Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9B0_LEIMA

TriTrypDb:

LmjF.26.0840 , LMJLV39_260013900 , LMJSD75_260012300

Length:

946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9B0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.652
CLV_NRD_NRD_1	110	112	PF00675	0.630
CLV_NRD_NRD_1	275	277	PF00675	0.631
CLV_NRD_NRD_1	590	592	PF00675	0.541
CLV_NRD_NRD_1	63	65	PF00675	0.535
CLV_NRD_NRD_1	731	733	PF00675	0.616
CLV_NRD_NRD_1	856	858	PF00675	0.604
CLV_PCSK_KEX2_1	110	112	PF00082	0.630
CLV_PCSK_KEX2_1	381	383	PF00082	0.627
CLV_PCSK_KEX2_1	440	442	PF00082	0.441
CLV_PCSK_KEX2_1	590	592	PF00082	0.541
CLV_PCSK_KEX2_1	61	63	PF00082	0.585
CLV_PCSK_KEX2_1	731	733	PF00082	0.616
CLV_PCSK_KEX2_1	856	858	PF00082	0.574
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.627
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.517
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.559
CLV_PCSK_PC7_1	58	64	PF00082	0.544
CLV_PCSK_SKI1_1	309	313	PF00082	0.657
CLV_PCSK_SKI1_1	454	458	PF00082	0.470
CLV_PCSK_SKI1_1	491	495	PF00082	0.505
CLV_PCSK_SKI1_1	53	57	PF00082	0.559
CLV_PCSK_SKI1_1	746	750	PF00082	0.531
CLV_PCSK_SKI1_1	77	81	PF00082	0.545
CLV_PCSK_SKI1_1	823	827	PF00082	0.507
CLV_PCSK_SKI1_1	850	854	PF00082	0.627
CLV_PCSK_SKI1_1	868	872	PF00082	0.495
CLV_PCSK_SKI1_1	87	91	PF00082	0.554
DEG_APCC_DBOX_1	769	777	PF00400	0.572
DEG_SPOP_SBC_1	11	15	PF00917	0.611
DEG_SPOP_SBC_1	255	259	PF00917	0.704
DEG_SPOP_SBC_1	369	373	PF00917	0.550
DEG_SPOP_SBC_1	533	537	PF00917	0.512
DOC_ANK_TNKS_1	797	804	PF00023	0.537
DOC_CKS1_1	207	212	PF01111	0.593
DOC_CKS1_1	486	491	PF01111	0.496
DOC_CKS1_1	702	707	PF01111	0.657
DOC_CYCLIN_RxL_1	50	60	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	328	334	PF00134	0.689
DOC_MAPK_DCC_7	651	661	PF00069	0.614
DOC_MAPK_gen_1	274	281	PF00069	0.580
DOC_MAPK_gen_1	451	459	PF00069	0.463
DOC_MAPK_gen_1	61	69	PF00069	0.511
DOC_MAPK_gen_1	97	106	PF00069	0.512
DOC_MAPK_HePTP_8	94	106	PF00069	0.510
DOC_MAPK_MEF2A_6	463	471	PF00069	0.516
DOC_MAPK_MEF2A_6	97	106	PF00069	0.512
DOC_PP1_RVXF_1	51	58	PF00149	0.536
DOC_PP1_RVXF_1	538	544	PF00149	0.465
DOC_PP1_RVXF_1	885	891	PF00149	0.543
DOC_PP2B_LxvP_1	644	647	PF13499	0.578
DOC_SPAK_OSR1_1	40	44	PF12202	0.537
DOC_USP7_MATH_1	12	16	PF00917	0.569
DOC_USP7_MATH_1	226	230	PF00917	0.685
DOC_USP7_MATH_1	255	259	PF00917	0.704
DOC_USP7_MATH_1	333	337	PF00917	0.633
DOC_USP7_MATH_1	34	38	PF00917	0.494
DOC_USP7_MATH_1	369	373	PF00917	0.656
DOC_USP7_MATH_1	517	521	PF00917	0.492
DOC_USP7_MATH_1	533	537	PF00917	0.512
DOC_USP7_MATH_1	600	604	PF00917	0.668
DOC_USP7_MATH_1	698	702	PF00917	0.706
DOC_USP7_MATH_1	904	908	PF00917	0.550
DOC_USP7_UBL2_3	699	703	PF12436	0.661
DOC_USP7_UBL2_3	883	887	PF12436	0.622
DOC_USP7_UBL2_3	93	97	PF12436	0.515
DOC_WW_Pin1_4	15	20	PF00397	0.676
DOC_WW_Pin1_4	192	197	PF00397	0.659
DOC_WW_Pin1_4	206	211	PF00397	0.590
DOC_WW_Pin1_4	218	223	PF00397	0.640
DOC_WW_Pin1_4	315	320	PF00397	0.684
DOC_WW_Pin1_4	327	332	PF00397	0.541
DOC_WW_Pin1_4	431	436	PF00397	0.485
DOC_WW_Pin1_4	485	490	PF00397	0.509
DOC_WW_Pin1_4	614	619	PF00397	0.705
DOC_WW_Pin1_4	701	706	PF00397	0.652
DOC_WW_Pin1_4	871	876	PF00397	0.549
LIG_14-3-3_CanoR_1	441	446	PF00244	0.429
LIG_14-3-3_CanoR_1	454	460	PF00244	0.505
LIG_14-3-3_CanoR_1	501	510	PF00244	0.440
LIG_14-3-3_CanoR_1	715	720	PF00244	0.602
LIG_14-3-3_CanoR_1	77	82	PF00244	0.547
LIG_14-3-3_CanoR_1	903	909	PF00244	0.544
LIG_BRCT_BRCA1_1	528	532	PF00533	0.517
LIG_CaM_IQ_9	69	84	PF13499	0.607
LIG_Clathr_ClatBox_1	456	460	PF01394	0.476
LIG_Clathr_ClatBox_1	567	571	PF01394	0.450
LIG_EH1_1	247	255	PF00400	0.684
LIG_FHA_1	21	27	PF00498	0.606
LIG_FHA_1	536	542	PF00498	0.475
LIG_FHA_1	611	617	PF00498	0.632
LIG_FHA_1	670	676	PF00498	0.632
LIG_FHA_1	74	80	PF00498	0.535
LIG_FHA_1	794	800	PF00498	0.523
LIG_FHA_1	802	808	PF00498	0.530
LIG_FHA_1	809	815	PF00498	0.479
LIG_FHA_1	883	889	PF00498	0.583
LIG_FHA_1	914	920	PF00498	0.581
LIG_FHA_2	137	143	PF00498	0.649
LIG_FHA_2	161	167	PF00498	0.590
LIG_FHA_2	230	236	PF00498	0.683
LIG_FHA_2	369	375	PF00498	0.584
LIG_FHA_2	492	498	PF00498	0.456
LIG_FHA_2	680	686	PF00498	0.702
LIG_FHA_2	702	708	PF00498	0.656
LIG_FHA_2	872	878	PF00498	0.615
LIG_FHA_2	926	932	PF00498	0.533
LIG_GBD_Chelix_1	744	752	PF00786	0.531
LIG_HCF-1_HBM_1	756	759	PF13415	0.543
LIG_LIR_Apic_2	204	210	PF02991	0.607
LIG_LIR_Apic_2	485	489	PF02991	0.507
LIG_LIR_Apic_2	700	705	PF02991	0.658
LIG_LIR_Gen_1	576	584	PF02991	0.529
LIG_LIR_Gen_1	765	776	PF02991	0.565
LIG_LIR_Nem_3	452	456	PF02991	0.452
LIG_LIR_Nem_3	494	498	PF02991	0.448
LIG_LIR_Nem_3	563	568	PF02991	0.440
LIG_LIR_Nem_3	576	582	PF02991	0.536
LIG_LIR_Nem_3	724	730	PF02991	0.586
LIG_LIR_Nem_3	830	835	PF02991	0.528
LIG_MYND_1	641	645	PF01753	0.601
LIG_PCNA_yPIPBox_3	90	102	PF02747	0.516
LIG_PDZ_Class_3	941	946	PF00595	0.679
LIG_Pex14_2	449	453	PF04695	0.426
LIG_Pex14_2	723	727	PF04695	0.579
LIG_Pex14_2	815	819	PF04695	0.496
LIG_REV1ctd_RIR_1	888	898	PF16727	0.539
LIG_RPA_C_Fungi	28	40	PF08784	0.485
LIG_SH2_CRK	207	211	PF00017	0.634
LIG_SH2_CRK	477	481	PF00017	0.451
LIG_SH2_CRK	486	490	PF00017	0.498
LIG_SH2_CRK	65	69	PF00017	0.531
LIG_SH2_CRK	702	706	PF00017	0.635
LIG_SH2_CRK	832	836	PF00017	0.524
LIG_SH2_NCK_1	207	211	PF00017	0.609
LIG_SH2_SRC	759	762	PF00017	0.622
LIG_SH2_STAP1	427	431	PF00017	0.574
LIG_SH2_STAT5	404	407	PF00017	0.651
LIG_SH2_STAT5	448	451	PF00017	0.428
LIG_SH2_STAT5	477	480	PF00017	0.443
LIG_SH2_STAT5	510	513	PF00017	0.476
LIG_SH2_STAT5	65	68	PF00017	0.527
LIG_SH2_STAT5	759	762	PF00017	0.546
LIG_SH3_3	292	298	PF00018	0.610
LIG_SH3_3	360	366	PF00018	0.701
LIG_SH3_3	639	645	PF00018	0.621
LIG_SH3_3	662	668	PF00018	0.609
LIG_SH3_3	716	722	PF00018	0.597
LIG_SH3_3	737	743	PF00018	0.565
LIG_SH3_3	878	884	PF00018	0.531
LIG_SH3_4	883	890	PF00018	0.620
LIG_SUMO_SIM_par_1	330	337	PF11976	0.635
LIG_SUMO_SIM_par_1	455	461	PF11976	0.511
LIG_SUMO_SIM_par_1	566	571	PF11976	0.454
LIG_TRAF2_1	133	136	PF00917	0.731
LIG_TRAF2_1	141	144	PF00917	0.602
LIG_TRAF2_1	269	272	PF00917	0.529
LIG_TRAF2_1	694	697	PF00917	0.705
LIG_TRAF2_1	907	910	PF00917	0.536
LIG_TRAF2_2	223	228	PF00917	0.640
LIG_TYR_ITSM	828	835	PF00017	0.444
MOD_CDK_SPK_2	614	619	PF00069	0.560
MOD_CDK_SPxK_1	485	491	PF00069	0.494
MOD_CK1_1	15	21	PF00069	0.566
MOD_CK1_1	229	235	PF00069	0.690
MOD_CK1_1	257	263	PF00069	0.710
MOD_CK1_1	342	348	PF00069	0.555
MOD_CK1_1	485	491	PF00069	0.517
MOD_CK1_1	535	541	PF00069	0.482
MOD_CK1_1	580	586	PF00069	0.541
MOD_CK1_1	687	693	PF00069	0.646
MOD_CK1_1	701	707	PF00069	0.644
MOD_CK1_1	886	892	PF00069	0.546
MOD_CK1_1	893	899	PF00069	0.535
MOD_CK2_1	138	144	PF00069	0.644
MOD_CK2_1	229	235	PF00069	0.690
MOD_CK2_1	257	263	PF00069	0.705
MOD_CK2_1	368	374	PF00069	0.643
MOD_CK2_1	491	497	PF00069	0.506
MOD_CK2_1	580	586	PF00069	0.541
MOD_CK2_1	670	676	PF00069	0.619
MOD_CK2_1	679	685	PF00069	0.659
MOD_CK2_1	750	756	PF00069	0.527
MOD_CK2_1	871	877	PF00069	0.545
MOD_CK2_1	903	909	PF00069	0.548
MOD_CK2_1	925	931	PF00069	0.602
MOD_GlcNHglycan	214	217	PF01048	0.658
MOD_GlcNHglycan	341	344	PF01048	0.548
MOD_GlcNHglycan	354	357	PF01048	0.547
MOD_GlcNHglycan	526	529	PF01048	0.507
MOD_GlcNHglycan	601	605	PF01048	0.672
MOD_GlcNHglycan	631	634	PF01048	0.801
MOD_GlcNHglycan	683	689	PF01048	0.621
MOD_GlcNHglycan	935	938	PF01048	0.595
MOD_GSK3_1	11	18	PF00069	0.587
MOD_GSK3_1	151	158	PF00069	0.775
MOD_GSK3_1	254	261	PF00069	0.653
MOD_GSK3_1	338	345	PF00069	0.691
MOD_GSK3_1	427	434	PF00069	0.541
MOD_GSK3_1	461	468	PF00069	0.608
MOD_GSK3_1	573	580	PF00069	0.505
MOD_GSK3_1	600	607	PF00069	0.609
MOD_GSK3_1	610	617	PF00069	0.593
MOD_GSK3_1	631	638	PF00069	0.664
MOD_GSK3_1	697	704	PF00069	0.675
MOD_GSK3_1	73	80	PF00069	0.540
MOD_GSK3_1	882	889	PF00069	0.543
MOD_GSK3_1	890	897	PF00069	0.542
MOD_GSK3_1	913	920	PF00069	0.584
MOD_N-GLC_1	102	107	PF02516	0.523
MOD_N-GLC_1	239	244	PF02516	0.658
MOD_N-GLC_1	352	357	PF02516	0.563
MOD_N-GLC_1	465	470	PF02516	0.530
MOD_N-GLC_1	48	53	PF02516	0.558
MOD_N-GLC_1	577	582	PF02516	0.524
MOD_N-GLC_1	670	675	PF02516	0.654
MOD_N-GLC_1	715	720	PF02516	0.602
MOD_N-GLC_1	73	78	PF02516	0.619
MOD_N-GLC_1	809	814	PF02516	0.478
MOD_N-GLC_1	904	909	PF02516	0.549
MOD_N-GLC_2	775	777	PF02516	0.574
MOD_NEK2_1	20	25	PF00069	0.594
MOD_NEK2_1	227	232	PF00069	0.710
MOD_NEK2_1	256	261	PF00069	0.659
MOD_NEK2_1	426	431	PF00069	0.653
MOD_NEK2_1	577	582	PF00069	0.524
MOD_NEK2_1	584	589	PF00069	0.533
MOD_NEK2_1	605	610	PF00069	0.550
MOD_NEK2_1	669	674	PF00069	0.627
MOD_NEK2_1	771	776	PF00069	0.568
MOD_NEK2_1	848	853	PF00069	0.626
MOD_NEK2_1	890	895	PF00069	0.545
MOD_PIKK_1	227	233	PF00454	0.708
MOD_PIKK_1	461	467	PF00454	0.520
MOD_PKA_1	110	116	PF00069	0.631
MOD_PKA_2	110	116	PF00069	0.631
MOD_PKA_2	275	281	PF00069	0.574
MOD_PKA_2	547	553	PF00069	0.502
MOD_PKA_2	893	899	PF00069	0.535
MOD_PKA_2	933	939	PF00069	0.583
MOD_PKB_1	892	900	PF00069	0.537
MOD_Plk_1	102	108	PF00069	0.538
MOD_Plk_1	427	433	PF00069	0.552
MOD_Plk_1	465	471	PF00069	0.546
MOD_Plk_1	577	583	PF00069	0.528
MOD_Plk_1	584	590	PF00069	0.536
MOD_Plk_1	670	676	PF00069	0.656
MOD_Plk_1	715	721	PF00069	0.600
MOD_Plk_1	750	756	PF00069	0.527
MOD_Plk_1	809	815	PF00069	0.479
MOD_Plk_1	904	910	PF00069	0.546
MOD_Plk_2-3	136	142	PF00069	0.690
MOD_Plk_2-3	299	305	PF00069	0.717
MOD_Plk_2-3	679	685	PF00069	0.600
MOD_Plk_2-3	750	756	PF00069	0.527
MOD_Plk_4	421	427	PF00069	0.609
MOD_Plk_4	584	590	PF00069	0.536
MOD_Plk_4	670	676	PF00069	0.632
MOD_Plk_4	787	793	PF00069	0.537
MOD_Plk_4	810	816	PF00069	0.477
MOD_Plk_4	886	892	PF00069	0.546
MOD_Plk_4	917	923	PF00069	0.511
MOD_ProDKin_1	15	21	PF00069	0.668
MOD_ProDKin_1	192	198	PF00069	0.658
MOD_ProDKin_1	206	212	PF00069	0.592
MOD_ProDKin_1	218	224	PF00069	0.640
MOD_ProDKin_1	315	321	PF00069	0.684
MOD_ProDKin_1	327	333	PF00069	0.538
MOD_ProDKin_1	431	437	PF00069	0.476
MOD_ProDKin_1	485	491	PF00069	0.508
MOD_ProDKin_1	614	620	PF00069	0.705
MOD_ProDKin_1	701	707	PF00069	0.650
MOD_ProDKin_1	871	877	PF00069	0.545
MOD_SUMO_for_1	799	802	PF00179	0.539
MOD_SUMO_rev_2	302	311	PF00179	0.647
MOD_SUMO_rev_2	673	680	PF00179	0.634
MOD_SUMO_rev_2	696	701	PF00179	0.699
TRG_DiLeu_BaEn_1	452	457	PF01217	0.450
TRG_DiLeu_BaEn_1	756	761	PF01217	0.621
TRG_DiLeu_BaEn_1	802	807	PF01217	0.538
TRG_DiLeu_BaEn_2	916	922	PF01217	0.508
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.436
TRG_DiLeu_LyEn_5	639	644	PF01217	0.539
TRG_ENDOCYTIC_2	477	480	PF00928	0.443
TRG_ENDOCYTIC_2	65	68	PF00928	0.527
TRG_ENDOCYTIC_2	768	771	PF00928	0.571
TRG_ENDOCYTIC_2	832	835	PF00928	0.527
TRG_ER_diArg_1	109	111	PF00400	0.646
TRG_ER_diArg_1	38	41	PF00400	0.539
TRG_ER_diArg_1	589	591	PF00400	0.534
TRG_ER_diArg_1	62	64	PF00400	0.553
TRG_ER_diArg_1	730	732	PF00400	0.607
TRG_ER_diArg_1	891	894	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	566	571	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	823	827	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I256	Leptomonas seymouri	63%	95%
A0A3S7WZV1	Leishmania donovani	94%	100%
A4HET9	Leishmania braziliensis	81%	100%
A4I214	Leishmania infantum	94%	100%
E9AY62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%