.387
LIG_SH2_STAT5	29	32	PF00017	0.384
LIG_SH2_STAT5	408	411	PF00017	0.339
LIG_SH2_STAT5	580	583	PF00017	0.344
LIG_SH2_STAT5	679	682	PF00017	0.330
LIG_SH2_STAT5	698	701	PF00017	0.354
LIG_SH2_STAT5	710	713	PF00017	0.252
LIG_SH2_STAT5	745	748	PF00017	0.327
LIG_SH3_3	113	119	PF00018	0.410
LIG_SH3_3	228	234	PF00018	0.486
LIG_SH3_3	343	349	PF00018	0.442
LIG_SH3_3	497	503	PF00018	0.381
LIG_SH3_3	625	631	PF00018	0.419
LIG_SH3_3	724	730	PF00018	0.444
LIG_SH3_3	96	102	PF00018	0.385
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.340
LIG_SUMO_SIM_par_1	441	447	PF11976	0.486
LIG_SUMO_SIM_par_1	463	468	PF11976	0.403
LIG_SUMO_SIM_par_1	630	636	PF11976	0.446
LIG_SUMO_SIM_par_1	804	811	PF11976	0.393
LIG_UBA3_1	633	638	PF00899	0.455
MOD_CDK_SPxK_1	677	683	PF00069	0.354
MOD_CDK_SPxxK_3	16	23	PF00069	0.395
MOD_CK1_1	19	25	PF00069	0.484
MOD_CK1_1	191	197	PF00069	0.369
MOD_CK1_1	233	239	PF00069	0.532
MOD_CK1_1	274	280	PF00069	0.386
MOD_CK1_1	315	321	PF00069	0.284
MOD_CK1_1	415	421	PF00069	0.396
MOD_CK1_1	444	450	PF00069	0.576
MOD_CK1_1	472	478	PF00069	0.354
MOD_CK1_1	576	582	PF00069	0.449
MOD_CK1_1	593	599	PF00069	0.312
MOD_CK1_1	621	627	PF00069	0.499
MOD_CK1_1	768	774	PF00069	0.498
MOD_CK2_1	181	187	PF00069	0.369
MOD_CK2_1	215	221	PF00069	0.376
MOD_CK2_1	527	533	PF00069	0.478
MOD_CK2_1	776	782	PF00069	0.579
MOD_Cter_Amidation	304	307	PF01082	0.275
MOD_Cter_Amidation	356	359	PF01082	0.350
MOD_GlcNHglycan	139	142	PF01048	0.434
MOD_GlcNHglycan	200	203	PF01048	0.385
MOD_GlcNHglycan	260	263	PF01048	0.412
MOD_GlcNHglycan	269	272	PF01048	0.365
MOD_GlcNHglycan	282	285	PF01048	0.372
MOD_GlcNHglycan	30	33	PF01048	0.490
MOD_GlcNHglycan	414	417	PF01048	0.353
MOD_GlcNHglycan	585	588	PF01048	0.396
MOD_GlcNHglycan	620	623	PF01048	0.657
MOD_GlcNHglycan	758	761	PF01048	0.379
MOD_GlcNHglycan	765	768	PF01048	0.476
MOD_GSK3_1	267	274	PF00069	0.428
MOD_GSK3_1	406	413	PF00069	0.378
MOD_GSK3_1	415	422	PF00069	0.374
MOD_GSK3_1	461	468	PF00069	0.388
MOD_GSK3_1	511	518	PF00069	0.344
MOD_GSK3_1	523	530	PF00069	0.281
MOD_GSK3_1	722	729	PF00069	0.432
MOD_GSK3_1	744	751	PF00069	0.352
MOD_GSK3_1	752	759	PF00069	0.348
MOD_N-GLC_1	16	21	PF02516	0.487
MOD_N-GLC_1	167	172	PF02516	0.416
MOD_N-GLC_1	191	196	PF02516	0.357
MOD_N-GLC_1	352	357	PF02516	0.350
MOD_N-GLC_1	406	411	PF02516	0.363
MOD_N-GLC_1	427	432	PF02516	0.381
MOD_N-GLC_1	539	544	PF02516	0.428
MOD_N-GLC_1	618	623	PF02516	0.620
MOD_N-GLC_1	752	757	PF02516	0.516
MOD_N-GLC_2	158	160	PF02516	0.412
MOD_N-GLC_2	169	171	PF02516	0.398
MOD_NEK2_1	167	172	PF00069	0.368
MOD_NEK2_1	196	201	PF00069	0.340
MOD_NEK2_1	258	263	PF00069	0.487
MOD_NEK2_1	352	357	PF00069	0.370
MOD_NEK2_1	368	373	PF00069	0.345
MOD_NEK2_1	421	426	PF00069	0.382
MOD_NEK2_1	465	470	PF00069	0.421
MOD_NEK2_1	486	491	PF00069	0.285
MOD_NEK2_1	511	516	PF00069	0.319
MOD_NEK2_1	523	528	PF00069	0.376
MOD_NEK2_1	583	588	PF00069	0.362
MOD_NEK2_1	633	638	PF00069	0.548
MOD_NEK2_1	722	727	PF00069	0.371
MOD_NEK2_1	748	753	PF00069	0.338
MOD_NEK2_1	756	761	PF00069	0.352
MOD_NEK2_2	144	149	PF00069	0.356
MOD_NEK2_2	271	276	PF00069	0.413
MOD_NEK2_2	312	317	PF00069	0.354
MOD_PIKK_1	125	131	PF00454	0.555
MOD_PIKK_1	486	492	PF00454	0.339
MOD_PIKK_1	556	562	PF00454	0.418
MOD_PKA_1	469	475	PF00069	0.354
MOD_PKA_2	215	221	PF00069	0.504
MOD_PKA_2	469	475	PF00069	0.354
MOD_PKA_2	556	562	PF00069	0.428
MOD_PKA_2	682	688	PF00069	0.350
MOD_Plk_1	191	197	PF00069	0.349
MOD_Plk_1	208	214	PF00069	0.383
MOD_Plk_1	342	348	PF00069	0.458
MOD_Plk_1	406	412	PF00069	0.364
MOD_Plk_1	427	433	PF00069	0.385
MOD_Plk_1	539	545	PF00069	0.420
MOD_Plk_1	562	568	PF00069	0.321
MOD_Plk_1	752	758	PF00069	0.470
MOD_Plk_2-3	215	221	PF00069	0.504
MOD_Plk_2-3	776	782	PF00069	0.563
MOD_Plk_4	181	187	PF00069	0.463
MOD_Plk_4	191	197	PF00069	0.299
MOD_Plk_4	208	214	PF00069	0.349
MOD_Plk_4	271	277	PF00069	0.384
MOD_Plk_4	315	321	PF00069	0.423
MOD_Plk_4	368	374	PF00069	0.314
MOD_Plk_4	406	412	PF00069	0.386
MOD_Plk_4	427	433	PF00069	0.375
MOD_Plk_4	576	582	PF00069	0.386
MOD_Plk_4	74	80	PF00069	0.367
MOD_ProDKin_1	16	22	PF00069	0.446
MOD_ProDKin_1	230	236	PF00069	0.562
MOD_ProDKin_1	293	299	PF00069	0.317
MOD_ProDKin_1	4	10	PF00069	0.514
MOD_ProDKin_1	54	60	PF00069	0.398
MOD_ProDKin_1	627	633	PF00069	0.480
MOD_ProDKin_1	677	683	PF00069	0.341
MOD_ProDKin_1	726	732	PF00069	0.516
MOD_SUMO_for_1	784	787	PF00179	0.453
MOD_SUMO_rev_2	249	256	PF00179	0.517
MOD_SUMO_rev_2	605	611	PF00179	0.545
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.402
TRG_ENDOCYTIC_2	12	15	PF00928	0.465
TRG_ENDOCYTIC_2	143	146	PF00928	0.441
TRG_ENDOCYTIC_2	174	177	PF00928	0.493
TRG_ENDOCYTIC_2	193	196	PF00928	0.381
TRG_ENDOCYTIC_2	266	269	PF00928	0.453
TRG_ENDOCYTIC_2	408	411	PF00928	0.339
TRG_ENDOCYTIC_2	53	56	PF00928	0.581
TRG_ENDOCYTIC_2	555	558	PF00928	0.354
TRG_ENDOCYTIC_2	580	583	PF00928	0.388
TRG_ENDOCYTIC_2	679	682	PF00928	0.428
TRG_ENDOCYTIC_2	745	748	PF00928	0.346
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P531	Leptomonas seymouri	81%	98%
A0A1X0NSD6	Trypanosomatidae	49%	99%
A0A1X0NT20	Trypanosomatidae	25%	72%
A0A3S7WZR9	Leishmania donovani	98%	100%
A0A422NN30	Trypanosoma rangeli	48%	100%
A4HES9	Leishmania braziliensis	92%	100%
A4I206	Leishmania infantum	98%	100%
C9ZS06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	73%
C9ZS09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AY53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BPX5	Trypanosoma cruzi	49%	100%
V5BUH8	Trypanosoma cruzi	27%	74%