RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q9B6_LEIMA

TriTrypDb:

LmjF.26.0780 , LMJLV39_260013300 , LMJSD75_260011800

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q9B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9B6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.501
CLV_NRD_NRD_1	18	20	PF00675	0.500
CLV_PCSK_FUR_1	16	20	PF00082	0.499
CLV_PCSK_KEX2_1	15	17	PF00082	0.478
CLV_PCSK_KEX2_1	150	152	PF00082	0.555
CLV_PCSK_KEX2_1	18	20	PF00082	0.476
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.555
DEG_Nend_UBRbox_2	1	3	PF02207	0.629
DEG_SPOP_SBC_1	53	57	PF00917	0.449
DOC_USP7_MATH_1	38	42	PF00917	0.352
LIG_14-3-3_CanoR_1	18	27	PF00244	0.605
LIG_Clathr_ClatBox_1	97	101	PF01394	0.410
LIG_deltaCOP1_diTrp_1	43	49	PF00928	0.311
LIG_FHA_2	20	26	PF00498	0.599
LIG_FHA_2	54	60	PF00498	0.440
LIG_LIR_Gen_1	22	30	PF02991	0.502
LIG_LIR_Gen_1	43	53	PF02991	0.243
LIG_LIR_LC3C_4	122	127	PF02991	0.369
LIG_LIR_Nem_3	22	27	PF02991	0.507
LIG_LIR_Nem_3	43	48	PF02991	0.315
LIG_LIR_Nem_3	74	79	PF02991	0.501
LIG_PCNA_PIPBox_1	58	67	PF02747	0.492
LIG_PCNA_yPIPBox_3	58	69	PF02747	0.520
LIG_Pex14_1	45	49	PF04695	0.360
LIG_SH2_NCK_1	95	99	PF00017	0.426
LIG_SH2_STAP1	106	110	PF00017	0.455
LIG_SH2_STAT5	64	67	PF00017	0.529
LIG_SH2_STAT5	75	78	PF00017	0.456
LIG_SH3_3	123	129	PF00018	0.489
LIG_SH3_3	32	38	PF00018	0.464
LIG_SUMO_SIM_par_1	96	102	PF11976	0.410
LIG_TRAF2_1	56	59	PF00917	0.492
LIG_WRC_WIRS_1	65	70	PF05994	0.492
MOD_CK2_1	19	25	PF00069	0.542
MOD_CK2_1	53	59	PF00069	0.503
MOD_CK2_1	64	70	PF00069	0.496
MOD_GlcNHglycan	119	122	PF01048	0.337
MOD_GSK3_1	1	8	PF00069	0.575
MOD_GSK3_1	113	120	PF00069	0.484
MOD_N-GLC_1	113	118	PF02516	0.177
MOD_NEK2_1	1	6	PF00069	0.595
MOD_NEK2_1	113	118	PF00069	0.477
MOD_NEK2_1	47	52	PF00069	0.413
MOD_NEK2_2	64	69	PF00069	0.455
MOD_PIKK_1	19	25	PF00454	0.600
MOD_PIKK_1	54	60	PF00454	0.504
MOD_Plk_1	1	7	PF00069	0.510
MOD_Plk_4	113	119	PF00069	0.408
MOD_Plk_4	127	133	PF00069	0.395
TRG_ENDOCYTIC_2	24	27	PF00928	0.595
TRG_ENDOCYTIC_2	95	98	PF00928	0.426
TRG_ER_diArg_1	14	16	PF00400	0.494
TRG_ER_diArg_1	17	19	PF00400	0.489
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVV4	Leptomonas seymouri	77%	100%
A0A0S4J314	Bodo saltans	34%	100%
A0A3R7NI30	Trypanosoma rangeli	46%	95%
A0A3S7WZQ8	Leishmania donovani	96%	100%
A4HET3	Leishmania braziliensis	88%	100%
A4I209	Leishmania infantum	96%	100%
C9ZS03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	97%
E9AY57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q21832	Caenorhabditis elegans	33%	100%