Glutathione peroxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

type II (glutathione peroxidase-like) tryparedoxin peroxidase

Species:

Leishmania major

UniProt:

Q4Q9B3_LEIMA

TriTrypDb:

LmjF.26.0810 , LMJLV39_260013600 , LMJSD75_260012100

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9B3

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	25
GO:0006979	response to oxidative stress	3	25
GO:0050896	response to stimulus	1	25

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004601	peroxidase activity	2	25
GO:0004602	glutathione peroxidase activity	3	25
GO:0016209	antioxidant activity	1	25
GO:0016491	oxidoreductase activity	2	25
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	25
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.509
CLV_PCSK_SKI1_1	131	135	PF00082	0.547
CLV_PCSK_SKI1_1	169	173	PF00082	0.535
DEG_Nend_Nbox_1	1	3	PF02207	0.692
DOC_MAPK_gen_1	67	76	PF00069	0.470
DOC_MAPK_MEF2A_6	69	78	PF00069	0.349
DOC_PP1_RVXF_1	67	74	PF00149	0.533
DOC_PP2B_LxvP_1	2	5	PF13499	0.579
DOC_USP7_MATH_1	14	18	PF00917	0.582
DOC_USP7_MATH_1	162	166	PF00917	0.481
DOC_USP7_UBL2_3	127	131	PF12436	0.615
LIG_DCNL_PONY_1	1	4	PF03556	0.587
LIG_EVH1_1	4	8	PF00568	0.502
LIG_FHA_1	134	140	PF00498	0.476
LIG_FHA_1	142	148	PF00498	0.388
LIG_FHA_2	161	167	PF00498	0.571
LIG_FHA_2	88	94	PF00498	0.420
LIG_LIR_Nem_3	62	68	PF02991	0.390
LIG_Pex14_2	102	106	PF04695	0.389
LIG_SH2_CRK	123	127	PF00017	0.520
LIG_SH2_NCK_1	45	49	PF00017	0.406
LIG_SH2_NCK_1	58	62	PF00017	0.384
LIG_SH2_STAP1	20	24	PF00017	0.412
LIG_SH2_STAT5	125	128	PF00017	0.429
LIG_SH3_3	2	8	PF00018	0.694
LIG_TRAF2_1	84	87	PF00917	0.425
LIG_TRAF2_1	90	93	PF00917	0.380
LIG_WRC_WIRS_1	94	99	PF05994	0.409
MOD_CK2_1	160	166	PF00069	0.530
MOD_CK2_1	87	93	PF00069	0.402
MOD_GlcNHglycan	178	181	PF01048	0.610
MOD_GSK3_1	93	100	PF00069	0.409
MOD_N-GLC_1	141	146	PF02516	0.414
MOD_N-GLC_1	24	29	PF02516	0.518
MOD_N-GLC_2	128	130	PF02516	0.517
MOD_NEK2_1	126	131	PF00069	0.498
MOD_NEK2_1	134	139	PF00069	0.500
MOD_NEK2_1	97	102	PF00069	0.412
MOD_Plk_1	141	147	PF00069	0.412
MOD_Plk_2-3	87	93	PF00069	0.500
MOD_Plk_4	134	140	PF00069	0.517
MOD_Plk_4	15	21	PF00069	0.433
MOD_SUMO_for_1	102	105	PF00179	0.453
MOD_SUMO_rev_2	165	172	PF00179	0.510
MOD_SUMO_rev_2	17	24	PF00179	0.489
MOD_SUMO_rev_2	178	185	PF00179	0.687
MOD_SUMO_rev_2	87	97	PF00179	0.378
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.497
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.392
TRG_ENDOCYTIC_2	123	126	PF00928	0.389
TRG_ENDOCYTIC_2	68	71	PF00928	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZD2	Leptomonas seymouri	30%	100%
A0A0S4IL06	Bodo saltans	71%	100%
A0A0S4IL19	Bodo saltans	71%	100%
A0A0S4IZF2	Bodo saltans	70%	100%
A0A0S4JV67	Bodo saltans	35%	100%
A0A1X0NS99	Trypanosomatidae	34%	100%
A0A1X0NSC3	Trypanosomatidae	67%	100%
A0A1X0NSD3	Trypanosomatidae	72%	100%
A0A1X0NSE0	Trypanosomatidae	66%	100%
A0A3Q8IDK7	Leishmania donovani	94%	100%
A0A3Q8IDS3	Leishmania donovani	95%	100%
A0A3Q8IKY0	Leishmania donovani	31%	100%
A0A422NMY9	Trypanosoma rangeli	70%	100%
A0A422NMZ4	Trypanosoma rangeli	70%	100%
A0A422NNB6	Trypanosoma rangeli	72%	99%
A0A422NZP6	Trypanosoma rangeli	31%	100%
A1KV41	Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)	38%	100%
A4HET6	Leishmania braziliensis	85%	100%
A4HET7	Leishmania braziliensis	80%	100%
A4HPG7	Leishmania braziliensis	31%	100%
A4I211	Leishmania infantum	95%	100%
A4I212	Leishmania infantum	94%	100%
A4ID89	Leishmania infantum	31%	100%
A6QLY2	Bos taurus	36%	100%
C9ZRZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
C9ZS00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
D0AAG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AT79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AY59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AY60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
G9JJU2	Procambarus clarkii	31%	100%
O02621	Caenorhabditis elegans	44%	100%
O04922	Arabidopsis thaliana	51%	100%
O08368	Pseudomonas wisconsinensis	31%	86%
O18994	Sus scrofa	33%	87%
O22850	Arabidopsis thaliana	46%	92%
O23814	Spinacia oleracea	52%	100%
O23968	Helianthus annuus	50%	100%
O23970	Helianthus annuus	47%	100%
O24031	Solanum lycopersicum	48%	100%
O24296	Pisum sativum	50%	81%
O32770	Lactococcus lactis subsp. cremoris (strain MG1363)	42%	100%
O46607	Canis lupus familiaris	31%	86%
O48646	Arabidopsis thaliana	53%	82%
O49069	Gossypium hirsutum	48%	100%
O59858	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
O62327	Caenorhabditis elegans	40%	100%
O70325	Mus musculus	40%	96%
O75715	Homo sapiens	35%	86%
P00435	Bos taurus	33%	93%
P04041	Rattus norvegicus	35%	95%
P06610	Escherichia coli (strain K12)	39%	100%
P07203	Homo sapiens	33%	94%
P0A0T4	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	38%	100%
P0A0T5	Neisseria meningitidis serogroup B (strain MC58)	38%	100%
P0C2T0	Neisseria meningitidis serogroup C	38%	100%
P11352	Mus musculus	35%	95%
P11909	Oryctolagus cuniculus	32%	95%
P18283	Homo sapiens	30%	100%
P21765	Mus musculus	33%	86%
P22352	Homo sapiens	33%	84%
P23764	Rattus norvegicus	32%	84%
P28714	Macaca fascicularis	35%	86%
P30708	Nicotiana sylvestris	49%	100%
P30710	Rattus norvegicus	32%	86%
P35666	Wuchereria bancrofti	32%	85%
P36014	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P36968	Sus scrofa	40%	96%
P36969	Homo sapiens	41%	96%
P36970	Rattus norvegicus	40%	96%
P37141	Bos taurus	32%	84%
P38143	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P40581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P46412	Mus musculus	32%	84%
P52032	Arabidopsis thaliana	49%	81%
P52033	Dirofilaria immitis	34%	86%
P52035	Bacillus subtilis (strain 168)	43%	100%
P59796	Homo sapiens	34%	86%
P64290	Staphylococcus aureus (strain Mu50 / ATCC 700699)	45%	100%
P64291	Staphylococcus aureus (strain MW2)	45%	100%
P67877	Brugia malayi	32%	85%
P67878	Brugia pahangi	32%	85%
P74250	Synechocystis sp. (strain PCC 6803 / Kazusa)	45%	100%
P83564	Chlamydomonas reinhardtii	40%	95%
P83645	Rattus norvegicus	31%	100%
P99097	Staphylococcus aureus (strain N315)	45%	100%
Q00277	Schistosoma mansoni	37%	100%
Q06652	Citrus sinensis	50%	100%
Q0EF98	Callithrix jacchus	29%	100%
Q0EF99	Callithrix jacchus	30%	95%
Q0EFA0	Pan troglodytes	32%	95%
Q2NL01	Bos taurus	32%	91%
Q32QL6	Callithrix jacchus	41%	96%
Q4AEG9	Sapajus apella	41%	96%
Q4AEH0	Macaca fuscata fuscata	40%	96%
Q4AEH1	Hylobates lar	40%	96%
Q4AEH2	Pongo pygmaeus	41%	96%
Q4AEH3	Sapajus apella	33%	84%
Q4AEH4	Macaca fuscata fuscata	33%	84%
Q4AEH5	Hylobates lar	33%	84%
Q4AEH7	Sapajus apella	30%	100%
Q4AEH8	Macaca fuscata fuscata	29%	100%
Q4AEH9	Hylobates lar	30%	100%
Q4AEI0	Pongo pygmaeus	30%	100%
Q4AEI1	Sapajus apella	30%	95%
Q4AEI2	Hylobates lar	33%	95%
Q4AEI3	Pongo pygmaeus	33%	95%
Q4Q1B8	Leishmania major	31%	100%
Q4Q9B2	Leishmania major	100%	100%
Q4Q9B4	Leishmania major	100%	100%
Q4RSM6	Tetraodon nigroviridis	26%	90%
Q59WD3	Candida albicans (strain SC5314 / ATCC MYA-2876)	41%	100%
Q5HGC7	Staphylococcus aureus (strain COL)	45%	100%
Q5HKZ3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	42%	100%
Q5RFG3	Pongo pygmaeus	33%	84%
Q5U583	Xenopus laevis	31%	91%
Q64625	Rattus norvegicus	31%	86%
Q6G9Q8	Staphylococcus aureus (strain MSSA476)	45%	100%
Q6GHD0	Staphylococcus aureus (strain MRSA252)	45%	100%
Q6IRC8	Xenopus laevis	30%	91%
Q7ZV14	Danio rerio	29%	90%
Q865R2	Macaca fuscata fuscata	34%	95%
Q8CSR9	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	45%	100%
Q8L910	Arabidopsis thaliana	47%	100%
Q8LBU2	Arabidopsis thaliana	45%	100%
Q8MJ14	Sus scrofa	30%	92%
Q8SSH7	Encephalitozoon cuniculi (strain GB-M1)	36%	100%
Q8TED1	Homo sapiens	31%	91%
Q91WR8	Mus musculus	30%	86%
Q95003	Caenorhabditis elegans	32%	85%
Q96SL4	Homo sapiens	36%	100%
Q98234	Molluscum contagiosum virus subtype 1	32%	86%
Q99LJ6	Mus musculus	40%	100%
Q9CFV1	Lactococcus lactis subsp. lactis (strain IL1403)	40%	100%
Q9D7B7	Mus musculus	33%	91%
Q9FXS3	Nicotiana tabacum	49%	100%
Q9JHC0	Mus musculus	31%	100%
Q9LEF0	Mesembryanthemum crystallinum	50%	100%
Q9LYB4	Arabidopsis thaliana	53%	100%
Q9N2J2	Bos taurus	40%	96%
Q9SZ54	Arabidopsis thaliana	50%	82%
Q9Z9N7	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	44%	100%
V5B9J0	Trypanosoma cruzi	69%	100%
V5BZH0	Trypanosoma cruzi	67%	100%