RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q9B8_LEIMA

TriTrypDb:

LmjF.26.0760 , LMJLV39_260013000 , LMJSD75_260011500

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0005686	U2 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0071011	precatalytic spliceosome	4	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q9B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9B8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.470
CLV_NRD_NRD_1	71	73	PF00675	0.272
CLV_PCSK_KEX2_1	29	31	PF00082	0.459
CLV_PCSK_SKI1_1	124	128	PF00082	0.571
CLV_PCSK_SKI1_1	29	33	PF00082	0.582
DEG_Kelch_Keap1_1	117	122	PF01344	0.575
DEG_Nend_UBRbox_1	1	4	PF02207	0.710
DOC_CKS1_1	11	16	PF01111	0.533
DOC_CYCLIN_RxL_1	26	33	PF00134	0.521
DOC_PP2B_PxIxI_1	23	29	PF00149	0.398
DOC_WW_Pin1_4	10	15	PF00397	0.578
LIG_14-3-3_CanoR_1	29	35	PF00244	0.632
LIG_14-3-3_CterR_2	153	158	PF00244	0.541
LIG_FHA_1	78	84	PF00498	0.445
LIG_LIR_Gen_1	13	24	PF02991	0.451
LIG_LIR_Gen_1	55	64	PF02991	0.448
LIG_LIR_Gen_1	80	88	PF02991	0.455
LIG_LIR_Nem_3	13	19	PF02991	0.513
LIG_LIR_Nem_3	22	28	PF02991	0.407
LIG_LIR_Nem_3	55	60	PF02991	0.448
LIG_LIR_Nem_3	80	85	PF02991	0.445
LIG_PDZ_Class_2	153	158	PF00595	0.490
LIG_SH2_CRK	16	20	PF00017	0.474
LIG_SH2_STAP1	147	151	PF00017	0.433
LIG_SH2_STAT5	12	15	PF00017	0.536
LIG_SH3_3	131	137	PF00018	0.503
LIG_SH3_3	8	14	PF00018	0.555
LIG_SUMO_SIM_par_1	52	58	PF11976	0.533
MOD_CK1_1	117	123	PF00069	0.705
MOD_CK1_1	6	12	PF00069	0.596
MOD_CK2_1	116	122	PF00069	0.658
MOD_GlcNHglycan	119	122	PF01048	0.717
MOD_GlcNHglycan	21	24	PF01048	0.384
MOD_GlcNHglycan	5	8	PF01048	0.577
MOD_GlcNHglycan	89	92	PF01048	0.256
MOD_GSK3_1	110	117	PF00069	0.595
MOD_GSK3_1	6	13	PF00069	0.570
MOD_NEK2_1	19	24	PF00069	0.490
MOD_NEK2_1	77	82	PF00069	0.460
MOD_PIKK_1	110	116	PF00454	0.600
MOD_PIKK_1	30	36	PF00454	0.558
MOD_PIKK_1	55	61	PF00454	0.444
MOD_PKA_2	71	77	PF00069	0.456
MOD_Plk_1	41	47	PF00069	0.455
MOD_Plk_4	52	58	PF00069	0.444
MOD_ProDKin_1	10	16	PF00069	0.574
MOD_SUMO_rev_2	117	126	PF00179	0.593
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.538
TRG_ENDOCYTIC_2	16	19	PF00928	0.476
TRG_ER_diArg_1	28	30	PF00400	0.457
TRG_ER_diArg_1	69	72	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP8	Leptomonas seymouri	70%	99%
A0A0S4J184	Bodo saltans	39%	99%
A0A1X0NSD2	Trypanosomatidae	55%	98%
A0A3R7KI07	Trypanosoma rangeli	51%	100%
A0A3S7WZQ4	Leishmania donovani	94%	100%
A4HET1	Leishmania braziliensis	82%	97%
A4I207	Leishmania infantum	94%	100%
C9ZS05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	93%
E9AY55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BUP6	Trypanosoma cruzi	51%	100%