JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q9B7_LEIMA

TriTrypDb:

LmjF.26.0770 , LMJLV39_260013100 , LMJSD75_260011600

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9B7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	381	385	PF00656	0.552
CLV_NRD_NRD_1	271	273	PF00675	0.633
CLV_NRD_NRD_1	304	306	PF00675	0.598
CLV_NRD_NRD_1	347	349	PF00675	0.575
CLV_NRD_NRD_1	352	354	PF00675	0.583
CLV_NRD_NRD_1	465	467	PF00675	0.649
CLV_NRD_NRD_1	54	56	PF00675	0.638
CLV_PCSK_KEX2_1	271	273	PF00082	0.633
CLV_PCSK_KEX2_1	304	306	PF00082	0.580
CLV_PCSK_KEX2_1	346	348	PF00082	0.571
CLV_PCSK_KEX2_1	352	354	PF00082	0.577
CLV_PCSK_KEX2_1	417	419	PF00082	0.463
CLV_PCSK_KEX2_1	465	467	PF00082	0.638
CLV_PCSK_KEX2_1	499	501	PF00082	0.534
CLV_PCSK_KEX2_1	510	512	PF00082	0.413
CLV_PCSK_KEX2_1	54	56	PF00082	0.638
CLV_PCSK_KEX2_1	7	9	PF00082	0.569
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.603
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.518
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.534
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.413
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.569
CLV_PCSK_PC7_1	348	354	PF00082	0.524
CLV_PCSK_SKI1_1	390	394	PF00082	0.475
CLV_PCSK_SKI1_1	453	457	PF00082	0.680
CLV_PCSK_SKI1_1	472	476	PF00082	0.450
CLV_PCSK_SKI1_1	527	531	PF00082	0.503
CLV_Separin_Metazoa	51	55	PF03568	0.630
DEG_Nend_UBRbox_2	1	3	PF02207	0.611
DOC_ANK_TNKS_1	212	219	PF00023	0.530
DOC_CKS1_1	33	38	PF01111	0.584
DOC_MAPK_gen_1	477	486	PF00069	0.494
DOC_MAPK_MEF2A_6	480	488	PF00069	0.530
DOC_PP4_FxxP_1	375	378	PF00568	0.648
DOC_USP7_MATH_1	147	151	PF00917	0.626
DOC_USP7_MATH_1	378	382	PF00917	0.588
DOC_USP7_MATH_1	459	463	PF00917	0.710
DOC_USP7_MATH_1	509	513	PF00917	0.597
DOC_USP7_MATH_1	525	529	PF00917	0.413
DOC_USP7_MATH_2	240	246	PF00917	0.627
DOC_WW_Pin1_4	114	119	PF00397	0.576
DOC_WW_Pin1_4	128	133	PF00397	0.513
DOC_WW_Pin1_4	206	211	PF00397	0.565
DOC_WW_Pin1_4	25	30	PF00397	0.576
DOC_WW_Pin1_4	32	37	PF00397	0.543
DOC_WW_Pin1_4	91	96	PF00397	0.481
LIG_14-3-3_CanoR_1	121	127	PF00244	0.657
LIG_14-3-3_CanoR_1	146	152	PF00244	0.567
LIG_14-3-3_CanoR_1	24	29	PF00244	0.578
LIG_14-3-3_CanoR_1	271	279	PF00244	0.589
LIG_14-3-3_CanoR_1	319	324	PF00244	0.632
LIG_14-3-3_CanoR_1	372	376	PF00244	0.642
LIG_14-3-3_CanoR_1	480	485	PF00244	0.608
LIG_14-3-3_CanoR_1	54	60	PF00244	0.640
LIG_APCC_ABBA_1	394	399	PF00400	0.439
LIG_BRCT_BRCA1_1	2	6	PF00533	0.500
LIG_BRCT_BRCA1_1	27	31	PF00533	0.495
LIG_BRCT_BRCA1_1	525	529	PF00533	0.517
LIG_FHA_1	469	475	PF00498	0.543
LIG_FHA_1	481	487	PF00498	0.466
LIG_FHA_1	512	518	PF00498	0.484
LIG_FHA_2	311	317	PF00498	0.663
LIG_FHA_2	359	365	PF00498	0.461
LIG_FHA_2	528	534	PF00498	0.497
LIG_Integrin_RGD_1	327	329	PF01839	0.549
LIG_LIR_Apic_2	373	378	PF02991	0.647
LIG_LIR_Apic_2	521	525	PF02991	0.512
LIG_LIR_Gen_1	280	289	PF02991	0.542
LIG_LIR_Gen_1	391	400	PF02991	0.444
LIG_LIR_Gen_1	473	481	PF02991	0.556
LIG_LIR_Gen_1	528	539	PF02991	0.498
LIG_LIR_Nem_3	104	109	PF02991	0.615
LIG_LIR_Nem_3	179	185	PF02991	0.528
LIG_LIR_Nem_3	3	9	PF02991	0.497
LIG_LIR_Nem_3	391	396	PF02991	0.450
LIG_LIR_Nem_3	473	478	PF02991	0.559
LIG_LIR_Nem_3	528	534	PF02991	0.494
LIG_LIR_Nem_3	78	83	PF02991	0.478
LIG_LYPXL_yS_3	182	185	PF13949	0.537
LIG_RPA_C_Fungi	343	355	PF08784	0.557
LIG_SH2_CRK	11	15	PF00017	0.516
LIG_SH2_NCK_1	11	15	PF00017	0.516
LIG_SH2_NCK_1	190	194	PF00017	0.542
LIG_SH2_NCK_1	397	401	PF00017	0.430
LIG_SH2_SRC	397	400	PF00017	0.432
LIG_SH2_STAT3	246	249	PF00017	0.648
LIG_SH2_STAT3	83	86	PF00017	0.506
LIG_SH2_STAT5	20	23	PF00017	0.507
LIG_SH2_STAT5	268	271	PF00017	0.616
LIG_SH2_STAT5	83	86	PF00017	0.542
LIG_SH3_2	33	38	PF14604	0.569
LIG_SH3_3	30	36	PF00018	0.585
LIG_TRAF2_1	408	411	PF00917	0.457
LIG_TRAF2_1	495	498	PF00917	0.686
LIG_UBA3_1	413	417	PF00899	0.519
MOD_CDK_SPxK_1	32	38	PF00069	0.570
MOD_CDK_SPxxK_3	114	121	PF00069	0.578
MOD_CDK_SPxxK_3	206	213	PF00069	0.599
MOD_CDK_SPxxK_3	91	98	PF00069	0.487
MOD_CK1_1	101	107	PF00069	0.620
MOD_CK1_1	133	139	PF00069	0.649
MOD_CK1_1	201	207	PF00069	0.669
MOD_CK1_1	209	215	PF00069	0.575
MOD_CK1_1	222	228	PF00069	0.636
MOD_CK1_1	368	374	PF00069	0.600
MOD_CK2_1	222	228	PF00069	0.644
MOD_CK2_1	310	316	PF00069	0.666
MOD_CK2_1	358	364	PF00069	0.457
MOD_CK2_1	382	388	PF00069	0.475
MOD_CK2_1	446	452	PF00069	0.725
MOD_CK2_1	509	515	PF00069	0.511
MOD_CK2_1	529	535	PF00069	0.514
MOD_CK2_1	72	78	PF00069	0.525
MOD_GlcNHglycan	100	103	PF01048	0.609
MOD_GlcNHglycan	162	166	PF01048	0.528
MOD_GlcNHglycan	203	206	PF01048	0.776
MOD_GlcNHglycan	221	224	PF01048	0.551
MOD_GlcNHglycan	228	232	PF01048	0.630
MOD_GlcNHglycan	380	383	PF01048	0.573
MOD_GlcNHglycan	468	471	PF01048	0.547
MOD_GSK3_1	126	133	PF00069	0.600
MOD_GSK3_1	169	176	PF00069	0.536
MOD_GSK3_1	20	27	PF00069	0.530
MOD_GSK3_1	218	225	PF00069	0.655
MOD_GSK3_1	238	245	PF00069	0.495
MOD_GSK3_1	310	317	PF00069	0.699
MOD_GSK3_1	319	326	PF00069	0.751
MOD_GSK3_1	378	385	PF00069	0.571
MOD_GSK3_1	476	483	PF00069	0.529
MOD_GSK3_1	511	518	PF00069	0.523
MOD_GSK3_1	523	530	PF00069	0.450
MOD_GSK3_1	68	75	PF00069	0.577
MOD_N-GLC_1	147	152	PF02516	0.538
MOD_N-GLC_1	290	295	PF02516	0.561
MOD_N-GLC_1	299	304	PF02516	0.580
MOD_N-GLC_1	365	370	PF02516	0.554
MOD_N-GLC_1	430	435	PF02516	0.616
MOD_NEK2_1	1	6	PF00069	0.609
MOD_NEK2_1	155	160	PF00069	0.595
MOD_NEK2_1	219	224	PF00069	0.593
MOD_NEK2_1	309	314	PF00069	0.633
MOD_NEK2_1	323	328	PF00069	0.523
MOD_PIKK_1	109	115	PF00454	0.675
MOD_PIKK_1	173	179	PF00454	0.513
MOD_PIKK_1	222	228	PF00454	0.654
MOD_PIKK_1	272	278	PF00454	0.631
MOD_PIKK_1	358	364	PF00454	0.539
MOD_PIKK_1	382	388	PF00454	0.532
MOD_PIKK_1	436	442	PF00454	0.629
MOD_PIKK_1	53	59	PF00454	0.656
MOD_PIKK_1	533	539	PF00454	0.480
MOD_PIKK_1	68	74	PF00454	0.464
MOD_PKA_1	346	352	PF00069	0.566
MOD_PKA_1	466	472	PF00069	0.536
MOD_PKA_2	120	126	PF00069	0.638
MOD_PKA_2	238	244	PF00069	0.561
MOD_PKA_2	310	316	PF00069	0.623
MOD_PKA_2	346	352	PF00069	0.556
MOD_PKA_2	371	377	PF00069	0.633
MOD_PKA_2	459	465	PF00069	0.607
MOD_PKA_2	476	482	PF00069	0.597
MOD_PKA_2	53	59	PF00069	0.640
MOD_Plk_1	1	7	PF00069	0.573
MOD_Plk_1	147	153	PF00069	0.538
MOD_Plk_1	227	233	PF00069	0.562
MOD_Plk_1	290	296	PF00069	0.560
MOD_Plk_1	299	305	PF00069	0.583
MOD_Plk_1	358	364	PF00069	0.457
MOD_Plk_1	451	457	PF00069	0.658
MOD_Plk_4	163	169	PF00069	0.594
MOD_Plk_4	242	248	PF00069	0.659
MOD_Plk_4	27	33	PF00069	0.493
MOD_Plk_4	371	377	PF00069	0.611
MOD_ProDKin_1	114	120	PF00069	0.576
MOD_ProDKin_1	128	134	PF00069	0.514
MOD_ProDKin_1	206	212	PF00069	0.566
MOD_ProDKin_1	25	31	PF00069	0.579
MOD_ProDKin_1	32	38	PF00069	0.542
MOD_ProDKin_1	91	97	PF00069	0.483
MOD_SUMO_for_1	486	489	PF00179	0.566
MOD_SUMO_for_1	63	66	PF00179	0.623
MOD_SUMO_rev_2	384	392	PF00179	0.507
MOD_SUMO_rev_2	449	455	PF00179	0.596
MOD_SUMO_rev_2	503	512	PF00179	0.514
TRG_DiLeu_BaEn_1	409	414	PF01217	0.466
TRG_DiLeu_LyEn_5	180	185	PF01217	0.531
TRG_DiLeu_LyEn_5	409	414	PF01217	0.466
TRG_ENDOCYTIC_2	182	185	PF00928	0.537
TRG_ENDOCYTIC_2	282	285	PF00928	0.542
TRG_ENDOCYTIC_2	335	338	PF00928	0.615
TRG_ER_diArg_1	271	273	PF00400	0.633
TRG_ER_diArg_1	303	305	PF00400	0.618
TRG_ER_diArg_1	53	55	PF00400	0.636
TRG_NLS_MonoExtN_4	304	309	PF00514	0.625
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2U8	Leptomonas seymouri	34%	95%
A0A3Q8IP13	Leishmania donovani	85%	100%
A4HET2	Leishmania braziliensis	50%	96%
A4I208	Leishmania infantum	85%	100%
E9AY56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%